UniProtKB - Q53YY0 (Q53YY0_HUMAN)
Protein
Submitted name:
Angiotensin II receptor, type 1
Gene
AGTR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- angiotensin type II receptor activity Source: InterPro
GO - Biological processi
- regulation of vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Angiotensin II receptor, type 1ImportedSubmitted name: Angiotensin II receptor, type 1, isoform CRA_bImportedSubmitted name: cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNAImported |
Gene namesi | Name:AGTR1Imported ORF Names:hCG_2022206Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144891.17 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 56 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 68 – 90 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 110 – 131 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 143 – 165 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 201 – 218 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 238 – 262 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 282 – 305 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000144891, Expressed in placenta and 184 other tissues |
ExpressionAtlasi | Q53YY0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 302 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 359 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 335 – 351 | PolarSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_8_3_1 |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53YY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK
KPAPCFEVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY436325 Genomic DNA Translation: AAR03503.1 EU332837 Genomic DNA Translation: ABY87526.1 AK291541 mRNA Translation: BAF84230.1 CH471052 Genomic DNA Translation: EAW78906.1 CH471052 Genomic DNA Translation: EAW78907.1 |
RefSeqi | NP_000676.1, NM_000685.4 NP_033611.1, NM_009585.3 |
Genome annotation databases
GeneIDi | 185 |
KEGGi | hsa:185 |
UCSCi | uc003ewi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY436325 Genomic DNA Translation: AAR03503.1 EU332837 Genomic DNA Translation: ABY87526.1 AK291541 mRNA Translation: BAF84230.1 CH471052 Genomic DNA Translation: EAW78906.1 CH471052 Genomic DNA Translation: EAW78907.1 |
RefSeqi | NP_000676.1, NM_000685.4 NP_033611.1, NM_009585.3 |
3D structure databases
SMRi | Q53YY0 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q53YY0 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 1002, 510 antibodies |
DNASUi | 185 |
Genome annotation databases
GeneIDi | 185 |
KEGGi | hsa:185 |
UCSCi | uc003ewi.3, human |
Organism-specific databases
CTDi | 185 |
EuPathDBi | HostDB:ENSG00000144891.17 |
PharmGKBi | PA43 |
Phylogenomic databases
HOGENOMi | CLU_009579_8_3_1 |
Miscellaneous databases
BioGRID-ORCSi | 185, 9 hits in 840 CRISPR screens |
ChiTaRSi | AGTR1, human |
GenomeRNAii | 185 |
Gene expression databases
Bgeei | ENSG00000144891, Expressed in placenta and 184 other tissues |
ExpressionAtlasi | Q53YY0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53YY0_HUMAN | |
Accessioni | Q53YY0Primary (citable) accession number: Q53YY0 Secondary accession number(s): D3DNG9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |