UniProtKB - Q53GI3 (ZN394_HUMAN)
Protein
Zinc finger protein 394
Gene
ZNF394
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 358 – 380 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 463 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 469 – 491 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 519 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 547 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q53GI3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 394Alternative name(s): Zinc finger protein with KRAB and SCAN domains 14 |
Gene namesi | Name:ZNF394 Synonyms:ZKSCAN14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160908.14 |
HGNCi | HGNC:18832, ZNF394 |
neXtProti | NX_Q53GI3 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84124 |
OpenTargetsi | ENSG00000160908 |
PharmGKBi | PA38702 |
Miscellaneous databases
Pharosi | Q53GI3, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF394 |
DMDMi | 81175102 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047557 | 1 – 561 | Zinc finger protein 394Add BLAST | 561 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Cross-linki | 40 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 203 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 228 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 254 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 282 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 443 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q53GI3 |
MassIVEi | Q53GI3 |
MaxQBi | Q53GI3 |
PaxDbi | Q53GI3 |
PeptideAtlasi | Q53GI3 |
PRIDEi | Q53GI3 |
ProteomicsDBi | 62482 [Q53GI3-1] |
PTM databases
iPTMneti | Q53GI3 |
PhosphoSitePlusi | Q53GI3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160908, Expressed in bone marrow and 223 other tissues |
Genevisiblei | Q53GI3, HS |
Organism-specific databases
HPAi | ENSG00000160908, Tissue enhanced (bone) |
Interactioni
Binary interactionsi
Hide detailsQ53GI3
Protein-protein interaction databases
BioGRIDi | 123898, 12 interactors |
IntActi | Q53GI3, 9 interactors |
STRINGi | 9606.ENSP00000337363 |
Miscellaneous databases
RNActi | Q53GI3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 146 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 155 – 230 | KRABPROSITE-ProRule annotationAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 358 – 380 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 463 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 469 – 491 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 519 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 547 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162347 |
HOGENOMi | CLU_002678_49_4_1 |
InParanoidi | Q53GI3 |
OMAi | GDTHENR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q53GI3 |
TreeFami | TF337913 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q53GI3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSSLTAQRR GSDAELGPWV MAARSKDAAP SQRDGLLPVK VEEDSPGSWE
60 70 80 90 100
PNYPAASPDP ETSRLHFRQL RYQEVAGPEE ALSRLRELCR RWLRPELLSK
110 120 130 140 150
EQILELLVLE QFLTILPEEL QAWVREHCPE SGEEAVAVVR ALQRALDGTS
160 170 180 190 200
SQGMVTFEDT AVSLTWEEWE RLDPARRDFC RESAQKDSGS TVPPSLESRV
210 220 230 240 250
ENKELIPMQQ ILEEAEPQGQ LQEAFQGKRP LFSKCGSTHE DRVEKQSGDP
260 270 280 290 300
LPLKLENSPE AEGLNSISDV NKNGSIEGED SKNNELQNSA RCSNLVLCQH
310 320 330 340 350
IPKAERPTDS EEHGNKCKQS FHMVTWHVLK PHKSDSGDSF HHSSLFETQR
360 370 380 390 400
QLHEERPYKC GNCGKSFKQR SDLFRHQRIH TGEKPYGCQE CGKSFSQSAA
410 420 430 440 450
LTKHQRTHTG EKPYTCLKCG ERFRQNSHLN RHQSTHSRDK HFKCEECGET
460 470 480 490 500
CHISNLFRHQ RLHKGERPYK CEECEKSFKQ RSDLFKHHRI HTGEKPYGCS
510 520 530 540 550
VCGKRFNQSA TLIKHQRIHT GEKPYKCLEC GERFRQSTHL IRHQRIHQNK
560
VLSAGRGGSR L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | S → C in BAB14021 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 21 | M → T in BAD96668 (Ref. 3) Curated | 1 | |
Sequence conflicti | 127 | H → Y (PubMed:8065901).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052816 | 325 | T → M. Corresponds to variant dbSNP:rs3735454Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056547 | 153 – 162 | GMVTFEDTAV → VWKAEWRTKS in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_056548 | 163 – 561 | Missing in isoform 2. 1 PublicationAdd BLAST | 399 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY642122 mRNA Translation: AAT67053.1 AK022360 mRNA Translation: BAB14021.1 AK222948 mRNA Translation: BAD96668.1 AC073063 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23874.1 CH471091 Genomic DNA Translation: EAW76659.1 BC017051 mRNA Translation: AAH17051.1 BC025241 mRNA Translation: AAH25241.1 BC051847 mRNA Translation: AAH51847.1 |
CCDSi | CCDS5666.1 [Q53GI3-1] CCDS87524.1 [Q53GI3-3] |
RefSeqi | NP_001332896.1, NM_001345967.1 [Q53GI3-3] NP_115540.2, NM_032164.3 [Q53GI3-1] |
Genome annotation databases
Ensembli | ENST00000337673; ENSP00000337363; ENSG00000160908 [Q53GI3-1] ENST00000426306; ENSP00000409565; ENSG00000160908 [Q53GI3-3] ENST00000651061; ENSP00000499131; ENSG00000160908 [Q53GI3-1] |
GeneIDi | 84124 |
KEGGi | hsa:84124 |
UCSCi | uc003uqs.4, human [Q53GI3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY642122 mRNA Translation: AAT67053.1 AK022360 mRNA Translation: BAB14021.1 AK222948 mRNA Translation: BAD96668.1 AC073063 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23874.1 CH471091 Genomic DNA Translation: EAW76659.1 BC017051 mRNA Translation: AAH17051.1 BC025241 mRNA Translation: AAH25241.1 BC051847 mRNA Translation: AAH51847.1 |
CCDSi | CCDS5666.1 [Q53GI3-1] CCDS87524.1 [Q53GI3-3] |
RefSeqi | NP_001332896.1, NM_001345967.1 [Q53GI3-3] NP_115540.2, NM_032164.3 [Q53GI3-1] |
3D structure databases
SMRi | Q53GI3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123898, 12 interactors |
IntActi | Q53GI3, 9 interactors |
STRINGi | 9606.ENSP00000337363 |
PTM databases
iPTMneti | Q53GI3 |
PhosphoSitePlusi | Q53GI3 |
Polymorphism and mutation databases
BioMutai | ZNF394 |
DMDMi | 81175102 |
Proteomic databases
jPOSTi | Q53GI3 |
MassIVEi | Q53GI3 |
MaxQBi | Q53GI3 |
PaxDbi | Q53GI3 |
PeptideAtlasi | Q53GI3 |
PRIDEi | Q53GI3 |
ProteomicsDBi | 62482 [Q53GI3-1] |
Protocols and materials databases
ABCDi | Q53GI3, 4 sequenced antibodies |
Antibodypediai | 16184, 215 antibodies |
DNASUi | 84124 |
Genome annotation databases
Ensembli | ENST00000337673; ENSP00000337363; ENSG00000160908 [Q53GI3-1] ENST00000426306; ENSP00000409565; ENSG00000160908 [Q53GI3-3] ENST00000651061; ENSP00000499131; ENSG00000160908 [Q53GI3-1] |
GeneIDi | 84124 |
KEGGi | hsa:84124 |
UCSCi | uc003uqs.4, human [Q53GI3-1] |
Organism-specific databases
CTDi | 84124 |
DisGeNETi | 84124 |
EuPathDBi | HostDB:ENSG00000160908.14 |
GeneCardsi | ZNF394 |
HGNCi | HGNC:18832, ZNF394 |
HPAi | ENSG00000160908, Tissue enhanced (bone) |
neXtProti | NX_Q53GI3 |
OpenTargetsi | ENSG00000160908 |
PharmGKBi | PA38702 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162347 |
HOGENOMi | CLU_002678_49_4_1 |
InParanoidi | Q53GI3 |
OMAi | GDTHENR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q53GI3 |
TreeFami | TF337913 |
Enzyme and pathway databases
PathwayCommonsi | Q53GI3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 84124, 7 hits in 865 CRISPR screens |
ChiTaRSi | ZNF394, human |
GenomeRNAii | 84124 |
Pharosi | Q53GI3, Tdark |
PROi | PR:Q53GI3 |
RNActi | Q53GI3, protein |
Gene expression databases
Bgeei | ENSG00000160908, Expressed in bone marrow and 223 other tissues |
Genevisiblei | Q53GI3, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN394_HUMAN | |
Accessioni | Q53GI3Primary (citable) accession number: Q53GI3 Secondary accession number(s): A4D281 Q9UD51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations