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Protein
Submitted name:

Cold inducible RNA binding protein

Gene

CIRBP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cold inducible RNA binding proteinImported
Submitted name:
Cold inducible RNA binding protein, isoform CRA_aImported
Submitted name:
Testicular tissue protein Li 39Imported
Gene namesi
Name:CIRBPImported
ORF Names:hCG_21575Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000099622.13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26519

Expressioni

Gene expression databases

BgeeiENSG00000099622 Expressed in 237 organ(s), highest expression level in oviduct epithelium

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMInterPro annotationAdd BLAST79

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
HOVERGENiHBG107480
KOiK13195

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q53XX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG
60 70 80 90 100
FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG
110 120 130 140 150
RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG
160 170
YSDRSSGGSY RDSYDSYATH NE
Length:172
Mass (Da):18,648
Last modified:May 24, 2005 - v1
Checksum:i003FABF28F5405D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei172Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007210 mRNA Translation: AAP35874.1
HM005352 mRNA Translation: AEE60952.1
AB451225 mRNA Translation: BAG70039.1
AB451348 mRNA Translation: BAG70162.1
CH471139 Genomic DNA Translation: EAW69520.1
CH471139 Genomic DNA Translation: EAW69523.1
RefSeqiNP_001271.1, NM_001280.2
XP_006722700.1, XM_006722637.1
UniGeneiHs.618145
Hs.634522

Genome annotation databases

GeneIDi1153
KEGGihsa:1153
UCSCiuc002lrr.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007210 mRNA Translation: AAP35874.1
HM005352 mRNA Translation: AEE60952.1
AB451225 mRNA Translation: BAG70039.1
AB451348 mRNA Translation: BAG70162.1
CH471139 Genomic DNA Translation: EAW69520.1
CH471139 Genomic DNA Translation: EAW69523.1
RefSeqiNP_001271.1, NM_001280.2
XP_006722700.1, XM_006722637.1
UniGeneiHs.618145
Hs.634522

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi1153
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1153
KEGGihsa:1153
UCSCiuc002lrr.5 human

Organism-specific databases

CTDi1153
EuPathDBiHostDB:ENSG00000099622.13
PharmGKBiPA26519

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
HOVERGENiHBG107480
KOiK13195

Miscellaneous databases

ChiTaRSiCIRBP human
GenomeRNAii1153

Gene expression databases

BgeeiENSG00000099622 Expressed in 237 organ(s), highest expression level in oviduct epithelium

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ53XX5_HUMAN
AccessioniPrimary (citable) accession number: Q53XX5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 10, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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