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Protein
Submitted name:

Growth differentiation factor 8

Gene

GDF8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Growth differentiation factor 8Imported
Submitted name:
MyostatinImported
Submitted name:
cDNA FLJ75269, highly similar to Homo sapiens myostatin (GDF8) mRNAImported
Gene namesi
Name:GDF8Imported
ORF Names:hCG_24799Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000138379.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396253

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501430955219 – 375Sequence analysisAdd BLAST357

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000138379
ExpressionAtlasiQ53S46 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ53S46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 375TGF_BETA_2InterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
HOVERGENiHBG000217
KOiK05497
OMAiKDGLCNA
OrthoDBiEOG091G078V

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR015616 GDF_8
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF150 PTHR11848:SF150, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q53S46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS
60 70 80 90 100
SRIEAIKIQI LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD
110 120 130 140 150
SSDGSLEDDD YHATTETIIT MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK
160 170 180 190 200
VVKAQLWIYL RPVETPTTVF VQILRLIKPM KDGTRYTGIR SLKLDMNPGT
210 220 230 240 250
GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT FPGPGEDGLN
260 270 280 290 300
PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
310 320 330 340 350
PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM
360 370
LYFNGKEQII YGKIPAMVVD RCGCS
Length:375
Mass (Da):42,750
Last modified:May 24, 2005 - v1
Checksum:iEBFF6129725E6AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073120 Genomic DNA Translation: AAY24188.1
DQ927048 Genomic DNA Translation: ABI48371.1
DQ927050 Genomic DNA Translation: ABI48373.1
DQ927053 Genomic DNA Translation: ABI48376.1
DQ927055 Genomic DNA Translation: ABI48378.1
DQ927057 Genomic DNA Translation: ABI48380.1
DQ927058 Genomic DNA Translation: ABI48381.1
DQ927059 Genomic DNA Translation: ABI48382.1
DQ927061 Genomic DNA Translation: ABI48384.1
DQ927064 Genomic DNA Translation: ABI48387.1
DQ927065 Genomic DNA Translation: ABI48388.1
DQ927068 Genomic DNA Translation: ABI48391.1
DQ927069 Genomic DNA Translation: ABI48392.1
DQ927070 Genomic DNA Translation: ABI48393.1
DQ927072 Genomic DNA Translation: ABI48395.1
DQ927080 Genomic DNA Translation: ABI48403.1
DQ927081 Genomic DNA Translation: ABI48404.1
DQ927083 Genomic DNA Translation: ABI48406.1
DQ927087 Genomic DNA Translation: ABI48410.1
DQ927088 Genomic DNA Translation: ABI48411.1
DQ927090 Genomic DNA Translation: ABI48413.1
DQ927091 Genomic DNA Translation: ABI48414.1
DQ927092 Genomic DNA Translation: ABI48415.1
DQ927093 Genomic DNA Translation: ABI48416.1
DQ927094 Genomic DNA Translation: ABI48417.1
DQ927097 Genomic DNA Translation: ABI48420.1
DQ927100 Genomic DNA Translation: ABI48423.1
DQ927101 Genomic DNA Translation: ABI48424.1
DQ927102 Genomic DNA Translation: ABI48425.1
DQ927104 Genomic DNA Translation: ABI48427.1
DQ927105 Genomic DNA Translation: ABI48428.1
DQ927107 Genomic DNA Translation: ABI48430.1
DQ927110 Genomic DNA Translation: ABI48433.1
DQ927111 Genomic DNA Translation: ABI48434.1
DQ927113 Genomic DNA Translation: ABI48436.1
DQ927117 Genomic DNA Translation: ABI48440.1
DQ927120 Genomic DNA Translation: ABI48443.1
DQ927121 Genomic DNA Translation: ABI48444.1
DQ927122 Genomic DNA Translation: ABI48445.1
DQ927123 Genomic DNA Translation: ABI48446.1
DQ927124 Genomic DNA Translation: ABI48447.1
DQ927125 Genomic DNA Translation: ABI48448.1
DQ927126 Genomic DNA Translation: ABI48449.1
DQ927127 Genomic DNA Translation: ABI48450.1
DQ927128 Genomic DNA Translation: ABI48451.1
DQ927130 Genomic DNA Translation: ABI48453.1
DQ927131 Genomic DNA Translation: ABI48454.1
DQ927133 Genomic DNA Translation: ABI48456.1
DQ927134 Genomic DNA Translation: ABI48457.1
DQ927135 Genomic DNA Translation: ABI48458.1
DQ927136 Genomic DNA Translation: ABI48459.1
DQ927137 Genomic DNA Translation: ABI48460.1
DQ927138 Genomic DNA Translation: ABI48461.1
DQ927139 Genomic DNA Translation: ABI48462.1
DQ927140 Genomic DNA Translation: ABI48463.1
DQ927141 Genomic DNA Translation: ABI48464.1
DQ927143 Genomic DNA Translation: ABI48466.1
DQ927144 Genomic DNA Translation: ABI48467.1
DQ927145 Genomic DNA Translation: ABI48468.1
DQ927146 Genomic DNA Translation: ABI48469.1
DQ927147 Genomic DNA Translation: ABI48470.1
DQ927148 Genomic DNA Translation: ABI48471.1
DQ927149 Genomic DNA Translation: ABI48472.1
DQ927150 Genomic DNA Translation: ABI48473.1
DQ927151 Genomic DNA Translation: ABI48474.1
DQ927152 Genomic DNA Translation: ABI48475.1
DQ927153 Genomic DNA Translation: ABI48476.1
DQ927154 Genomic DNA Translation: ABI48477.1
DQ927155 Genomic DNA Translation: ABI48478.1
DQ927156 Genomic DNA Translation: ABI48479.1
DQ927157 Genomic DNA Translation: ABI48480.1
DQ927158 Genomic DNA Translation: ABI48481.1
DQ927159 Genomic DNA Translation: ABI48482.1
DQ927160 Genomic DNA Translation: ABI48483.1
DQ927161 Genomic DNA Translation: ABI48484.1
DQ927162 Genomic DNA Translation: ABI48485.1
DQ927163 Genomic DNA Translation: ABI48486.1
DQ927164 Genomic DNA Translation: ABI48487.1
DQ927165 Genomic DNA Translation: ABI48488.1
DQ927166 Genomic DNA Translation: ABI48489.1
DQ927167 Genomic DNA Translation: ABI48490.1
DQ927168 Genomic DNA Translation: ABI48491.1
DQ927169 Genomic DNA Translation: ABI48492.1
DQ927170 Genomic DNA Translation: ABI48493.1
DQ927171 Genomic DNA Translation: ABI48494.1
DQ927172 Genomic DNA Translation: ABI48495.1
DQ927173 Genomic DNA Translation: ABI48496.1
DQ927174 Genomic DNA Translation: ABI48497.1
DQ927175 Genomic DNA Translation: ABI48498.1
DQ927176 Genomic DNA Translation: ABI48499.1
DQ927177 Genomic DNA Translation: ABI48500.1
DQ927179 Genomic DNA Translation: ABI48502.1
DQ927180 Genomic DNA Translation: ABI48503.1
DQ927181 Genomic DNA Translation: ABI48504.1
DQ927183 Genomic DNA Translation: ABI48506.1
DQ927184 Genomic DNA Translation: ABI48507.1
DQ927186 Genomic DNA Translation: ABI48509.1
DQ927187 Genomic DNA Translation: ABI48510.1
DQ927188 Genomic DNA Translation: ABI48511.1
DQ927189 Genomic DNA Translation: ABI48512.1
DQ927190 Genomic DNA Translation: ABI48513.1
DQ927191 Genomic DNA Translation: ABI48514.1
AK291524 mRNA Translation: BAF84213.1
CH471058 Genomic DNA Translation: EAX10880.1
RefSeqiNP_005250.1, NM_005259.2
UniGeneiHs.41565

Genome annotation databases

GeneIDi2660
KEGGihsa:2660
UCSCiuc002urp.4 human

Similar proteinsi

Entry informationi

Entry nameiQ53S46_HUMAN
AccessioniPrimary (citable) accession number: Q53S46
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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