UniProtKB - Q53YJ9 (Q53YJ9_MOUSE)
Protein
Submitted name:
Neuronal nicotinic acetylcholine receptor alpha7 subunit
Gene
Chrna7
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- acetylcholine-gated cation-selective channel activity Source: InterPro
- transmembrane signaling receptor activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelARBA annotation, ReceptorImportedARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Neuronal nicotinic acetylcholine receptor alpha7 subunitImported |
Gene namesi | Name:Chrna7Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:99779, Chrna7 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 231 – 255 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 262 – 280 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 292 – 317 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 470 – 490 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | UniRule annotationAdd BLAST | 22 | |
ChainiPRO_5010843962 | 23 – 502 | UniRule annotationAdd BLAST | 480 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030525, Expressed in cerebral cortex marginal layer and 85 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 230 | Neur_chan_LBDInterPro annotationAdd BLAST | 204 | |
Domaini | 237 – 487 | Neur_chan_membInterPro annotationAdd BLAST | 251 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_018074_0_3_1 |
OMAi | SETHEMG |
OrthoDBi | 845098at2759 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53YJ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNASGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL QMQEADISSY IPNGEWDLMG
210 220 230 240 250
IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT
410 420 430 440 450
PDSGVVCGRL ACSPTHDEHL MHGTHPSDGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEVICSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD
FA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY574266 mRNA Translation: AAS90362.1 AK157809 mRNA Translation: BAE34205.1 |
RefSeqi | NP_031416.3, NM_007390.3 |
Genome annotation databases
GeneIDi | 11441 |
KEGGi | mmu:11441 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY574266 mRNA Translation: AAS90362.1 AK157809 mRNA Translation: BAE34205.1 |
RefSeqi | NP_031416.3, NM_007390.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | Q53YJ9 |
Protocols and materials databases
DNASUi | 11441 |
Genome annotation databases
GeneIDi | 11441 |
KEGGi | mmu:11441 |
Organism-specific databases
CTDi | 1139 |
MGIi | MGI:99779, Chrna7 |
Phylogenomic databases
HOGENOMi | CLU_018074_0_3_1 |
OMAi | SETHEMG |
OrthoDBi | 845098at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11441, 2 hits in 53 CRISPR screens |
ChiTaRSi | Chrna7, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030525, Expressed in cerebral cortex marginal layer and 85 other tissues |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53YJ9_MOUSE | |
Accessioni | Q53YJ9Primary (citable) accession number: Q53YJ9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |