UniProtKB - Q53S46 (Q53S46_HUMAN)
Protein
Submitted name:
Growth differentiation factor 8
Gene
GDF8
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- heparin binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- cellular response to dexamethasone stimulus Source: Ensembl
- myoblast migration involved in skeletal muscle regeneration Source: Ensembl
- negative regulation of insulin receptor signaling pathway Source: Ensembl
- negative regulation of kinase activity Source: Ensembl
- negative regulation of muscle hypertrophy Source: Ensembl
- negative regulation of myoblast proliferation Source: AgBase
- negative regulation of satellite cell differentiation Source: AgBase
- negative regulation of skeletal muscle satellite cell proliferation Source: AgBase
- negative regulation of skeletal muscle tissue growth Source: Ensembl
- ovulation cycle process Source: Ensembl
- positive regulation of lamellipodium assembly Source: Ensembl
- positive regulation of macrophage chemotaxis Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to gravity Source: Ensembl
- response to heat Source: Ensembl
- response to muscle activity Source: Ensembl
- response to testosterone Source: Ensembl
- skeletal muscle atrophy Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Growth differentiation factor 8ImportedSubmitted name: MyostatinImportedSubmitted name: cDNA FLJ75269, highly similar to Homo sapiens myostatin (GDF8) mRNAImported |
Gene namesi | Name:GDF8Imported ORF Names:hCG_24799Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138379.4 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5014309552 | 19 – 375 | Sequence analysisAdd BLAST | 357 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138379, Expressed in quadriceps femoris and 117 other tissues |
ExpressionAtlasi | Q53S46, baseline and differential |
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: Ensembl
Chemistry databases
BindingDBi | Q53S46 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 263 – 375 | TGF_BETA_2InterPro annotationAdd BLAST | 113 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_020515_6_1_1 |
OMAi | QICVYIY |
OrthoDBi | 892873at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53S46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS
60 70 80 90 100
SRIEAIKIQI LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD
110 120 130 140 150
SSDGSLEDDD YHATTETIIT MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK
160 170 180 190 200
VVKAQLWIYL RPVETPTTVF VQILRLIKPM KDGTRYTGIR SLKLDMNPGT
210 220 230 240 250
GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT FPGPGEDGLN
260 270 280 290 300
PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
310 320 330 340 350
PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM
360 370
LYFNGKEQII YGKIPAMVVD RCGCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073120 Genomic DNA Translation: AAY24188.1 DQ927048 Genomic DNA Translation: ABI48371.1 DQ927050 Genomic DNA Translation: ABI48373.1 DQ927053 Genomic DNA Translation: ABI48376.1 DQ927055 Genomic DNA Translation: ABI48378.1 DQ927057 Genomic DNA Translation: ABI48380.1 DQ927058 Genomic DNA Translation: ABI48381.1 DQ927059 Genomic DNA Translation: ABI48382.1 DQ927061 Genomic DNA Translation: ABI48384.1 DQ927064 Genomic DNA Translation: ABI48387.1 DQ927065 Genomic DNA Translation: ABI48388.1 DQ927068 Genomic DNA Translation: ABI48391.1 DQ927069 Genomic DNA Translation: ABI48392.1 DQ927070 Genomic DNA Translation: ABI48393.1 DQ927072 Genomic DNA Translation: ABI48395.1 DQ927080 Genomic DNA Translation: ABI48403.1 DQ927081 Genomic DNA Translation: ABI48404.1 DQ927083 Genomic DNA Translation: ABI48406.1 DQ927087 Genomic DNA Translation: ABI48410.1 DQ927088 Genomic DNA Translation: ABI48411.1 DQ927090 Genomic DNA Translation: ABI48413.1 DQ927091 Genomic DNA Translation: ABI48414.1 DQ927092 Genomic DNA Translation: ABI48415.1 DQ927093 Genomic DNA Translation: ABI48416.1 DQ927094 Genomic DNA Translation: ABI48417.1 DQ927097 Genomic DNA Translation: ABI48420.1 DQ927100 Genomic DNA Translation: ABI48423.1 DQ927101 Genomic DNA Translation: ABI48424.1 DQ927102 Genomic DNA Translation: ABI48425.1 DQ927104 Genomic DNA Translation: ABI48427.1 DQ927105 Genomic DNA Translation: ABI48428.1 DQ927107 Genomic DNA Translation: ABI48430.1 DQ927110 Genomic DNA Translation: ABI48433.1 DQ927111 Genomic DNA Translation: ABI48434.1 DQ927113 Genomic DNA Translation: ABI48436.1 DQ927117 Genomic DNA Translation: ABI48440.1 DQ927120 Genomic DNA Translation: ABI48443.1 DQ927121 Genomic DNA Translation: ABI48444.1 DQ927122 Genomic DNA Translation: ABI48445.1 DQ927123 Genomic DNA Translation: ABI48446.1 DQ927124 Genomic DNA Translation: ABI48447.1 DQ927125 Genomic DNA Translation: ABI48448.1 DQ927126 Genomic DNA Translation: ABI48449.1 DQ927127 Genomic DNA Translation: ABI48450.1 DQ927128 Genomic DNA Translation: ABI48451.1 DQ927130 Genomic DNA Translation: ABI48453.1 DQ927131 Genomic DNA Translation: ABI48454.1 DQ927133 Genomic DNA Translation: ABI48456.1 DQ927134 Genomic DNA Translation: ABI48457.1 DQ927135 Genomic DNA Translation: ABI48458.1 DQ927136 Genomic DNA Translation: ABI48459.1 DQ927137 Genomic DNA Translation: ABI48460.1 DQ927138 Genomic DNA Translation: ABI48461.1 DQ927139 Genomic DNA Translation: ABI48462.1 DQ927140 Genomic DNA Translation: ABI48463.1 DQ927141 Genomic DNA Translation: ABI48464.1 DQ927143 Genomic DNA Translation: ABI48466.1 DQ927144 Genomic DNA Translation: ABI48467.1 DQ927145 Genomic DNA Translation: ABI48468.1 DQ927146 Genomic DNA Translation: ABI48469.1 DQ927147 Genomic DNA Translation: ABI48470.1 DQ927148 Genomic DNA Translation: ABI48471.1 DQ927149 Genomic DNA Translation: ABI48472.1 DQ927150 Genomic DNA Translation: ABI48473.1 DQ927151 Genomic DNA Translation: ABI48474.1 DQ927152 Genomic DNA Translation: ABI48475.1 DQ927153 Genomic DNA Translation: ABI48476.1 DQ927154 Genomic DNA Translation: ABI48477.1 DQ927155 Genomic DNA Translation: ABI48478.1 DQ927156 Genomic DNA Translation: ABI48479.1 DQ927157 Genomic DNA Translation: ABI48480.1 DQ927158 Genomic DNA Translation: ABI48481.1 DQ927159 Genomic DNA Translation: ABI48482.1 DQ927160 Genomic DNA Translation: ABI48483.1 DQ927161 Genomic DNA Translation: ABI48484.1 DQ927162 Genomic DNA Translation: ABI48485.1 DQ927163 Genomic DNA Translation: ABI48486.1 DQ927164 Genomic DNA Translation: ABI48487.1 DQ927165 Genomic DNA Translation: ABI48488.1 DQ927166 Genomic DNA Translation: ABI48489.1 DQ927167 Genomic DNA Translation: ABI48490.1 DQ927168 Genomic DNA Translation: ABI48491.1 DQ927169 Genomic DNA Translation: ABI48492.1 DQ927170 Genomic DNA Translation: ABI48493.1 DQ927171 Genomic DNA Translation: ABI48494.1 DQ927172 Genomic DNA Translation: ABI48495.1 DQ927173 Genomic DNA Translation: ABI48496.1 DQ927174 Genomic DNA Translation: ABI48497.1 DQ927175 Genomic DNA Translation: ABI48498.1 DQ927176 Genomic DNA Translation: ABI48499.1 DQ927177 Genomic DNA Translation: ABI48500.1 DQ927179 Genomic DNA Translation: ABI48502.1 DQ927180 Genomic DNA Translation: ABI48503.1 DQ927181 Genomic DNA Translation: ABI48504.1 DQ927183 Genomic DNA Translation: ABI48506.1 DQ927184 Genomic DNA Translation: ABI48507.1 DQ927186 Genomic DNA Translation: ABI48509.1 DQ927187 Genomic DNA Translation: ABI48510.1 DQ927188 Genomic DNA Translation: ABI48511.1 DQ927189 Genomic DNA Translation: ABI48512.1 DQ927190 Genomic DNA Translation: ABI48513.1 DQ927191 Genomic DNA Translation: ABI48514.1 AK291524 mRNA Translation: BAF84213.1 CH471058 Genomic DNA Translation: EAX10880.1 |
RefSeqi | NP_005250.1, NM_005259.2 |
Genome annotation databases
GeneIDi | 2660 |
KEGGi | hsa:2660 |
UCSCi | uc002urp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073120 Genomic DNA Translation: AAY24188.1 DQ927048 Genomic DNA Translation: ABI48371.1 DQ927050 Genomic DNA Translation: ABI48373.1 DQ927053 Genomic DNA Translation: ABI48376.1 DQ927055 Genomic DNA Translation: ABI48378.1 DQ927057 Genomic DNA Translation: ABI48380.1 DQ927058 Genomic DNA Translation: ABI48381.1 DQ927059 Genomic DNA Translation: ABI48382.1 DQ927061 Genomic DNA Translation: ABI48384.1 DQ927064 Genomic DNA Translation: ABI48387.1 DQ927065 Genomic DNA Translation: ABI48388.1 DQ927068 Genomic DNA Translation: ABI48391.1 DQ927069 Genomic DNA Translation: ABI48392.1 DQ927070 Genomic DNA Translation: ABI48393.1 DQ927072 Genomic DNA Translation: ABI48395.1 DQ927080 Genomic DNA Translation: ABI48403.1 DQ927081 Genomic DNA Translation: ABI48404.1 DQ927083 Genomic DNA Translation: ABI48406.1 DQ927087 Genomic DNA Translation: ABI48410.1 DQ927088 Genomic DNA Translation: ABI48411.1 DQ927090 Genomic DNA Translation: ABI48413.1 DQ927091 Genomic DNA Translation: ABI48414.1 DQ927092 Genomic DNA Translation: ABI48415.1 DQ927093 Genomic DNA Translation: ABI48416.1 DQ927094 Genomic DNA Translation: ABI48417.1 DQ927097 Genomic DNA Translation: ABI48420.1 DQ927100 Genomic DNA Translation: ABI48423.1 DQ927101 Genomic DNA Translation: ABI48424.1 DQ927102 Genomic DNA Translation: ABI48425.1 DQ927104 Genomic DNA Translation: ABI48427.1 DQ927105 Genomic DNA Translation: ABI48428.1 DQ927107 Genomic DNA Translation: ABI48430.1 DQ927110 Genomic DNA Translation: ABI48433.1 DQ927111 Genomic DNA Translation: ABI48434.1 DQ927113 Genomic DNA Translation: ABI48436.1 DQ927117 Genomic DNA Translation: ABI48440.1 DQ927120 Genomic DNA Translation: ABI48443.1 DQ927121 Genomic DNA Translation: ABI48444.1 DQ927122 Genomic DNA Translation: ABI48445.1 DQ927123 Genomic DNA Translation: ABI48446.1 DQ927124 Genomic DNA Translation: ABI48447.1 DQ927125 Genomic DNA Translation: ABI48448.1 DQ927126 Genomic DNA Translation: ABI48449.1 DQ927127 Genomic DNA Translation: ABI48450.1 DQ927128 Genomic DNA Translation: ABI48451.1 DQ927130 Genomic DNA Translation: ABI48453.1 DQ927131 Genomic DNA Translation: ABI48454.1 DQ927133 Genomic DNA Translation: ABI48456.1 DQ927134 Genomic DNA Translation: ABI48457.1 DQ927135 Genomic DNA Translation: ABI48458.1 DQ927136 Genomic DNA Translation: ABI48459.1 DQ927137 Genomic DNA Translation: ABI48460.1 DQ927138 Genomic DNA Translation: ABI48461.1 DQ927139 Genomic DNA Translation: ABI48462.1 DQ927140 Genomic DNA Translation: ABI48463.1 DQ927141 Genomic DNA Translation: ABI48464.1 DQ927143 Genomic DNA Translation: ABI48466.1 DQ927144 Genomic DNA Translation: ABI48467.1 DQ927145 Genomic DNA Translation: ABI48468.1 DQ927146 Genomic DNA Translation: ABI48469.1 DQ927147 Genomic DNA Translation: ABI48470.1 DQ927148 Genomic DNA Translation: ABI48471.1 DQ927149 Genomic DNA Translation: ABI48472.1 DQ927150 Genomic DNA Translation: ABI48473.1 DQ927151 Genomic DNA Translation: ABI48474.1 DQ927152 Genomic DNA Translation: ABI48475.1 DQ927153 Genomic DNA Translation: ABI48476.1 DQ927154 Genomic DNA Translation: ABI48477.1 DQ927155 Genomic DNA Translation: ABI48478.1 DQ927156 Genomic DNA Translation: ABI48479.1 DQ927157 Genomic DNA Translation: ABI48480.1 DQ927158 Genomic DNA Translation: ABI48481.1 DQ927159 Genomic DNA Translation: ABI48482.1 DQ927160 Genomic DNA Translation: ABI48483.1 DQ927161 Genomic DNA Translation: ABI48484.1 DQ927162 Genomic DNA Translation: ABI48485.1 DQ927163 Genomic DNA Translation: ABI48486.1 DQ927164 Genomic DNA Translation: ABI48487.1 DQ927165 Genomic DNA Translation: ABI48488.1 DQ927166 Genomic DNA Translation: ABI48489.1 DQ927167 Genomic DNA Translation: ABI48490.1 DQ927168 Genomic DNA Translation: ABI48491.1 DQ927169 Genomic DNA Translation: ABI48492.1 DQ927170 Genomic DNA Translation: ABI48493.1 DQ927171 Genomic DNA Translation: ABI48494.1 DQ927172 Genomic DNA Translation: ABI48495.1 DQ927173 Genomic DNA Translation: ABI48496.1 DQ927174 Genomic DNA Translation: ABI48497.1 DQ927175 Genomic DNA Translation: ABI48498.1 DQ927176 Genomic DNA Translation: ABI48499.1 DQ927177 Genomic DNA Translation: ABI48500.1 DQ927179 Genomic DNA Translation: ABI48502.1 DQ927180 Genomic DNA Translation: ABI48503.1 DQ927181 Genomic DNA Translation: ABI48504.1 DQ927183 Genomic DNA Translation: ABI48506.1 DQ927184 Genomic DNA Translation: ABI48507.1 DQ927186 Genomic DNA Translation: ABI48509.1 DQ927187 Genomic DNA Translation: ABI48510.1 DQ927188 Genomic DNA Translation: ABI48511.1 DQ927189 Genomic DNA Translation: ABI48512.1 DQ927190 Genomic DNA Translation: ABI48513.1 DQ927191 Genomic DNA Translation: ABI48514.1 AK291524 mRNA Translation: BAF84213.1 CH471058 Genomic DNA Translation: EAX10880.1 |
RefSeqi | NP_005250.1, NM_005259.2 |
3D structure databases
SMRi | Q53S46 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q53S46 |
Protocols and materials databases
Antibodypediai | 4098, 816 antibodies |
DNASUi | 2660 |
Genome annotation databases
GeneIDi | 2660 |
KEGGi | hsa:2660 |
UCSCi | uc002urp.4, human |
Organism-specific databases
CTDi | 2660 |
EuPathDBi | HostDB:ENSG00000138379.4 |
PharmGKBi | PA162396253 |
Phylogenomic databases
HOGENOMi | CLU_020515_6_1_1 |
OMAi | QICVYIY |
OrthoDBi | 892873at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2660, 2 hits in 842 CRISPR screens |
GenomeRNAii | 2660 |
Gene expression databases
Bgeei | ENSG00000138379, Expressed in quadriceps femoris and 117 other tissues |
ExpressionAtlasi | Q53S46, baseline and differential |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53S46_HUMAN | |
Accessioni | Q53S46Primary (citable) accession number: Q53S46 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |