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UniProtKB - Q54151 (PIC_SHIFL)

Entry version 131 (10 Feb 2021)
Sequence version 3 (19 Jul 2005)
Previous versions | rss
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Protein

Serine protease pic autotransporter

Gene

pic

Organism
Shigella flexneri
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in intestinal colonization, displays in vitro mucinolytic activity, serum resistance, and hemagglutination. Important to penetrate the intestinal mucus layer.1 Publication

Miscellaneous

The S.flexneri genes encoding ShET1 enterotoxin subunits set1A and set1B are contained within the pic gene, on the complementary non-coding strand.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei127Charge relay systemPROSITE-ProRule annotation1
Active sitei155Charge relay systemPROSITE-ProRule annotation1
Active sitei258Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processVirulence

Protein family/group databases

MEROPS protease database

More...MEROPSi		S06.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease pic autotransporter (EC:3.4.21.-)
Alternative name(s):
ShMu
Cleaved into the following 2 chains:
Serine protease pic
Serine protease pic translocator
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pic
Synonyms:she, sigA
Ordered Locus Names:SF2973, S3178
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiShigella flexneri
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri623 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002673 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:2980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 55Sequence analysisAdd BLAST55
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038760756 – 1372Serine protease pic autotransporterAdd BLAST1317
ChainiPRO_000002697656 – 1095Serine protease picAdd BLAST1040
ChainiPRO_00000269771096 – 1372Serine protease pic translocatorSequence analysisAdd BLAST277

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved to release the mature protein from the outer membrane.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1095 – 1096CleavageSequence analysis2

Keywords - PTMi

Zymogen

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q54151

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 301Peptidase S6PROSITE-ProRule annotationAdd BLAST246
Domaini1106 – 1372AutotransporterPROSITE-ProRule annotationAdd BLAST267

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000723_0_0_6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.160.20.20, 1 hit
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR024973, ESPR
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03797, Autotransporter, 1 hit
PF13018, ESPR, 1 hit
PF02395, Peptidase_S6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00921, IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01414, autotrans_barl, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q54151-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKVYSLKYC PVTGGLIAVS ELARRVIKKT CRRLTHILLA GIPAICLCYS 
        60         70         80         90        100
QISQAGIVRS DIAYQIYRDF AENKGLFVPG ANDIPVYDKD GKLVGRLGKA 
       110        120        130        140        150
PMADFSSVSS NGVATLVSPQ YIVSVKHNGG YRSVSFGNGK NTYSLVDRNN 
       160        170        180        190        200
HPSIDFHAPR LNKLVTEVIP SAVTSEGTKA NAYKYTERYT AFYRVGSGTQ 
       210        220        230        240        250
YTKDKDGNLV KVAGGYAFKT GGTTGVPLIS DATIVSNPGQ TYNPVNGPLP 
       260        270        280        290        300
DYGAPGDSGS PLFAYDKQQK KWVIVAVLRA YAGINGATNW WNVIPTDYLN 
       310        320        330        340        350
QVMQDDFDAP VDFVSGLGPL NWTYDKTSGT GTLSQGSKNW TMHGQKDNDL 
       360        370        380        390        400
NAGKNLVFSG QNGAIILKDS VTQGAGYLEF KDSYTVSAES GKTWTGAGII 
       410        420        430        440        450
TDKGTNVTWK VNGVAGDNLH KLGEGTLTIN GTGVNPGGLK TGDGIVVLNQ 
       460        470        480        490        500
QADTAGNIQA FSSVNLASGR PTVVLGDARQ VNPDNISWGY RGGKLDLNGN 
       510        520        530        540        550
AVTFTRLQAA DYGAVITNNA QQKSQLLLDL KAQDTNVSEP TIGNISPFGG 
       560        570        580        590        600
TGTPGNLYSM ILNSQTRFYI LKSASYGNTL WGNSLNDPAQ WEFVGMNKNK 
       610        620        630        640        650
AVQTVKDRIL AGRAKQPVIF HGQLTGNMDV AIPQVPGGRK VIFDGSVNLP 
       660        670        680        690        700
EGTLSQDSGT LIFQGHPVIH ASISGSAPVS LNQKDWENRQ FTMKTLSLKD 
       710        720        730        740        750
ADFHLSRNAS LNSDIKSDNS HITLGSDRAF VDKNDGTGNY VIPEEGTSVP 
       760        770        780        790        800
DTVNDRSQYE GNITLNHNSA LDIGSRFTGG IDAYDSAVSI TSPDVLLTAP 
       810        820        830        840        850
GAFAGSSLTV HDGGHLTALN GLFSDGHIQA GKNGKITLSG TPVKDTANQY 
       860        870        880        890        900
APAVYLTDGY DLTGDNAALE ITRGAHASGD IHASAASTVT IGSDTPAELA 
       910        920        930        940        950
SAETAASAFA GSLLEGYNAA FNGAITGGRA DVSMHNALWT LGGDSAIHSL 
       960        970        980        990       1000
TVRNSRISSE GDRTFRTLTV NKLDATGSDF VLRTDLKNAD KINVTEKATG 
      1010       1020       1030       1040       1050
SDNSLNVSFM NNPAQGQALN IPLVTAPAGT SAEMFKAGTR VTGFSRVTPT 
      1060       1070       1080       1090       1100
LHVDTSGGNT KWILDGFKAE ADKAAAAKAD SFMNAGYKNF MTEVNNLNKR 
      1110       1120       1130       1140       1150
MGDLRDTNGD AGAWARIMSG AGSADGGYSD NYTHVQVGFD KKHELDGVDL 
      1160       1170       1180       1190       1200
FTGVTMTYTD SSADSHAFSG KTKSVGGGLY ASALFESGAY IDLIGKYIHH 
      1210       1220       1230       1240       1250
DNDYTGNFAS LGTKHYNTHS WYAGAETGYR YHLTEDTFIE PQAELVYGAV 
      1260       1270       1280       1290       1300
SGKTFRWKDG DMDLSMKNRD FSPLVGRTGV ELGKTFSGKD WSVTARAGTS 
      1310       1320       1330       1340       1350
WQFDLLNNGE TVLRDASGEK RIKGEKDSRM LFNVGMNAQI KDNMRFGLEF 
      1360       1370 
EKSAFGKYNV DNAVNANFRY MF
Length:1,372
Mass (Da):146,453
Last modified:July 19, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE47B3C621A61F67
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK00464 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAN44454 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP18274 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti354K → E in strain: M4243 and YSH6000T. 1
Natural varianti385T → P in strain: M4243 and YSH6000T. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U35656 Genomic DNA Translation: AAB58244.1
AF200692 Genomic DNA Translation: AAK00464.1 Different initiation.
AE005674 Genomic DNA Translation: AAN44454.2 Different initiation.
AE014073 Genomic DNA Translation: AAP18274.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		WP_001045650.1, NZ_WPGN01000146.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAN44454; AAN44454; SF2973
AAP18274; AAP18274; S3178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sfx:S3178

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35656 Genomic DNA Translation: AAB58244.1
AF200692 Genomic DNA Translation: AAK00464.1 Different initiation.
AE005674 Genomic DNA Translation: AAN44454.2 Different initiation.
AE014073 Genomic DNA Translation: AAP18274.1 Different initiation.
RefSeqiWP_001045650.1, NZ_WPGN01000146.1

3D structure databases

SMRiQ54151
ModBaseiSearch...

Protein family/group databases

MEROPSiS06.005

Genome annotation databases

EnsemblBacteriaiAAN44454; AAN44454; SF2973
AAP18274; AAP18274; S3178
KEGGisfx:S3178

Phylogenomic databases

HOGENOMiCLU_000723_0_0_6

Miscellaneous databases

PHI-baseiPHI:2980

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR024973, ESPR
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
PfamiView protein in Pfam
PF03797, Autotransporter, 1 hit
PF13018, ESPR, 1 hit
PF02395, Peptidase_S6, 1 hit
PRINTSiPR00921, IGASERPTASE
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 2 hits
TIGRFAMsiTIGR01414, autotrans_barl, 1 hit
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIC_SHIFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54151
Secondary accession number(s): Q7UBM2, Q83Q79, Q9AL58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: February 10, 2021
This is version 131 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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