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Entry version 119 (07 Oct 2020)
Sequence version 1 (24 May 2005)
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Protein
Submitted name:

Germ cell-less homolog 1 (Drosophila)

Gene

FLJ13057

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Germ cell-less homolog 1 (Drosophila)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLJ13057Imported
Synonyms:GMCL1Imported
ORF Names:hCG_40576Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000087338.4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485477

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000087338, Expressed in testis and 222 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q53SE7
With#Exp.IntAct
APLF [Q8IW19]3EBI-10172181,EBI-1256044
ApoL6 [B3KTP4]3EBI-10172181,EBI-10175904
BYSL [Q13895]3EBI-10172181,EBI-358049
C5orf60 - isoform 4 [A6NFR6-4]3EBI-10172181,EBI-10173955
CCDC25 [Q86WR0]3EBI-10172181,EBI-2690264
CFAP410 [O43822]3EBI-10172181,EBI-2835332
CHIC2 [Q9UKJ5]3EBI-10172181,EBI-741528
CIB3 [Q96Q77]3EBI-10172181,EBI-10292696
CLK2 [P49760]3EBI-10172181,EBI-750020
CUL3 [Q13618]3EBI-10172181,EBI-456129
ELOA [Q14241]3EBI-10172181,EBI-742350
FAM167A [Q96KS9]3EBI-10172181,EBI-10290462
FKBP1B [P68106]3EBI-10172181,EBI-6693977
FOSL2 [P15408]3EBI-10172181,EBI-3893419
FOXR1 [Q6PIV2]3EBI-10172181,EBI-10253815
FRMD6 [Q96NE9]3EBI-10172181,EBI-741729
FSBP [O95073]3EBI-10172181,EBI-1059030
GAGE1 [Q13065]3EBI-10172181,EBI-10227730
GAGE12E [A1L429]3EBI-10172181,EBI-10172187
GAGE12I [P0CL82]3EBI-10172181,EBI-10196803
GAGE2D [Q9UEU5]5EBI-10172181,EBI-751641
GAGE5 [Q13069]3EBI-10172181,EBI-745702
GLRX3 [O76003]3EBI-10172181,EBI-374781
GMCL2 [Q8NEA9]3EBI-10172181,EBI-745707
GRAMD1A [Q96CP6]3EBI-10172181,EBI-1384139
HYKK [A0A0C4DGM4]3EBI-10172181,EBI-10236738
IL17F [Q96PD4]3EBI-10172181,EBI-10292310
KAT5 [Q92993]3EBI-10172181,EBI-399080
KIFC3 [Q9BVG8]3EBI-10172181,EBI-2125614
KPNA2 [P52292]3EBI-10172181,EBI-349938
MID1 [O15344]3EBI-10172181,EBI-2340316
MID2 - isoform 2 [Q9UJV3-2]3EBI-10172181,EBI-10172526
MINDY1 [Q8N5J2]3EBI-10172181,EBI-372322
MORF4L1 [Q9UBU8]3EBI-10172181,EBI-399246
MPPE1 [Q53F39]3EBI-10172181,EBI-10242229
MTRR [Q9UBK8]3EBI-10172181,EBI-10319161
NEBL [O76041]3EBI-10172181,EBI-2880203
NUMA1 [Q14980]3EBI-10172181,EBI-521611
PARD6B [Q9BYG5]3EBI-10172181,EBI-295391
PARP16 [Q8N5Y8]3EBI-10172181,EBI-10266912
PAX4 [Q3KNR5]3EBI-10172181,EBI-10240813
PBXIP1 [Q96AQ6]3EBI-10172181,EBI-740845
PTPN7 [P35236]3EBI-10172181,EBI-2265723
QRICH1 [Q2TAL8]3EBI-10172181,EBI-2798044
SHQ1 [Q6PI26]3EBI-10172181,EBI-2515568
SLC15A3 [Q05CH4]3EBI-10172181,EBI-10223741
SNX20 [Q7Z614]3EBI-10172181,EBI-744896
STK3 [Q13188]3EBI-10172181,EBI-992580
SUMO1 [P63165]3EBI-10172181,EBI-80140
SUMO1P1 [G2XKQ0]3EBI-10172181,EBI-10175576
SYT17 [Q9BSW7]3EBI-10172181,EBI-745392
TRIM13 [O60858]3EBI-10172181,EBI-9867345
TRIM38 [O00635]3EBI-10172181,EBI-2130415
TRIM54 [Q9BYV2]3EBI-10172181,EBI-2130429
TSSC4 [Q9Y5U2]3EBI-10172181,EBI-717229
XAGE2 [Q96GT9]3EBI-10172181,EBI-750167
XAGE3 [Q8WTP9]3EBI-10172181,EBI-6448284
ZNF250 - isoform 3 [P15622-3]3EBI-10172181,EBI-10177272

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q53SE7, 58 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q53SE7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 178BTBInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni65 – 85DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025961_2_0_1

KEGG Orthology (KO)

More...
KOi
K10485

Identification of Orthologs from Complete Genome Data

More...
OMAi
YACASIY

Database of Orthologous Groups

More...
OrthoDBi
1111791at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705, BACK
IPR000210, BTB/POZ_dom
IPR043380, Gcl-like
IPR011333, SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23231, PTHR23231, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q53SE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH
60 70 80 90 100
KRKRSSGSFC YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT
110 120 130 140 150
LFLNGENSDI KICALGEEWS LHKIYLCQSG YFSSMFSGSW KESSMNIIEL
160 170 180 190 200
EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR VVAILAAACL LQLDGLIQQC
210 220 230 240 250
GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL MTHQNVELFK
260 270 280 290 300
ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT
310 320 330 340 350
ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE
360 370 380 390 400
QDAVVPSEWL SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK
410 420 430 440 450
LAKDGEYCWR WTGFNFGFDL LVTYTNRYII FKRNTLNQPC SGSVSLQPRR
460 470 480 490 500
SIAFRLRLAS FDSSGKLICS RTTGYQILTL EKDQEQVVMN LDSRLLIFPL
510
YICCNFLYIS PEKKN
Length:515
Mass (Da):58,685
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA310AEE9CE1AEEE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC019206 Genomic DNA Translation: AAY14865.1
CH471053 Genomic DNA Translation: EAW99842.1

NCBI Reference Sequences

More...
RefSeqi
NP_848526.1, NM_178439.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64395

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64395

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019206 Genomic DNA Translation: AAY14865.1
CH471053 Genomic DNA Translation: EAW99842.1
RefSeqiNP_848526.1, NM_178439.4

3D structure databases

SMRiQ53SE7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ53SE7, 58 interactors

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48205, 64 antibodies

The DNASU plasmid repository

More...
DNASUi
64395

Genome annotation databases

GeneIDi64395
KEGGihsa:64395

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64395
EuPathDBiHostDB:ENSG00000087338.4
PharmGKBiPA143485477

Phylogenomic databases

HOGENOMiCLU_025961_2_0_1
KOiK10485
OMAiYACASIY
OrthoDBi1111791at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
64395, 3 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GMCL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64395

Gene expression databases

BgeeiENSG00000087338, Expressed in testis and 222 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011705, BACK
IPR000210, BTB/POZ_dom
IPR043380, Gcl-like
IPR011333, SKP1/BTB/POZ_sf
PANTHERiPTHR23231, PTHR23231, 1 hit
PfamiView protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
SMARTiView protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ53SE7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53SE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 7, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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