UniProtKB - Q53G59 (KLH12_HUMAN)

BLAST

>sp|Q53G59|KLH12_HUMAN Kelch-like protein 12 OS=Homo sapiens OX=9606 GN=KLHL12 PE=1 SV=2
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCA
MFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQ
ACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVE
KLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEP
FIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE
KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY
SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG
LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG
FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY
DPIIDSWEVVTSMGTQRCDAGVCVLREK

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History
Entry version 134 (12 Sep 2018)
Sequence version 2 (16 May 2006)
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Protein

Kelch-like protein 12

Gene

KLHL12

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508).6 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

COPII vesicle coating
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22358839
- 27716508
ER to Golgi vesicle-mediated transport
Source: UniProtKB
Inferred from direct assayⁱ
- 22358839
negative regulation of canonical Wnt signaling pathway Source: Reactome
neural crest cell development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
neural crest formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
protein monoubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 22358839
- 27716508
Wnt signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20970343

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Transport, Ubl conjugation pathway, Wnt signaling pathway

Biological process

ER-Golgi transport, Transport, Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4641258 Degradation of DVL
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kelch-like protein 12 Alternative name(s): CUL3-interacting protein 11 Publication DKIR homolog1 Publication Short name: hDKIR1 Publication
Gene namesⁱ	Name:KLHL12 Synonyms:C3IP11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117153.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19360 KLHL12
MIMⁱ	614522 gene
neXtProtⁱ	NX_Q53G59

Keywords - Cellular componentⁱ

Cytoplasmic vesicle

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	289 – 290	FG → AA: Abolishes interaction with SEC31A and subsequent monoubiquitination of SEC31A. Abolishes ubiquitination of PEF1. 2 Publications		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	59349
Open Targets More...OpenTargetsⁱ	ENSG00000117153
PharmGKBⁱ	PA134952416

Polymorphism and mutation databases

BioMutaⁱ	KLHL12
DMDMⁱ	97054498

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000234349	1 – 568	Kelch-like protein 12Add BLAST		568

Proteomic databases

EPDⁱ	Q53G59
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q53G59
PaxDbⁱ	Q53G59
PeptideAtlas More...PeptideAtlasⁱ	Q53G59
PRIDEⁱ	Q53G59
ProteomicsDBⁱ	62474 62475 [Q53G59-2]

PTM databases

iPTMnetⁱ	Q53G59
PhosphoSitePlusⁱ	Q53G59

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000117153 Expressed in 200 organ(s), highest expression level in oocyte
CleanExⁱ	HS_KLHL12
ExpressionAtlasⁱ	Q53G59 baseline and differential
Genevisibleⁱ	Q53G59 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071324

HPAⁱ

HPA071324

Interactionⁱ

Subunit structureⁱ

Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1 (PubMed:22358839). This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A (PubMed:16547521). Interacts with DRD4, KLHL2 and SEC31A (PubMed:15383316,PubMed:18303015, PubMed:22358839). Interacts with PEF1 and PDCD6/ALG-2; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B) (PubMed:27716508).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		6	EBI-740929,EBI-740929
ATXN1	P54253	2	EBI-740929,EBI-930964
BAG6	P46379	4	EBI-740929,EBI-347552
C1QTNF2	Q9BXJ5	5	EBI-740929,EBI-2817707
CARD10	Q17RA1	3	EBI-740929,EBI-10238571
CCBE1	Q6UXH8	3	EBI-740929,EBI-3923278
COL8A1	P27658	3	EBI-740929,EBI-747133
CUL3	Q13618	5	EBI-740929,EBI-456129
DVL3	Q92997	3	EBI-740929,EBI-739789
FGD2	Q7Z6J4	3	EBI-740929,EBI-1057190
FLNA	P21333-2	5	EBI-740929,EBI-9641086
GLYCTK	Q8IVS8	3	EBI-740929,EBI-748515
INMT	O95050	5	EBI-740929,EBI-10191038
KLHL2	O95198	6	EBI-740929,EBI-746999
KLHL3	Q8N4I8	3	EBI-740929,EBI-10230467
LNPK	Q9C0E8-2	4	EBI-740929,EBI-11024283
LNX1	Q8TBB1	3	EBI-740929,EBI-739832
MPP1	Q00013	5	EBI-740929,EBI-711788
MRPL10	Q7Z7H8	3	EBI-740929,EBI-723524
PDGFRB	P09619	5	EBI-740929,EBI-641237
PEF1	Q9UBV8	7	EBI-740929,EBI-724639
PRR13	Q9NZ81	6	EBI-740929,EBI-740924
RPP25L	Q8N5L8	5	EBI-740929,EBI-10189722
SDCBP	O00560	7	EBI-740929,EBI-727004
SNX20	Q7Z614	4	EBI-740929,EBI-744896
SYNE4	Q8N205	3	EBI-740929,EBI-7131783
TBC1D10C	Q8IV04	5	EBI-740929,EBI-10261452
TTBK2	Q6IQ55	5	EBI-740929,EBI-1050303
UBE2I	Q7KZS0	5	EBI-740929,EBI-10180829
VEGFB	Q7LAP4	3	EBI-740929,EBI-10256629
WDYHV1	Q96HA8	7	EBI-740929,EBI-741158
ZBP1	A2RRL9	3	EBI-740929,EBI-10173066

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121890, 67 interactors
CORUMⁱ	Q53G59
IntActⁱ	Q53G59, 72 interactors
Molecular INTeraction database More...MINTⁱ	Q53G59
STRINGⁱ	9606.ENSP00000356230

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	281 – 286	Combined sources	6
Turnⁱ	291 – 293	Combined sources	3
Beta strandⁱ	299 – 303	Combined sources	5
Turnⁱ	304 – 307	Combined sources	4
Beta strandⁱ	308 – 311	Combined sources	4
Beta strandⁱ	323 – 327	Combined sources	5
Beta strandⁱ	330 – 334	Combined sources	5
Beta strandⁱ	346 – 350	Combined sources	5
Beta strandⁱ	360 – 362	Combined sources	3
Beta strandⁱ	373 – 377	Combined sources	5
Beta strandⁱ	380 – 384	Combined sources	5
Beta strandⁱ	395 – 400	Combined sources	6
Turnⁱ	401 – 404	Combined sources	4
Beta strandⁱ	405 – 411	Combined sources	7
Beta strandⁱ	420 – 424	Combined sources	5
Beta strandⁱ	427 – 431	Combined sources	5
Beta strandⁱ	443 – 446	Combined sources	4
Turnⁱ	448 – 450	Combined sources	3
Beta strandⁱ	453 – 456	Combined sources	4
Beta strandⁱ	467 – 471	Combined sources	5
Beta strandⁱ	474 – 478	Combined sources	5
Beta strandⁱ	483 – 486	Combined sources	4
Beta strandⁱ	490 – 494	Combined sources	5
Turnⁱ	495 – 498	Combined sources	4
Beta strandⁱ	499 – 503	Combined sources	5
Beta strandⁱ	514 – 518	Combined sources	5
Beta strandⁱ	521 – 525	Combined sources	5
Beta strandⁱ	530 – 541	Combined sources	12
Turnⁱ	542 – 545	Combined sources	4
Beta strandⁱ	546 – 559	Combined sources	14
Beta strandⁱ	561 – 566	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q53G59
SMRⁱ	Q53G59
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q53G59

EvolutionaryTraceⁱ

Q53G59

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	33 – 100	BTBPROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	135 – 236	BACKAdd BLAST	102
Repeatⁱ	282 – 329	Kelch 1Add BLAST	48
Repeatⁱ	331 – 379	Kelch 2Add BLAST	49
Repeatⁱ	380 – 426	Kelch 3Add BLAST	47
Repeatⁱ	427 – 473	Kelch 4Add BLAST	47
Repeatⁱ	475 – 520	Kelch 5Add BLAST	46
Repeatⁱ	522 – 567	Kelch 6Add BLAST	46

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	405 – 568	Interaction with DVL31 PublicationAdd BLAST		164

Domainⁱ

The BTB domain is required for interaction with CUL3.

Keywords - Domainⁱ

Kelch repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4441 Eukaryota ENOG410XNX8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118931
HOGENOMⁱ	HOG000230814
HOVERGENⁱ	HBG014286
InParanoidⁱ	Q53G59
KEGG Orthology (KO) More...KOⁱ	K10450
OMAⁱ	TEPFIRC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04QJ
PhylomeDBⁱ	Q53G59
TreeFamⁱ	TF329218

Family and domain databases

Gene3Dⁱ	2.120.10.80, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR017096 BTB-kelch_protein IPR000210 BTB/POZ_dom IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1 IPR011333 SKP1/BTB/POZ_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00651 BTB, 1 hit PF01344 Kelch_1, 6 hits
PIRSFⁱ	PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00225 BTB, 1 hit SM00612 Kelch, 6 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q53G59-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV 
        60         70         80         90        100
LAACSDYFCA MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV 
       110        120        130        140        150
ENVQELLPAA CLLQLKGVKQ ACCEFLESQL DPSNCLGIRD FAETHNCVDL 
       160        170        180        190        200
MQAAEVFSQK HFPEVVQHEE FILLSQGEVE KLIKCDEIQV DSEEPVFEAV 
       210        220        230        240        250
INWVKHAKKE REESLPNLLQ YVRMPLLTPR YITDVIDAEP FIRCSLQCRD 
       260        270        280        290        300
LVDEAKKFHL RPELRSQMQG PRTRARLGAN EVLLVVGGFG SQQSPIDVVE 
       310        320        330        340        350
KYDPKTQEWS FLPSITRKRR YVASVSLHDR IYVIGGYDGR SRLSSVECLD 
       360        370        380        390        400
YTADEDGVWY SVAPMNVRRG LAGATTLGDM IYVSGGFDGS RRHTSMERYD 
       410        420        430        440        450
PNIDQWSMLG DMQTAREGAG LVVASGVIYC LGGYDGLNIL NSVEKYDPHT 
       460        470        480        490        500
GHWTNVTPMA TKRSGAGVAL LNDHIYVVGG FDGTAHLSSV EAYNIRTDSW 
       510        520        530        540        550
TTVTSMTTPR CYVGATVLRG RLYAIAGYDG NSLLSSIECY DPIIDSWEVV 
       560 
TSMGTQRCDA GVCVLREK

Length:568

Mass (Da):63,277

Last modified:May 16, 2006 - v2

Checksum:ⁱ4EB1BC33B6351B5D

Isoform 2 (identifier: Q53G59-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDVNKFEASVGFLDVKKFLSTWKLQNPRTHFVLSPHCFM

« Hide

        10         20         30         40         50
MDVNKFEASV GFLDVKKFLS TWKLQNPRTH FVLSPHCFMG GIMAPKDIMT 
        60         70         80         90        100
NTHAKSILNS MNSLRKSNTL CDVTLRVEQK DFPAHRIVLA ACSDYFCAMF 
       110        120        130        140        150
TSELSEKGKP YVDIQGLTAS TMEILLDFVY TETVHVTVEN VQELLPAACL 
       160        170        180        190        200
LQLKGVKQAC CEFLESQLDP SNCLGIRDFA ETHNCVDLMQ AAEVFSQKHF 
       210        220        230        240        250
PEVVQHEEFI LLSQGEVEKL IKCDEIQVDS EEPVFEAVIN WVKHAKKERE 
       260        270        280        290        300
ESLPNLLQYV RMPLLTPRYI TDVIDAEPFI RCSLQCRDLV DEAKKFHLRP 
       310        320        330        340        350
ELRSQMQGPR TRARLGANEV LLVVGGFGSQ QSPIDVVEKY DPKTQEWSFL 
       360        370        380        390        400
PSITRKRRYV ASVSLHDRIY VIGGYDGRSR LSSVECLDYT ADEDGVWYSV 
       410        420        430        440        450
APMNVRRGLA GATTLGDMIY VSGGFDGSRR HTSMERYDPN IDQWSMLGDM 
       460        470        480        490        500
QTAREGAGLV VASGVIYCLG GYDGLNILNS VEKYDPHTGH WTNVTPMATK 
       510        520        530        540        550
RSGAGVALLN DHIYVVGGFD GTAHLSSVEA YNIRTDSWTT VTSMTTPRCY 
       560        570        580        590        600
VGATVLRGRL YAIAGYDGNS LLSSIECYDP IIDSWEVVTS MGTQRCDAGV 

CVLREK

Show »

Length:606

Mass (Da):67,727

Checksum:ⁱ47F91BE5B8ED7C33

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QSX3	J3QSX3_HUMAN	Kelch-like protein 12 Kelch-like protein 12	KLHL12	315	Annotation score:
Q9H7R2	Q9H7R2_HUMAN	Kelch-like protein 12 Kelch-like protein 12 (cDNA FLJ14350 fis, clone THYRO1001721, weakly similar to RING CANAL PROTEIN)	KLHL12	204	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	122	C → R in BAD96792 (Ref. 3) Curated	1
Sequence conflictⁱ	197 – 198	FE → LG in BAD96792 (Ref. 3) Curated	2
Sequence conflictⁱ	394	T → A in BAD96792 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050049	72	P → L. Corresponds to variant dbSNP:rs12569087Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042975	1	M → MDVNKFEASVGFLDVKKFLS TWKLQNPRTHFVLSPHCFM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF190900 mRNA Translation: AAG17175.1 AK027656 mRNA Translation: BAB55271.1 AK301791 mRNA Translation: BAH13554.1 AK223072 mRNA Translation: BAD96792.1 AC096632 Genomic DNA No translation available. BC003183 mRNA Translation: AAH03183.1 BC004175 mRNA Translation: AAH04175.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1429.1 [Q53G59-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001289980.1, NM_001303051.1 [Q53G59-2] NP_001290038.1, NM_001303109.1 NP_067646.1, NM_021633.3 [Q53G59-1]
UniGeneⁱ	Hs.706793

Genome annotation databases

Ensemblⁱ	ENST00000367261; ENSP00000356230; ENSG00000117153 [Q53G59-1]
GeneIDⁱ	59349
KEGGⁱ	hsa:59349
UCSC genome browser More...UCSCⁱ	uc001gyo.2 human [Q53G59-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q53G59	Kelch like family member 12		CHLSB		527	UniRef100_Q53G59
Kelch-like protein 12		MACMU		568
KLHL12 isoform 2		PANTR		568
Uncharacterized protein		COLAP		568
Uncharacterized protein		CERAT		568
+8
Q53G59-2	Kelch-like protein 12 (Fragment)		HUMAN		315	UniRef100_Q53G59-2

Protein	Similar proteins		Species	Score	Length	Source
Q53G59	Kelch like family member 12		CHLSB		527	UniRef90_Q53G59
Kelch-like protein 12		MACMU		568
KLHL12 isoform 2		PANTR		568
Uncharacterized protein		COLAP		568
Uncharacterized protein		CERAT		568
+43
Q53G59-2	Kelch-like protein 12 (Fragment)		HUMAN		315	UniRef90_Q53G59-2
kelch-like protein 12 isoform X4		TURTR		616
Kelch-like 12 (Drosophila) (Fragment)		NEOVI		613
kelch-like protein 12 isoform X3		DELLE		606
KLHL12 isoform 1		PANTR		606
+38

Protein	Similar proteins		Species	Score	Length	Source
Q53G59	Kelch-like protein 12		MOUSE		568	UniRef50_Q53G59
Kelch-like protein 12		RAT		568
Kelch-like protein 12		BOVIN		568
Kelch-like protein 12		XENLA		564
Kelch-like protein 12		DANRE		564
+361
Q53G59-2	Kelch-like protein 12 (Fragment)		HUMAN		315	UniRef50_Q53G59-2
kelch-like protein 12 isoform X4		TURTR		616
Kelch-like 12 (Drosophila) (Fragment)		NEOVI		613
KLHL12 isoform 1		PANTR		606
kelch-like protein 12		LIPVE		606
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF190900 mRNA Translation: AAG17175.1 AK027656 mRNA Translation: BAB55271.1 AK301791 mRNA Translation: BAH13554.1 AK223072 mRNA Translation: BAD96792.1 AC096632 Genomic DNA No translation available. BC003183 mRNA Translation: AAH03183.1 BC004175 mRNA Translation: AAH04175.1
CCDSⁱ	CCDS1429.1 [Q53G59-1]
RefSeqⁱ	NP_001289980.1, NM_001303051.1 [Q53G59-2] NP_001290038.1, NM_001303109.1 NP_067646.1, NM_021633.3 [Q53G59-1]
UniGeneⁱ	Hs.706793

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VPJ	X-ray	1.85	A	268-567	[»]
ProteinModelPortalⁱ	Q53G59
SMRⁱ	Q53G59
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121890, 67 interactors
CORUMⁱ	Q53G59
IntActⁱ	Q53G59, 72 interactors
MINTⁱ	Q53G59
STRINGⁱ	9606.ENSP00000356230

PTM databases

iPTMnetⁱ	Q53G59
PhosphoSitePlusⁱ	Q53G59

Polymorphism and mutation databases

BioMutaⁱ	KLHL12
DMDMⁱ	97054498

Proteomic databases

EPDⁱ	Q53G59
MaxQBⁱ	Q53G59
PaxDbⁱ	Q53G59
PeptideAtlasⁱ	Q53G59
PRIDEⁱ	Q53G59
ProteomicsDBⁱ	62474 62475 [Q53G59-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	59349
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367261; ENSP00000356230; ENSG00000117153 [Q53G59-1]
GeneIDⁱ	59349
KEGGⁱ	hsa:59349
UCSCⁱ	uc001gyo.2 human [Q53G59-1]

Organism-specific databases

CTDⁱ	59349
DisGeNETⁱ	59349
EuPathDBⁱ	HostDB:ENSG00000117153.15
GeneCardsⁱ	KLHL12
HGNCⁱ	HGNC:19360 KLHL12
HPAⁱ	HPA071324
MIMⁱ	614522 gene
neXtProtⁱ	NX_Q53G59
OpenTargetsⁱ	ENSG00000117153
PharmGKBⁱ	PA134952416
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4441 Eukaryota ENOG410XNX8 LUCA
GeneTreeⁱ	ENSGT00760000118931
HOGENOMⁱ	HOG000230814
HOVERGENⁱ	HBG014286
InParanoidⁱ	Q53G59
KOⁱ	K10450
OMAⁱ	TEPFIRC
OrthoDBⁱ	EOG091G04QJ
PhylomeDBⁱ	Q53G59
TreeFamⁱ	TF329218

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-4641258 Degradation of DVL

Miscellaneous databases

ChiTaRSⁱ	KLHL12 human
EvolutionaryTraceⁱ	Q53G59
GeneWikiⁱ	KLHL12
GenomeRNAiⁱ	59349
Protein Ontology More...PROⁱ	PR:Q53G59
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117153 Expressed in 200 organ(s), highest expression level in oocyte
CleanExⁱ	HS_KLHL12
ExpressionAtlasⁱ	Q53G59 baseline and differential
Genevisibleⁱ	Q53G59 HS

Family and domain databases

Gene3Dⁱ	2.120.10.80, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR017096 BTB-kelch_protein IPR000210 BTB/POZ_dom IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1 IPR011333 SKP1/BTB/POZ_sf
Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00651 BTB, 1 hit PF01344 Kelch_1, 6 hits
PIRSFⁱ	PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00225 BTB, 1 hit SM00612 Kelch, 6 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLH12_HUMAN
Accessionⁱ	Q53G59Primary (citable) accession number: Q53G59 Secondary accession number(s): A6NEN8, B7Z7B8, Q9HBX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	May 16, 2006
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniProtKB - Q53G59 (KLH12_HUMAN)

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Kelch-like protein 12

KLHL12

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ