CLIC5

Functionⁱ

GO - Molecular functionⁱ

chloride channel activity Source: UniProtKB-KW
voltage-gated ion channel activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological process	Ion transport, Transport
Ligand	Chloride

Protein family/group databases

TCDBⁱ	1.A.12.1.3 the intracellular chloride channel (clic) family

TCDBⁱ

1.A.12.1.3 the intracellular chloride channel (clic) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chloride intracellular channel proteinUniRule annotation
Gene namesⁱ	Name:CLIC5Imported ORF Names:hCG_2001062Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112782.15

EuPathDBⁱ

HostDB:ENSG00000112782.15

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA26592

PharmGKBⁱ

PA26592

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000112782 Expressed in 209 organ(s), highest expression level in renal glomerulus

Bgeeⁱ

ENSG00000112782 Expressed in 209 organ(s), highest expression level in renal glomerulus

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	101 – 241	GST C-terminalInterPro annotationAdd BLAST		141

Domainⁱ

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesⁱ

Belongs to the chloride channel CLIC family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1422 Eukaryota ENOG410ZRK6 LUCA
HOVERGENⁱ	HBG050994
KEGG Orthology (KO) More...KOⁱ	K05025

Family and domain databases

InterProⁱ	View protein in InterPro IPR002946 CLIC IPR030264 CLIC-5 IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR040079 Glutathione_S-Trfase IPR004045 Glutathione_S-Trfase_N IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR43920:SF6 PTHR43920:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13417 GST_N_3, 1 hit
PRINTSⁱ	PR01263 INTCLCHANNEL
SFLDⁱ	SFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR00862 O-ClC, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q53G01-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVFN 
        60         70         80         90        100
VTTVDLKRKP ADLHNLAPGT HPPFLTFNGD VKTDVNKIEE FLEETLTPEK 
       110        120        130        140        150
YPKLAAKHRE SNTAGIDIFS KFSAYIKNTK QQNNAALERG LTKALKKLDD 
       160        170        180        190        200
YLNTPLPEEI DANTCGEDKG SRRKFLDGDE LTLADCNLLP KLHVVKIVAK 
       210        220        230        240        250
KYRNYDIPAE MTGLWRYLKN AYARDEFTNT CAADSEIELA YADVAKRLSR 

S

Length:251

Mass (Da):28,179

Last modified:May 24, 2005 - v1

Checksum:ⁱ1E8658EB7687C60D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ679794 mRNA Translation: ABG46342.1 AK222544 mRNA Translation: BAD96264.1 AK223130 mRNA Translation: BAD96850.1 CH471081 Genomic DNA Translation: EAX04285.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001107558.1, NM_001114086.1 NP_058625.2, NM_016929.4
UniGeneⁱ	Hs.485489 Hs.734348

Genome annotation databases

GeneIDⁱ	53405
KEGGⁱ	hsa:53405

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q53G01	Chloride intracellular channel protein		PANTR		251	UniRef100_H2QT41
Chloride intracellular channel protein		COLAP		251
Chloride intracellular channel protein		PONAB		251
Chloride intracellular channel protein		CERAT		251
Chloride intracellular channel protein		PAPAN		251
+3

Protein	Similar proteins		Species	Score	Length	Source
Q53G01	Chloride intracellular channel protein		HORSE		252	UniRef90_F7CPV2
chloride intracellular channel protein 5-like		BALAS		252
Chloride intracellular channel protein		DELLE		252
Chloride intracellular channel protein		TARSY		252
Chloride intracellular channel protein		SHEEP		252
+28

Protein	Similar proteins		Species	Score	Length	Source
Q53G01	Chloride intracellular channel protein		PELSI		238	UniRef50_K7G1Y8
Chloride intracellular channel protein		Patagioenas fasciata monilis		295
Chloride intracellular channel protein		DESRO		253
Chloride intracellular channel protein		LATCH		252
Chloride intracellular channel protein		HUMAN		245
+278

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ679794 mRNA Translation: ABG46342.1 AK222544 mRNA Translation: BAD96264.1 AK223130 mRNA Translation: BAD96850.1 CH471081 Genomic DNA Translation: EAX04285.1
RefSeqⁱ	NP_001107558.1, NM_001114086.1 NP_058625.2, NM_016929.4
UniGeneⁱ	Hs.485489 Hs.734348

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

TCDBⁱ	1.A.12.1.3 the intracellular chloride channel (clic) family

TCDBⁱ

1.A.12.1.3 the intracellular chloride channel (clic) family

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	53405
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	53405
KEGGⁱ	hsa:53405

Organism-specific databases

CTDⁱ	53405
EuPathDBⁱ	HostDB:ENSG00000112782.15
PharmGKBⁱ	PA26592

Phylogenomic databases

eggNOGⁱ	KOG1422 Eukaryota ENOG410ZRK6 LUCA
HOVERGENⁱ	HBG050994
KOⁱ	K05025

Miscellaneous databases

ChiTaRSⁱ	CLIC5 human
GenomeRNAiⁱ	53405

Gene expression databases

Bgeeⁱ	ENSG00000112782 Expressed in 209 organ(s), highest expression level in renal glomerulus

Bgeeⁱ

ENSG00000112782 Expressed in 209 organ(s), highest expression level in renal glomerulus

Family and domain databases

InterProⁱ	View protein in InterPro IPR002946 CLIC IPR030264 CLIC-5 IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR040079 Glutathione_S-Trfase IPR004045 Glutathione_S-Trfase_N IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR43920:SF6 PTHR43920:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF13417 GST_N_3, 1 hit
PRINTSⁱ	PR01263 INTCLCHANNEL
SFLDⁱ	SFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR00862 O-ClC, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q53G01_HUMAN
Accessionⁱ	Q53G01Primary (citable) accession number: Q53G01
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 24, 2005
	Last sequence update:	May 24, 2005
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q53G01 (Q53G01_HUMAN)

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Chloride intracellular channel protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ