Major prion protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: Ensembl
• aspartic-type endopeptidase inhibitor activity Source: Ensembl
• ATP-dependent protein binding Source: Ensembl
• chaperone binding Source: Ensembl
• cupric ion binding Source: Ensembl
• glycosaminoglycan binding Source: Ensembl
• identical protein binding Source: Ensembl
• ion channel binding Source: Ensembl
• lamin binding Source: Ensembl
• protease binding Source: Ensembl
• protein-containing complex binding Source: Ensembl
• signaling receptor activity Source: Ensembl
• type 5 metabotropic glutamate receptor binding Source: Ensembl

GO - Biological processⁱ

• activation of protein kinase activity Source: Ensembl
• calcium-mediated signaling using intracellular calcium source Source: Ensembl
• cellular response to amyloid-beta Source: Ensembl
• cellular response to drug Source: Ensembl
• learning or memory Source: Ensembl
• modulation of age-related behavioral decline Source: Ensembl
• negative regulation of activated T cell proliferation Source: Ensembl
• negative regulation of amyloid-beta formation Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
• negative regulation of dendritic spine maintenance Source: Ensembl
• negative regulation of DNA-binding transcription factor activity Source: Ensembl
• negative regulation of interferon-gamma production Source: Ensembl
• negative regulation of interleukin-17 production Source: Ensembl
• negative regulation of interleukin-2 production Source: Ensembl
• negative regulation of long-term synaptic potentiation Source: Ensembl
• negative regulation of protein phosphorylation Source: Ensembl
• negative regulation of T cell receptor signaling pathway Source: Ensembl
• neuron projection maintenance Source: Ensembl
• positive regulation of neuron death Source: Ensembl
• positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
• positive regulation of protein localization to plasma membrane Source: Ensembl
• positive regulation of protein targeting to membrane Source: Ensembl
• protein homooligomerization Source: InterPro
• regulation of calcium ion import across plasma membrane Source: Ensembl
• regulation of glutamate receptor signaling pathway Source: Ensembl
• regulation of potassium ion transmembrane transport Source: Ensembl
• response to cadmium ion Source: Ensembl
• response to copper ion Source: Ensembl
• response to oxidative stress Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• ATP-dependent protein binding Source: Ensembl
• chaperone binding Source: Ensembl
• identical protein binding Source: Ensembl
• ion channel binding Source: Ensembl
• lamin binding Source: Ensembl
• protease binding Source: Ensembl
• type 5 metabotropic glutamate receptor binding Source: Ensembl

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP 
        60         70         80         90        100
PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN 
       110        120        130        140        150
KPSKPKTNMK HMAGAAAAGA VVGGLGGYML GSAMSRPIIH FGSDYEDRYY 
       160        170        180        190        200
RENMHRYPNQ VYYRPMDEYS NQNNFVHDCV NITIKQHTVT TTTKGENFTE 
       210        220        230        240        250
TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV ILLISFLIFL 

IVG                                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ