UniProtKB - Q53X93 (Q53X93_HUMAN)
Protein
Submitted name:
CREB1 protein
Gene
CREB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: CREB1 proteinImportedSubmitted name: cAMP responsive element binding protein 1ImportedSubmitted name: cAMP responsive element binding protein 1, isoform CRA_bImportedSubmitted name: cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNAImported |
Gene namesi | Name:CREB1Imported ORF Names:hCG_15208Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000118260.14 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000118260, Expressed in lung and 253 other tissues |
ExpressionAtlasi | Q53X93, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 146 | KIDInterPro annotationAdd BLAST | 60 | |
Domaini | 269 – 320 | BZIPInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 94 – 113 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 125 – 148 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 287 – 321 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OMAi | QXISTIA |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR003102, Coactivator_CBP_pKID IPR029802, CREB1 IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF1, PTHR45879:SF1, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q53X93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA
60 70 80 90 100
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES
110 120 130 140 150
VDSVTDSQKR REILSRRPSY RKILNDLSSD APGVPRIEEE KSEEETSAPA
160 170 180 190 200
ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA NNGTDGVQGL QTLTMTNAAA
210 220 230 240 250
TQPGTTILQY AQTTDGQQIL VPSNQVVVQA ASGDVQTYQI RTAPTSTIAP
260 270 280 290 300
GVVMASSPAL PTQPAEEAAR KREVRLMKNR EAARECRRKK KEYVKCLENR
310 320
VAVLENQNKT LIEELKALKD LYCHKSD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 327 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC095407 mRNA Translation: AAH95407.1 AK315226 mRNA Translation: BAG37655.1 CR407617 mRNA Translation: CAG28545.1 CH471063 Genomic DNA Translation: EAW70406.1 CH471063 Genomic DNA Translation: EAW70407.1 CH471063 Genomic DNA Translation: EAW70409.1 |
RefSeqi | NP_004370.1, NM_004379.4 XP_011508949.1, XM_011510647.2 |
Genome annotation databases
GeneIDi | 1385 |
KEGGi | hsa:1385 |
UCSCi | uc002vcd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC095407 mRNA Translation: AAH95407.1 AK315226 mRNA Translation: BAG37655.1 CR407617 mRNA Translation: CAG28545.1 CH471063 Genomic DNA Translation: EAW70406.1 CH471063 Genomic DNA Translation: EAW70407.1 CH471063 Genomic DNA Translation: EAW70409.1 |
RefSeqi | NP_004370.1, NM_004379.4 XP_011508949.1, XM_011510647.2 |
3D structure databases
SMRi | Q53X93 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q53X93 |
Protocols and materials databases
Antibodypediai | 3536, 2170 antibodies |
DNASUi | 1385 |
Genome annotation databases
GeneIDi | 1385 |
KEGGi | hsa:1385 |
UCSCi | uc002vcd.4, human |
Organism-specific databases
CTDi | 1385 |
PharmGKBi | PA26864 |
VEuPathDBi | HostDB:ENSG00000118260.14 |
Phylogenomic databases
OMAi | QXISTIA |
Miscellaneous databases
BioGRID-ORCSi | 1385, 30 hits in 1026 CRISPR screens |
ChiTaRSi | CREB1, human |
GenomeRNAii | 1385 |
Gene expression databases
Bgeei | ENSG00000118260, Expressed in lung and 253 other tissues |
ExpressionAtlasi | Q53X93, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR003102, Coactivator_CBP_pKID IPR029802, CREB1 IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF1, PTHR45879:SF1, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53X93_HUMAN | |
Accessioni | Q53X93Primary (citable) accession number: Q53X93 Secondary accession number(s): A0A024R437 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |