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UniProtKB - Q53QZ3 (RHG15_HUMAN)

Entry version 139 (25 May 2022)
Sequence version 2 (05 Feb 2008)
Previous versions | rss
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Protein

Rho GTPase-activating protein 15

Gene

ARHGAP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q53QZ3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q53QZ3

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q53QZ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 15
Alternative name(s):
ArhGAP15
Rho-type GTPase-activating protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP15
ORF Names:BM-024, BM-030, BM-046
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21030, ARHGAP15

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610578, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q53QZ3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000075884

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55843

Open Targets

More...OpenTargetsi		ENSG00000075884

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134938065

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q53QZ3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARHGAP15

Domain mapping of disease mutations (DMDM)

More...DMDMi		166977704

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003175741 – 475Rho GTPase-activating protein 15Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei199PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q53QZ3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q53QZ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q53QZ3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q53QZ3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q53QZ3

PeptideAtlas

More...PeptideAtlasi		Q53QZ3

PRoteomics IDEntifications database

More...PRIDEi		Q53QZ3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62513

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q53QZ3, 2 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q53QZ3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q53QZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q53QZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, liver and lymphoid cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075884, Expressed in lung and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q53QZ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q53QZ3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075884, Group enriched (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120945, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q53QZ3, 4 interactors

Molecular INTeraction database

More...MINTi		Q53QZ3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295095

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q53QZ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q53QZ3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q53QZ3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q53QZ3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 189PHPROSITE-ProRule annotationAdd BLAST111
Domaini281 – 470Rho-GAPPROSITE-ProRule annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain is required for localization to the membrane.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1449, Eukaryota
KOG1450, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015883_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q53QZ3

Identification of Orthologs from Complete Genome Data

More...OMAi		DHNQWED

Database of Orthologous Groups

More...OrthoDBi		1300981at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q53QZ3

TreeFam database of animal gene trees

More...TreeFami		TF329345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q53QZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKSTNSDTS VETLNSTRQG TGAVQMRIKN ANSHHDRLSQ SKSMILTDVG 
        60         70         80         90        100
KVTEPISRHR RNHSQHILKD VIPPLEQLMV EKEGYLQKAK IADGGKKLRK 
       110        120        130        140        150
NWSTSWIVLS SRRIEFYKES KQQALSNMKT GHKPESVDLC GAHIEWAKEK 
       160        170        180        190        200
SSRKNVFQIT TVSGNEFLLQ SDIDFIILDW FHAIKNAIDR LPKDSSCPSR 
       210        220        230        240        250
NLELFKIQRS SSTELLSHYD SDIKEQKPEH RKSLMFRLHH SASDTSDKNR 
       260        270        280        290        300
VKSRLKKFIT RRPSLKTLQE KGLIKDQIFG SHLHKVCERE NSTVPWFVKQ 
       310        320        330        340        350
CIEAVEKRGL DVDGIYRVSG NLATIQKLRF IVNQEEKLNL DDSQWEDIHV 
       360        370        380        390        400
VTGALKMFFR ELPEPLFPYS FFEQFVEAIK KQDNNTRIEA VKSLVQKLPP 
       410        420        430        440        450
PNRDTMKVLF GHLTKIVAKA SKNLMSTQSL GIVFGPTLLR AENETGNMAI 
       460        470 
HMVYQNQIAE LMLSEYSKIF GSEED
Length:475
Mass (Da):54,544
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35C26B1960694119
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZK0B8ZZK0_HUMAN
Rho GTPase-activating protein 15
ARHGAP15
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZM0H7BZM0_HUMAN
Rho GTPase-activating protein 15
ARHGAP15
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF67618 differs from that shown. Reason: Frameshift.Curated
The sequence AAF67633 differs from that shown. Reason: Frameshift.Curated
The sequence AAF87324 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti260T → P in AAF67618 (PubMed:11042152).Curated1
Sequence conflicti261R → P in AAF87324 (PubMed:11042152).Curated1
Sequence conflicti314G → A in AAO34684 (PubMed:12650940).Curated1
Sequence conflicti323A → G in AAF67618 (PubMed:11042152).Curated1
Sequence conflicti323A → Q in AAO34684 (PubMed:12650940).Curated1
Sequence conflicti409L → P in AAH16701 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY219338 mRNA Translation: AAO34684.1
AF212222 mRNA Translation: AAF87324.1 Frameshift.
AF217507 mRNA Translation: AAF67618.1 Frameshift.
AF217522 mRNA Translation: AAF67633.1 Frameshift.
AC013437 Genomic DNA Translation: AAX93160.1
AC079584 Genomic DNA Translation: AAX82009.1
AC079793 Genomic DNA Translation: AAY24215.1
AC092652 Genomic DNA Translation: AAY14811.1
AC096558 Genomic DNA Translation: AAX93158.1
AC098857 Genomic DNA Translation: AAX93245.1
CH471058 Genomic DNA Translation: EAX11590.1
BC016701 mRNA Translation: AAH16701.1
BC038976 mRNA Translation: AAH38976.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2184.1

NCBI Reference Sequences

More...RefSeqi		NP_060930.3, NM_018460.3
XP_011509781.1, XM_011511479.2
XP_016859988.1, XM_017004499.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295095.11; ENSP00000295095.6; ENSG00000075884.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55843

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000295095.11; ENSP00000295095.6; NM_018460.4; NP_060930.3

UCSC genome browser

More...UCSCi		uc002tvm.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219338 mRNA Translation: AAO34684.1
AF212222 mRNA Translation: AAF87324.1 Frameshift.
AF217507 mRNA Translation: AAF67618.1 Frameshift.
AF217522 mRNA Translation: AAF67633.1 Frameshift.
AC013437 Genomic DNA Translation: AAX93160.1
AC079584 Genomic DNA Translation: AAX82009.1
AC079793 Genomic DNA Translation: AAY24215.1
AC092652 Genomic DNA Translation: AAY14811.1
AC096558 Genomic DNA Translation: AAX93158.1
AC098857 Genomic DNA Translation: AAX93245.1
CH471058 Genomic DNA Translation: EAX11590.1
BC016701 mRNA Translation: AAH16701.1
BC038976 mRNA Translation: AAH38976.2
CCDSiCCDS2184.1
RefSeqiNP_060930.3, NM_018460.3
XP_011509781.1, XM_011511479.2
XP_016859988.1, XM_017004499.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BYIX-ray2.25A/B/C/D262-473[»]
AlphaFoldDBiQ53QZ3
SMRiQ53QZ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120945, 15 interactors
IntActiQ53QZ3, 4 interactors
MINTiQ53QZ3
STRINGi9606.ENSP00000295095

PTM databases

GlyGeniQ53QZ3, 2 sites, 1 O-linked glycan (1 site)
iPTMnetiQ53QZ3
MetOSiteiQ53QZ3
PhosphoSitePlusiQ53QZ3

Genetic variation databases

BioMutaiARHGAP15
DMDMi166977704

Proteomic databases

EPDiQ53QZ3
jPOSTiQ53QZ3
MassIVEiQ53QZ3
MaxQBiQ53QZ3
PaxDbiQ53QZ3
PeptideAtlasiQ53QZ3
PRIDEiQ53QZ3
ProteomicsDBi62513

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33613, 125 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		55843

Genome annotation databases

EnsembliENST00000295095.11; ENSP00000295095.6; ENSG00000075884.14
GeneIDi55843
KEGGihsa:55843
MANE-SelectiENST00000295095.11; ENSP00000295095.6; NM_018460.4; NP_060930.3
UCSCiuc002tvm.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55843
DisGeNETi55843

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGAP15
HGNCiHGNC:21030, ARHGAP15
HPAiENSG00000075884, Group enriched (bone marrow, lymphoid tissue)
MIMi610578, gene
neXtProtiNX_Q53QZ3
OpenTargetsiENSG00000075884
PharmGKBiPA134938065
VEuPathDBiHostDB:ENSG00000075884

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1449, Eukaryota
KOG1450, Eukaryota
GeneTreeiENSGT00950000182860
HOGENOMiCLU_015883_1_0_1
InParanoidiQ53QZ3
OMAiDHNQWED
OrthoDBi1300981at2759
PhylomeDBiQ53QZ3
TreeFamiTF329345

Enzyme and pathway databases

PathwayCommonsiQ53QZ3
ReactomeiR-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
SignaLinkiQ53QZ3
SIGNORiQ53QZ3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55843, 11 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGAP15, human
EvolutionaryTraceiQ53QZ3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55843
PharosiQ53QZ3, Tbio

Protein Ontology

More...PROi		PR:Q53QZ3
RNActiQ53QZ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075884, Expressed in lung and 171 other tissues
ExpressionAtlasiQ53QZ3, baseline and differential
GenevisibleiQ53QZ3, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53QZ3
Secondary accession number(s): Q53R36
, Q53RD7, Q53RT6, Q53SX9, Q584N9, Q6PJE6, Q86WP1, Q8IXX1, Q9NRL8, Q9NZ77, Q9NZ91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 25, 2022
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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