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Protein

Chloride intracellular channel protein

Gene

CLIC5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processIon transport, Transport
LigandChloride

Protein family/group databases

TCDBi1.A.12.1.3 the intracellular chloride channel (clic) family

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel proteinUniRule annotation
Gene namesi
Name:CLIC5Imported
ORF Names:hCG_2001062Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000112782.15

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26592

Expressioni

Gene expression databases

BgeeiENSG00000112782 Expressed in 209 organ(s), highest expression level in renal glomerulus

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 241GST C-terminalInterPro annotationAdd BLAST141

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesi

Belongs to the chloride channel CLIC family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
HOVERGENiHBG050994
KOiK05025

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030264 CLIC-5
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF6 PTHR43920:SF6, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Fragment.

Q53G01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVFN
60 70 80 90 100
VTTVDLKRKP ADLHNLAPGT HPPFLTFNGD VKTDVNKIEE FLEETLTPEK
110 120 130 140 150
YPKLAAKHRE SNTAGIDIFS KFSAYIKNTK QQNNAALERG LTKALKKLDD
160 170 180 190 200
YLNTPLPEEI DANTCGEDKG SRRKFLDGDE LTLADCNLLP KLHVVKIVAK
210 220 230 240 250
KYRNYDIPAE MTGLWRYLKN AYARDEFTNT CAADSEIELA YADVAKRLSR

S
Length:251
Mass (Da):28,179
Last modified:May 24, 2005 - v1
Checksum:i1E8658EB7687C60D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ679794 mRNA Translation: ABG46342.1
AK222544 mRNA Translation: BAD96264.1
AK223130 mRNA Translation: BAD96850.1
CH471081 Genomic DNA Translation: EAX04285.1
RefSeqiNP_001107558.1, NM_001114086.1
NP_058625.2, NM_016929.4
UniGeneiHs.485489
Hs.734348

Genome annotation databases

GeneIDi53405
KEGGihsa:53405

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ679794 mRNA Translation: ABG46342.1
AK222544 mRNA Translation: BAD96264.1
AK223130 mRNA Translation: BAD96850.1
CH471081 Genomic DNA Translation: EAX04285.1
RefSeqiNP_001107558.1, NM_001114086.1
NP_058625.2, NM_016929.4
UniGeneiHs.485489
Hs.734348

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.A.12.1.3 the intracellular chloride channel (clic) family

Protocols and materials databases

DNASUi53405
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi53405
KEGGihsa:53405

Organism-specific databases

CTDi53405
EuPathDBiHostDB:ENSG00000112782.15
PharmGKBiPA26592

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
HOVERGENiHBG050994
KOiK05025

Miscellaneous databases

ChiTaRSiCLIC5 human
GenomeRNAii53405

Gene expression databases

BgeeiENSG00000112782 Expressed in 209 organ(s), highest expression level in renal glomerulus

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030264 CLIC-5
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF6 PTHR43920:SF6, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ53G01_HUMAN
AccessioniPrimary (citable) accession number: Q53G01
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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