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UniProtKB - Q53HI1 (UNC50_HUMAN)
Protein
Protein unc-50 homolog
Gene
UNC50
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the cell surface expression of neuronal nicotinic receptors (By similarity).
Binds RNA (By similarity).
By similarityGO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- protein localization to cell surface Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q53HI1 |
SignaLinki | Q53HI1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein unc-50 homologAlternative name(s): Periodontal ligament-specific protein 22 Short name: PDLs22 Protein GMH1 homolog Short name: hGMH1 Uncoordinated-like protein |
Gene namesi | Name:UNC50 Synonyms:UNCL ORF Names:HSD-23, HSD23 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16046, UNC50 |
MIMi | 617826, gene |
neXtProti | NX_Q53HI1 |
VEuPathDBi | HostDB:ENSG00000115446 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Multi-pass membrane protein By similarity
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- integral component of Golgi membrane Source: GO_Central
Nucleus
- nuclear inner membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 82 | CytoplasmicSequence analysisAdd BLAST | 82 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 115 | LumenalSequence analysisAdd BLAST | 12 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 137 – 163 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 187 | LumenalSequence analysis | 3 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 222 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 223 – 243 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 259 | LumenalSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
Golgi apparatus, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 25972 |
OpenTargetsi | ENSG00000115446 |
PharmGKBi | PA134984566 |
Miscellaneous databases
Pharosi | Q53HI1, Tbio |
Genetic variation databases
BioMutai | UNC50 |
DMDMi | 160358938 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308961 | 1 – 259 | Protein unc-50 homologAdd BLAST | 259 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 6 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q53HI1 |
jPOSTi | Q53HI1 |
MassIVEi | Q53HI1 |
MaxQBi | Q53HI1 |
PaxDbi | Q53HI1 |
PeptideAtlasi | Q53HI1 |
PRIDEi | Q53HI1 |
ProteomicsDBi | 62506 |
PTM databases
iPTMneti | Q53HI1 |
PhosphoSitePlusi | Q53HI1 |
Expressioni
Tissue specificityi
Present in periodontal ligament fibroblasts (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000115446, Expressed in left lobe of thyroid gland and 244 other tissues |
ExpressionAtlasi | Q53HI1, baseline and differential |
Genevisiblei | Q53HI1, HS |
Organism-specific databases
HPAi | ENSG00000115446, Low tissue specificity |
Interactioni
Binary interactionsi
Q53HI1
Protein-protein interaction databases
BioGRIDi | 117456, 45 interactors |
IntActi | Q53HI1, 35 interactors |
MINTi | Q53HI1 |
STRINGi | 9606.ENSP00000350409 |
Miscellaneous databases
RNActi | Q53HI1, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the unc-50 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3012, Eukaryota |
GeneTreei | ENSGT00390000018553 |
HOGENOMi | CLU_066239_0_0_1 |
InParanoidi | Q53HI1 |
OMAi | FDIHLNA |
OrthoDBi | 1351297at2759 |
PhylomeDBi | Q53HI1 |
TreeFami | TF105624 |
Family and domain databases
InterProi | View protein in InterPro IPR007881, UNC-50 |
PANTHERi | PTHR12841, PTHR12841, 1 hit |
Pfami | View protein in Pfam PF05216, UNC-50, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q53HI1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPSTSVNSL VQGNGVLNSR DAARHTAGAK RYKYLRRLFR FRQMDFEFAA
60 70 80 90 100
WQMLYLFTSP QRVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTIGFG
110 120 130 140 150
FVLDMGFFET IKLLLWVVLI DCVGVGLLIA TLMWFISNKY LVKRQSRDYD
160 170 180 190 200
VEWGYAFDVH LNAFYPLLVI LHFIQLFFIN HVILTDTFIG YLVGNTLWLV
210 220 230 240 250
AVGYYIYVTF LGYSALPFLK NTVILLYPFA PLILLYGLSL ALGWNFTHTL
CSFYKYRVK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQ47 | J3KQ47_HUMAN | Protein unc-50 homolog | UNC50 | 276 | Annotation score: | ||
H7C3J5 | H7C3J5_HUMAN | Protein unc-50 homolog | UNC50 | 92 | Annotation score: | ||
H7BYK3 | H7BYK3_HUMAN | Protein unc-50 homolog | UNC50 | 128 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | Y → C in AAP20057 (Ref. 4) Curated | 1 | |
Sequence conflicti | 66 | N → S in BAD96319 (Ref. 6) Curated | 1 | |
Sequence conflicti | 115 | L → P in AAH39078 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 119 | L → F in BAD96319 (Ref. 6) Curated | 1 | |
Sequence conflicti | 173 | F → L in AAK08987 (Ref. 1) Curated | 1 | |
Sequence conflicti | 173 | F → L in CAB45714 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 173 | F → L in CAG38495 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY017215 mRNA Translation: AAK08987.1 AF077038 mRNA Translation: AAD27771.1 AL080115 mRNA Translation: CAB45714.1 AY251534 mRNA Translation: AAP20057.1 CR533464 mRNA Translation: CAG38495.1 AK222599 mRNA Translation: BAD96319.1 AC010134 Genomic DNA Translation: AAX93232.1 AC064860 Genomic DNA Translation: AAY14975.1 CH471127 Genomic DNA Translation: EAX01900.1 CH471127 Genomic DNA Translation: EAX01901.1 CH471127 Genomic DNA Translation: EAX01902.1 BC017019 mRNA Translation: AAH17019.1 BC025992 mRNA Translation: AAH25992.1 BC039078 mRNA Translation: AAH39078.1 BC091481 mRNA Translation: AAH91481.1 |
CCDSi | CCDS2035.1 |
PIRi | T12451 |
RefSeqi | NP_054763.2, NM_014044.6 |
Genome annotation databases
Ensembli | ENST00000357765; ENSP00000350409; ENSG00000115446 |
GeneIDi | 25972 |
KEGGi | hsa:25972 |
MANE-Selecti | ENST00000357765.7; ENSP00000350409.2; NM_014044.7; NP_054763.2 |
UCSCi | uc002szc.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY017215 mRNA Translation: AAK08987.1 AF077038 mRNA Translation: AAD27771.1 AL080115 mRNA Translation: CAB45714.1 AY251534 mRNA Translation: AAP20057.1 CR533464 mRNA Translation: CAG38495.1 AK222599 mRNA Translation: BAD96319.1 AC010134 Genomic DNA Translation: AAX93232.1 AC064860 Genomic DNA Translation: AAY14975.1 CH471127 Genomic DNA Translation: EAX01900.1 CH471127 Genomic DNA Translation: EAX01901.1 CH471127 Genomic DNA Translation: EAX01902.1 BC017019 mRNA Translation: AAH17019.1 BC025992 mRNA Translation: AAH25992.1 BC039078 mRNA Translation: AAH39078.1 BC091481 mRNA Translation: AAH91481.1 |
CCDSi | CCDS2035.1 |
PIRi | T12451 |
RefSeqi | NP_054763.2, NM_014044.6 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117456, 45 interactors |
IntActi | Q53HI1, 35 interactors |
MINTi | Q53HI1 |
STRINGi | 9606.ENSP00000350409 |
PTM databases
iPTMneti | Q53HI1 |
PhosphoSitePlusi | Q53HI1 |
Genetic variation databases
BioMutai | UNC50 |
DMDMi | 160358938 |
Proteomic databases
EPDi | Q53HI1 |
jPOSTi | Q53HI1 |
MassIVEi | Q53HI1 |
MaxQBi | Q53HI1 |
PaxDbi | Q53HI1 |
PeptideAtlasi | Q53HI1 |
PRIDEi | Q53HI1 |
ProteomicsDBi | 62506 |
Protocols and materials databases
Antibodypediai | 17600, 65 antibodies from 20 providers |
DNASUi | 25972 |
Genome annotation databases
Ensembli | ENST00000357765; ENSP00000350409; ENSG00000115446 |
GeneIDi | 25972 |
KEGGi | hsa:25972 |
MANE-Selecti | ENST00000357765.7; ENSP00000350409.2; NM_014044.7; NP_054763.2 |
UCSCi | uc002szc.5, human |
Organism-specific databases
CTDi | 25972 |
DisGeNETi | 25972 |
GeneCardsi | UNC50 |
HGNCi | HGNC:16046, UNC50 |
HPAi | ENSG00000115446, Low tissue specificity |
MIMi | 617826, gene |
neXtProti | NX_Q53HI1 |
OpenTargetsi | ENSG00000115446 |
PharmGKBi | PA134984566 |
VEuPathDBi | HostDB:ENSG00000115446 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3012, Eukaryota |
GeneTreei | ENSGT00390000018553 |
HOGENOMi | CLU_066239_0_0_1 |
InParanoidi | Q53HI1 |
OMAi | FDIHLNA |
OrthoDBi | 1351297at2759 |
PhylomeDBi | Q53HI1 |
TreeFami | TF105624 |
Enzyme and pathway databases
PathwayCommonsi | Q53HI1 |
SignaLinki | Q53HI1 |
Miscellaneous databases
BioGRID-ORCSi | 25972, 322 hits in 1053 CRISPR screens |
ChiTaRSi | UNC50, human |
GenomeRNAii | 25972 |
Pharosi | Q53HI1, Tbio |
PROi | PR:Q53HI1 |
RNActi | Q53HI1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115446, Expressed in left lobe of thyroid gland and 244 other tissues |
ExpressionAtlasi | Q53HI1, baseline and differential |
Genevisiblei | Q53HI1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007881, UNC-50 |
PANTHERi | PTHR12841, PTHR12841, 1 hit |
Pfami | View protein in Pfam PF05216, UNC-50, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UNC50_HUMAN | |
Accessioni | Q53HI1Primary (citable) accession number: Q53HI1 Secondary accession number(s): D3DVH4 Q9Y4S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 23, 2022 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families