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Protein

Tubulin alpha-2 chain

Gene

TUBA

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei451Involved in polymerizationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-114608 Platelet degranulation
R-OSA-5617833 Cilium Assembly
R-OSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-OSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha-2 chain
Gene namesi
Name:TUBA
Ordered Locus Names:Os11g0247300, LOC_Os11g14220
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474651 – 451Tubulin alpha-2 chainAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-acetyllysineBy similarity1

Post-translational modificationi

Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.By similarity
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ53M52
PRIDEiQ53M52

Expressioni

Gene expression databases

ExpressionAtlasiQ53M52 differential
GenevisibleiQ53M52 OS

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

STRINGi39947.LOC_Os11g14220.1

Structurei

3D structure databases

ProteinModelPortaliQ53M52
SMRiQ53M52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1376 Eukaryota
COG5023 LUCA
HOGENOMiHOG000165711
InParanoidiQ53M52
KOiK07374
OMAiIKMRECI
OrthoDBiEOG093609MK

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q53M52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRECISIHIG QAGIQVGNAC WELYCLEHGI QPDGQMPGDK TVGGGDDAFN
60 70 80 90 100
TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GDYRQLFHPE QLISGKEDAA
110 120 130 140 150
NNFARGHYTI GKEIVDLCLD RIRKLADNCT GLQGFLVFNA VGGGTGSGLG
160 170 180 190 200
SLLLERLSVD YGKKSKLGFT VYPSPQVSTS VVEPYNSVLS THSLLEHTDV
210 220 230 240 250
AVLLDNEAIY DICRRSLDIE RPTYTNLNRL VSQVISSLTA SLRFDGALNV
260 270 280 290 300
DVNEFQTNLV PYPRIHFMLS SYAPVISAEK AYHEQLSVAE ITNSAFEPSS
310 320 330 340 350
MMAKCDPRHG KYMACCLMYR GDVVPKDVNA AVATIKTKRT IQFVDWCPTG
360 370 380 390 400
FKCGINYQPP SVVPGGDLAK VQRAVCMISN STSVVEVFSR IDIKFDLMYS
410 420 430 440 450
KRAFVHWYVG EGMEEGEFSE AREDLAALEK DYEEVGSEFD DGDEGDEGDE

Y
Length:451
Mass (Da):49,737
Last modified:May 24, 2005 - v1
Checksum:i4EB46E096C684F0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74V → M in CAA62917 (Ref. 1) Curated1
Sequence conflicti92L → V in CAA62917 (Ref. 1) Curated1
Sequence conflicti227L → R in CAA62917 (Ref. 1) Curated1
Sequence conflicti275V → A in CAA62917 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91807 mRNA Translation: CAA62917.1
AC137924 Genomic DNA Translation: AAX96762.1
DP000010 Genomic DNA Translation: ABA92352.1
AP014967 Genomic DNA Translation: BAT13424.1
RefSeqiXP_015616885.1, XM_015761399.1
UniGeneiOs.21762
Os.96350

Genome annotation databases

EnsemblPlantsiOs11t0247300-01; Os11t0247300-01; Os11g0247300
GeneIDi4350197
GrameneiOs11t0247300-01; Os11t0247300-01; Os11g0247300
KEGGiosa:4350197

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91807 mRNA Translation: CAA62917.1
AC137924 Genomic DNA Translation: AAX96762.1
DP000010 Genomic DNA Translation: ABA92352.1
AP014967 Genomic DNA Translation: BAT13424.1
RefSeqiXP_015616885.1, XM_015761399.1
UniGeneiOs.21762
Os.96350

3D structure databases

ProteinModelPortaliQ53M52
SMRiQ53M52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os11g14220.1

Proteomic databases

PaxDbiQ53M52
PRIDEiQ53M52

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOs11t0247300-01; Os11t0247300-01; Os11g0247300
GeneIDi4350197
GrameneiOs11t0247300-01; Os11t0247300-01; Os11g0247300
KEGGiosa:4350197

Phylogenomic databases

eggNOGiKOG1376 Eukaryota
COG5023 LUCA
HOGENOMiHOG000165711
InParanoidiQ53M52
KOiK07374
OMAiIKMRECI
OrthoDBiEOG093609MK

Enzyme and pathway databases

ReactomeiR-OSA-114608 Platelet degranulation
R-OSA-5617833 Cilium Assembly
R-OSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-OSA-983189 Kinesins

Gene expression databases

ExpressionAtlasiQ53M52 differential
GenevisibleiQ53M52 OS

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBA2_ORYSJ
AccessioniPrimary (citable) accession number: Q53M52
Secondary accession number(s): Q43606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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Main funding by: National Institutes of Health

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