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Entry version 137 (02 Dec 2020)
Sequence version 1 (24 May 2005)
Previous versions | rss
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Protein
Submitted name:

Growth differentiation factor 8

Gene

GDF8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factorUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Growth differentiation factor 8Imported
Submitted name:
MyostatinImported
Submitted name:
cDNA FLJ75269, highly similar to Homo sapiens myostatin (GDF8) mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GDF8Imported
ORF Names:hCG_24799Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000138379.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162396253

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501430955219 – 375Sequence analysisAdd BLAST357

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138379, Expressed in quadriceps femoris and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q53S46, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q53S46

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q53S46

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini263 – 375TGF_BETA_2InterPro annotationAdd BLAST113

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020515_6_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QICVYIY

Database of Orthologous Groups

More...
OrthoDBi
892873at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR001839, TGF-b_C
IPR001111, TGF-b_propeptide
IPR015615, TGF-beta-rel
IPR017948, TGFb_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11848, PTHR11848, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00019, TGF_beta, 1 hit
PF00688, TGFb_propeptide, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00204, TGFB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00250, TGF_BETA_1, 1 hit
PS51362, TGF_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q53S46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS
60 70 80 90 100
SRIEAIKIQI LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD
110 120 130 140 150
SSDGSLEDDD YHATTETIIT MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK
160 170 180 190 200
VVKAQLWIYL RPVETPTTVF VQILRLIKPM KDGTRYTGIR SLKLDMNPGT
210 220 230 240 250
GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT FPGPGEDGLN
260 270 280 290 300
PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
310 320 330 340 350
PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM
360 370
LYFNGKEQII YGKIPAMVVD RCGCS
Length:375
Mass (Da):42,750
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBFF6129725E6AFA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC073120 Genomic DNA Translation: AAY24188.1
DQ927048 Genomic DNA Translation: ABI48371.1
DQ927050 Genomic DNA Translation: ABI48373.1
DQ927053 Genomic DNA Translation: ABI48376.1
DQ927055 Genomic DNA Translation: ABI48378.1
DQ927057 Genomic DNA Translation: ABI48380.1
DQ927058 Genomic DNA Translation: ABI48381.1
DQ927059 Genomic DNA Translation: ABI48382.1
DQ927061 Genomic DNA Translation: ABI48384.1
DQ927064 Genomic DNA Translation: ABI48387.1
DQ927065 Genomic DNA Translation: ABI48388.1
DQ927068 Genomic DNA Translation: ABI48391.1
DQ927069 Genomic DNA Translation: ABI48392.1
DQ927070 Genomic DNA Translation: ABI48393.1
DQ927072 Genomic DNA Translation: ABI48395.1
DQ927080 Genomic DNA Translation: ABI48403.1
DQ927081 Genomic DNA Translation: ABI48404.1
DQ927083 Genomic DNA Translation: ABI48406.1
DQ927087 Genomic DNA Translation: ABI48410.1
DQ927088 Genomic DNA Translation: ABI48411.1
DQ927090 Genomic DNA Translation: ABI48413.1
DQ927091 Genomic DNA Translation: ABI48414.1
DQ927092 Genomic DNA Translation: ABI48415.1
DQ927093 Genomic DNA Translation: ABI48416.1
DQ927094 Genomic DNA Translation: ABI48417.1
DQ927097 Genomic DNA Translation: ABI48420.1
DQ927100 Genomic DNA Translation: ABI48423.1
DQ927101 Genomic DNA Translation: ABI48424.1
DQ927102 Genomic DNA Translation: ABI48425.1
DQ927104 Genomic DNA Translation: ABI48427.1
DQ927105 Genomic DNA Translation: ABI48428.1
DQ927107 Genomic DNA Translation: ABI48430.1
DQ927110 Genomic DNA Translation: ABI48433.1
DQ927111 Genomic DNA Translation: ABI48434.1
DQ927113 Genomic DNA Translation: ABI48436.1
DQ927117 Genomic DNA Translation: ABI48440.1
DQ927120 Genomic DNA Translation: ABI48443.1
DQ927121 Genomic DNA Translation: ABI48444.1
DQ927122 Genomic DNA Translation: ABI48445.1
DQ927123 Genomic DNA Translation: ABI48446.1
DQ927124 Genomic DNA Translation: ABI48447.1
DQ927125 Genomic DNA Translation: ABI48448.1
DQ927126 Genomic DNA Translation: ABI48449.1
DQ927127 Genomic DNA Translation: ABI48450.1
DQ927128 Genomic DNA Translation: ABI48451.1
DQ927130 Genomic DNA Translation: ABI48453.1
DQ927131 Genomic DNA Translation: ABI48454.1
DQ927133 Genomic DNA Translation: ABI48456.1
DQ927134 Genomic DNA Translation: ABI48457.1
DQ927135 Genomic DNA Translation: ABI48458.1
DQ927136 Genomic DNA Translation: ABI48459.1
DQ927137 Genomic DNA Translation: ABI48460.1
DQ927138 Genomic DNA Translation: ABI48461.1
DQ927139 Genomic DNA Translation: ABI48462.1
DQ927140 Genomic DNA Translation: ABI48463.1
DQ927141 Genomic DNA Translation: ABI48464.1
DQ927143 Genomic DNA Translation: ABI48466.1
DQ927144 Genomic DNA Translation: ABI48467.1
DQ927145 Genomic DNA Translation: ABI48468.1
DQ927146 Genomic DNA Translation: ABI48469.1
DQ927147 Genomic DNA Translation: ABI48470.1
DQ927148 Genomic DNA Translation: ABI48471.1
DQ927149 Genomic DNA Translation: ABI48472.1
DQ927150 Genomic DNA Translation: ABI48473.1
DQ927151 Genomic DNA Translation: ABI48474.1
DQ927152 Genomic DNA Translation: ABI48475.1
DQ927153 Genomic DNA Translation: ABI48476.1
DQ927154 Genomic DNA Translation: ABI48477.1
DQ927155 Genomic DNA Translation: ABI48478.1
DQ927156 Genomic DNA Translation: ABI48479.1
DQ927157 Genomic DNA Translation: ABI48480.1
DQ927158 Genomic DNA Translation: ABI48481.1
DQ927159 Genomic DNA Translation: ABI48482.1
DQ927160 Genomic DNA Translation: ABI48483.1
DQ927161 Genomic DNA Translation: ABI48484.1
DQ927162 Genomic DNA Translation: ABI48485.1
DQ927163 Genomic DNA Translation: ABI48486.1
DQ927164 Genomic DNA Translation: ABI48487.1
DQ927165 Genomic DNA Translation: ABI48488.1
DQ927166 Genomic DNA Translation: ABI48489.1
DQ927167 Genomic DNA Translation: ABI48490.1
DQ927168 Genomic DNA Translation: ABI48491.1
DQ927169 Genomic DNA Translation: ABI48492.1
DQ927170 Genomic DNA Translation: ABI48493.1
DQ927171 Genomic DNA Translation: ABI48494.1
DQ927172 Genomic DNA Translation: ABI48495.1
DQ927173 Genomic DNA Translation: ABI48496.1
DQ927174 Genomic DNA Translation: ABI48497.1
DQ927175 Genomic DNA Translation: ABI48498.1
DQ927176 Genomic DNA Translation: ABI48499.1
DQ927177 Genomic DNA Translation: ABI48500.1
DQ927179 Genomic DNA Translation: ABI48502.1
DQ927180 Genomic DNA Translation: ABI48503.1
DQ927181 Genomic DNA Translation: ABI48504.1
DQ927183 Genomic DNA Translation: ABI48506.1
DQ927184 Genomic DNA Translation: ABI48507.1
DQ927186 Genomic DNA Translation: ABI48509.1
DQ927187 Genomic DNA Translation: ABI48510.1
DQ927188 Genomic DNA Translation: ABI48511.1
DQ927189 Genomic DNA Translation: ABI48512.1
DQ927190 Genomic DNA Translation: ABI48513.1
DQ927191 Genomic DNA Translation: ABI48514.1
AK291524 mRNA Translation: BAF84213.1
CH471058 Genomic DNA Translation: EAX10880.1

NCBI Reference Sequences

More...
RefSeqi
NP_005250.1, NM_005259.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2660

UCSC genome browser

More...
UCSCi
uc002urp.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073120 Genomic DNA Translation: AAY24188.1
DQ927048 Genomic DNA Translation: ABI48371.1
DQ927050 Genomic DNA Translation: ABI48373.1
DQ927053 Genomic DNA Translation: ABI48376.1
DQ927055 Genomic DNA Translation: ABI48378.1
DQ927057 Genomic DNA Translation: ABI48380.1
DQ927058 Genomic DNA Translation: ABI48381.1
DQ927059 Genomic DNA Translation: ABI48382.1
DQ927061 Genomic DNA Translation: ABI48384.1
DQ927064 Genomic DNA Translation: ABI48387.1
DQ927065 Genomic DNA Translation: ABI48388.1
DQ927068 Genomic DNA Translation: ABI48391.1
DQ927069 Genomic DNA Translation: ABI48392.1
DQ927070 Genomic DNA Translation: ABI48393.1
DQ927072 Genomic DNA Translation: ABI48395.1
DQ927080 Genomic DNA Translation: ABI48403.1
DQ927081 Genomic DNA Translation: ABI48404.1
DQ927083 Genomic DNA Translation: ABI48406.1
DQ927087 Genomic DNA Translation: ABI48410.1
DQ927088 Genomic DNA Translation: ABI48411.1
DQ927090 Genomic DNA Translation: ABI48413.1
DQ927091 Genomic DNA Translation: ABI48414.1
DQ927092 Genomic DNA Translation: ABI48415.1
DQ927093 Genomic DNA Translation: ABI48416.1
DQ927094 Genomic DNA Translation: ABI48417.1
DQ927097 Genomic DNA Translation: ABI48420.1
DQ927100 Genomic DNA Translation: ABI48423.1
DQ927101 Genomic DNA Translation: ABI48424.1
DQ927102 Genomic DNA Translation: ABI48425.1
DQ927104 Genomic DNA Translation: ABI48427.1
DQ927105 Genomic DNA Translation: ABI48428.1
DQ927107 Genomic DNA Translation: ABI48430.1
DQ927110 Genomic DNA Translation: ABI48433.1
DQ927111 Genomic DNA Translation: ABI48434.1
DQ927113 Genomic DNA Translation: ABI48436.1
DQ927117 Genomic DNA Translation: ABI48440.1
DQ927120 Genomic DNA Translation: ABI48443.1
DQ927121 Genomic DNA Translation: ABI48444.1
DQ927122 Genomic DNA Translation: ABI48445.1
DQ927123 Genomic DNA Translation: ABI48446.1
DQ927124 Genomic DNA Translation: ABI48447.1
DQ927125 Genomic DNA Translation: ABI48448.1
DQ927126 Genomic DNA Translation: ABI48449.1
DQ927127 Genomic DNA Translation: ABI48450.1
DQ927128 Genomic DNA Translation: ABI48451.1
DQ927130 Genomic DNA Translation: ABI48453.1
DQ927131 Genomic DNA Translation: ABI48454.1
DQ927133 Genomic DNA Translation: ABI48456.1
DQ927134 Genomic DNA Translation: ABI48457.1
DQ927135 Genomic DNA Translation: ABI48458.1
DQ927136 Genomic DNA Translation: ABI48459.1
DQ927137 Genomic DNA Translation: ABI48460.1
DQ927138 Genomic DNA Translation: ABI48461.1
DQ927139 Genomic DNA Translation: ABI48462.1
DQ927140 Genomic DNA Translation: ABI48463.1
DQ927141 Genomic DNA Translation: ABI48464.1
DQ927143 Genomic DNA Translation: ABI48466.1
DQ927144 Genomic DNA Translation: ABI48467.1
DQ927145 Genomic DNA Translation: ABI48468.1
DQ927146 Genomic DNA Translation: ABI48469.1
DQ927147 Genomic DNA Translation: ABI48470.1
DQ927148 Genomic DNA Translation: ABI48471.1
DQ927149 Genomic DNA Translation: ABI48472.1
DQ927150 Genomic DNA Translation: ABI48473.1
DQ927151 Genomic DNA Translation: ABI48474.1
DQ927152 Genomic DNA Translation: ABI48475.1
DQ927153 Genomic DNA Translation: ABI48476.1
DQ927154 Genomic DNA Translation: ABI48477.1
DQ927155 Genomic DNA Translation: ABI48478.1
DQ927156 Genomic DNA Translation: ABI48479.1
DQ927157 Genomic DNA Translation: ABI48480.1
DQ927158 Genomic DNA Translation: ABI48481.1
DQ927159 Genomic DNA Translation: ABI48482.1
DQ927160 Genomic DNA Translation: ABI48483.1
DQ927161 Genomic DNA Translation: ABI48484.1
DQ927162 Genomic DNA Translation: ABI48485.1
DQ927163 Genomic DNA Translation: ABI48486.1
DQ927164 Genomic DNA Translation: ABI48487.1
DQ927165 Genomic DNA Translation: ABI48488.1
DQ927166 Genomic DNA Translation: ABI48489.1
DQ927167 Genomic DNA Translation: ABI48490.1
DQ927168 Genomic DNA Translation: ABI48491.1
DQ927169 Genomic DNA Translation: ABI48492.1
DQ927170 Genomic DNA Translation: ABI48493.1
DQ927171 Genomic DNA Translation: ABI48494.1
DQ927172 Genomic DNA Translation: ABI48495.1
DQ927173 Genomic DNA Translation: ABI48496.1
DQ927174 Genomic DNA Translation: ABI48497.1
DQ927175 Genomic DNA Translation: ABI48498.1
DQ927176 Genomic DNA Translation: ABI48499.1
DQ927177 Genomic DNA Translation: ABI48500.1
DQ927179 Genomic DNA Translation: ABI48502.1
DQ927180 Genomic DNA Translation: ABI48503.1
DQ927181 Genomic DNA Translation: ABI48504.1
DQ927183 Genomic DNA Translation: ABI48506.1
DQ927184 Genomic DNA Translation: ABI48507.1
DQ927186 Genomic DNA Translation: ABI48509.1
DQ927187 Genomic DNA Translation: ABI48510.1
DQ927188 Genomic DNA Translation: ABI48511.1
DQ927189 Genomic DNA Translation: ABI48512.1
DQ927190 Genomic DNA Translation: ABI48513.1
DQ927191 Genomic DNA Translation: ABI48514.1
AK291524 mRNA Translation: BAF84213.1
CH471058 Genomic DNA Translation: EAX10880.1
RefSeqiNP_005250.1, NM_005259.2

3D structure databases

SMRiQ53S46
ModBaseiSearch...

Chemistry databases

BindingDBiQ53S46

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4098, 816 antibodies

The DNASU plasmid repository

More...
DNASUi
2660

Genome annotation databases

GeneIDi2660
KEGGihsa:2660
UCSCiuc002urp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2660
EuPathDBiHostDB:ENSG00000138379.4
PharmGKBiPA162396253

Phylogenomic databases

HOGENOMiCLU_020515_6_1_1
OMAiQICVYIY
OrthoDBi892873at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2660, 2 hits in 842 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2660

Gene expression databases

BgeeiENSG00000138379, Expressed in quadriceps femoris and 117 other tissues
ExpressionAtlasiQ53S46, baseline and differential

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR001839, TGF-b_C
IPR001111, TGF-b_propeptide
IPR015615, TGF-beta-rel
IPR017948, TGFb_CS
PANTHERiPTHR11848, PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019, TGF_beta, 1 hit
PF00688, TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204, TGFB, 1 hit
SUPFAMiSSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250, TGF_BETA_1, 1 hit
PS51362, TGF_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ53S46_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53S46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: December 2, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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