UniProtKB - Q53T99 (Q53T99_HUMAN)
Protein
Ribosome biogenesis protein WDR12
Gene
WDR12
Organism
Homo sapiens (Human)
Status
Functioni
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation
GO - Molecular functioni
- ribonucleoprotein complex binding Source: UniProtKB-UniRule
GO - Biological processi
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB-UniRule
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB-UniRule
- Notch signaling pathway Source: Ensembl
Keywordsi
Biological process | Ribosome biogenesisUniRule annotationARBA annotation, rRNA processingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosome biogenesis protein WDR12UniRule annotationAlternative name(s): WD repeat-containing protein 12UniRule annotation |
Gene namesi | Name:WDR12UniRule annotationImported ORF Names:hCG_1779944Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138442.9 |
Subcellular locationi
Nucleus
- nucleolus UniRule annotation
- nucleoplasm UniRule annotation
Nucleus
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: UniProtKB-SubCell
Other locations
- preribosome, large subunit precursor Source: UniProtKB-UniRule
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000138442, Expressed in subventricular zone (outer) (primate) and 236 other tissues |
ExpressionAtlasi | Q53T99, baseline and differential |
Interactioni
Subunit structurei
Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 97 – 422 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 326 | |
Repeati | 136 – 171 | WDPROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 185 – 217 | WDPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 253 – 293 | WDPROSITE-ProRule annotationAdd BLAST | 41 | |
Repeati | 303 – 325 | WDPROSITE-ProRule annotationAdd BLAST | 23 | |
Repeati | 338 – 374 | WDPROSITE-ProRule annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 220 – 242 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 228 – 242 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the WD repeat WDR12/YTM1 family.UniRule annotation
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_000288_57_0_1 |
OMAi | PFDFLIN |
OrthoDBi | 1540178at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_03029, WDR12, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR012972, NLE IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR028599, WDR12/Ytm1 |
Pfami | View protein in Pfam PF08154, NLE, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53T99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQLQTRFYT DNKKYAVDDV PFSIPAASEI ADLSNIINKL LKDKNEFHKH
60 70 80 90 100
VEFDFLIKGQ FLRMPLDKHM EMENISSEEV VEIEYVEKYT APQPEQCMFH
110 120 130 140 150
DDWISSIKGA EEWILTGSYD KTSRIWSLEG KSIMTIVGHT DVVKDVAWVK
160 170 180 190 200
KDSLSCLLLS ASMDQTILLW EWNVERNKVK ALHCCRGHAG SVDSIAVDGS
210 220 230 240 250
GTKFCSGSWD KMLKIWSTVP TDEEDEMEES TNRPRKKQKT EQLGLTRTPI
260 270 280 290 300
VTLSGHMEAV SSVLWSDAEE ICSASWDHTI RVWDVESGSL KSTLTGNKVF
310 320 330 340 350
NCISYSPLCK RLASGSTDRH IRLWDPRTKD GSLVSLSLTS HTGWVTSVKW
360 370 380 390 400
SPTHEQQLIS GSLDNIVKLW DTRSCKAPLY DLAAHEDKVL SVDWTDTGLL
410 420
LSGGADNKLY SYRYSPTTSH VGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010900 Genomic DNA Translation: AAY24287.1 EF011617 mRNA Translation: ABK41107.1 CH471063 Genomic DNA Translation: EAW70318.1 |
RefSeqi | NP_060726.3, NM_018256.3 |
Genome annotation databases
GeneIDi | 55759 |
KEGGi | hsa:55759 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010900 Genomic DNA Translation: AAY24287.1 EF011617 mRNA Translation: ABK41107.1 CH471063 Genomic DNA Translation: EAW70318.1 |
RefSeqi | NP_060726.3, NM_018256.3 |
3D structure databases
SMRi | Q53T99 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 19949, 143 antibodies |
DNASUi | 55759 |
Genome annotation databases
GeneIDi | 55759 |
KEGGi | hsa:55759 |
Organism-specific databases
CTDi | 55759 |
EuPathDBi | HostDB:ENSG00000138442.9 |
PharmGKBi | PA37841 |
Phylogenomic databases
HOGENOMi | CLU_000288_57_0_1 |
OMAi | PFDFLIN |
OrthoDBi | 1540178at2759 |
Miscellaneous databases
BioGRID-ORCSi | 55759, 707 hits in 848 CRISPR screens |
ChiTaRSi | WDR12, human |
GenomeRNAii | 55759 |
Gene expression databases
Bgeei | ENSG00000138442, Expressed in subventricular zone (outer) (primate) and 236 other tissues |
ExpressionAtlasi | Q53T99, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_03029, WDR12, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR012972, NLE IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR028599, WDR12/Ytm1 |
Pfami | View protein in Pfam PF08154, NLE, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53T99_HUMAN | |
Accessioni | Q53T99Primary (citable) accession number: Q53T99 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |