UniProtKB - Q53YM3 (Q53YM3_HUMAN)
Protein
Submitted name:
E2F transcription factor 6, isoform CRA_d
Gene
E2F6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: E2F transcription factor 6, isoform CRA_dImportedSubmitted name: E2F6 splice variant cImportedSubmitted name: E2F6 splice variant dImportedSubmitted name: E2F6 splice variant eImportedSubmitted name: cDNA FLJ38878 fis, clone MESAN2015365, highly similar to TRANSCRIPTION FACTOR E2F6Imported |
Gene namesi | Name:E2F6Imported ORF Names:hCG_1989492Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000169016.16 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: HPA
Other locations
- transcription regulator complex Source: InterPro
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000169016, Expressed in gastrocnemius and 116 other tissues |
ExpressionAtlasi | Q53YM3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 53 | E2F_TDPInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 206 | DisorderedSequence analysisAdd BLAST | 41 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 68 – 88 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 184 | PolarSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_032091_4_0_1 |
OrthoDBi | 1087250at2759 |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR015635, Transcription_factor_E2F6 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF19, PTHR12081:SF19, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53YM3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLVRSAPGG ILDLNKVATK LGVRKRRVYD ITNVLDGIDL VEKKSKNHIR
60 70 80 90 100
WIGSDLSNFG AVPQQKKLQE ELSDLSAMED ALDELIKDCA QQLFELTDDK
110 120 130 140 150
ENERLAYVTY QDIHSIQAFH EQIVIAVKAP AETRLDVPAP REDSITVHIR
160 170 180 190 200
STNGPIDVYL CEVEQGQTSN KRSEGVGTSS SESTHPEGPE EEENPQQSEE
LLEVSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY551348 mRNA Translation: AAT02638.1 AY551349 mRNA Translation: AAT02639.1 AY551350 mRNA Translation: AAT02640.1 AK096197 mRNA Translation: BAG53228.1 CH471053 Genomic DNA Translation: EAX00934.1 CH471053 Genomic DNA Translation: EAX00935.1 CH471053 Genomic DNA Translation: EAX00936.1 |
RefSeqi | NP_001265205.1, NM_001278276.1 NP_001265206.1, NM_001278277.1 NP_001265207.1, NM_001278278.1 NP_997705.1, NM_212540.2 |
Genome annotation databases
GeneIDi | 1876 |
UCSCi | uc002rbe.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY551348 mRNA Translation: AAT02638.1 AY551349 mRNA Translation: AAT02639.1 AY551350 mRNA Translation: AAT02640.1 AK096197 mRNA Translation: BAG53228.1 CH471053 Genomic DNA Translation: EAX00934.1 CH471053 Genomic DNA Translation: EAX00935.1 CH471053 Genomic DNA Translation: EAX00936.1 |
RefSeqi | NP_001265205.1, NM_001278276.1 NP_001265206.1, NM_001278277.1 NP_001265207.1, NM_001278278.1 NP_997705.1, NM_212540.2 |
3D structure databases
SMRi | Q53YM3 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q53YM3 |
Protocols and materials databases
Antibodypediai | 12671, 323 antibodies |
DNASUi | 1876 |
Genome annotation databases
GeneIDi | 1876 |
UCSCi | uc002rbe.4, human |
Organism-specific databases
CTDi | 1876 |
VEuPathDBi | HostDB:ENSG00000169016.16 |
Phylogenomic databases
HOGENOMi | CLU_032091_4_0_1 |
OrthoDBi | 1087250at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1876, 173 hits in 1019 CRISPR screens |
GenomeRNAii | 1876 |
Gene expression databases
Bgeei | ENSG00000169016, Expressed in gastrocnemius and 116 other tissues |
ExpressionAtlasi | Q53YM3, baseline and differential |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR015635, Transcription_factor_E2F6 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF19, PTHR12081:SF19, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53YM3_HUMAN | |
Accessioni | Q53YM3Primary (citable) accession number: Q53YM3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |