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Protein
Submitted name:

Syntaxin 3A

Gene

STX3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Syntaxin 3AImported
Submitted name:
Syntaxin 3A, isoform CRA_cImported
Submitted name:
cDNA FLJ43672 fis, clone SYNOV4007671, highly similar to Syntaxin-3Imported
Submitted name:
cDNA FLJ78704, highly similar to Homo sapiens syntaxin 3A (STX3A), mRNAImported
Submitted name:
cDNA, FLJ93356, Homo sapiens syntaxin 3A (STX3A), mRNAImported
Gene namesi
Name:STX3AImported
ORF Names:hCG_40920Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000166900.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei264 – 288HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36235

Expressioni

Gene expression databases

BgeeiENSG00000166900 Expressed in 208 organ(s), highest expression level in blood

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253T-SNARE coiled-coil homologyInterPro annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 59Sequence analysisAdd BLAST21
Coiled coili74 – 108Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the syntaxin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
HOVERGENiHBG000497
KOiK08486
OrthoDBiEOG091G0EUK

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q53YE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN
Length:289
Mass (Da):33,155
Last modified:May 24, 2005 - v1
Checksum:i0E12EBC7CBEDB81E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006666 mRNA Translation: AAP35312.1
AK290251 mRNA Translation: BAF82940.1
AK312909 mRNA Translation: BAG35755.1
AK125660 mRNA Translation: BAG54232.1
CH471076 Genomic DNA Translation: EAW73855.1
RefSeqiNP_001171511.1, NM_001178040.1
NP_004168.1, NM_004177.4
XP_005274252.1, XM_005274195.3
UniGeneiHs.180711

Genome annotation databases

GeneIDi6809
KEGGihsa:6809
UCSCiuc001nog.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006666 mRNA Translation: AAP35312.1
AK290251 mRNA Translation: BAF82940.1
AK312909 mRNA Translation: BAG35755.1
AK125660 mRNA Translation: BAG54232.1
CH471076 Genomic DNA Translation: EAW73855.1
RefSeqiNP_001171511.1, NM_001178040.1
NP_004168.1, NM_004177.4
XP_005274252.1, XM_005274195.3
UniGeneiHs.180711

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi6809
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6809
KEGGihsa:6809
UCSCiuc001nog.4 human

Organism-specific databases

CTDi6809
EuPathDBiHostDB:ENSG00000166900.14
PharmGKBiPA36235

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
HOVERGENiHBG000497
KOiK08486
OrthoDBiEOG091G0EUK

Miscellaneous databases

ChiTaRSiSTX3 human
GenomeRNAii6809

Gene expression databases

BgeeiENSG00000166900 Expressed in 208 organ(s), highest expression level in blood

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ53YE2_HUMAN
AccessioniPrimary (citable) accession number: Q53YE2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 10, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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