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Protein
Submitted name:

Interleukin 8 receptor, beta

Gene

IL8RB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 8 receptor, betaImported
Submitted name:
cDNA FLJ78215, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNAImported
Submitted name:
cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNAImported
Gene namesi
Name:IL8RBImported
ORF Names:hCG_16291Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000180871.7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 74HelicalSequence analysisAdd BLAST26
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Transmembranei130 – 148HelicalSequence analysisAdd BLAST19
Transmembranei160 – 183HelicalSequence analysisAdd BLAST24
Transmembranei218 – 239HelicalSequence analysisAdd BLAST22
Transmembranei251 – 273HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29843

Expressioni

Gene expression databases

BgeeiENSG00000180871 Expressed in 159 organ(s), highest expression level in blood

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 314G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
HOVERGENiHBG106917
KOiK05050
OMAiINKHAVV
OrthoDBiEOG091G0C7W

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR000057 Chemokine_CXCR2
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00573 INTRLEUKN8BR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q53PC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
60 70 80 90 100
VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT
110 120 130 140 150
LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH
160 170 180 190 200
ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM
210 220 230 240 250
GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM
260 270 280 290 300
RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
310 320 330 340 350
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG
360
SSSGHTSTTL
Length:360
Mass (Da):40,759
Last modified:May 24, 2005 - v1
Checksum:i564F04A8BCC0A197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124768 Genomic DNA Translation: AAY24026.1
AK290906 mRNA Translation: BAF83595.1
AK312664 mRNA Translation: BAG35546.1
CH471063 Genomic DNA Translation: EAW70589.1
RefSeqiNP_001161770.1, NM_001168298.1
NP_001548.1, NM_001557.3
XP_005246587.1, XM_005246530.3
XP_016859479.1, XM_017003990.1
XP_016859480.1, XM_017003991.1
XP_016859481.1, XM_017003992.1
UniGeneiHs.846

Genome annotation databases

GeneIDi3579
KEGGihsa:3579
UCSCiuc002vha.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124768 Genomic DNA Translation: AAY24026.1
AK290906 mRNA Translation: BAF83595.1
AK312664 mRNA Translation: BAG35546.1
CH471063 Genomic DNA Translation: EAW70589.1
RefSeqiNP_001161770.1, NM_001168298.1
NP_001548.1, NM_001557.3
XP_005246587.1, XM_005246530.3
XP_016859479.1, XM_017003990.1
XP_016859480.1, XM_017003991.1
XP_016859481.1, XM_017003992.1
UniGeneiHs.846

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

DNASUi3579
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3579
KEGGihsa:3579
UCSCiuc002vha.3 human

Organism-specific databases

CTDi3579
EuPathDBiHostDB:ENSG00000180871.7
PharmGKBiPA29843

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
HOVERGENiHBG106917
KOiK05050
OMAiINKHAVV
OrthoDBiEOG091G0C7W

Miscellaneous databases

GenomeRNAii3579

Gene expression databases

BgeeiENSG00000180871 Expressed in 159 organ(s), highest expression level in blood

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR000057 Chemokine_CXCR2
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00573 INTRLEUKN8BR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ53PC4_HUMAN
AccessioniPrimary (citable) accession number: Q53PC4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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