CHRM1

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.UniRule annotation

GO - Molecular functionⁱ

G protein-coupled acetylcholine receptor activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cognition Source: InterPro
regulation of locomotion Source: InterPro
saliva secretion Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptorUniRule annotation
Gene namesⁱ	Name:CHRM1Imported ORF Names:hCG_2020133Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168539.3

EuPathDBⁱ

HostDB:ENSG00000168539.3

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	25 – 50	HelicalUniRule annotationAdd BLAST	26
Transmembraneⁱ	62 – 88	HelicalUniRule annotationAdd BLAST	27
Transmembraneⁱ	100 – 121	HelicalUniRule annotationAdd BLAST	22
Transmembraneⁱ	142 – 167	HelicalUniRule annotationAdd BLAST	26
Transmembraneⁱ	187 – 209	HelicalUniRule annotationAdd BLAST	23
Transmembraneⁱ	369 – 390	HelicalUniRule annotationAdd BLAST	22
Transmembraneⁱ	402 – 421	HelicalUniRule annotationAdd BLAST	20

Keywords - Cellular componentⁱ

Cell junction, Cell membraneUniRule annotation, Membrane, Postsynaptic cell membraneUniRule annotation, Synapse

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA26484

PharmGKBⁱ

PA26484

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168539 Expressed in 80 organ(s), highest expression level in anterior cingulate cortex

Bgeeⁱ

ENSG00000168539 Expressed in 80 organ(s), highest expression level in anterior cingulate cortex

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	42 – 418	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		377

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
HOVERGENⁱ	HBG105720
KEGG Orthology (KO) More...KOⁱ	K04129
OMAⁱ	RCCRTPR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15049 7tmA_mAChR, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002228 Musac_Ach_M1_rcpt IPR000995 Musac_Ach_rcpt
PANTHERⁱ	PTHR43914:SF7 PTHR43914:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00538 MUSCRINICM1R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q53XZ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF 
        60         70         80         90        100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 
       110        120        130        140        150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 
       160        170        180        190        200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 
       210        220        230        240        250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 
       260        270        280        290        300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
       310        320        330        340        350
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA 
       360        370        380        390        400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW 
       410        420        430        440        450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 
       460
SVHRTPSRQC

Length:460

Mass (Da):51,421

Last modified:May 24, 2005 - v1

Checksum:ⁱ567C20F63541C8D0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT007166 mRNA Translation: AAP35830.1 AK312374 mRNA Translation: BAG35292.1 CH471076 Genomic DNA Translation: EAW74124.1 CH471076 Genomic DNA Translation: EAW74125.1 CH471076 Genomic DNA Translation: EAW74126.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000729.2, NM_000738.2 XP_011543044.1, XM_011544742.2
UniGeneⁱ	Hs.632119

Genome annotation databases

GeneIDⁱ	1128
KEGGⁱ	hsa:1128
UCSC genome browser More...UCSCⁱ	uc001nwi.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q53XZ3	Muscarinic acetylcholine receptor M1	)	HUMAN		460	UniRef100_P11229
Muscarinic acetylcholine receptor		PANTR		460
Muscarinic acetylcholine receptor		PONAB		460
Muscarinic acetylcholine receptor		COLAP		460
Muscarinic acetylcholine receptor		RHIRO		460
+6

Protein	Similar proteins		Species	Score	Length	Source
Q53XZ3	Muscarinic acetylcholine receptor M1	)	HUMAN		460	UniRef90_P11229
Muscarinic acetylcholine receptor M1		MACMU		460
Muscarinic acetylcholine receptor M1		MOUSE		460
Muscarinic acetylcholine receptor M1		PIG		460
Muscarinic acetylcholine receptor M1		PONAB		460
+105

Protein	Similar proteins		Species	Score	Length	Source
Q53XZ3	Muscarinic acetylcholine receptor M1	)	HUMAN		460	UniRef50_P11229
Muscarinic acetylcholine receptor M1		PIG		460
Muscarinic acetylcholine receptor M1		RAT		460
Muscarinic acetylcholine receptor M1		MACMU		460
Muscarinic acetylcholine receptor M1		MOUSE		460
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT007166 mRNA Translation: AAP35830.1 AK312374 mRNA Translation: BAG35292.1 CH471076 Genomic DNA Translation: EAW74124.1 CH471076 Genomic DNA Translation: EAW74125.1 CH471076 Genomic DNA Translation: EAW74126.1
RefSeqⁱ	NP_000729.2, NM_000738.2 XP_011543044.1, XM_011544742.2
UniGeneⁱ	Hs.632119

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1128
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	1128
KEGGⁱ	hsa:1128
UCSCⁱ	uc001nwi.4 human

Organism-specific databases

CTDⁱ	1128
EuPathDBⁱ	HostDB:ENSG00000168539.3
PharmGKBⁱ	PA26484

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
HOVERGENⁱ	HBG105720
KOⁱ	K04129
OMAⁱ	RCCRTPR
OrthoDBⁱ	EOG091G06VI

Miscellaneous databases

GenomeRNAiⁱ	1128

GenomeRNAiⁱ

1128

Gene expression databases

Bgeeⁱ	ENSG00000168539 Expressed in 80 organ(s), highest expression level in anterior cingulate cortex

Bgeeⁱ

ENSG00000168539 Expressed in 80 organ(s), highest expression level in anterior cingulate cortex

Family and domain databases

CDDⁱ	cd15049 7tmA_mAChR, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002228 Musac_Ach_M1_rcpt IPR000995 Musac_Ach_rcpt
PANTHERⁱ	PTHR43914:SF7 PTHR43914:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00538 MUSCRINICM1R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q53XZ3_HUMAN
Accessionⁱ	Q53XZ3Primary (citable) accession number: Q53XZ3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 24, 2005
	Last sequence update:	May 24, 2005
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q53XZ3 (Q53XZ3_HUMAN)

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Muscarinic acetylcholine receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ