UniProtKB - Q53XM7 (Q53XM7_HUMAN)
Protein
Submitted name:
VAMP (Vesicle-associated membrane protein)-associated protein B and C
Gene
VAPB
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: VAMP (Vesicle-associated membrane protein)-associated protein B and CImportedSubmitted name: VAMP (Vesicle-associated membrane protein)-associated protein B and C, isoform CRA_bImportedSubmitted name: cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/CImported |
Gene namesi | Name:VAPBImported ORF Names:hCG_26693Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000124164.15 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 224 – 242 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000124164, Expressed in middle temporal gyrus and 246 other tissues |
ExpressionAtlasi | Q53XM7, baseline and differential |
Interactioni
Binary interactionsi
Hide detailsQ53XM7
With | #Exp. | IntAct |
---|---|---|
GPR25 [O00155] | 3 | EBI-10178947,EBI-10178951 |
OSBPL2 [Q9H1P3] | 3 | EBI-10178947,EBI-2828285 |
RMDN2 [Q96LZ7] | 3 | EBI-10178947,EBI-2806908 |
USP20 [Q9Y2K6] | 3 | EBI-10178947,EBI-2511991 |
Protein-protein interaction databases
IntActi | Q53XM7, 4 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 124 | MSPInterPro annotationAdd BLAST | 118 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 166 – 193 | Sequence analysisAdd BLAST | 28 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_032848_0_1_1 |
OMAi | NTGVIHP |
OrthoDBi | 1332028at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR000535, MSP_dom IPR008962, PapD-like_sf IPR016763, VAP |
PANTHERi | PTHR10809, PTHR10809, 2 hits |
Pfami | View protein in Pfam PF00635, Motile_Sperm, 1 hit |
PIRSFi | PIRSF019693, VAMP-associated, 1 hit |
SUPFAMi | SSF49354, SSF49354, 1 hit |
PROSITEi | View protein in PROSITE PS50202, MSP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53XM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR
60 70 80 90 100
RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET
160 170 180 190 200
PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK
210 220 230 240
TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT009811 mRNA Translation: AAP88813.1 AK023241 mRNA Translation: BAG51174.1 CH471077 Genomic DNA Translation: EAW75494.1 CH471077 Genomic DNA Translation: EAW75495.1 |
RefSeqi | NP_004729.1, NM_004738.4 |
Genome annotation databases
GeneIDi | 9217 |
KEGGi | hsa:9217 |
UCSCi | uc002xza.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT009811 mRNA Translation: AAP88813.1 AK023241 mRNA Translation: BAG51174.1 CH471077 Genomic DNA Translation: EAW75494.1 CH471077 Genomic DNA Translation: EAW75495.1 |
RefSeqi | NP_004729.1, NM_004738.4 |
3D structure databases
SMRi | Q53XM7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q53XM7, 4 interactors |
Proteomic databases
MaxQBi | Q53XM7 |
PRIDEi | Q53XM7 |
Protocols and materials databases
Antibodypediai | 2398, 325 antibodies |
DNASUi | 9217 |
Genome annotation databases
GeneIDi | 9217 |
KEGGi | hsa:9217 |
UCSCi | uc002xza.4, human |
Organism-specific databases
CTDi | 9217 |
PharmGKBi | PA37273 |
VEuPathDBi | HostDB:ENSG00000124164.15 |
Phylogenomic databases
HOGENOMi | CLU_032848_0_1_1 |
OMAi | NTGVIHP |
OrthoDBi | 1332028at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9217, 6 hits in 878 CRISPR screens |
ChiTaRSi | VAPB, human |
GenomeRNAii | 9217 |
Gene expression databases
Bgeei | ENSG00000124164, Expressed in middle temporal gyrus and 246 other tissues |
ExpressionAtlasi | Q53XM7, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR000535, MSP_dom IPR008962, PapD-like_sf IPR016763, VAP |
PANTHERi | PTHR10809, PTHR10809, 2 hits |
Pfami | View protein in Pfam PF00635, Motile_Sperm, 1 hit |
PIRSFi | PIRSF019693, VAMP-associated, 1 hit |
SUPFAMi | SSF49354, SSF49354, 1 hit |
PROSITEi | View protein in PROSITE PS50202, MSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53XM7_HUMAN | |
Accessioni | Q53XM7Primary (citable) accession number: Q53XM7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |