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UniProtKB - Q53HI1 (UNC50_HUMAN)

Entry version 98 (18 Sep 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Protein unc-50 homolog

Gene

UNC50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-50 homolog
Alternative name(s):
Periodontal ligament-specific protein 22
Short name:
PDLs22
Protein GMH1 homolog
Short name:
hGMH1
Uncoordinated-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UNC50
Synonyms:UNCL
ORF Names:HSD-23, HSD23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16046 UNC50

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617826 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q53HI1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 115LumenalSequence analysisAdd BLAST12
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 163CytoplasmicSequence analysisAdd BLAST27
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 187LumenalSequence analysis3
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 222CytoplasmicSequence analysisAdd BLAST14
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 259LumenalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25972

Open Targets

More...OpenTargetsi		ENSG00000115446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134984566

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q53HI1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UNC50

Domain mapping of disease mutations (DMDM)

More...DMDMi		160358938

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003089611 – 259Protein unc-50 homologAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q53HI1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q53HI1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q53HI1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q53HI1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q53HI1

PeptideAtlas

More...PeptideAtlasi		Q53HI1

PRoteomics IDEntifications database

More...PRIDEi		Q53HI1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62506

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q53HI1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q53HI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in periodontal ligament fibroblasts (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115446 Expressed in 232 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q53HI1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q53HI1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA027009

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117456, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q53HI1, 26 interactors

Molecular INTeraction database

More...MINTi		Q53HI1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350409

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-50 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3012 Eukaryota
ENOG410XT05 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018553

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q53HI1

Database of Orthologous Groups

More...OrthoDBi		1351297at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q53HI1

TreeFam database of animal gene trees

More...TreeFami		TF105624

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007881 UNC-50

The PANTHER Classification System

More...PANTHERi		PTHR12841 PTHR12841, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05216 UNC-50, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q53HI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPSTSVNSL VQGNGVLNSR DAARHTAGAK RYKYLRRLFR FRQMDFEFAA 
        60         70         80         90        100
WQMLYLFTSP QRVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTIGFG 
       110        120        130        140        150
FVLDMGFFET IKLLLWVVLI DCVGVGLLIA TLMWFISNKY LVKRQSRDYD 
       160        170        180        190        200
VEWGYAFDVH LNAFYPLLVI LHFIQLFFIN HVILTDTFIG YLVGNTLWLV 
       210        220        230        240        250
AVGYYIYVTF LGYSALPFLK NTVILLYPFA PLILLYGLSL ALGWNFTHTL 

CSFYKYRVK
Length:259
Mass (Da):30,373
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0BAF2594B84330B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ47J3KQ47_HUMAN
Protein unc-50 homolog
UNC50
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYK3H7BYK3_HUMAN
Protein unc-50 homolog
UNC50
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3J5H7C3J5_HUMAN
Protein unc-50 homolog
UNC50
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34Y → C in AAP20057 (Ref. 4) Curated1
Sequence conflicti66N → S in BAD96319 (Ref. 6) Curated1
Sequence conflicti115L → P in AAH39078 (PubMed:15489334).Curated1
Sequence conflicti119L → F in BAD96319 (Ref. 6) Curated1
Sequence conflicti173F → L in AAK08987 (Ref. 1) Curated1
Sequence conflicti173F → L in CAB45714 (PubMed:11230166).Curated1
Sequence conflicti173F → L in CAG38495 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY017215 mRNA Translation: AAK08987.1
AF077038 mRNA Translation: AAD27771.1
AL080115 mRNA Translation: CAB45714.1
AY251534 mRNA Translation: AAP20057.1
CR533464 mRNA Translation: CAG38495.1
AK222599 mRNA Translation: BAD96319.1
AC010134 Genomic DNA Translation: AAX93232.1
AC064860 Genomic DNA Translation: AAY14975.1
CH471127 Genomic DNA Translation: EAX01900.1
CH471127 Genomic DNA Translation: EAX01901.1
CH471127 Genomic DNA Translation: EAX01902.1
BC017019 mRNA Translation: AAH17019.1
BC025992 mRNA Translation: AAH25992.1
BC039078 mRNA Translation: AAH39078.1
BC091481 mRNA Translation: AAH91481.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2035.1

Protein sequence database of the Protein Information Resource

More...PIRi		T12451

NCBI Reference Sequences

More...RefSeqi		NP_054763.2, NM_014044.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357765; ENSP00000350409; ENSG00000115446

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25972

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25972

UCSC genome browser

More...UCSCi		uc002szc.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017215 mRNA Translation: AAK08987.1
AF077038 mRNA Translation: AAD27771.1
AL080115 mRNA Translation: CAB45714.1
AY251534 mRNA Translation: AAP20057.1
CR533464 mRNA Translation: CAG38495.1
AK222599 mRNA Translation: BAD96319.1
AC010134 Genomic DNA Translation: AAX93232.1
AC064860 Genomic DNA Translation: AAY14975.1
CH471127 Genomic DNA Translation: EAX01900.1
CH471127 Genomic DNA Translation: EAX01901.1
CH471127 Genomic DNA Translation: EAX01902.1
BC017019 mRNA Translation: AAH17019.1
BC025992 mRNA Translation: AAH25992.1
BC039078 mRNA Translation: AAH39078.1
BC091481 mRNA Translation: AAH91481.1
CCDSiCCDS2035.1
PIRiT12451
RefSeqiNP_054763.2, NM_014044.6

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi117456, 5 interactors
IntActiQ53HI1, 26 interactors
MINTiQ53HI1
STRINGi9606.ENSP00000350409

PTM databases

iPTMnetiQ53HI1
PhosphoSitePlusiQ53HI1

Polymorphism and mutation databases

BioMutaiUNC50
DMDMi160358938

Proteomic databases

EPDiQ53HI1
jPOSTiQ53HI1
MassIVEiQ53HI1
MaxQBiQ53HI1
PaxDbiQ53HI1
PeptideAtlasiQ53HI1
PRIDEiQ53HI1
ProteomicsDBi62506

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		25972

Genome annotation databases

EnsembliENST00000357765; ENSP00000350409; ENSG00000115446
GeneIDi25972
KEGGihsa:25972
UCSCiuc002szc.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25972
DisGeNETi25972

GeneCards: human genes, protein and diseases

More...GeneCardsi		UNC50
HGNCiHGNC:16046 UNC50
HPAiHPA027009
MIMi617826 gene
neXtProtiNX_Q53HI1
OpenTargetsiENSG00000115446
PharmGKBiPA134984566

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3012 Eukaryota
ENOG410XT05 LUCA
GeneTreeiENSGT00390000018553
InParanoidiQ53HI1
OrthoDBi1351297at2759
PhylomeDBiQ53HI1
TreeFamiTF105624

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UNC50 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25972
PharosiQ53HI1

Protein Ontology

More...PROi		PR:Q53HI1

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115446 Expressed in 232 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ53HI1 baseline and differential
GenevisibleiQ53HI1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007881 UNC-50
PANTHERiPTHR12841 PTHR12841, 1 hit
PfamiView protein in Pfam
PF05216 UNC-50, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC50_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53HI1
Secondary accession number(s): D3DVH4
, Q53S98, Q53TD6, Q5U5U2, Q6X7B9, Q9UQF4, Q9Y4S6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 18, 2019
This is version 98 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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