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Protein

HCLS1-binding protein 3

Gene

HS1BP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a modulator of IL-2 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

  • regulation of apoptotic process Source: ParkinsonsUK-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
HCLS1-binding protein 3
Alternative name(s):
HS1-binding protein 3
Short name:
HSP1BP-3
Gene namesi
Name:HS1BP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000118960.12
HGNCiHGNC:24979 HS1BP3
MIMi609359 gene
neXtProtiNX_Q53T59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi64342
OpenTargetsiENSG00000118960
PharmGKBiPA162391602

Polymorphism and mutation databases

BioMutaiHS1BP3
DMDMi74726842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138021 – 392HCLS1-binding protein 3Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei337N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ53T59
MaxQBiQ53T59
PaxDbiQ53T59
PeptideAtlasiQ53T59
PRIDEiQ53T59
ProteomicsDBi62542

PTM databases

iPTMnetiQ53T59
PhosphoSitePlusiQ53T59

Expressioni

Gene expression databases

BgeeiENSG00000118960 Expressed in 193 organ(s), highest expression level in right adrenal gland
CleanExiHS_HS1BP3
ExpressionAtlasiQ53T59 baseline and differential
GenevisibleiQ53T59 HS

Organism-specific databases

HPAiHPA035050

Interactioni

Subunit structurei

Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro (By similarity).By similarity

Protein-protein interaction databases

BioGridi122141, 11 interactors
IntActiQ53T59, 1 interactor
STRINGi9606.ENSP00000305193

Structurei

3D structure databases

ProteinModelPortaliQ53T59
SMRiQ53T59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 142PXPROSITE-ProRule annotationAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 199Poly-Glu4
Compositional biasi212 – 237Pro-richAdd BLAST26
Compositional biasi324 – 352Pro-richAdd BLAST29

Phylogenomic databases

eggNOGiENOG410IGRU Eukaryota
ENOG41121IK LUCA
GeneTreeiENSGT00390000013092
HOGENOMiHOG000112839
HOVERGENiHBG098900
InParanoidiQ53T59
OMAiIRDHDTP
OrthoDBiEOG091G12JB
PhylomeDBiQ53T59
TreeFamiTF335484

Family and domain databases

CDDicd06868 PX_HS1BP3, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR037901 HS1BP3_PX
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

Q53T59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSPAVLVTS RRLQNAHTGL DLTVPQHQEV RGKMMSGHVE YQILVVTRLA
60 70 80 90 100
AFKSAKHRPE DVVQFLVSKK YSEIEEFYQK LSSRYAAASL PPLPRKVLFV
110 120 130 140 150
GESDIRERRA VFNEILRCVS KDAELAGSPE LLEFLGTRSP GAAGLTSRDS
160 170 180 190 200
SVLDGTDSQT GNDEEAFDFF EEQDQVAEEG PPVQSLKGED AEESLEEEEA
210 220 230 240 250
LDPLGIMRSK KPKKHPKVAV KAKPSPRLTI FDEEVDPDEG LFGPGRKLSP
260 270 280 290 300
QDPSEDVSSV DPLKLFDDPD LGGAIPLGDS LLLPAACESG GPTPSLSHRD
310 320 330 340 350
ASKELFRVEE DLDQILNLGA EPKPKPQLKP KPPVAAKPVI PRKPAVPPKA
360 370 380 390
GPAEAVAGQQ KPQEQIQAMD EMDILQYIQD HDTPAQAAPS LF
Length:392
Mass (Da):42,780
Last modified:May 24, 2005 - v1
Checksum:i2A360915F833FAE8
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TR53F6TR53_HUMAN
HCLS1-binding protein 3
HS1BP3
213Annotation score:
B5MC96B5MC96_HUMAN
HCLS1-binding protein 3
HS1BP3
199Annotation score:
H7C0Y9H7C0Y9_HUMAN
HCLS1-binding protein 3
HS1BP3
111Annotation score:
H7BZZ1H7BZZ1_HUMAN
HCLS1-binding protein 3
HS1BP3
132Annotation score:
H7BZ19H7BZ19_HUMAN
HCLS1-binding protein 3
HS1BP3
74Annotation score:
F8WDN8F8WDN8_HUMAN
HCLS1-binding protein 3
HS1BP3
123Annotation score:
A0A0D9SFN1A0A0D9SFN1_HUMAN
HCLS1-binding protein 3
HS1BP3
25Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037741260V → M2 PublicationsCorresponds to variant dbSNP:rs2305458Ensembl.1
Natural variantiVAR_037742273G → R. Corresponds to variant dbSNP:rs35589938Ensembl.1
Natural variantiVAR_037743348P → R. Corresponds to variant dbSNP:rs35579164Ensembl.1
Natural variantiVAR_037744388A → T1 PublicationCorresponds to variant dbSNP:rs3732149Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314383 mRNA Translation: BAG37009.1
AC012065 Genomic DNA Translation: AAX93235.1
CH471053 Genomic DNA Translation: EAX00814.1
CH471053 Genomic DNA Translation: EAX00816.1
BC050636 mRNA Translation: AAH50636.1
CCDSiCCDS1700.1
RefSeqiNP_071905.3, NM_022460.3
UniGeneiHs.531785

Genome annotation databases

EnsembliENST00000304031; ENSP00000305193; ENSG00000118960
GeneIDi64342
KEGGihsa:64342
UCSCiuc002rdw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiH1BP3_HUMAN
AccessioniPrimary (citable) accession number: Q53T59
Secondary accession number(s): B2RAW2
, D6W529, Q86VC2, Q8N367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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