UniProtKB - Q53YE7 (Q53YE7_HUMAN)
Protein
Amine oxidase
Gene
MAOA
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
FADUniRule annotationARBA annotation
GO - Molecular functioni
- primary amine oxidase activity Source: Ensembl
GO - Biological processi
- dopamine catabolic process Source: Ensembl
- positive regulation of signal transduction Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | FADUniRule annotationARBA annotation, Flavoprotein |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MAOAImported ORF Names:hCG_16826Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000189221.9 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000189221, Expressed in small intestine and 238 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 460 | Amino_oxidaseInterPro annotationAdd BLAST | 438 |
Sequence similaritiesi
Belongs to the flavin monoamine oxidase family.UniRule annotation
Phylogenomic databases
OMAi | EWTRGAY |
OrthoDBi | 1034142at2759 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR001613, Flavin_amine_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 1 hit |
PRINTSi | PR00757, AMINEOXDASEF |
SUPFAMi | SSF51905, SSF51905, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53YE7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG
60 70 80 90 100
RTYTIRNEHV DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT IDNMGKEIPT DAPWEAQHAD
160 170 180 190 200
KWDKMTMKEL IDKICWTKTA RRFAYLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL NHPVTHVDQS
260 270 280 290 300
SDNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM
310 320 330 340 350
GAVIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI FFAGTETATK WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NGLGKVTEKD IWVQEPESKD VPAVEITHTF WERNLPSVSG
510 520
LLKIIGFSTS VTALGFVLYK YKLLPRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT006651 mRNA Translation: AAP35297.1 AK291769 mRNA Translation: BAF84458.1 CH471141 Genomic DNA Translation: EAW59381.1 CH471141 Genomic DNA Translation: EAW59383.1 |
RefSeqi | NP_000231.1, NM_000240.3 |
Genome annotation databases
GeneIDi | 4128 |
KEGGi | hsa:4128 |
UCSCi | uc004dfy.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT006651 mRNA Translation: AAP35297.1 AK291769 mRNA Translation: BAF84458.1 CH471141 Genomic DNA Translation: EAW59381.1 CH471141 Genomic DNA Translation: EAW59383.1 |
RefSeqi | NP_000231.1, NM_000240.3 |
3D structure databases
SMRi | Q53YE7 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q53YE7 |
Proteomic databases
MaxQBi | Q53YE7 |
Protocols and materials databases
Antibodypediai | 10933, 445 antibodies |
DNASUi | 4128 |
Genome annotation databases
GeneIDi | 4128 |
KEGGi | hsa:4128 |
UCSCi | uc004dfy.5, human |
Organism-specific databases
CTDi | 4128 |
EuPathDBi | HostDB:ENSG00000189221.9 |
PharmGKBi | PA236 |
Phylogenomic databases
OMAi | EWTRGAY |
OrthoDBi | 1034142at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4128, 4 hits in 471 CRISPR screens |
ChiTaRSi | MAOA, human |
GenomeRNAii | 4128 |
Gene expression databases
Bgeei | ENSG00000189221, Expressed in small intestine and 238 other tissues |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR001613, Flavin_amine_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 1 hit |
PRINTSi | PR00757, AMINEOXDASEF |
SUPFAMi | SSF51905, SSF51905, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53YE7_HUMAN | |
Accessioni | Q53YE7Primary (citable) accession number: Q53YE7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |