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UniProtKB - Q53XR2 (Q53XR2_HUMAN)
Protein
Submitted name:
Stem-loop (Histone) binding protein
Gene
SLBP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histone pre-mRNA stem-loop binding Source: Ensembl
- mRNA binding Source: Ensembl
GO - Biological processi
- mRNA 3'-end processing by stem-loop binding and cleavage Source: Ensembl
Keywordsi
Molecular function | RNA-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Stem-loop (Histone) binding proteinImportedSubmitted name: Stem-loop (Histone) binding protein, isoform CRA_bImportedSubmitted name: cDNA, FLJ96722, Homo sapiens stem-loop (histone) binding protein (SLBP), mRNAImported |
Gene namesi | Name:SLBPImported ORF Names:hCG_19671Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000163950 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- histone pre-mRNA 3'end processing complex Source: Ensembl
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000163950, Expressed in oocyte and 241 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 199 | SLBP_RNA_bindInterPro annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 132 | DisorderedSequence analysisAdd BLAST | 132 | |
Regioni | 215 – 241 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 62 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 74 – 114 | Basic and acidic residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 218 – 235 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the SLBP family.ARBA annotation
Phylogenomic databases
OrthoDBi | 1284291at2759 |
Family and domain databases
Gene3Di | 1.10.8.1120, 1 hit |
InterProi | View protein in InterPro IPR026502, SLBP1/SLBP2 IPR029344, SLBP_RNA_bind IPR038294, SLBP_RNA_bind_sf |
PANTHERi | PTHR17408, PTHR17408, 1 hit |
Pfami | View protein in Pfam PF15247, SLBP_RNA_bind, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53XR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACRPRSPPR HQSRCDGDAS PPSPARWSLG RKRRADGRRW RPEDAEEAEH
60 70 80 90 100
RGAERRPESF TTPEGPKPRS RCSDWASAVE EDEMRTRVNK EMARYKRKLL
110 120 130 140 150
INDFGRERKS SSGSSDSKES MSTVPADFET DESVLMRRQK QINYGKNTIA
160 170 180 190 200
YDRYIKEVPR HLRQPGIHPK TPNKFKKYSR RSWDQQIKLW KVALHFWDPP
210 220 230 240 250
AEEGCDLQEI HPVDLESAES SSEPQTSSQD DFDVYSGTPT KVRHMDSQVE
260 270
DEFDLEACLT EPLRDFSAMS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007433 mRNA Translation: AAP36101.1 AK315635 mRNA Translation: BAG38003.1 CH471131 Genomic DNA Translation: EAW82577.1 CH471131 Genomic DNA Translation: EAW82578.1 |
RefSeqi | NP_006518.1, NM_006527.3 |
Genome annotation databases
GeneIDi | 7884 |
KEGGi | hsa:7884 |
MANE-Selecti | ENST00000489418.6; ENSP00000417686.1; NM_006527.4; NP_006518.1 |
UCSCi | uc003gdi.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007433 mRNA Translation: AAP36101.1 AK315635 mRNA Translation: BAG38003.1 CH471131 Genomic DNA Translation: EAW82577.1 CH471131 Genomic DNA Translation: EAW82578.1 |
RefSeqi | NP_006518.1, NM_006527.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 8450, 84 antibodies from 23 providers |
DNASUi | 7884 |
Genome annotation databases
GeneIDi | 7884 |
KEGGi | hsa:7884 |
MANE-Selecti | ENST00000489418.6; ENSP00000417686.1; NM_006527.4; NP_006518.1 |
UCSCi | uc003gdi.2, human |
Organism-specific databases
CTDi | 7884 |
PharmGKBi | PA35804 |
VEuPathDBi | HostDB:ENSG00000163950 |
Phylogenomic databases
OrthoDBi | 1284291at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7884, 369 hits in 1083 CRISPR screens |
ChiTaRSi | SLBP, human |
GenomeRNAii | 7884 |
Gene expression databases
Bgeei | ENSG00000163950, Expressed in oocyte and 241 other tissues |
Family and domain databases
Gene3Di | 1.10.8.1120, 1 hit |
InterProi | View protein in InterPro IPR026502, SLBP1/SLBP2 IPR029344, SLBP_RNA_bind IPR038294, SLBP_RNA_bind_sf |
PANTHERi | PTHR17408, PTHR17408, 1 hit |
Pfami | View protein in Pfam PF15247, SLBP_RNA_bind, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53XR2_HUMAN | |
Accessioni | Q53XR2Primary (citable) accession number: Q53XR2 Secondary accession number(s): D3DVP7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |