PLEKHO1

Functionⁱ

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.7 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	155	Capping protein		1
Binding siteⁱ	157	Capping protein		1

GO - Biological processⁱ

lamellipodium morphogenesis Source: Ensembl
myoblast fusion Source: Ensembl
myoblast migration Source: Ensembl
regulation of cell shape Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pleckstrin homology domain-containing family O member 1 Short name: PH domain-containing family O member 1 Alternative name(s): C-Jun-binding protein Short name: JBP Casein kinase 2-interacting protein 1 Short name: CK2-interacting protein 1 Short name: CKIP-1 Osteoclast maturation-associated gene 120 protein
Gene namesⁱ	Name:PLEKHO1 Synonyms:CKIP1, OC120 ORF Names:HQ0024c
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000023902.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24310 PLEKHO1
MIMⁱ	608335 gene
neXtProtⁱ	NX_Q53GL0

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	42	K → C: No effect on subcellular localization. No effect on subcellular localization; when associated with C-44. Disruption of membrane localization, loss of phospholipid binding and impaired interaction with CK2; when associated with W-123. Disruption of membrane localization, loss of phospholipid binding and impaired interaction with CK2; when associated with C-44 and W-123. 1 Publication	1
Mutagenesisⁱ	44	R → C: No effect on subcellular localization. No effect on subcellular localization; when associated with C-42. Disruption of membrane localization, loss of phospholipid binding and impaired interaction with CK2; when associated with W-123. Disruption of membrane localization, loss of phospholipid binding and impaired interaction with CK2; when associated with C-42 and W-123. 1 Publication	1
Mutagenesisⁱ	123	W → A: Disruption of membrane localization and impaired interaction with CK2. Loss of phospholipid binding; when associated with C-42. Loss of phospholipid binding; when associated with C-44. Disruption of membrane localization, loss of phospholipid binding and impaired interaction with CK2; when associated with C-42 and C-44. 1 Publication	1
Mutagenesisⁱ	133	R → A: No effect on binding to capping proteins and loss of phospholipid binding; when associated with A-135 and A-137.	1
Mutagenesisⁱ	133	R → E: No effect on binding to capping proteins; when associated with E-135.	1
Mutagenesisⁱ	135	K → A: No effect on binding to capping proteins; when associated with A-133 and A-137.	1
Mutagenesisⁱ	135	K → E: No effect on binding to capping proteins; when associated with E-133.	1
Mutagenesisⁱ	137	R → A: No effect on binding to capping proteins; when associated with A-133 and A-135.	1
Mutagenesisⁱ	155	R → A: No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins; when associated with A-157. Great loss of binding to capping proteins; when associated with A-157 and A-159. 1 Publication	1
Mutagenesisⁱ	155	R → E: No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins and no change in cell morphology and actin cytoskeleton; when associated with E-157. 1 Publication	1
Mutagenesisⁱ	157	R → A: No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins; when associated with A-155. Great loss of binding to capping proteins; when associated with A-155 and A-159. 1 Publication	1
Mutagenesisⁱ	157	R → E: No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins and no change in cell morphology and actin cytoskeleton; when associated with E-155. 1 Publication	1
Mutagenesisⁱ	159	K → A: Great loss of binding to capping proteins; when associated with A-155 and A-157.	1

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51177
Open Targets More...OpenTargetsⁱ	ENSG00000023902
PharmGKBⁱ	PA142671167

Polymorphism and mutation databases

BioMutaⁱ	PLEKHO1
DMDMⁱ	160419242

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000310423	1 – 409	Pleckstrin homology domain-containing family O member 1Add BLAST		409

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	227	PhosphoserineBy similarity	1
Modified residueⁱ	271	PhosphoserineBy similarity	1
Modified residueⁱ	342	PhosphoserineBy similarity	1

Post-translational modificationⁱ

C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	310 – 311	Cleavage; by caspase-3Sequence analysis		2
Siteⁱ	345 – 346	Cleavage; by caspase-3Sequence analysis		2

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q53GL0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q53GL0
PaxDbⁱ	Q53GL0
PeptideAtlas More...PeptideAtlasⁱ	Q53GL0
PRIDEⁱ	Q53GL0
ProteomicsDBⁱ	62483 62484 [Q53GL0-2]

PTM databases

iPTMnetⁱ	Q53GL0
PhosphoSitePlusⁱ	Q53GL0

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat.1 Publication

Inductionⁱ

Up-regulated by IFNG/IFN-gamma and IL2/interleukin-2 or in C2C12 cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000023902 Expressed in 201 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_PLEKHO1
ExpressionAtlasⁱ	Q53GL0 baseline and differential
Genevisibleⁱ	Q53GL0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA061018

HPAⁱ

HPA061018

Interactionⁱ

Subunit structureⁱ

Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2.10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PSMC5	P62195	10	EBI-949945,EBI-357745
SMURF1	Q9HCE7	2	EBI-949945,EBI-976466
SMURF1	Q9HCE7-2	4	EBI-949945,EBI-9845742

Protein-protein interaction databases

BioGridⁱ	119355, 62 interactors
Database of interacting proteins More...DIPⁱ	DIP-46903N
IntActⁱ	Q53GL0, 42 interactors
Molecular INTeraction database More...MINTⁱ	Q53GL0
STRINGⁱ	9606.ENSP00000358120

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	153 – 155	Combined sources		3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q53GL0
SMRⁱ	Q53GL0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q53GL0

EvolutionaryTraceⁱ

Q53GL0

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – 132	PHPROSITE-ProRule annotationAdd BLAST		112

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	133 – 193	Interaction with capping proteins (CPs)Add BLAST	61
Regionⁱ	136 – 308	Interaction with ATM, CKIP, IFP35 and NMI2 PublicationsAdd BLAST	173
Regionⁱ	308 – 409	Negative regulator of AP-1 activityAdd BLAST	102

Phylogenomic databases

eggNOGⁱ	ENOG410IEJU Eukaryota ENOG4110ACW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063760
HOGENOMⁱ	HOG000115563
HOVERGENⁱ	HBG108259
InParanoidⁱ	Q53GL0
OMAⁱ	KRGPQDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CAS
PhylomeDBⁱ	Q53GL0
TreeFamⁱ	TF333115

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR028452 CKIP-1 IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR15871:SF1 PTHR15871:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q53GL0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG 
        60         70         80         90        100
DQLYISEKEV KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS 
       110        120        130        140        150
KQPGNTAPNL IFLAVSPEEK ESWINALNSA ITRAKNRILD EVTVEEDSYL 
       160        170        180        190        200
AHPTRDRAKI QHSRRPPTRG HLMAVASTST SDGMLTLDLI QEEDPSPEEP 
       210        220        230        240        250
TSCAESFRVD LDKSVAQLAG SRRRADSDRI QPSADRASSL SRPWEKTDKG 
       260        270        280        290        300
ATYTPQAPKK LTPTEKGRCA SLEEILSQRD AASARTLQLR AEEPPTPALP 
       310        320        330        340        350
NPGQLSRIQD LVARKLEETQ ELLAEVQGLG DGKRKAKDPP RSPPDSESEQ 
       360        370        380        390        400
LLLETERLLG EASSNWSQAK RVLQEVRELR DLYRQMDLQT PDSHLRQTTP 

HSQYRKSLM

Length:409

Mass (Da):46,237

Last modified:November 13, 2007 - v2

Checksum:ⁱ5077D6B559EB9F78

GO

Isoform 2 (identifier: Q53GL0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
142-175: Missing.

« Hide

        10         20         30         40         50
MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG 
        60         70         80         90        100
DQLYISEKEV KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS 
       110        120        130        140        150
KQPGNTAPNL IFLAVSPEEK ESWINALNSA ITRAKNRILD EASTSTSDGM 
       160        170        180        190        200
LTLDLIQEED PSPEEPTSCA ESFRVDLDKS VAQLAGSRRR ADSDRIQPSA 
       210        220        230        240        250
DRASSLSRPW EKTDKGATYT PQAPKKLTPT EKGRCASLEE ILSQRDAASA 
       260        270        280        290        300
RTLQLRAEEP PTPALPNPGQ LSRIQDLVAR KLEETQELLA EVQGLGDGKR 
       310        320        330        340        350
KAKDPPRSPP DSESEQLLLE TERLLGEASS NWSQAKRVLQ EVRELRDLYR 
       360        370 
QMDLQTPDSH LRQTTPHSQY RKSLM

Note: No experimental confirmation available.

Show »

Length:375

Mass (Da):42,330

Checksum:ⁱ65CC4D44156031EA

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5T4P9	Q5T4P9_HUMAN		Pleckstrin homology domain containi... Pleckstrin homology domain containing, family O member 1, isoform CRA_c (Pleckstrin homology domain-containing family O member 1)	PLEKHO1 hCG_39382, RP11-458I7.3-002	226	Annotation score:

Sequence cautionⁱ

The sequence AAF13461 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAQ13826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1 – 10	MMKKNNSAKR → VRRCCRGWRSPVFTNPHVSP LSTAPAHWAPGRPAAGSLGL RVSPEPPPERGSLPPGERSP AASKPPSSPS in AAH23533 (PubMed:15489334).Curated		10
Sequence conflictⁱ	285	R → H in BAD96641 (Ref. 5) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037034	21	P → A. Corresponds to variant dbSNP:rs2306235Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_029282	142 – 175	Missing in isoform 2. CuratedAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF168676 mRNA Translation: AAF89644.1 AF192912 mRNA Translation: AAQ13826.1 Different initiation. AF291105 mRNA Translation: AAK28027.1 AF217956 mRNA Translation: AAK71509.1 AK222921 mRNA Translation: BAD96641.1 AL358073 Genomic DNA Translation: CAI14264.1 CH471121 Genomic DNA Translation: EAW53580.1 BC010149 mRNA Translation: AAH10149.1 BC023533 mRNA Translation: AAH23533.2 AF073836 mRNA Translation: AAF13461.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS945.1 [Q53GL0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001291651.1, NM_001304722.1 NP_001291652.1, NM_001304723.1 NP_001291653.1, NM_001304724.1 NP_057358.2, NM_016274.5 [Q53GL0-1] XP_016856909.1, XM_017001420.1
UniGeneⁱ	Hs.438824

Genome annotation databases

Ensemblⁱ	ENST00000369124; ENSP00000358120; ENSG00000023902 [Q53GL0-1]
GeneIDⁱ	51177
KEGGⁱ	hsa:51177
UCSC genome browser More...UCSCⁱ	uc001ett.4 human [Q53GL0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q53GL0	Pleckstrin homology domain containing, family O member 1, isoform CRA_c		HUMAN		226	UniRef100_Q53GL0
cDNA FLJ61462, highly similar to Homo sapiens CK2 interacting protein 1; HQ0024c protein (CKIP-1), mRNA		HUMAN		441
UPI000006D4D0		HUMAN		237

Protein	Similar proteins		Species	Score	Length	Source
Q53GL0	Pleckstrin homology domain containing, family O member 1, isoform CRA_c		HUMAN		226	UniRef90_Q53GL0
Uncharacterized protein		NEOLE		408
UPI000840058D		CALJA		412
UPI000A306189		MUSPA		408
cDNA FLJ61462, highly similar to Homo sapiens CK2 interacting protein 1; HQ0024c protein (CKIP-1), mRNA		HUMAN		441
+2
Q53GL0-2	Uncharacterized protein		PIG		375	UniRef90_Q53GL0-2
Pleckstrin homology domain-containing family O member 1 (Fragment)		MOUSE		365
UPI000DC1B6FE		THEGE		454
UPI000A335EC1		HETGA		374

Protein	Similar proteins		Species	Score	Length	Source
Q53GL0	Pleckstrin homology domain-containing family O member 1		RAT		408	UniRef50_Q53GL0
Pleckstrin homology domain-containing family O member 1		MOUSE		408
Pleckstrin homology domain containing, family O member 1, isoform CRA_c		HUMAN		226
Uncharacterized protein		NEOLE		408
pleckstrin homology domain-containing family O member 1		MESAU		425
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF168676 mRNA Translation: AAF89644.1 AF192912 mRNA Translation: AAQ13826.1 Different initiation. AF291105 mRNA Translation: AAK28027.1 AF217956 mRNA Translation: AAK71509.1 AK222921 mRNA Translation: BAD96641.1 AL358073 Genomic DNA Translation: CAI14264.1 CH471121 Genomic DNA Translation: EAW53580.1 BC010149 mRNA Translation: AAH10149.1 BC023533 mRNA Translation: AAH23533.2 AF073836 mRNA Translation: AAF13461.1 Different initiation.
CCDSⁱ	CCDS945.1 [Q53GL0-1]
RefSeqⁱ	NP_001291651.1, NM_001304722.1 NP_001291652.1, NM_001304723.1 NP_001291653.1, NM_001304724.1 NP_057358.2, NM_016274.5 [Q53GL0-1] XP_016856909.1, XM_017001420.1
UniGeneⁱ	Hs.438824

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3AA1	X-ray	1.90	C	148-170	[»]
ProteinModelPortalⁱ	Q53GL0
SMRⁱ	Q53GL0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119355, 62 interactors
DIPⁱ	DIP-46903N
IntActⁱ	Q53GL0, 42 interactors
MINTⁱ	Q53GL0
STRINGⁱ	9606.ENSP00000358120

PTM databases

iPTMnetⁱ	Q53GL0
PhosphoSitePlusⁱ	Q53GL0

Polymorphism and mutation databases

BioMutaⁱ	PLEKHO1
DMDMⁱ	160419242

Proteomic databases

EPDⁱ	Q53GL0
MaxQBⁱ	Q53GL0
PaxDbⁱ	Q53GL0
PeptideAtlasⁱ	Q53GL0
PRIDEⁱ	Q53GL0
ProteomicsDBⁱ	62483 62484 [Q53GL0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51177
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369124; ENSP00000358120; ENSG00000023902 [Q53GL0-1]
GeneIDⁱ	51177
KEGGⁱ	hsa:51177
UCSCⁱ	uc001ett.4 human [Q53GL0-1]

Organism-specific databases

CTDⁱ	51177
DisGeNETⁱ	51177
EuPathDBⁱ	HostDB:ENSG00000023902.13
GeneCardsⁱ	PLEKHO1
HGNCⁱ	HGNC:24310 PLEKHO1
HPAⁱ	HPA061018
MIMⁱ	608335 gene
neXtProtⁱ	NX_Q53GL0
OpenTargetsⁱ	ENSG00000023902
PharmGKBⁱ	PA142671167
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEJU Eukaryota ENOG4110ACW LUCA
GeneTreeⁱ	ENSGT00530000063760
HOGENOMⁱ	HOG000115563
HOVERGENⁱ	HBG108259
InParanoidⁱ	Q53GL0
OMAⁱ	KRGPQDG
OrthoDBⁱ	EOG091G0CAS
PhylomeDBⁱ	Q53GL0
TreeFamⁱ	TF333115

Miscellaneous databases

ChiTaRSⁱ	PLEKHO1 human
EvolutionaryTraceⁱ	Q53GL0
GeneWikiⁱ	PLEKHO1
GenomeRNAiⁱ	51177
Protein Ontology More...PROⁱ	PR:Q53GL0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000023902 Expressed in 201 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_PLEKHO1
ExpressionAtlasⁱ	Q53GL0 baseline and differential
Genevisibleⁱ	Q53GL0 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR028452 CKIP-1 IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR15871:SF1 PTHR15871:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PKHO1_HUMAN
Accessionⁱ	Q53GL0Primary (citable) accession number: Q53GL0 Secondary accession number(s): Q336K5 , Q8IZ51, Q9NRV3, Q9UL48
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	November 13, 2007
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q53GL0 (PKHO1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Pleckstrin homology domain-containing family O member 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma membrane

Other locations

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ