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Protein

EARP and GARP complex-interacting protein 1

Gene

EIPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.1 Publication

GO - Biological processi

  • protein ubiquitination Source: GO_Central

Enzyme and pathway databases

SignaLinkiQ53HC9

Names & Taxonomyi

Protein namesi
Recommended name:
EARP and GARP complex-interacting protein 11 Publication
Alternative name(s):
Endosome-associated recycling protein-interacting protein1 Publication
Golgi-associated retrograde protein-interacting protein1 Publication
Tumor-suppressing STF cDNA 1 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein1 Publication
Gene namesi
Name:EIPR1Imported
Synonyms:TSSC11 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000032389.12
HGNCiHGNC:12383 EIPR1
MIMi608998 gene
neXtProtiNX_Q53HC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7260
OpenTargetsiENSG00000032389
PharmGKBiPA37051

Polymorphism and mutation databases

BioMutaiTSSC1
DMDMi84029603

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512981 – 387EARP and GARP complex-interacting protein 1Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ53HC9
MaxQBiQ53HC9
PaxDbiQ53HC9
PeptideAtlasiQ53HC9
PRIDEiQ53HC9
ProteomicsDBi62505

2D gel databases

OGPiO43179

PTM databases

iPTMnetiQ53HC9
PhosphoSitePlusiQ53HC9

Expressioni

Gene expression databases

BgeeiENSG00000032389 Expressed in 197 organ(s), highest expression level in prostate gland
CleanExiHS_TSSC1
ExpressionAtlasiQ53HC9 baseline and differential
GenevisibleiQ53HC9 HS

Organism-specific databases

HPAiHPA031231
HPA031232
HPA031233
HPA031234

Interactioni

Subunit structurei

Interacts with two multisubunit tethering complexes: EARP composed of VPS50, VPS51, VPS52 and VPS53 subunits and GARP complex composed of VPS51, VPS52, VPS53 and VPS54 subunits. Interacts with SNAP29.1 Publication

Protein-protein interaction databases

BioGridi113111, 75 interactors
IntActiQ53HC9, 18 interactors
STRINGi9606.ENSP00000371559

Structurei

3D structure databases

ProteinModelPortaliQ53HC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 48WD 1Add BLAST45
Repeati55 – 101WD 2Add BLAST47
Repeati124 – 164WD 3Add BLAST41
Repeati172 – 214WD 4Add BLAST43
Repeati219 – 258WD 5Add BLAST40
Repeati263 – 302WD 6Add BLAST40
Repeati338 – 379WD 7Add BLAST42

Sequence similaritiesi

Belongs to the WD repeat EIPR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1007 Eukaryota
ENOG410XRIE LUCA
GeneTreeiENSGT00730000111137
HOGENOMiHOG000264967
HOVERGENiHBG052937
InParanoidiQ53HC9
PhylomeDBiQ53HC9
TreeFamiTF105847

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q53HC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD
60 70 80 90 100
ENNIINKNVL LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR
110 120 130 140 150
MPKELESGSH ESPDDSSSTA QTLELLCHLD NTAHGNMACV VWEPMGDGKK
160 170 180 190 200
IISLADNHIL LWDLQESSSQ AVLASSASLE GKGQLKFTSG RWSPHHNCTQ
210 220 230 240 250
VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK QYYLASCGDD
260 270 280 290 300
CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS
310 320 330 340 350
NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV
360 370 380
YAVDWSSADP WLFASLSYDG RLVINRVPRA LKYHILL
Length:387
Mass (Da):43,603
Last modified:December 20, 2005 - v2
Checksum:i7B1CCD35B7C38780
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUM1A8MUM1_HUMAN
EARP and GARP complex-interacting p...
EIPR1
414Annotation score:
C9JVR6C9JVR6_HUMAN
EARP and GARP complex-interacting p...
EIPR1
178Annotation score:
D3YTH5D3YTH5_HUMAN
EARP and GARP complex-interacting p...
EIPR1
314Annotation score:
C9J0U9C9J0U9_HUMAN
EARP and GARP complex-interacting p...
EIPR1
155Annotation score:
F8WB12F8WB12_HUMAN
EARP and GARP complex-interacting p...
EIPR1
87Annotation score:
F8WDX0F8WDX0_HUMAN
EARP and GARP complex-interacting p...
EIPR1
58Annotation score:
F8WDS8F8WDS8_HUMAN
EARP and GARP complex-interacting p...
EIPR1
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58N → S in BAD96372 (Ref. 2) Curated1
Sequence conflicti214T → A in BAD96372 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019952 mRNA Translation: AAC51911.1
AK222652 mRNA Translation: BAD96372.1
AC019118 Genomic DNA Translation: AAY24338.1
AC073502 Genomic DNA Translation: AAY24193.1
CH471053 Genomic DNA Translation: EAX01070.1
CH471053 Genomic DNA Translation: EAX01071.1
BC002485 mRNA Translation: AAH02485.1
CCDSiCCDS1651.1
RefSeqiNP_003301.1, NM_003310.3
UniGeneiHs.502770

Genome annotation databases

EnsembliENST00000382125; ENSP00000371559; ENSG00000032389
GeneIDi7260
KEGGihsa:7260
UCSCiuc002qxj.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019952 mRNA Translation: AAC51911.1
AK222652 mRNA Translation: BAD96372.1
AC019118 Genomic DNA Translation: AAY24338.1
AC073502 Genomic DNA Translation: AAY24193.1
CH471053 Genomic DNA Translation: EAX01070.1
CH471053 Genomic DNA Translation: EAX01071.1
BC002485 mRNA Translation: AAH02485.1
CCDSiCCDS1651.1
RefSeqiNP_003301.1, NM_003310.3
UniGeneiHs.502770

3D structure databases

ProteinModelPortaliQ53HC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113111, 75 interactors
IntActiQ53HC9, 18 interactors
STRINGi9606.ENSP00000371559

PTM databases

iPTMnetiQ53HC9
PhosphoSitePlusiQ53HC9

Polymorphism and mutation databases

BioMutaiTSSC1
DMDMi84029603

2D gel databases

OGPiO43179

Proteomic databases

EPDiQ53HC9
MaxQBiQ53HC9
PaxDbiQ53HC9
PeptideAtlasiQ53HC9
PRIDEiQ53HC9
ProteomicsDBi62505

Protocols and materials databases

DNASUi7260
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382125; ENSP00000371559; ENSG00000032389
GeneIDi7260
KEGGihsa:7260
UCSCiuc002qxj.3 human

Organism-specific databases

CTDi7260
DisGeNETi7260
EuPathDBiHostDB:ENSG00000032389.12
GeneCardsiEIPR1
HGNCiHGNC:12383 EIPR1
HPAiHPA031231
HPA031232
HPA031233
HPA031234
MIMi608998 gene
neXtProtiNX_Q53HC9
OpenTargetsiENSG00000032389
PharmGKBiPA37051
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1007 Eukaryota
ENOG410XRIE LUCA
GeneTreeiENSGT00730000111137
HOGENOMiHOG000264967
HOVERGENiHBG052937
InParanoidiQ53HC9
PhylomeDBiQ53HC9
TreeFamiTF105847

Enzyme and pathway databases

SignaLinkiQ53HC9

Miscellaneous databases

ChiTaRSiTSSC1 human
GeneWikiiTSSC1
GenomeRNAii7260
PROiPR:Q53HC9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000032389 Expressed in 197 organ(s), highest expression level in prostate gland
CleanExiHS_TSSC1
ExpressionAtlasiQ53HC9 baseline and differential
GenevisibleiQ53HC9 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIPR1_HUMAN
AccessioniPrimary (citable) accession number: Q53HC9
Secondary accession number(s): D6W4Y1
, O43179, Q53S19, Q53SG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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