UniProtKB - Q53H12 (AGK_HUMAN)
Protein
Acylglycerol kinase, mitochondrial
Gene
AGK
Organism
Homo sapiens (Human)
Status
Functioni
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762).By similarity3 Publications
Caution
According to a report, the N-terminal hydrophobic region forms a transmembrane region that crosses the mitochondrion inner membrane (PubMed:28712726). According to another report, the N-terminal hydrophobic region associates with the membrane without crossing it (PubMed:28712724).2 Publications
Catalytic activityi
- EC:2.7.1.941 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:2.7.1.1071 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:2.7.1.138By similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forward1 Publication direction.
Cofactori
Mg2+1 Publication
: glycerolipid metabolism Pathwayi
This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.
GO - Molecular functioni
- acylglycerol kinase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- ceramide kinase activity Source: GO_Central
- D-erythro-sphingosine kinase activity Source: GO_Central
- diacylglycerol kinase activity Source: UniProtKB
- dihydroceramide kinase activity Source: UniProtKB-EC
- lipid kinase activity Source: GO_Central
- NAD+ kinase activity Source: InterPro
GO - Biological processi
- ceramide biosynthetic process Source: GO_Central
- glycerophospholipid biosynthetic process Source: Reactome
- phosphorylation Source: GO_Central
- protein insertion into mitochondrial inner membrane Source: UniProtKB
- sphingolipid metabolic process Source: GO_Central
- sphingosine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.94, 2681 |
PathwayCommonsi | Q53H12 |
Reactomei | R-HSA-1483206, Glycerophospholipid biosynthesis R-HSA-6802952, Signaling by BRAF and RAF fusions |
SABIO-RKi | Q53H12 |
UniPathwayi | UPA00230 |
Chemistry databases
SwissLipidsi | SLP:000000638 |
Names & Taxonomyi
Protein namesi | Recommended name: Acylglycerol kinase, mitochondrial1 Publication (EC:2.7.1.1071 Publication, EC:2.7.1.138By similarity, EC:2.7.1.941 Publication)Short name: hAGK1 Publication Alternative name(s): Multiple substrate lipid kinase1 Publication Short name: HsMuLK1 Publication Short name: MuLK1 Publication Short name: Multi-substrate lipid kinase1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21869, AGK |
MIMi | 610345, gene |
neXtProti | NX_Q53H12 |
VEuPathDBi | HostDB:ENSG00000006530.15 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 4 Publications; Peripheral membrane protein 1 Publication
- Mitochondrion intermembrane space 2 Publications
Note: Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726).2 Publications
Cytosol
- cytosol Source: Reactome
Mitochondrion
- integral component of mitochondrial inner membrane Source: UniProtKB
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial intermembrane space Source: UniProtKB
- mitochondrial membrane Source: UniProtKB
- mitochondrial outer membrane Source: Reactome
- mitochondrion Source: HPA
- TIM22 mitochondrial import inner membrane insertion complex Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: GO_Central
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Involvement in diseasei
Mitochondrial DNA depletion syndrome 10 (MTDPS10)5 Publications
The disease is caused by variants affecting the gene represented in this entry. The TIM22 complex and import of proteins into mitochondrion are affected in patients suffering of MTDPS10 (PubMed:28712726).1 Publication
Disease descriptionAn autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079050 | 137 – 422 | Missing in MTDPS10. 1 PublicationAdd BLAST | 286 | |
Natural variantiVAR_079051 | 291 – 422 | Missing in MTDPS10. 1 PublicationAdd BLAST | 132 | |
Natural variantiVAR_079052 | 327 – 422 | Missing in MTDPS10. 1 PublicationAdd BLAST | 96 |
Cataract 38 (CTRCT38)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 126 | G → E: Abolishes lipid kinase activity. Does not affect ability to associate with the TIM22 complex and mediate import of transmembrane proteins into the mitochondrial inner membrane. 3 Publications | 1 |
Keywords - Diseasei
Cardiomyopathy, Cataract, Disease variant, Primary mitochondrial diseaseOrganism-specific databases
DisGeNETi | 55750 |
MalaCardsi | AGK |
MIMi | 212350, phenotype 614691, phenotype |
OpenTargetsi | ENSG00000006530 |
Orphaneti | 1369, Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome 98994, Total early-onset cataract |
PharmGKBi | PA162375851 |
Miscellaneous databases
Pharosi | Q53H12, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2417354 |
Genetic variation databases
BioMutai | AGK |
DMDMi | 116248550 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252380 | 1 – 422 | Acylglycerol kinase, mitochondrialAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 6 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q53H12 |
jPOSTi | Q53H12 |
MassIVEi | Q53H12 |
MaxQBi | Q53H12 |
PaxDbi | Q53H12 |
PeptideAtlasi | Q53H12 |
PRIDEi | Q53H12 |
ProteomicsDBi | 62491 [Q53H12-1] 62492 [Q53H12-2] |
PTM databases
iPTMneti | Q53H12 |
PhosphoSitePlusi | Q53H12 |
SwissPalmi | Q53H12 |
Expressioni
Tissue specificityi
Highly expressed in muscle, heart, kidney and brain.1 Publication
Inductioni
Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which lysophosphatidic acid (LPA) plays key roles.1 Publication
Gene expression databases
Bgeei | ENSG00000006530, Expressed in secondary oocyte and 224 other tissues |
ExpressionAtlasi | Q53H12, baseline and differential |
Genevisiblei | Q53H12, HS |
Organism-specific databases
HPAi | ENSG00000006530, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ53H12
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 3 | EBI-2269837,EBI-466029 |
Isoform 2 [Q53H12-2]
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 12 | EBI-25944242,EBI-466029 |
Protein-protein interaction databases
BioGRIDi | 120868, 64 interactors |
ComplexPortali | CPX-6124, TIM22 mitochondrial inner membrane twin-pore carrier translocase complex |
IntActi | Q53H12, 39 interactors |
MINTi | Q53H12 |
STRINGi | 9606.ENSP00000347581 |
Miscellaneous databases
RNActi | Q53H12, protein |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 199 | DAGKcPROSITE-ProRule annotationAdd BLAST | 142 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 31 | HydrophobicCuratedAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the AGK family.Curated
Phylogenomic databases
eggNOGi | KOG4435, Eukaryota |
GeneTreei | ENSGT00940000154961 |
HOGENOMi | CLU_042458_0_0_1 |
InParanoidi | Q53H12 |
OMAi | KEWPQIH |
OrthoDBi | 1312024at2759 |
PhylomeDBi | Q53H12 |
TreeFami | TF320485 |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf |
Pfami | View protein in Pfam PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q53H12-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVFFKTLRN HWKKTTAGLC LLTWGGHWLY GKHCDNLLRR AACQEAQVFG
60 70 80 90 100
NQLIPPNAQV KKATVFLNPA ACKGKARTLF EKNAAPILHL SGMDVTIVKT
110 120 130 140 150
DYEGQAKKLL ELMENTDVII VAGGDGTLQE VVTGVLRRTD EATFSKIPIG
160 170 180 190 200
FIPLGETSSL SHTLFAESGN KVQHITDATL AIVKGETVPL DVLQIKGEKE
210 220 230 240 250
QPVFAMTGLR WGSFRDAGVK VSKYWYLGPL KIKAAHFFST LKEWPQTHQA
260 270 280 290 300
SISYTGPTER PPNEPEETPV QRPSLYRRIL RRLASYWAQP QDALSQEVSP
310 320 330 340 350
EVWKDVQLST IELSITTRNN QLDPTSKEDF LNICIEPDTI SKGDFITIGS
360 370 380 390 400
RKVRNPKLHV EGTECLQASQ CTLLIPEGAG GSFSIDSEEY EAMPVEVKLL
410 420
PRKLQFFCDP RKREQMLTSP TQ
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC15 | E9PC15_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 394 | Annotation score: | ||
A0A3B3ISZ0 | A0A3B3ISZ0_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 350 | Annotation score: | ||
A0A3B3ITD0 | A0A3B3ITD0_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 418 | Annotation score: | ||
A0A3B3ISY9 | A0A3B3ISY9_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 330 | Annotation score: | ||
E9PG39 | E9PG39_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 244 | Annotation score: | ||
A0A3B3ITV0 | A0A3B3ITV0_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 138 | Annotation score: | ||
A0A3B3ITX7 | A0A3B3ITX7_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 214 | Annotation score: | ||
A0A3B3IS09 | A0A3B3IS09_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 146 | Annotation score: | ||
A0A3B3IUC9 | A0A3B3IUC9_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 134 | Annotation score: | ||
A0A0G2JLG5 | A0A0G2JLG5_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 226 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 94 | D → V in BAD96489 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027848 | 3 | V → M. Corresponds to variant dbSNP:rs10262855Ensembl. | 1 | |
Natural variantiVAR_079050 | 137 – 422 | Missing in MTDPS10. 1 PublicationAdd BLAST | 286 | |
Natural variantiVAR_079051 | 291 – 422 | Missing in MTDPS10. 1 PublicationAdd BLAST | 132 | |
Natural variantiVAR_079052 | 327 – 422 | Missing in MTDPS10. 1 PublicationAdd BLAST | 96 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020925 | 48 – 65 | VFGNQ…KKATV → HYQDESRWEPTLSRTPGS in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_020926 | 66 – 422 | Missing in isoform 2. 1 PublicationAdd BLAST | 357 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278150 mRNA Translation: CAB93536.1 AK001704 mRNA Translation: BAA91848.1 AK222769 mRNA Translation: BAD96489.1 AC004918 Genomic DNA No translation available. AC073878 Genomic DNA No translation available. AC099547 Genomic DNA Translation: AAS07537.1 BC009775 mRNA Translation: AAH09775.1 BC022777 mRNA Translation: AAH22777.1 |
CCDSi | CCDS5865.1 [Q53H12-1] |
RefSeqi | NP_060708.1, NM_018238.3 [Q53H12-1] XP_011514699.1, XM_011516397.2 [Q53H12-1] |
Genome annotation databases
Ensembli | ENST00000492693; ENSP00000418789; ENSG00000006530 [Q53H12-2] ENST00000575872; ENSP00000458417; ENSG00000262327 ENST00000648068; ENSP00000498112; ENSG00000006530 [Q53H12-1] ENST00000649286; ENSP00000497280; ENSG00000006530 [Q53H12-1] ENST00000650547; ENSP00000496789; ENSG00000006530 [Q53H12-1] |
GeneIDi | 55750 |
KEGGi | hsa:55750 |
UCSCi | uc003vwi.3, human [Q53H12-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278150 mRNA Translation: CAB93536.1 AK001704 mRNA Translation: BAA91848.1 AK222769 mRNA Translation: BAD96489.1 AC004918 Genomic DNA No translation available. AC073878 Genomic DNA No translation available. AC099547 Genomic DNA Translation: AAS07537.1 BC009775 mRNA Translation: AAH09775.1 BC022777 mRNA Translation: AAH22777.1 |
CCDSi | CCDS5865.1 [Q53H12-1] |
RefSeqi | NP_060708.1, NM_018238.3 [Q53H12-1] XP_011514699.1, XM_011516397.2 [Q53H12-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7CGP | electron microscopy | 3.70 | B | 1-422 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120868, 64 interactors |
ComplexPortali | CPX-6124, TIM22 mitochondrial inner membrane twin-pore carrier translocase complex |
IntActi | Q53H12, 39 interactors |
MINTi | Q53H12 |
STRINGi | 9606.ENSP00000347581 |
Chemistry databases
ChEMBLi | CHEMBL2417354 |
SwissLipidsi | SLP:000000638 |
PTM databases
iPTMneti | Q53H12 |
PhosphoSitePlusi | Q53H12 |
SwissPalmi | Q53H12 |
Genetic variation databases
BioMutai | AGK |
DMDMi | 116248550 |
Proteomic databases
EPDi | Q53H12 |
jPOSTi | Q53H12 |
MassIVEi | Q53H12 |
MaxQBi | Q53H12 |
PaxDbi | Q53H12 |
PeptideAtlasi | Q53H12 |
PRIDEi | Q53H12 |
ProteomicsDBi | 62491 [Q53H12-1] 62492 [Q53H12-2] |
Protocols and materials databases
Antibodypediai | 18305, 191 antibodies |
DNASUi | 55750 |
Genome annotation databases
Ensembli | ENST00000492693; ENSP00000418789; ENSG00000006530 [Q53H12-2] ENST00000575872; ENSP00000458417; ENSG00000262327 ENST00000648068; ENSP00000498112; ENSG00000006530 [Q53H12-1] ENST00000649286; ENSP00000497280; ENSG00000006530 [Q53H12-1] ENST00000650547; ENSP00000496789; ENSG00000006530 [Q53H12-1] |
GeneIDi | 55750 |
KEGGi | hsa:55750 |
UCSCi | uc003vwi.3, human [Q53H12-1] |
Organism-specific databases
CTDi | 55750 |
DisGeNETi | 55750 |
GeneCardsi | AGK |
HGNCi | HGNC:21869, AGK |
HPAi | ENSG00000006530, Low tissue specificity |
MalaCardsi | AGK |
MIMi | 212350, phenotype 610345, gene 614691, phenotype |
neXtProti | NX_Q53H12 |
OpenTargetsi | ENSG00000006530 |
Orphaneti | 1369, Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome 98994, Total early-onset cataract |
PharmGKBi | PA162375851 |
VEuPathDBi | HostDB:ENSG00000006530.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4435, Eukaryota |
GeneTreei | ENSGT00940000154961 |
HOGENOMi | CLU_042458_0_0_1 |
InParanoidi | Q53H12 |
OMAi | KEWPQIH |
OrthoDBi | 1312024at2759 |
PhylomeDBi | Q53H12 |
TreeFami | TF320485 |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
BRENDAi | 2.7.1.94, 2681 |
PathwayCommonsi | Q53H12 |
Reactomei | R-HSA-1483206, Glycerophospholipid biosynthesis R-HSA-6802952, Signaling by BRAF and RAF fusions |
SABIO-RKi | Q53H12 |
Miscellaneous databases
BioGRID-ORCSi | 55750, 12 hits in 884 CRISPR screens |
ChiTaRSi | AGK, human |
GeneWikii | AGK_(gene) |
GenomeRNAii | 55750 |
Pharosi | Q53H12, Tbio |
PROi | PR:Q53H12 |
RNActi | Q53H12, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000006530, Expressed in secondary oocyte and 224 other tissues |
ExpressionAtlasi | Q53H12, baseline and differential |
Genevisiblei | Q53H12, HS |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf |
Pfami | View protein in Pfam PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGK_HUMAN | |
Accessioni | Q53H12Primary (citable) accession number: Q53H12 Secondary accession number(s): Q75KN1, Q96GC3, Q9NP48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM