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Entry version 152 (02 Jun 2021)
Sequence version 1 (24 May 2005)
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Protein
Submitted name:

HLA class I histocompatibility antigen

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HLA class I histocompatibility antigenImported
Submitted name:
HLA class I histocompatibility antigen C alpha chainImported
Submitted name:
HLA class I histocompatibility antigen, C alpha chainImported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class I proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-CImported
Synonyms:HLA-CwImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4933, HLA-C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei306 – 331HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509775225 – 366Sequence analysisAdd BLAST342

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni337 – 366DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 359Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011161, MHC_I-like_Ag-recog
IPR037055, MHC_I-like_Ag-recog_sf
IPR011162, MHC_I/II-like_Ag-recog
IPR001039, MHC_I_a_a1/a2
IPR010579, MHC_I_a_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654, C1-set, 1 hit
PF00129, MHC_I, 1 hit
PF06623, MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01638, MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407, IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 44 potential isoforms that are computationally mapped.Show allAlign All

Q53YP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV
110 120 130 140 150
SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK
210 220 230 240 250
ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS
360
SNSAQGSDES LIACKA
Length:366
Mass (Da):40,861
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E55680EA1F6D97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 44 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P10321HLAC_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QT33Q5QT33_HUMAN
HLA class I antigen
HLA-C HLA-Cw, HLAC
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O78179O78179_HUMAN
HLA class I histocompatibility anti...
HLA-C HLA-Cw
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5RIP0Q5RIP0_HUMAN
HLA class I histocompatibility anti...
HLA-C HLA-Cw
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9J9A0A140T9J9_HUMAN
HLA class I histocompatibility anti...
HLA-C
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JH50A0A0G2JH50_HUMAN
HLA class I histocompatibility anti...
HLA-C
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O19617O19617_HUMAN
HLA class I antigen
HLA-C HLA-Cw
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AEA2A2AEA2_HUMAN
HLA class I histocompatibility anti...
HLA-C
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNZ7A0A1W2PNZ7_HUMAN
HLA class I histocompatibility anti...
HLA-C
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PP77A0A1W2PP77_HUMAN
HLA class I histocompatibility anti...
HLA-C
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR759828 Genomic DNA No translation available.
AY530953 Genomic DNA Translation: AAS98883.1
FJ515903 Genomic DNA Translation: ACL37147.1
FJ827034 Genomic DNA Translation: ACO58590.1
HM543699 Genomic DNA Translation: ADU18051.1
KU319225 Genomic DNA Translation: ANG08641.1
KU319226 Genomic DNA Translation: ANG08642.1
KU319227 Genomic DNA Translation: ANG08643.1
KX649942 Genomic DNA Translation: ANZ73053.1
KX649947 Genomic DNA Translation: ANZ73058.1
KX622677 Genomic DNA Translation: AOV81314.1
KX523606 Genomic DNA Translation: ARE89964.1
KX686518 Genomic DNA Translation: ARX98026.1
KY419384 Genomic DNA Translation: ASU50275.1
KY419385 Genomic DNA Translation: ASU50276.1
KY419386 Genomic DNA Translation: ASU50277.1
KY419387 Genomic DNA Translation: ASU50278.1
MF582480 Genomic DNA Translation: ATG80407.1
MF927949 Genomic DNA Translation: ATN38486.1
MG701553 Genomic DNA Translation: AUQ33557.1
MG724875 Genomic DNA Translation: AUQ33600.1
MG724896 Genomic DNA Translation: AUQ33621.1
MG756850 Genomic DNA Translation: AUQ33644.1
MG769824 Genomic DNA Translation: AUQ33706.1
MG930594 Genomic DNA Translation: AVV62682.1
MG944947 Genomic DNA Translation: AVV63097.1
MG911195 Genomic DNA Translation: AWC68078.1
MH108956 Genomic DNA Translation: AWD73919.1
MH173518 Genomic DNA Translation: AWM62565.1
MH215847 Genomic DNA Translation: AWM62637.1
MH294676 Genomic DNA Translation: AWM62657.1
MH347677 Genomic DNA Translation: AWM62685.1
MH347682 Genomic DNA Translation: AWM62690.1
MH347696 Genomic DNA Translation: AWM62704.1
MH704671 Genomic DNA Translation: AXN55775.1
MG905210 Genomic DNA Translation: AYE21474.1
MH924939 Genomic DNA Translation: AZL48831.1
MH924942 Genomic DNA Translation: AZL48834.1
MH974026 Genomic DNA Translation: AZL48863.1
MH974054 Genomic DNA Translation: AZL48891.1
MH974091 Genomic DNA Translation: AZL48928.1
MK143771 Genomic DNA Translation: AZU90344.1
MK257852 Genomic DNA Translation: AZU90408.1
MK257894 Genomic DNA Translation: AZU90450.1
MK257902 Genomic DNA Translation: AZU90458.1
MK257908 Genomic DNA Translation: AZU90464.1
MK309010 Genomic DNA Translation: AZU90536.1
MK309014 Genomic DNA Translation: AZU90540.1
MK309053 Genomic DNA Translation: AZU90570.1
LC257754 Genomic DNA Translation: BBD34072.1
LC257755 Genomic DNA Translation: BBD34073.1
LC326209 Genomic DNA Translation: BBD74445.1
LC326210 Genomic DNA Translation: BBD74446.1
LC326211 Genomic DNA Translation: BBD74447.1
LC326212 Genomic DNA Translation: BBD74448.1
LC326213 Genomic DNA Translation: BBD74449.1
LR761777 Genomic DNA Translation: CAA9893168.1
LR761863 Genomic DNA Translation: CAA9893257.1
LR761876 Genomic DNA Translation: CAA9893270.1
LR794125 Genomic DNA Translation: CAB3563622.1
LR798181 Genomic DNA Translation: CAB4529320.1
FN908176 Genomic DNA Translation: CBM42647.1
LN811501 Genomic DNA Translation: CEP25328.1
LN912839 Genomic DNA Translation: CUU97166.1
LN912876 Genomic DNA Translation: CUU97203.1
MH254922 mRNA Translation: QAV56454.1
MH254925 mRNA Translation: QAV56456.1
MH254926 mRNA Translation: QAV56457.1
MH254928 mRNA Translation: QAV56458.1
MH254932 mRNA Translation: QAV56462.1
MH254933 mRNA Translation: QAV56463.1
MK394448 Genomic DNA Translation: QBM15629.1
MK532651 Genomic DNA Translation: QBM15735.1
MK607109 Genomic DNA Translation: QBM15758.1
MK372378 Genomic DNA Translation: QCE30927.1
MK829438 Genomic DNA Translation: QCQ66952.1
MK844035 Genomic DNA Translation: QCQ66966.1
MK814911 Genomic DNA Translation: QDC33466.1
MK814913 Genomic DNA Translation: QDC33468.1
MK814916 Genomic DNA Translation: QDC33471.1
MK629722 Genomic DNA Translation: QDK56925.1
MK938187 Genomic DNA Translation: QDK63341.1
MK938188 Genomic DNA Translation: QDK63342.1
MK938196 Genomic DNA Translation: QDK63350.1
MK938199 Genomic DNA Translation: QDK63353.1
MK938225 Genomic DNA Translation: QDK63377.1
MK938236 Genomic DNA Translation: QDK63387.1
MK938242 Genomic DNA Translation: QDK63393.1
MK938296 Genomic DNA Translation: QDK63447.1
MK954519 Genomic DNA Translation: QDK63499.1
MK954521 Genomic DNA Translation: QDK63501.1
MK954522 Genomic DNA Translation: QDK63502.1
MK954523 Genomic DNA Translation: QDK63503.1
MK954526 Genomic DNA Translation: QDK63506.1
MK954531 Genomic DNA Translation: QDK63511.1
MK954535 Genomic DNA Translation: QDK63515.1
MK954545 Genomic DNA Translation: QDK63525.1
MK954554 Genomic DNA Translation: QDK63534.1
MK954566 Genomic DNA Translation: QDK63546.1
MK954573 Genomic DNA Translation: QDK63553.1
MK954586 Genomic DNA Translation: QDK63566.1
MK954597 Genomic DNA Translation: QDK63577.1
MK954605 Genomic DNA Translation: QDK63585.1
MK954614 Genomic DNA Translation: QDK63593.1
MK954646 Genomic DNA Translation: QDK63624.1
MK954661 Genomic DNA Translation: QDK63639.1
MK954675 Genomic DNA Translation: QDK63651.1
MK954694 Genomic DNA Translation: QDK63669.1
MK954726 Genomic DNA Translation: QDK63701.1
MK954753 Genomic DNA Translation: QDK63727.1
MK954756 Genomic DNA Translation: QDK63730.1
MK954767 Genomic DNA Translation: QDK63740.1
MK954768 Genomic DNA Translation: QDK63741.1
MK954777 Genomic DNA Translation: QDK63750.1
MK954819 Genomic DNA Translation: QDK63792.1
MK954827 Genomic DNA Translation: QDK63800.1
MN016545 Genomic DNA Translation: QDK63820.1
MN016546 Genomic DNA Translation: QDK63821.1
MN016568 Genomic DNA Translation: QDK63843.1
MN016580 Genomic DNA Translation: QDK63855.1
MN016587 Genomic DNA Translation: QDK63862.1
MN016604 Genomic DNA Translation: QDK63879.1
MN016605 Genomic DNA Translation: QDK63880.1
MN016607 Genomic DNA Translation: QDK63882.1
MN016618 Genomic DNA Translation: QDK63893.1
MN016621 Genomic DNA Translation: QDK63896.1
MN016642 Genomic DNA Translation: QDK63917.1
MN016643 Genomic DNA Translation: QDK63918.1
MN016644 Genomic DNA Translation: QDK63919.1
MN016645 Genomic DNA Translation: QDK63920.1
MN016653 Genomic DNA Translation: QDK63928.1
MN016654 Genomic DNA Translation: QDK63929.1
MN016660 Genomic DNA Translation: QDK63935.1
MN016661 Genomic DNA Translation: QDK63936.1
MN016667 Genomic DNA Translation: QDK63942.1
MN016673 Genomic DNA Translation: QDK63947.1
MN016694 Genomic DNA Translation: QDK63968.1
MN016703 Genomic DNA Translation: QDK63977.1
MN016713 Genomic DNA Translation: QDK63987.1
MN016730 Genomic DNA Translation: QDK64004.1
MN016739 Genomic DNA Translation: QDK64012.1
MN016779 Genomic DNA Translation: QDK64052.1
MN016798 Genomic DNA Translation: QDK64071.1
MN016804 Genomic DNA Translation: QDK64077.1
MN016817 Genomic DNA Translation: QDK64090.1
MN016818 Genomic DNA Translation: QDK64091.1
MN016822 Genomic DNA Translation: QDK64095.1
MN016851 Genomic DNA Translation: QDK64124.1
MN016853 Genomic DNA Translation: QDK64126.1
MN016854 Genomic DNA Translation: QDK64127.1
MN016855 Genomic DNA Translation: QDK64128.1
MN016877 Genomic DNA Translation: QDK64150.1
MN016884 Genomic DNA Translation: QDK64157.1
MN016888 Genomic DNA Translation: QDK64161.1
MN016893 Genomic DNA Translation: QDK64166.1
MN016898 Genomic DNA Translation: QDK64171.1
MN053467 Genomic DNA Translation: QDK64209.1
MN380621 Genomic DNA Translation: QEQ28600.1
MN380624 Genomic DNA Translation: QEQ28603.1
MN187918 Genomic DNA Translation: QFG58529.1
MN187922 Genomic DNA Translation: QFG58532.1
MN398890 Genomic DNA Translation: QFZ94659.1
MN563051 Genomic DNA Translation: QFZ94704.1
MN787324 Genomic DNA Translation: QGY63753.1
MN787332 Genomic DNA Translation: QGY63760.1
MN787334 Genomic DNA Translation: QGY63762.1
MN787350 Genomic DNA Translation: QGY63778.1
MN787355 Genomic DNA Translation: QGY63782.1
MN787358 Genomic DNA Translation: QGY63785.1
MN787367 Genomic DNA Translation: QGY63793.1
MN787370 Genomic DNA Translation: QGY63796.1
MN787385 Genomic DNA Translation: QGY63811.1
MN787386 Genomic DNA Translation: QGY63812.1
MN787388 Genomic DNA Translation: QGY63814.1
MN787389 Genomic DNA Translation: QGY63815.1
MN787397 Genomic DNA Translation: QGY63822.1
MN787406 Genomic DNA Translation: QGY63831.1
MN812904 Genomic DNA Translation: QGY63842.1
MN812905 Genomic DNA Translation: QGY63843.1
MN812907 Genomic DNA Translation: QGY63845.1
MN840512 Genomic DNA Translation: QGY63853.1
MN840513 Genomic DNA Translation: QGY63854.1
MN150541 Genomic DNA Translation: QGY93921.1
MN454858 Genomic DNA Translation: QGZ98400.1
MN640646 Genomic DNA Translation: QHQ71306.1
MN055486 Genomic DNA Translation: QHS02115.1
MN208448 Genomic DNA Translation: QIB00624.1
MN966977 Genomic DNA Translation: QIJ58231.1
MN966978 Genomic DNA Translation: QIJ58232.1
MT210520 Genomic DNA Translation: QIX12206.1
MT303876 Genomic DNA Translation: QJS41621.1
MT303878 Genomic DNA Translation: QJS41623.1
MT316392 Genomic DNA Translation: QJS41625.1
MT415936 Genomic DNA Translation: QJS41635.1
MT336163 Genomic DNA Translation: QLB38399.1
MT604080 Genomic DNA Translation: QQP18434.1
LT599321 Genomic DNA Translation: SBW38542.1
LT599341 Genomic DNA Translation: SBW38562.1
LT599349 Genomic DNA Translation: SBW38570.1
LT599407 Genomic DNA Translation: SBW38628.1
LT618797 Genomic DNA Translation: SCQ83613.1
LT963191 Genomic DNA Translation: SOR74735.1
LT963216 Genomic DNA Translation: SOR74760.1
LT964783 Genomic DNA Translation: SOT92887.2
LT964816 Genomic DNA Translation: SOT92920.2
LT966212 Genomic DNA Translation: SOU90366.1
LS453251 Genomic DNA Translation: SPS67940.1
LS992367 Genomic DNA Translation: SYY42667.1
LS992405 Genomic DNA Translation: SYY42705.1
LS992406 Genomic DNA Translation: SYY42706.1
LR027043 Genomic DNA Translation: VCU43083.1
LR027074 Genomic DNA Translation: VCU43114.1
LR137045 Genomic DNA Translation: VEM17959.1
LR137051 Genomic DNA Translation: VEM17965.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000457903; ENSP00000390851; ENSG00000225691

UCSC genome browser

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UCSCi
uc011hpd.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759828 Genomic DNA No translation available.
AY530953 Genomic DNA Translation: AAS98883.1
FJ515903 Genomic DNA Translation: ACL37147.1
FJ827034 Genomic DNA Translation: ACO58590.1
HM543699 Genomic DNA Translation: ADU18051.1
KU319225 Genomic DNA Translation: ANG08641.1
KU319226 Genomic DNA Translation: ANG08642.1
KU319227 Genomic DNA Translation: ANG08643.1
KX649942 Genomic DNA Translation: ANZ73053.1
KX649947 Genomic DNA Translation: ANZ73058.1
KX622677 Genomic DNA Translation: AOV81314.1
KX523606 Genomic DNA Translation: ARE89964.1
KX686518 Genomic DNA Translation: ARX98026.1
KY419384 Genomic DNA Translation: ASU50275.1
KY419385 Genomic DNA Translation: ASU50276.1
KY419386 Genomic DNA Translation: ASU50277.1
KY419387 Genomic DNA Translation: ASU50278.1
MF582480 Genomic DNA Translation: ATG80407.1
MF927949 Genomic DNA Translation: ATN38486.1
MG701553 Genomic DNA Translation: AUQ33557.1
MG724875 Genomic DNA Translation: AUQ33600.1
MG724896 Genomic DNA Translation: AUQ33621.1
MG756850 Genomic DNA Translation: AUQ33644.1
MG769824 Genomic DNA Translation: AUQ33706.1
MG930594 Genomic DNA Translation: AVV62682.1
MG944947 Genomic DNA Translation: AVV63097.1
MG911195 Genomic DNA Translation: AWC68078.1
MH108956 Genomic DNA Translation: AWD73919.1
MH173518 Genomic DNA Translation: AWM62565.1
MH215847 Genomic DNA Translation: AWM62637.1
MH294676 Genomic DNA Translation: AWM62657.1
MH347677 Genomic DNA Translation: AWM62685.1
MH347682 Genomic DNA Translation: AWM62690.1
MH347696 Genomic DNA Translation: AWM62704.1
MH704671 Genomic DNA Translation: AXN55775.1
MG905210 Genomic DNA Translation: AYE21474.1
MH924939 Genomic DNA Translation: AZL48831.1
MH924942 Genomic DNA Translation: AZL48834.1
MH974026 Genomic DNA Translation: AZL48863.1
MH974054 Genomic DNA Translation: AZL48891.1
MH974091 Genomic DNA Translation: AZL48928.1
MK143771 Genomic DNA Translation: AZU90344.1
MK257852 Genomic DNA Translation: AZU90408.1
MK257894 Genomic DNA Translation: AZU90450.1
MK257902 Genomic DNA Translation: AZU90458.1
MK257908 Genomic DNA Translation: AZU90464.1
MK309010 Genomic DNA Translation: AZU90536.1
MK309014 Genomic DNA Translation: AZU90540.1
MK309053 Genomic DNA Translation: AZU90570.1
LC257754 Genomic DNA Translation: BBD34072.1
LC257755 Genomic DNA Translation: BBD34073.1
LC326209 Genomic DNA Translation: BBD74445.1
LC326210 Genomic DNA Translation: BBD74446.1
LC326211 Genomic DNA Translation: BBD74447.1
LC326212 Genomic DNA Translation: BBD74448.1
LC326213 Genomic DNA Translation: BBD74449.1
LR761777 Genomic DNA Translation: CAA9893168.1
LR761863 Genomic DNA Translation: CAA9893257.1
LR761876 Genomic DNA Translation: CAA9893270.1
LR794125 Genomic DNA Translation: CAB3563622.1
LR798181 Genomic DNA Translation: CAB4529320.1
FN908176 Genomic DNA Translation: CBM42647.1
LN811501 Genomic DNA Translation: CEP25328.1
LN912839 Genomic DNA Translation: CUU97166.1
LN912876 Genomic DNA Translation: CUU97203.1
MH254922 mRNA Translation: QAV56454.1
MH254925 mRNA Translation: QAV56456.1
MH254926 mRNA Translation: QAV56457.1
MH254928 mRNA Translation: QAV56458.1
MH254932 mRNA Translation: QAV56462.1
MH254933 mRNA Translation: QAV56463.1
MK394448 Genomic DNA Translation: QBM15629.1
MK532651 Genomic DNA Translation: QBM15735.1
MK607109 Genomic DNA Translation: QBM15758.1
MK372378 Genomic DNA Translation: QCE30927.1
MK829438 Genomic DNA Translation: QCQ66952.1
MK844035 Genomic DNA Translation: QCQ66966.1
MK814911 Genomic DNA Translation: QDC33466.1
MK814913 Genomic DNA Translation: QDC33468.1
MK814916 Genomic DNA Translation: QDC33471.1
MK629722 Genomic DNA Translation: QDK56925.1
MK938187 Genomic DNA Translation: QDK63341.1
MK938188 Genomic DNA Translation: QDK63342.1
MK938196 Genomic DNA Translation: QDK63350.1
MK938199 Genomic DNA Translation: QDK63353.1
MK938225 Genomic DNA Translation: QDK63377.1
MK938236 Genomic DNA Translation: QDK63387.1
MK938242 Genomic DNA Translation: QDK63393.1
MK938296 Genomic DNA Translation: QDK63447.1
MK954519 Genomic DNA Translation: QDK63499.1
MK954521 Genomic DNA Translation: QDK63501.1
MK954522 Genomic DNA Translation: QDK63502.1
MK954523 Genomic DNA Translation: QDK63503.1
MK954526 Genomic DNA Translation: QDK63506.1
MK954531 Genomic DNA Translation: QDK63511.1
MK954535 Genomic DNA Translation: QDK63515.1
MK954545 Genomic DNA Translation: QDK63525.1
MK954554 Genomic DNA Translation: QDK63534.1
MK954566 Genomic DNA Translation: QDK63546.1
MK954573 Genomic DNA Translation: QDK63553.1
MK954586 Genomic DNA Translation: QDK63566.1
MK954597 Genomic DNA Translation: QDK63577.1
MK954605 Genomic DNA Translation: QDK63585.1
MK954614 Genomic DNA Translation: QDK63593.1
MK954646 Genomic DNA Translation: QDK63624.1
MK954661 Genomic DNA Translation: QDK63639.1
MK954675 Genomic DNA Translation: QDK63651.1
MK954694 Genomic DNA Translation: QDK63669.1
MK954726 Genomic DNA Translation: QDK63701.1
MK954753 Genomic DNA Translation: QDK63727.1
MK954756 Genomic DNA Translation: QDK63730.1
MK954767 Genomic DNA Translation: QDK63740.1
MK954768 Genomic DNA Translation: QDK63741.1
MK954777 Genomic DNA Translation: QDK63750.1
MK954819 Genomic DNA Translation: QDK63792.1
MK954827 Genomic DNA Translation: QDK63800.1
MN016545 Genomic DNA Translation: QDK63820.1
MN016546 Genomic DNA Translation: QDK63821.1
MN016568 Genomic DNA Translation: QDK63843.1
MN016580 Genomic DNA Translation: QDK63855.1
MN016587 Genomic DNA Translation: QDK63862.1
MN016604 Genomic DNA Translation: QDK63879.1
MN016605 Genomic DNA Translation: QDK63880.1
MN016607 Genomic DNA Translation: QDK63882.1
MN016618 Genomic DNA Translation: QDK63893.1
MN016621 Genomic DNA Translation: QDK63896.1
MN016642 Genomic DNA Translation: QDK63917.1
MN016643 Genomic DNA Translation: QDK63918.1
MN016644 Genomic DNA Translation: QDK63919.1
MN016645 Genomic DNA Translation: QDK63920.1
MN016653 Genomic DNA Translation: QDK63928.1
MN016654 Genomic DNA Translation: QDK63929.1
MN016660 Genomic DNA Translation: QDK63935.1
MN016661 Genomic DNA Translation: QDK63936.1
MN016667 Genomic DNA Translation: QDK63942.1
MN016673 Genomic DNA Translation: QDK63947.1
MN016694 Genomic DNA Translation: QDK63968.1
MN016703 Genomic DNA Translation: QDK63977.1
MN016713 Genomic DNA Translation: QDK63987.1
MN016730 Genomic DNA Translation: QDK64004.1
MN016739 Genomic DNA Translation: QDK64012.1
MN016779 Genomic DNA Translation: QDK64052.1
MN016798 Genomic DNA Translation: QDK64071.1
MN016804 Genomic DNA Translation: QDK64077.1
MN016817 Genomic DNA Translation: QDK64090.1
MN016818 Genomic DNA Translation: QDK64091.1
MN016822 Genomic DNA Translation: QDK64095.1
MN016851 Genomic DNA Translation: QDK64124.1
MN016853 Genomic DNA Translation: QDK64126.1
MN016854 Genomic DNA Translation: QDK64127.1
MN016855 Genomic DNA Translation: QDK64128.1
MN016877 Genomic DNA Translation: QDK64150.1
MN016884 Genomic DNA Translation: QDK64157.1
MN016888 Genomic DNA Translation: QDK64161.1
MN016893 Genomic DNA Translation: QDK64166.1
MN016898 Genomic DNA Translation: QDK64171.1
MN053467 Genomic DNA Translation: QDK64209.1
MN380621 Genomic DNA Translation: QEQ28600.1
MN380624 Genomic DNA Translation: QEQ28603.1
MN187918 Genomic DNA Translation: QFG58529.1
MN187922 Genomic DNA Translation: QFG58532.1
MN398890 Genomic DNA Translation: QFZ94659.1
MN563051 Genomic DNA Translation: QFZ94704.1
MN787324 Genomic DNA Translation: QGY63753.1
MN787332 Genomic DNA Translation: QGY63760.1
MN787334 Genomic DNA Translation: QGY63762.1
MN787350 Genomic DNA Translation: QGY63778.1
MN787355 Genomic DNA Translation: QGY63782.1
MN787358 Genomic DNA Translation: QGY63785.1
MN787367 Genomic DNA Translation: QGY63793.1
MN787370 Genomic DNA Translation: QGY63796.1
MN787385 Genomic DNA Translation: QGY63811.1
MN787386 Genomic DNA Translation: QGY63812.1
MN787388 Genomic DNA Translation: QGY63814.1
MN787389 Genomic DNA Translation: QGY63815.1
MN787397 Genomic DNA Translation: QGY63822.1
MN787406 Genomic DNA Translation: QGY63831.1
MN812904 Genomic DNA Translation: QGY63842.1
MN812905 Genomic DNA Translation: QGY63843.1
MN812907 Genomic DNA Translation: QGY63845.1
MN840512 Genomic DNA Translation: QGY63853.1
MN840513 Genomic DNA Translation: QGY63854.1
MN150541 Genomic DNA Translation: QGY93921.1
MN454858 Genomic DNA Translation: QGZ98400.1
MN640646 Genomic DNA Translation: QHQ71306.1
MN055486 Genomic DNA Translation: QHS02115.1
MN208448 Genomic DNA Translation: QIB00624.1
MN966977 Genomic DNA Translation: QIJ58231.1
MN966978 Genomic DNA Translation: QIJ58232.1
MT210520 Genomic DNA Translation: QIX12206.1
MT303876 Genomic DNA Translation: QJS41621.1
MT303878 Genomic DNA Translation: QJS41623.1
MT316392 Genomic DNA Translation: QJS41625.1
MT415936 Genomic DNA Translation: QJS41635.1
MT336163 Genomic DNA Translation: QLB38399.1
MT604080 Genomic DNA Translation: QQP18434.1
LT599321 Genomic DNA Translation: SBW38542.1
LT599341 Genomic DNA Translation: SBW38562.1
LT599349 Genomic DNA Translation: SBW38570.1
LT599407 Genomic DNA Translation: SBW38628.1
LT618797 Genomic DNA Translation: SCQ83613.1
LT963191 Genomic DNA Translation: SOR74735.1
LT963216 Genomic DNA Translation: SOR74760.1
LT964783 Genomic DNA Translation: SOT92887.2
LT964816 Genomic DNA Translation: SOT92920.2
LT966212 Genomic DNA Translation: SOU90366.1
LS453251 Genomic DNA Translation: SPS67940.1
LS992367 Genomic DNA Translation: SYY42667.1
LS992405 Genomic DNA Translation: SYY42705.1
LS992406 Genomic DNA Translation: SYY42706.1
LR027043 Genomic DNA Translation: VCU43083.1
LR027074 Genomic DNA Translation: VCU43114.1
LR137045 Genomic DNA Translation: VEM17959.1
LR137051 Genomic DNA Translation: VEM17965.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENST00000457903; ENSP00000390851; ENSG00000225691
UCSCiuc011hpd.3, human

Organism-specific databases

HGNCiHGNC:4933, HLA-C

GenAtlas: human gene database

More...
GenAtlasi
Search...

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-C, human

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011161, MHC_I-like_Ag-recog
IPR037055, MHC_I-like_Ag-recog_sf
IPR011162, MHC_I/II-like_Ag-recog
IPR001039, MHC_I_a_a1/a2
IPR010579, MHC_I_a_C
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00129, MHC_I, 1 hit
PF06623, MHC_I_C, 1 hit
PRINTSiPR01638, MHCCLASSI
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ53YP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53YP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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