UniProtKB - Q53XZ3 (Q53XZ3_HUMAN)
Protein
Muscarinic acetylcholine receptor
Gene
CHRM1
Organism
Homo sapiens (Human)
Status
Functioni
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.UniRule annotation
GO - Molecular functioni
- G protein-coupled acetylcholine receptor activity Source: UniProtKB-UniRule
- neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Source: Ensembl
GO - Biological processi
- cognition Source: InterPro
- neuromuscular synaptic transmission Source: Ensembl
- positive regulation of intracellular protein transport Source: Ensembl
- regulation of locomotion Source: Ensembl
- saliva secretion Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Muscarinic acetylcholine receptorUniRule annotation |
Gene namesi | Name:CHRM1Imported ORF Names:hCG_2020133Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000168539.3 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of postsynaptic density membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
Other locations
- axon terminus Source: Ensembl
- cholinergic synapse Source: Ensembl
- dendrite Source: Ensembl
- glutamatergic synapse Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 50 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 62 – 88 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 100 – 121 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 142 – 167 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 187 – 209 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 369 – 390 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 402 – 421 | HelicalUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotation, SynapsePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
PRIDEi | Q53XZ3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168539, Expressed in anterior cingulate cortex and 100 other tissues |
ExpressionAtlasi | Q53XZ3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 418 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 377 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 225 – 256 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 274 – 297 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 310 – 351 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 231 – 248 | PolarSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | RCCRTPR |
OrthoDBi | 1245472at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002228, Musac_Ach_M1_rcpt IPR000995, Musac_Ach_rcpt |
PANTHERi | PTHR24248:SF155, PTHR24248:SF155, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00538, MUSCRINICM1R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53XZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF
60 70 80 90 100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL
110 120 130 140 150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW
160 170 180 190 200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP
210 220 230 240 250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG
260 270 280 290 300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV
310 320 330 340 350
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA
360 370 380 390 400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW
410 420 430 440 450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG
460
SVHRTPSRQC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007166 mRNA Translation: AAP35830.1 AK312374 mRNA Translation: BAG35292.1 CH471076 Genomic DNA Translation: EAW74124.1 CH471076 Genomic DNA Translation: EAW74125.1 CH471076 Genomic DNA Translation: EAW74126.1 |
RefSeqi | NP_000729.2, NM_000738.2 XP_011543044.1, XM_011544742.2 |
Genome annotation databases
GeneIDi | 1128 |
KEGGi | hsa:1128 |
UCSCi | uc001nwi.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007166 mRNA Translation: AAP35830.1 AK312374 mRNA Translation: BAG35292.1 CH471076 Genomic DNA Translation: EAW74124.1 CH471076 Genomic DNA Translation: EAW74125.1 CH471076 Genomic DNA Translation: EAW74126.1 |
RefSeqi | NP_000729.2, NM_000738.2 XP_011543044.1, XM_011544742.2 |
3D structure databases
SMRi | Q53XZ3 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q53XZ3 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PRIDEi | Q53XZ3 |
Protocols and materials databases
Antibodypediai | 2948, 315 antibodies |
DNASUi | 1128 |
Genome annotation databases
GeneIDi | 1128 |
KEGGi | hsa:1128 |
UCSCi | uc001nwi.4, human |
Organism-specific databases
CTDi | 1128 |
PharmGKBi | PA26484 |
VEuPathDBi | HostDB:ENSG00000168539.3 |
Phylogenomic databases
OMAi | RCCRTPR |
OrthoDBi | 1245472at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1128, 13 hits in 987 CRISPR screens |
ChiTaRSi | CHRM1, human |
GenomeRNAii | 1128 |
Gene expression databases
Bgeei | ENSG00000168539, Expressed in anterior cingulate cortex and 100 other tissues |
ExpressionAtlasi | Q53XZ3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002228, Musac_Ach_M1_rcpt IPR000995, Musac_Ach_rcpt |
PANTHERi | PTHR24248:SF155, PTHR24248:SF155, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00538, MUSCRINICM1R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53XZ3_HUMAN | |
Accessioni | Q53XZ3Primary (citable) accession number: Q53XZ3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |