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Protein

Akirin-2

Gene

AKIRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).By similarity

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-2
Gene namesi
Name:AKIRIN2
Synonyms:C6orf166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135334.8
HGNCiHGNC:21407 AKIRIN2
MIMi615165 gene
neXtProtiNX_Q53H80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55122
OpenTargetsiENSG00000135334
PharmGKBiPA162376195

Polymorphism and mutation databases

BioMutaiAKIRIN2
DMDMi71152385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895551 – 203Akirin-2Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53H80
MaxQBiQ53H80
PaxDbiQ53H80
PeptideAtlasiQ53H80
PRIDEiQ53H80
ProteomicsDBi62500

PTM databases

iPTMnetiQ53H80
PhosphoSitePlusiQ53H80

Expressioni

Tissue specificityi

Widely expressed with the highest expression in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000135334 Expressed in 198 organ(s), highest expression level in oocyte
CleanExiHS_AKIRIN2
GenevisibleiQ53H80 HS

Organism-specific databases

HPAiHPA064239

Interactioni

Subunit structurei

Interacts with YWHAB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SPG21Q9NZD85EBI-742928,EBI-742688

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120430, 27 interactors
IntActiQ53H80, 11 interactors

Structurei

3D structure databases

ProteinModelPortaliQ53H80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 27Nuclear localization signal6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 56Ala-richAdd BLAST29

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330 Eukaryota
ENOG4111J00 LUCA
GeneTreeiENSGT00390000007905
HOGENOMiHOG000231406
HOVERGENiHBG055078
InParanoidiQ53H80
OMAiKMAENLC
OrthoDBiEOG091G0PVD
PhylomeDBiQ53H80
TreeFamiTF317123

Family and domain databases

InterProiView protein in InterPro
IPR024132 Akirin
PANTHERiPTHR13293 PTHR13293, 1 hit

Sequencei

Sequence statusi: Complete.

Q53H80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPTSAAASP LSAAAATAAS
60 70 80 90 100
FSAAAASPQK YLRMEPSPFG DVSSRLTTEQ ILYNIKQEYK RMQKRRHLET
110 120 130 140 150
SFQQTDPCCT SDAQPHAFLL SGPASPGTSS AASSPLKKEQ PLFTLRQVGM
160 170 180 190 200
ICERLLKERE EKVREEYEEI LNTKLAEQYD AFVKFTHDQI MRRYGEQPAS

YVS
Length:203
Mass (Da):22,496
Last modified:July 19, 2005 - v2
Checksum:i33AA93AF94DE80A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171L → S in BAD96421 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222701 mRNA Translation: BAD96421.1
AL133211 Genomic DNA No translation available.
BC000764 mRNA Translation: AAH00764.1
BC003042 mRNA Translation: AAH03042.1
BC005051 mRNA Translation: AAH05051.1
CCDSiCCDS5013.1
RefSeqiNP_060534.1, NM_018064.3
UniGeneiHs.485915

Genome annotation databases

EnsembliENST00000257787; ENSP00000257787; ENSG00000135334
GeneIDi55122
KEGGihsa:55122
UCSCiuc003pmk.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222701 mRNA Translation: BAD96421.1
AL133211 Genomic DNA No translation available.
BC000764 mRNA Translation: AAH00764.1
BC003042 mRNA Translation: AAH03042.1
BC005051 mRNA Translation: AAH05051.1
CCDSiCCDS5013.1
RefSeqiNP_060534.1, NM_018064.3
UniGeneiHs.485915

3D structure databases

ProteinModelPortaliQ53H80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120430, 27 interactors
IntActiQ53H80, 11 interactors

PTM databases

iPTMnetiQ53H80
PhosphoSitePlusiQ53H80

Polymorphism and mutation databases

BioMutaiAKIRIN2
DMDMi71152385

Proteomic databases

EPDiQ53H80
MaxQBiQ53H80
PaxDbiQ53H80
PeptideAtlasiQ53H80
PRIDEiQ53H80
ProteomicsDBi62500

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257787; ENSP00000257787; ENSG00000135334
GeneIDi55122
KEGGihsa:55122
UCSCiuc003pmk.4 human

Organism-specific databases

CTDi55122
DisGeNETi55122
EuPathDBiHostDB:ENSG00000135334.8
GeneCardsiAKIRIN2
H-InvDBiHIX0006057
HGNCiHGNC:21407 AKIRIN2
HPAiHPA064239
MIMi615165 gene
neXtProtiNX_Q53H80
OpenTargetsiENSG00000135334
PharmGKBiPA162376195
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4330 Eukaryota
ENOG4111J00 LUCA
GeneTreeiENSGT00390000007905
HOGENOMiHOG000231406
HOVERGENiHBG055078
InParanoidiQ53H80
OMAiKMAENLC
OrthoDBiEOG091G0PVD
PhylomeDBiQ53H80
TreeFamiTF317123

Miscellaneous databases

ChiTaRSiAKIRIN2 human
GeneWikiiC6orf166
GenomeRNAii55122
PROiPR:Q53H80
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135334 Expressed in 198 organ(s), highest expression level in oocyte
CleanExiHS_AKIRIN2
GenevisibleiQ53H80 HS

Family and domain databases

InterProiView protein in InterPro
IPR024132 Akirin
PANTHERiPTHR13293 PTHR13293, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKIR2_HUMAN
AccessioniPrimary (citable) accession number: Q53H80
Secondary accession number(s): Q9BQB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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