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UniProtKB - Q541P7 (Q541P7_HUMAN)
Protein
Receptor protein-tyrosine kinase
Gene
EPHB4
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 647 | ATPUniRule annotation | 1 | |
Active sitei | 740 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 621 – 629 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ephrin receptor activity Source: InterPro
- protein serine/threonine/tyrosine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, ReceptorImportedARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EPHB4Imported ORF Names:hCG_20448Imported, tcag7.1248Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000196411 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 538 – 563 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5014309534 | 16 – 987 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 972 |
Keywords - PTMi
GlycoproteinARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000196411, Expressed in dorsal plus ventral thalamus and 242 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 202 | Eph LBDInterPro annotationAdd BLAST | 186 | |
Domaini | 323 – 432 | Fibronectin type-IIIInterPro annotationAdd BLAST | 110 | |
Domaini | 436 – 529 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 615 – 899 | Protein kinaseInterPro annotationAdd BLAST | 285 | |
Domaini | 907 – 971 | SAMInterPro annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 965 – 987 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OMAi | AYCIRRH |
OrthoDBi | 933071at2759 |
Family and domain databases
CDDi | cd10474, EphR_LBD_B4, 1 hit cd00063, FN3, 2 hits cd09554, SAM_EPH-B4, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR037636, EPH-B4_SAM IPR027936, Eph_TM IPR034290, EphB4_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF07699, Ephrin_rec_like, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q541P7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELRVLLCWA SLAAALEETL LNTKLETADL KWVTFPQVDG QWEELSGLDE
60 70 80 90 100
EQHSVRTYEV CDVQRAPGQA HWLRTGWVPR RGAVHVYATL RFTMLECLSL
110 120 130 140 150
PRAGRSCKET FTVFYYESDA DTATALTPAW MENPYIKVDT VAAEHLTRKR
160 170 180 190 200
PGAEATGKVN VKTLRLGPLS KAGFYLAFQD QGACMALLSL HLFYKKCAQL
210 220 230 240 250
TVNLTRFPET VPRELVVPVA GSCVVDAVPA PGPSPSLYCR EDGQWAEQPV
260 270 280 290 300
TGCSCAPGFE AAEGNTKCRA CAQGTFKPLS GEGSCQPCPA NSHSNTIGSA
310 320 330 340 350
VCQCRVGYFR ARTDPRGAPC TTPPSAPRSV VSRLNGSSLH LEWSAPLESG
360 370 380 390 400
GREDLTYALR CRECRPGGSC APCGGDLTFD PGPRDLVEPW VVVRGLRPDF
410 420 430 440 450
TYTFEVTALN GVSSLATGPV PFEPVNVTTD REVPPAVSDI RVTRSSPSSL
460 470 480 490 500
SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS SVRFLKTSEN RAELRGLKRG
510 520 530 540 550
ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE SEGWREQLAL IAGTAVVGVV
560 570 580 590 600
LVLVVIVVAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN
610 620 630 640 650
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK
660 670 680 690 700
GGYTERQRRE FLSEASIMGQ FEHPNIIRLE GVVTNSMPVM ILTEFMENGA
710 720 730 740 750
LDSFLRLNDG QFTVIQLVGM LRGIASGMRY LAEMSYVHRD LAARNILVNS
760 770 780 790 800
NLVCKVSDFG LSRFLEENSS DPTYTSSLGG KIPIRWTAPE AIAFRKFTSA
810 820 830 840 850
SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP PPPDCPTSLH
860 870 880 890 900
QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD
910 920 930 940 950
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI
960 970 980
GVTLAGHQKK ILASVQHMKS QAKPGTPGGT GGPAPQY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY056047 Genomic DNA Translation: AAL14194.1 CH236956 Genomic DNA Translation: EAL23820.1 CH471091 Genomic DNA Translation: EAW76468.1 CH471091 Genomic DNA Translation: EAW76470.1 |
RefSeqi | NP_004435.3, NM_004444.4 |
Genome annotation databases
GeneIDi | 2050 |
KEGGi | hsa:2050 |
MANE-Selecti | ENST00000358173.8; ENSP00000350896.3; NM_004444.5; NP_004435.3 |
UCSCi | uc003uwn.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY056047 Genomic DNA Translation: AAL14194.1 CH236956 Genomic DNA Translation: EAL23820.1 CH471091 Genomic DNA Translation: EAW76468.1 CH471091 Genomic DNA Translation: EAW76470.1 |
RefSeqi | NP_004435.3, NM_004444.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 4623, 722 antibodies from 41 providers |
DNASUi | 2050 |
Genome annotation databases
GeneIDi | 2050 |
KEGGi | hsa:2050 |
MANE-Selecti | ENST00000358173.8; ENSP00000350896.3; NM_004444.5; NP_004435.3 |
UCSCi | uc003uwn.2, human |
Organism-specific databases
CTDi | 2050 |
PharmGKBi | PA27827 |
VEuPathDBi | HostDB:ENSG00000196411 |
Phylogenomic databases
OMAi | AYCIRRH |
OrthoDBi | 933071at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2050, 11 hits in 1076 CRISPR screens |
ChiTaRSi | EPHB4, human |
GenomeRNAii | 2050 |
Gene expression databases
Bgeei | ENSG00000196411, Expressed in dorsal plus ventral thalamus and 242 other tissues |
Family and domain databases
CDDi | cd10474, EphR_LBD_B4, 1 hit cd00063, FN3, 2 hits cd09554, SAM_EPH-B4, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR037636, EPH-B4_SAM IPR027936, Eph_TM IPR034290, EphB4_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF07699, Ephrin_rec_like, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q541P7_HUMAN | |
Accessioni | Q541P7Primary (citable) accession number: Q541P7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | January 19, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |