UniProtKB - Q53Y06 (Q53Y06_HUMAN)
Protein
Submitted name:
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1
Gene
ATP6V1E1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- proton-transporting ATPase activity, rotational mechanism Source: InterPro
Keywordsi
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1ImportedSubmitted name: ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1, isoform CRA_bImportedSubmitted name: cDNA, FLJ92725, Homo sapiens ATPase, H+ transporting, lysosomal 31kDa, V1 subunit Eisoform 1 (ATP6V1E1), mRNAImported |
Gene namesi | Name:ATP6V1E1Imported ORF Names:hCG_21530Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000131100.12 |
Subcellular locationi
Lysosome
- lysosomal membrane Source: UniProtKB
Other locations
- proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000131100, Expressed in middle temporal gyrus and 245 other tissues |
ExpressionAtlasi | Q53Y06, baseline and differential |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 16 – 36 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the V-ATPase E subunit family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OMAi | YQTVLTK |
OrthoDBi | 1489718at2759 |
Family and domain databases
Gene3Di | 3.30.2320.30, 1 hit |
HAMAPi | MF_00311, ATP_synth_E_arch, 1 hit |
InterProi | View protein in InterPro IPR038495, ATPase_E_C IPR002842, ATPase_V1_Esu |
Pfami | View protein in Pfam PF01991, vATP-synt_E, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53Y06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSDADVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMEYYEKK EKQIEQQKKI QMSNLMNQAR LKVLRARDDL ITDLLNEAKQ
110 120 130 140 150
RLSKVVKDTT RYQVLLDGLV LQGLYQLLEP RMIVRCRKQD FPLVKAAVQK
160 170 180 190 200
AIPMYKIATK NDVDVQIDQE SYLPEDIAGG VEIYNGDRKI KVSNTLESRL
210 220
DLIAQQMMPE VRGALFGANA NRKFLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007128 mRNA Translation: AAP35792.1 AK312394 mRNA Translation: BAG35311.1 CH471193 Genomic DNA Translation: EAW57763.1 CH471193 Genomic DNA Translation: EAW57764.1 |
RefSeqi | NP_001687.1, NM_001696.3 |
Genome annotation databases
GeneIDi | 529 |
KEGGi | hsa:529 |
UCSCi | uc002zmr.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007128 mRNA Translation: AAP35792.1 AK312394 mRNA Translation: BAG35311.1 CH471193 Genomic DNA Translation: EAW57763.1 CH471193 Genomic DNA Translation: EAW57764.1 |
RefSeqi | NP_001687.1, NM_001696.3 |
3D structure databases
SMRi | Q53Y06 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q53Y06, 1 interactor |
Proteomic databases
MaxQBi | Q53Y06 |
Protocols and materials databases
Antibodypediai | 4024, 179 antibodies |
DNASUi | 529 |
Genome annotation databases
GeneIDi | 529 |
KEGGi | hsa:529 |
UCSCi | uc002zmr.3, human |
Organism-specific databases
CTDi | 529 |
PharmGKBi | PA25158 |
VEuPathDBi | HostDB:ENSG00000131100.12 |
Phylogenomic databases
OMAi | YQTVLTK |
OrthoDBi | 1489718at2759 |
Miscellaneous databases
BioGRID-ORCSi | 529, 694 hits in 876 CRISPR screens |
ChiTaRSi | ATP6V1E1, human |
GenomeRNAii | 529 |
Gene expression databases
Bgeei | ENSG00000131100, Expressed in middle temporal gyrus and 245 other tissues |
ExpressionAtlasi | Q53Y06, baseline and differential |
Family and domain databases
Gene3Di | 3.30.2320.30, 1 hit |
HAMAPi | MF_00311, ATP_synth_E_arch, 1 hit |
InterProi | View protein in InterPro IPR038495, ATPase_E_C IPR002842, ATPase_V1_Esu |
Pfami | View protein in Pfam PF01991, vATP-synt_E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53Y06_HUMAN | |
Accessioni | Q53Y06Primary (citable) accession number: Q53Y06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |