The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q53QZ3 (RHG15_HUMAN)
Protein
Rho GTPase-activating protein 15
Gene
ARHGAP15
Organism
Homo sapiens (Human)
Status
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
1 PublicationGO - Molecular functioni
- GTPase activator activity Source: MGI
GO - Biological processi
- regulation of cell shape Source: MGI
- regulation of GTPase activity Source: GO_Central
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q53QZ3 |
Reactomei | R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013423, RAC3 GTPase cycle |
SignaLinki | Q53QZ3 |
SIGNORi | Q53QZ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 15Alternative name(s): ArhGAP15 Rho-type GTPase-activating protein 15 |
Gene namesi | Name:ARHGAP15 ORF Names:BM-024, BM-030, BM-046 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21030, ARHGAP15 |
MIMi | 610578, gene |
neXtProti | NX_Q53QZ3 |
VEuPathDBi | HostDB:ENSG00000075884 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55843 |
OpenTargetsi | ENSG00000075884 |
PharmGKBi | PA134938065 |
Miscellaneous databases
Pharosi | Q53QZ3, Tbio |
Genetic variation databases
BioMutai | ARHGAP15 |
DMDMi | 166977704 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317574 | 1 – 475 | Rho GTPase-activating protein 15Add BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 43 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 | |
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 243 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q53QZ3 |
jPOSTi | Q53QZ3 |
MassIVEi | Q53QZ3 |
MaxQBi | Q53QZ3 |
PaxDbi | Q53QZ3 |
PeptideAtlasi | Q53QZ3 |
PRIDEi | Q53QZ3 |
ProteomicsDBi | 62513 |
PTM databases
GlyGeni | Q53QZ3, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q53QZ3 |
MetOSitei | Q53QZ3 |
PhosphoSitePlusi | Q53QZ3 |
Expressioni
Tissue specificityi
Expressed in lung, liver and lymphoid cells.1 Publication
Gene expression databases
Bgeei | ENSG00000075884, Expressed in lung and 171 other tissues |
ExpressionAtlasi | Q53QZ3, baseline and differential |
Genevisiblei | Q53QZ3, HS |
Organism-specific databases
HPAi | ENSG00000075884, Group enriched (bone marrow, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120945, 15 interactors |
IntActi | Q53QZ3, 4 interactors |
MINTi | Q53QZ3 |
STRINGi | 9606.ENSP00000295095 |
Miscellaneous databases
RNActi | Q53QZ3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q53QZ3 |
SMRi | Q53QZ3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q53QZ3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 189 | PHPROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 281 – 470 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 190 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 |
Domaini
The PH domain is required for localization to the membrane.1 Publication
Phylogenomic databases
eggNOGi | KOG1449, Eukaryota KOG1450, Eukaryota |
GeneTreei | ENSGT00950000182860 |
HOGENOMi | CLU_015883_1_0_1 |
InParanoidi | Q53QZ3 |
OMAi | DHNQWED |
OrthoDBi | 1300981at2759 |
PhylomeDBi | Q53QZ3 |
TreeFami | TF329345 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50238, RHOGAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q53QZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKSTNSDTS VETLNSTRQG TGAVQMRIKN ANSHHDRLSQ SKSMILTDVG
60 70 80 90 100
KVTEPISRHR RNHSQHILKD VIPPLEQLMV EKEGYLQKAK IADGGKKLRK
110 120 130 140 150
NWSTSWIVLS SRRIEFYKES KQQALSNMKT GHKPESVDLC GAHIEWAKEK
160 170 180 190 200
SSRKNVFQIT TVSGNEFLLQ SDIDFIILDW FHAIKNAIDR LPKDSSCPSR
210 220 230 240 250
NLELFKIQRS SSTELLSHYD SDIKEQKPEH RKSLMFRLHH SASDTSDKNR
260 270 280 290 300
VKSRLKKFIT RRPSLKTLQE KGLIKDQIFG SHLHKVCERE NSTVPWFVKQ
310 320 330 340 350
CIEAVEKRGL DVDGIYRVSG NLATIQKLRF IVNQEEKLNL DDSQWEDIHV
360 370 380 390 400
VTGALKMFFR ELPEPLFPYS FFEQFVEAIK KQDNNTRIEA VKSLVQKLPP
410 420 430 440 450
PNRDTMKVLF GHLTKIVAKA SKNLMSTQSL GIVFGPTLLR AENETGNMAI
460 470
HMVYQNQIAE LMLSEYSKIF GSEED
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8ZZK0 | B8ZZK0_HUMAN | Rho GTPase-activating protein 15 | ARHGAP15 | 138 | Annotation score: | ||
H7BZM0 | H7BZM0_HUMAN | Rho GTPase-activating protein 15 | ARHGAP15 | 56 | Annotation score: |
Sequence cautioni
The sequence AAF67618 differs from that shown. Reason: Frameshift.Curated
The sequence AAF67633 differs from that shown. Reason: Frameshift.Curated
The sequence AAF87324 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 260 | T → P in AAF67618 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 261 | R → P in AAF87324 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 314 | G → A in AAO34684 (PubMed:12650940).Curated | 1 | |
Sequence conflicti | 323 | A → G in AAF67618 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 323 | A → Q in AAO34684 (PubMed:12650940).Curated | 1 | |
Sequence conflicti | 409 | L → P in AAH16701 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY219338 mRNA Translation: AAO34684.1 AF212222 mRNA Translation: AAF87324.1 Frameshift. AF217507 mRNA Translation: AAF67618.1 Frameshift. AF217522 mRNA Translation: AAF67633.1 Frameshift. AC013437 Genomic DNA Translation: AAX93160.1 AC079584 Genomic DNA Translation: AAX82009.1 AC079793 Genomic DNA Translation: AAY24215.1 AC092652 Genomic DNA Translation: AAY14811.1 AC096558 Genomic DNA Translation: AAX93158.1 AC098857 Genomic DNA Translation: AAX93245.1 CH471058 Genomic DNA Translation: EAX11590.1 BC016701 mRNA Translation: AAH16701.1 BC038976 mRNA Translation: AAH38976.2 |
CCDSi | CCDS2184.1 |
RefSeqi | NP_060930.3, NM_018460.3 XP_011509781.1, XM_011511479.2 XP_016859988.1, XM_017004499.1 |
Genome annotation databases
Ensembli | ENST00000295095.11; ENSP00000295095.6; ENSG00000075884.14 |
GeneIDi | 55843 |
KEGGi | hsa:55843 |
MANE-Selecti | ENST00000295095.11; ENSP00000295095.6; NM_018460.4; NP_060930.3 |
UCSCi | uc002tvm.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY219338 mRNA Translation: AAO34684.1 AF212222 mRNA Translation: AAF87324.1 Frameshift. AF217507 mRNA Translation: AAF67618.1 Frameshift. AF217522 mRNA Translation: AAF67633.1 Frameshift. AC013437 Genomic DNA Translation: AAX93160.1 AC079584 Genomic DNA Translation: AAX82009.1 AC079793 Genomic DNA Translation: AAY24215.1 AC092652 Genomic DNA Translation: AAY14811.1 AC096558 Genomic DNA Translation: AAX93158.1 AC098857 Genomic DNA Translation: AAX93245.1 CH471058 Genomic DNA Translation: EAX11590.1 BC016701 mRNA Translation: AAH16701.1 BC038976 mRNA Translation: AAH38976.2 |
CCDSi | CCDS2184.1 |
RefSeqi | NP_060930.3, NM_018460.3 XP_011509781.1, XM_011511479.2 XP_016859988.1, XM_017004499.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BYI | X-ray | 2.25 | A/B/C/D | 262-473 | [»] | |
AlphaFoldDBi | Q53QZ3 | |||||
SMRi | Q53QZ3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120945, 15 interactors |
IntActi | Q53QZ3, 4 interactors |
MINTi | Q53QZ3 |
STRINGi | 9606.ENSP00000295095 |
PTM databases
GlyGeni | Q53QZ3, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q53QZ3 |
MetOSitei | Q53QZ3 |
PhosphoSitePlusi | Q53QZ3 |
Genetic variation databases
BioMutai | ARHGAP15 |
DMDMi | 166977704 |
Proteomic databases
EPDi | Q53QZ3 |
jPOSTi | Q53QZ3 |
MassIVEi | Q53QZ3 |
MaxQBi | Q53QZ3 |
PaxDbi | Q53QZ3 |
PeptideAtlasi | Q53QZ3 |
PRIDEi | Q53QZ3 |
ProteomicsDBi | 62513 |
Protocols and materials databases
Antibodypediai | 33613, 125 antibodies from 20 providers |
DNASUi | 55843 |
Genome annotation databases
Ensembli | ENST00000295095.11; ENSP00000295095.6; ENSG00000075884.14 |
GeneIDi | 55843 |
KEGGi | hsa:55843 |
MANE-Selecti | ENST00000295095.11; ENSP00000295095.6; NM_018460.4; NP_060930.3 |
UCSCi | uc002tvm.5, human |
Organism-specific databases
CTDi | 55843 |
DisGeNETi | 55843 |
GeneCardsi | ARHGAP15 |
HGNCi | HGNC:21030, ARHGAP15 |
HPAi | ENSG00000075884, Group enriched (bone marrow, lymphoid tissue) |
MIMi | 610578, gene |
neXtProti | NX_Q53QZ3 |
OpenTargetsi | ENSG00000075884 |
PharmGKBi | PA134938065 |
VEuPathDBi | HostDB:ENSG00000075884 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1449, Eukaryota KOG1450, Eukaryota |
GeneTreei | ENSGT00950000182860 |
HOGENOMi | CLU_015883_1_0_1 |
InParanoidi | Q53QZ3 |
OMAi | DHNQWED |
OrthoDBi | 1300981at2759 |
PhylomeDBi | Q53QZ3 |
TreeFami | TF329345 |
Enzyme and pathway databases
PathwayCommonsi | Q53QZ3 |
Reactomei | R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013423, RAC3 GTPase cycle |
SignaLinki | Q53QZ3 |
SIGNORi | Q53QZ3 |
Miscellaneous databases
BioGRID-ORCSi | 55843, 11 hits in 1073 CRISPR screens |
ChiTaRSi | ARHGAP15, human |
EvolutionaryTracei | Q53QZ3 |
GenomeRNAii | 55843 |
Pharosi | Q53QZ3, Tbio |
PROi | PR:Q53QZ3 |
RNActi | Q53QZ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075884, Expressed in lung and 171 other tissues |
ExpressionAtlasi | Q53QZ3, baseline and differential |
Genevisiblei | Q53QZ3, HS |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50238, RHOGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG15_HUMAN | |
Accessioni | Q53QZ3Primary (citable) accession number: Q53QZ3 Secondary accession number(s): Q53R36 Q9NZ91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references