UniProtKB - Q53XR6 (Q53XR6_HUMAN)
Protein
Mothers against decapentaplegic homolog
Gene
SMAD2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- double-stranded DNA binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- SMAD binding Source: Ensembl
- tau protein binding Source: Ensembl
- transcription factor binding Source: UniProtKB
GO - Biological processi
- adrenal gland development Source: Ensembl
- anterior/posterior pattern specification Source: UniProtKB
- cell fate commitment Source: UniProtKB
- embryonic cranial skeleton morphogenesis Source: Ensembl
- embryonic foregut morphogenesis Source: Ensembl
- embryonic pattern specification Source: Ensembl
- endoderm formation Source: Ensembl
- insulin secretion Source: Ensembl
- intracellular signal transduction Source: UniProtKB
- in utero embryonic development Source: Ensembl
- lung development Source: Ensembl
- mesoderm formation Source: UniProtKB
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- organ growth Source: Ensembl
- pancreas development Source: Ensembl
- paraxial mesoderm morphogenesis Source: UniProtKB
- pericardium development Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- post-embryonic development Source: Ensembl
- protein phosphorylation Source: Ensembl
- regulation of binding Source: UniProtKB
- response to glucose Source: Ensembl
- secondary palate development Source: Ensembl
- signal transduction involved in regulation of gene expression Source: Ensembl
- SMAD protein signal transduction Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- ureteric bud development Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | Name:SMAD2Imported ORF Names:hCG_22544Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000175387.15 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000175387, Expressed in calcaneal tendon and 245 other tissues |
ExpressionAtlasi | Q53XR6, baseline and differential |
Interactioni
GO - Molecular functioni
- SMAD binding Source: Ensembl
- tau protein binding Source: Ensembl
- transcription factor binding Source: UniProtKB
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 176 | MH1InterPro annotationAdd BLAST | 167 | |
Domaini | 274 – 467 | MH2InterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 207 – 251 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 229 – 251 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_026736_0_2_1 |
OMAi | PNNTEYN |
OrthoDBi | 608001at2759 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53XR6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK
60 70 80 90 100
KLKKTGRLDE LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG
110 120 130 140 150
LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE
160 170 180 190 200
YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEILTEL PPLDDYTHSI
210 220 230 240 250
PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS
260 270 280 290 300
PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD
310 320 330 340 350
GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL
360 370 380 390 400
SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ
410 420 430 440 450
GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD
460
KVLTQMGSPS VRCSSMS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007422 mRNA Translation: AAP36090.1 AK312963 mRNA Translation: BAG35802.1 CH471096 Genomic DNA Translation: EAW62915.1 CH471096 Genomic DNA Translation: EAW62916.1 CH471096 Genomic DNA Translation: EAW62917.1 |
RefSeqi | NP_001003652.1, NM_001003652.3 NP_005892.1, NM_005901.5 XP_005258316.1, XM_005258259.3 XP_006722514.1, XM_006722451.3 XP_016881234.1, XM_017025745.1 |
Genome annotation databases
GeneIDi | 4087 |
KEGGi | hsa:4087 |
UCSCi | uc002lcy.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007422 mRNA Translation: AAP36090.1 AK312963 mRNA Translation: BAG35802.1 CH471096 Genomic DNA Translation: EAW62915.1 CH471096 Genomic DNA Translation: EAW62916.1 CH471096 Genomic DNA Translation: EAW62917.1 |
RefSeqi | NP_001003652.1, NM_001003652.3 NP_005892.1, NM_005901.5 XP_005258316.1, XM_005258259.3 XP_006722514.1, XM_006722451.3 XP_016881234.1, XM_017025745.1 |
3D structure databases
SMRi | Q53XR6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q53XR6 |
PRIDEi | Q53XR6 |
Protocols and materials databases
Antibodypediai | 9235, 1923 antibodies |
DNASUi | 4087 |
Genome annotation databases
GeneIDi | 4087 |
KEGGi | hsa:4087 |
UCSCi | uc002lcy.5, human |
Organism-specific databases
CTDi | 4087 |
PharmGKBi | PA134959722 |
VEuPathDBi | HostDB:ENSG00000175387.15 |
Phylogenomic databases
HOGENOMi | CLU_026736_0_2_1 |
OMAi | PNNTEYN |
OrthoDBi | 608001at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4087, 9 hits in 1023 CRISPR screens |
ChiTaRSi | SMAD2, human |
GenomeRNAii | 4087 |
Gene expression databases
Bgeei | ENSG00000175387, Expressed in calcaneal tendon and 245 other tissues |
ExpressionAtlasi | Q53XR6, baseline and differential |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53XR6_HUMAN | |
Accessioni | Q53XR6Primary (citable) accession number: Q53XR6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |