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UniProtKB - Q53R19 (Q53R19_HUMAN)
Protein
Arp2/3 complex 34 kDa subunit
Gene
ARPC2
Organism
Homo sapiens (Human)
Status
Functioni
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin filament polymerization Source: InterPro
- Arp2/3 complex-mediated actin nucleation Source: InterPro
- positive regulation of actin filament polymerization Source: Ensembl
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
Keywordsi
Molecular function | Actin-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Arp2/3 complex 34 kDa subunitUniRule annotation |
Gene namesi | Name:ARPC2Imported ORF Names:hCG_16304Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000163466 |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Other locations
- synaptosome ARBA annotation
- Cell projection ARBA annotation
Cytoskeleton
- Arp2/3 protein complex Source: InterPro
Endosome
- endosome Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- muscle cell projection membrane Source: Ensembl
Other locations
- cell leading edge Source: Ensembl
- focal adhesion Source: Ensembl
- glutamatergic synapse Source: Ensembl
- neuron projection Source: UniProtKB-KW
Keywords - Cellular componenti
Cell junction, Cytoplasm, CytoskeletonUniRule annotation, Synapse, SynaptosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000163466, Expressed in bone marrow and 248 other tissues |
Interactioni
Subunit structurei
Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Structurei
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_059439_2_0_1 |
OMAi | GPYIVSP |
OrthoDBi | 1345377at2759 |
Family and domain databases
Gene3Di | 3.30.1460.20, 2 hits |
InterProi | View protein in InterPro IPR007188, ARPC2 IPR034666, ARPC2/4 |
PANTHERi | PTHR12058, PTHR12058, 1 hit |
Pfami | View protein in Pfam PF04045, P34-Arc, 1 hit |
SUPFAMi | SSF69645, SSF69645, 2 hits |
i Sequence
Sequence statusi: Complete.
Q53R19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097483 Genomic DNA Translation: AAX93213.1 HM005676 mRNA Translation: AEE61273.1 AK290268 mRNA Translation: BAF82957.1 CH471063 Genomic DNA Translation: EAW70591.1 CH471063 Genomic DNA Translation: EAW70593.1 |
RefSeqi | NP_005722.1, NM_005731.3 NP_690601.1, NM_152862.2 |
Genome annotation databases
GeneIDi | 10109 |
KEGGi | hsa:10109 |
MANE-Selecti | ENST00000315717.10; ENSP00000327137.5; NM_152862.3; NP_690601.1 |
UCSCi | uc002vhd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097483 Genomic DNA Translation: AAX93213.1 HM005676 mRNA Translation: AEE61273.1 AK290268 mRNA Translation: BAF82957.1 CH471063 Genomic DNA Translation: EAW70591.1 CH471063 Genomic DNA Translation: EAW70593.1 |
RefSeqi | NP_005722.1, NM_005731.3 NP_690601.1, NM_152862.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 1901, 369 antibodies from 37 providers |
DNASUi | 10109 |
Genome annotation databases
GeneIDi | 10109 |
KEGGi | hsa:10109 |
MANE-Selecti | ENST00000315717.10; ENSP00000327137.5; NM_152862.3; NP_690601.1 |
UCSCi | uc002vhd.4, human |
Organism-specific databases
CTDi | 10109 |
PharmGKBi | PA24999 |
VEuPathDBi | HostDB:ENSG00000163466 |
Phylogenomic databases
HOGENOMi | CLU_059439_2_0_1 |
OMAi | GPYIVSP |
OrthoDBi | 1345377at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10109, 342 hits in 1086 CRISPR screens |
ChiTaRSi | ARPC2, human |
GenomeRNAii | 10109 |
Gene expression databases
Bgeei | ENSG00000163466, Expressed in bone marrow and 248 other tissues |
Family and domain databases
Gene3Di | 3.30.1460.20, 2 hits |
InterProi | View protein in InterPro IPR007188, ARPC2 IPR034666, ARPC2/4 |
PANTHERi | PTHR12058, PTHR12058, 1 hit |
Pfami | View protein in Pfam PF04045, P34-Arc, 1 hit |
SUPFAMi | SSF69645, SSF69645, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53R19_HUMAN | |
Accessioni | Q53R19Primary (citable) accession number: Q53R19 Secondary accession number(s): A0A024R457 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |