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Entry version 104 (13 Feb 2019)
Sequence version 2 (15 Jan 2008)
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Protein

Endoribonuclease LACTB2

Gene

LACTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.1 Publication

Miscellaneous

RNAi-mediated down-regulation results in rapid cell death. The reason for this is not clear; there are only minor changes in mitochondrial mRNA levels.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi77Zinc 1; via tele nitrogenCombined sources1
Metal bindingi79Zinc 1; via pros nitrogenCombined sources1
Metal bindingi81Zinc 2Combined sources1
Metal bindingi82Zinc 2; via tele nitrogenCombined sources1
Metal bindingi118Zinc 1Combined sources1
Metal bindingi118Zinc 2Combined sources1
Metal bindingi145Zinc 1; via tele nitrogenCombined sources1
Metal bindingi164Zinc 1Combined sources1
Metal bindingi164Zinc 2Combined sources1
Metal bindingi199Zinc 2; via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endoribonuclease activity Source: UniProtKB
  • single-stranded RNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoribonuclease LACTB21 Publication (EC:3.1.27.-1 Publication)
Alternative name(s):
Beta-lactamase-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LACTB2
ORF Names:CGI-83
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147592.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18512 LACTB2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q53H82

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi77 – 82Missing : Loss of endoribonuclease activity. 1 Publication6
Mutagenesisi81D → A: Loss of endoribonuclease activity. 1 Publication1
Mutagenesisi110R → A: Mildly decreases endoribonuclease activity. No effect on RNA-binding. 1 Publication1
Mutagenesisi116N → A: Loss of endoribonuclease activity. No effect on RNA-binding. 1 Publication1
Mutagenesisi118E → A: Loss of endoribonuclease activity. No effect on RNA-binding. 1 Publication1
Mutagenesisi164D → A: Loss of endoribonuclease activity. 1 Publication1
Mutagenesisi216 – 217HR → AT: Loss of endoribonuclease activity. Strongly decreases RNA-binding. 1 Publication2
Mutagenesisi220R → T: Loss of endoribonuclease activity. Strongly decreases RNA-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51110

Open Targets

More...
OpenTargetsi
ENSG00000147592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952605

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LACTB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166223244

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157431 – 288Endoribonuclease LACTB2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102N6-acetyllysineBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei273N6-succinyllysineBy similarity1
Modified residuei282N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q53H82

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q53H82

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q53H82

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q53H82

PeptideAtlas

More...
PeptideAtlasi
Q53H82

PRoteomics IDEntifications database

More...
PRIDEi
Q53H82

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62501

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00006952

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q53H82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q53H82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147592 Expressed in 214 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q53H82 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q53H82 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044391
HPA053040

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-3943430,EBI-747107

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119299, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q53H82, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276590

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AD9X-ray2.60A/B/C/D/E/F1-288[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q53H82

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q53H82

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0813 Eukaryota
COG0491 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001710

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246879

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG099837

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q53H82

KEGG Orthology (KO)

More...
KOi
K16639

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTTDHVV

Database of Orthologous Groups

More...
OrthoDBi
576967at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q53H82

TreeFam database of animal gene trees

More...
TreeFami
TF314297

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.60.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR036388 WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00753 Lactamase_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00849 Lactamase_B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56281 SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q53H82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP
60 70 80 90 100
AIPEYISCLK QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC
110 120 130 140 150
IKKLPRNPQR EEIIGNGEQQ YVYLKDGDVI KTEGATLRVL YTPGHTDDHM
160 170 180 190 200
ALLLEEENAI FSGDCILGEG TTVFEDLYDY MNSLKELLKI KADIIYPGHG
210 220 230 240 250
PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME LVKIIYKNTP
260 270 280
ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL
Length:288
Mass (Da):32,806
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF569C7DFB070D52C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39G → S in BAF82890 (PubMed:14702039).Curated1
Sequence conflicti268L → P in BAD96419 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151841 mRNA Translation: AAD34078.1
AK290201 mRNA Translation: BAF82890.1
AK222699 mRNA Translation: BAD96419.1
CH471068 Genomic DNA Translation: EAW86969.1
BC000878 mRNA Translation: AAH00878.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6208.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T44603

NCBI Reference Sequences

More...
RefSeqi
NP_057111.1, NM_016027.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.118554

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276590; ENSP00000276590; ENSG00000147592
ENST00000522447; ENSP00000428801; ENSG00000147592

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51110

UCSC genome browser

More...
UCSCi
uc003xyp.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151841 mRNA Translation: AAD34078.1
AK290201 mRNA Translation: BAF82890.1
AK222699 mRNA Translation: BAD96419.1
CH471068 Genomic DNA Translation: EAW86969.1
BC000878 mRNA Translation: AAH00878.1
CCDSiCCDS6208.1
PIRiT44603
RefSeqiNP_057111.1, NM_016027.2
UniGeneiHs.118554

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AD9X-ray2.60A/B/C/D/E/F1-288[»]
ProteinModelPortaliQ53H82
SMRiQ53H82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119299, 20 interactors
IntActiQ53H82, 2 interactors
STRINGi9606.ENSP00000276590

PTM databases

iPTMnetiQ53H82
PhosphoSitePlusiQ53H82

Polymorphism and mutation databases

BioMutaiLACTB2
DMDMi166223244

2D gel databases

REPRODUCTION-2DPAGEiIPI00006952

Proteomic databases

EPDiQ53H82
jPOSTiQ53H82
MaxQBiQ53H82
PaxDbiQ53H82
PeptideAtlasiQ53H82
PRIDEiQ53H82
ProteomicsDBi62501

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51110
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276590; ENSP00000276590; ENSG00000147592
ENST00000522447; ENSP00000428801; ENSG00000147592
GeneIDi51110
KEGGihsa:51110
UCSCiuc003xyp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51110
DisGeNETi51110
EuPathDBiHostDB:ENSG00000147592.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LACTB2
HGNCiHGNC:18512 LACTB2
HPAiHPA044391
HPA053040
neXtProtiNX_Q53H82
OpenTargetsiENSG00000147592
PharmGKBiPA134952605

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0813 Eukaryota
COG0491 LUCA
GeneTreeiENSGT00390000001710
HOGENOMiHOG000246879
HOVERGENiHBG099837
InParanoidiQ53H82
KOiK16639
OMAiHTTDHVV
OrthoDBi576967at2759
PhylomeDBiQ53H82
TreeFamiTF314297

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51110

Protein Ontology

More...
PROi
PR:Q53H82

Gene expression databases

BgeeiENSG00000147592 Expressed in 214 organ(s), highest expression level in testis
ExpressionAtlasiQ53H82 baseline and differential
GenevisibleiQ53H82 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLACB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53H82
Secondary accession number(s): A8K2D6, Q9Y392
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 13, 2019
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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