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Protein
Submitted name:

Potassium voltage-gated channel, KQT-like subfamily, member 2, isoform CRA_e

Gene

KCNQ2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel, KQT-like subfamily, member 2, isoform CRA_eImported
Gene namesi
Name:KCNQ2Imported
ORF Names:hCG_23426Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000075043.17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei124 – 147HelicalSequence analysisAdd BLAST24
Transmembranei168 – 187HelicalSequence analysisAdd BLAST20
Transmembranei234 – 252HelicalSequence analysisAdd BLAST19
Transmembranei264 – 281HelicalSequence analysisAdd BLAST18
Transmembranei293 – 318HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30074

PTM / Processingi

Proteomic databases

PRIDEiQ53Y30

Expressioni

Gene expression databases

BgeeiENSG00000075043
ExpressionAtlasiQ53Y30 baseline and differential

Structurei

3D structure databases

SMRiQ53Y30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 318Ion_transInterPro annotationAdd BLAST223

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
HOGENOMiHOG000220839
HOVERGENiHBG059014

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003947 K_chnl_volt-dep_KCNQ2
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01461 KCNQ2CHANNEL
PR01459 KCNQCHANNEL

Sequencei

Sequence statusi: Complete.

Q53Y30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR
60 70 80 90 100
GSILSKPRAG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF
110 120 130 140 150
LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC
160 170 180 190 200
CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL
210 220 230 240 250
RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV
260 270 280 290 300
YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI
310 320 330 340 350
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN
360 370 380 390
LSRTDLHSTW QYYERTVTVP MYRYRRRAPA TKQLFHFLFS ICS
Length:393
Mass (Da):44,261
Last modified:February 5, 2008 - v1
Checksum:i9415BC4FC2F84675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007043 mRNA Translation: AAP35692.1
CH471077 Genomic DNA Translation: EAW75275.1
RefSeqiNP_742107.1, NM_172109.2
UniGeneiHs.161851
Hs.652468

Genome annotation databases

GeneIDi3785
UCSCiuc002yfc.2 human

Similar proteinsi

Entry informationi

Entry nameiQ53Y30_HUMAN
AccessioniPrimary (citable) accession number: Q53Y30
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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