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Protein

Ankyrin repeat domain-containing protein SOWAHC

Gene

SOWAHC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein SOWAHC
Alternative name(s):
Ankyrin repeat domain-containing protein 57
Protein sosondowah homolog C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOWAHC
Synonyms:ANKRD57, C2orf26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198142.4

Human Gene Nomenclature Database

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HGNCi
HGNC:26149 SOWAHC

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q53LP3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198142

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134882354

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SOWAHC

Domain mapping of disease mutations (DMDM)

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DMDMi
74740628

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743401 – 525Ankyrin repeat domain-containing protein SOWAHCAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei88PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q53LP3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q53LP3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q53LP3

PeptideAtlas

More...
PeptideAtlasi
Q53LP3

PRoteomics IDEntifications database

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PRIDEi
Q53LP3

ProteomicsDB human proteome resource

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ProteomicsDBi
62510

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q53LP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q53LP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198142 Expressed in 202 organ(s), highest expression level in mouth mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_ANKRD57

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q53LP3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056131

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122402, 6 interactors

Protein interaction database and analysis system

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IntActi
Q53LP3, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365830

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q53LP3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q53LP3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati301 – 330ANK 1Add BLAST30
Repeati340 – 370ANK 2Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 180Pro-richAdd BLAST94
Compositional biasi438 – 443Poly-His6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SOWAH family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154749

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116317

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079715

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q53LP3

Identification of Orthologs from Complete Genome Data

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OMAi
DGAKYVH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F4O

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q53LP3

TreeFam database of animal gene trees

More...
TreeFami
TF331362

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q53LP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGPAEWGPE AALGPEAVLR FLAERGGRAL HAELVQHFRG ALGGEPEQRA
60 70 80 90 100
RARAHFKELV NAVATVRVDP ADGAKYVHLK KRFCEGPSEP SGDPPRIQVT
110 120 130 140 150
AEPEAPDGPA GPEARDRLPD AAAPESLPGQ GRELGEGEPP APAHWPPLSA
160 170 180 190 200
GARRKNSRRD VQPLPRTPAP GPSEDLELPP HGCEEADRGS SLVGATAQRP
210 220 230 240 250
ARQNLRDLVM GSSPQLKRSV CPGGSSPGSS SGGGRGRGGG DSDSASVASS
260 270 280 290 300
SAEEESSGGG SVTLDPLEHA WMLSASDGKW DSLEGLLTCE PGLLVKRDFI
310 320 330 340 350
TGFTCLHWAA KHGRQELLAM LVNFANKHQL PVNIDARTSG GYTALHLAAM
360 370 380 390 400
HGHVEVVKLL VGAYDADVDI RDYSGKKASQ YLSRSIAEEI KNLVGALDEG
410 420 430 440 450
DGESAAGSGG GRWRLSKVLP SHLITYKLSH ALEDGGDHHH HHHSAEGWVG
460 470 480 490 500
GKAKDPGRKA SGSSSGRIKP RLNKIRFRTQ IVHTTPSFRD PEQPLEGRGE
510 520
EGVGEERPVK GHSPFTLRPK SNVFG
Length:525
Mass (Da):55,672
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E90B5E911D41B02
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15161 differs from that shown. Reason: Frameshift at position 311.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti307H → R in BAB15161 (PubMed:14702039).Curated1
Sequence conflicti318L → V in BAB15161 (PubMed:14702039).Curated1
Sequence conflicti334I → M in BAB15161 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK025523 mRNA Translation: BAB15161.1 Frameshift.
AC140485 Genomic DNA Translation: AAY24143.1
AC011753 Genomic DNA Translation: AAY24292.1
BC036652 mRNA Translation: AAH36652.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33270.1

NCBI Reference Sequences

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RefSeqi
NP_075392.2, NM_023016.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.355455

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356454; ENSP00000365830; ENSG00000198142

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65124

UCSC genome browser

More...
UCSCi
uc002tfb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025523 mRNA Translation: BAB15161.1 Frameshift.
AC140485 Genomic DNA Translation: AAY24143.1
AC011753 Genomic DNA Translation: AAY24292.1
BC036652 mRNA Translation: AAH36652.2
CCDSiCCDS33270.1
RefSeqiNP_075392.2, NM_023016.3
UniGeneiHs.355455

3D structure databases

ProteinModelPortaliQ53LP3
SMRiQ53LP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122402, 6 interactors
IntActiQ53LP3, 3 interactors
STRINGi9606.ENSP00000365830

PTM databases

iPTMnetiQ53LP3
PhosphoSitePlusiQ53LP3

Polymorphism and mutation databases

BioMutaiSOWAHC
DMDMi74740628

Proteomic databases

EPDiQ53LP3
MaxQBiQ53LP3
PaxDbiQ53LP3
PeptideAtlasiQ53LP3
PRIDEiQ53LP3
ProteomicsDBi62510

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356454; ENSP00000365830; ENSG00000198142
GeneIDi65124
KEGGihsa:65124
UCSCiuc002tfb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65124
EuPathDBiHostDB:ENSG00000198142.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SOWAHC
HGNCiHGNC:26149 SOWAHC
HPAiHPA056131
neXtProtiNX_Q53LP3
OpenTargetsiENSG00000198142
PharmGKBiPA134882354

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000154749
HOGENOMiHOG000116317
HOVERGENiHBG079715
InParanoidiQ53LP3
OMAiDGAKYVH
OrthoDBiEOG091G0F4O
PhylomeDBiQ53LP3
TreeFamiTF331362

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65124

Protein Ontology

More...
PROi
PR:Q53LP3

Gene expression databases

BgeeiENSG00000198142 Expressed in 202 organ(s), highest expression level in mouth mucosa
CleanExiHS_ANKRD57
GenevisibleiQ53LP3 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWAHC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53LP3
Secondary accession number(s): Q8NE15, Q9H6U1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 24, 2005
Last modified: December 5, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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