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UniProtKB - Q53S33 (BOLA3_HUMAN)

Entry version 112 (18 Sep 2019)
Sequence version 1 (24 May 2005)
Previous versions | rss
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Protein

BolA-like protein 3

Gene

BOLA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 (PubMed:27532772).By similarity1 Publication

Caution

Was initially reported to be secreted via a non-classical export pathway (PubMed:18548201). It was however later shown that it localizes to mitochondria, in agreement with other members of the family (PubMed:22746225).2 Publications

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BolA-like protein 3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BOLA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24415 BOLA3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613183 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q53S33

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Multiple mitochondrial dysfunctions syndrome 2 with hyperglycinemia (MMDS2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe disorder of systemic energy metabolism, resulting in weakness, respiratory failure, lack of neurologic development, lactic acidosis, hyperglycinemia and early death. Some patients show failure to thrive, pulmonary hypertension, hypotonia and irritability. Biochemical features include severe combined deficiency of the 2-oxoacid dehydrogenases, defective lipoic acid synthesis and reduction in activity of mitochondrial respiratory chain complexes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07791046 – 107Missing in MMDS2. 1 PublicationAdd BLAST62
Natural variantiVAR_07791167I → N in MMDS2. 1 PublicationCorresponds to variant dbSNP:rs550855238Ensembl.1
Natural variantiVAR_07618096H → R in MMDS2. 1 PublicationCorresponds to variant dbSNP:rs148674363Ensembl.1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		388962

MalaCards human disease database

More...MalaCardsi		BOLA3
MIMi614299 phenotype

Open Targets

More...OpenTargetsi		ENSG00000163170

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		401874 Multiple mitochondrial dysfunctions syndrome type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672554

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BOLA3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74726650

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455011 – 107BolA-like protein 3Add BLAST107

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q53S33

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q53S33

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q53S33

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q53S33

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q53S33

PeptideAtlas

More...PeptideAtlasi		Q53S33

PRoteomics IDEntifications database

More...PRIDEi		Q53S33

ProteomicsDB human proteome resource

More...ProteomicsDBi		33698
62531 [Q53S33-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q53S33-1 [Q53S33-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q53S33

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q53S33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163170 Expressed in 197 organ(s), highest expression level in deltoid

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q53S33 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA053162

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NFU1 (PubMed:27532772).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		132922, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q53S33, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331369

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q53S33

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3348 Eukaryota
COG0271 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013048

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000255169

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q53S33

KEGG Orthology (KO)

More...KOi		K22075

Identification of Orthologs from Complete Genome Data

More...OMAi		GAMYEIQ

Database of Orthologous Groups

More...OrthoDBi		1571278at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q53S33

TreeFam database of animal gene trees

More...TreeFami		TF332952

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002634 BolA
IPR036065 BolA-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01722 BolA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82657 SSF82657, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q53S33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAWSPAAAA PLLRGIRGLP LHHRMFATQT EGELRVTQIL KEKFPRATAI 
        60         70         80         90        100
KVTDISGGCG AMYEIKIESE EFKEKRTVQQ HQMVNQALKE EIKEMHGLRI 

FTSVPKR
Length:107
Mass (Da):12,114
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF3BF21DF14BD136
GO
Isoform 2 (identifier: Q53S33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-107: GCGAMYEIKI...LRIFTSVPKR → TKRRNQRDAW...WMNFTDIILP

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,569
Checksum:iB57EDE2A2A0A1F69
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07791046 – 107Missing in MMDS2. 1 PublicationAdd BLAST62
Natural variantiVAR_07791167I → N in MMDS2. 1 PublicationCorresponds to variant dbSNP:rs550855238Ensembl.1
Natural variantiVAR_07618096H → R in MMDS2. 1 PublicationCorresponds to variant dbSNP:rs148674363Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04578758 – 107GCGAM…SVPKR → TKRRNQRDAWIADIYLCPQT LTTPWLHRCCCLRPWMNFTD IILP in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ225187 mRNA Translation: ABB04094.1
AA316348 mRNA No translation available.
AC073263 Genomic DNA Translation: AAX93059.1
CH471053 Genomic DNA Translation: EAW99700.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33224.1 [Q53S33-2]
CCDS33225.1 [Q53S33-1]

NCBI Reference Sequences

More...RefSeqi		NP_001030582.1, NM_001035505.1 [Q53S33-2]
NP_997717.2, NM_212552.2 [Q53S33-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295326; ENSP00000295326; ENSG00000163170 [Q53S33-2]
ENST00000327428; ENSP00000331369; ENSG00000163170 [Q53S33-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388962

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388962

UCSC genome browser

More...UCSCi		uc002skc.2 human [Q53S33-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ225187 mRNA Translation: ABB04094.1
AA316348 mRNA No translation available.
AC073263 Genomic DNA Translation: AAX93059.1
CH471053 Genomic DNA Translation: EAW99700.1
CCDSiCCDS33224.1 [Q53S33-2]
CCDS33225.1 [Q53S33-1]
RefSeqiNP_001030582.1, NM_001035505.1 [Q53S33-2]
NP_997717.2, NM_212552.2 [Q53S33-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NCLNMR-A27-107[»]
SMRiQ53S33
ModBaseiSearch...

Protein-protein interaction databases

BioGridi132922, 21 interactors
IntActiQ53S33, 9 interactors
STRINGi9606.ENSP00000331369

PTM databases

iPTMnetiQ53S33
PhosphoSitePlusiQ53S33

Polymorphism and mutation databases

BioMutaiBOLA3
DMDMi74726650

Proteomic databases

EPDiQ53S33
jPOSTiQ53S33
MassIVEiQ53S33
MaxQBiQ53S33
PaxDbiQ53S33
PeptideAtlasiQ53S33
PRIDEiQ53S33
ProteomicsDBi33698
62531 [Q53S33-1]
TopDownProteomicsiQ53S33-1 [Q53S33-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		388962
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295326; ENSP00000295326; ENSG00000163170 [Q53S33-2]
ENST00000327428; ENSP00000331369; ENSG00000163170 [Q53S33-1]
GeneIDi388962
KEGGihsa:388962
UCSCiuc002skc.2 human [Q53S33-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388962
DisGeNETi388962

GeneCards: human genes, protein and diseases

More...GeneCardsi		BOLA3
HGNCiHGNC:24415 BOLA3
HPAiHPA053162
MalaCardsiBOLA3
MIMi613183 gene
614299 phenotype
neXtProtiNX_Q53S33
OpenTargetsiENSG00000163170
Orphaneti401874 Multiple mitochondrial dysfunctions syndrome type 2
PharmGKBiPA142672554

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3348 Eukaryota
COG0271 LUCA
GeneTreeiENSGT00390000013048
HOGENOMiHOG000255169
InParanoidiQ53S33
KOiK22075
OMAiGAMYEIQ
OrthoDBi1571278at2759
PhylomeDBiQ53S33
TreeFamiTF332952

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BOLA3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		388962

Pharos

More...Pharosi		Q53S33

Protein Ontology

More...PROi		PR:Q53S33

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163170 Expressed in 197 organ(s), highest expression level in deltoid
GenevisibleiQ53S33 HS

Family and domain databases

InterProiView protein in InterPro
IPR002634 BolA
IPR036065 BolA-like_sf
PfamiView protein in Pfam
PF01722 BolA, 1 hit
SUPFAMiSSF82657 SSF82657, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBOLA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53S33
Secondary accession number(s): G3XAB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 24, 2005
Last modified: September 18, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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