UniProtKB - Q53G01 (Q53G01_HUMAN)
Protein
Chloride intracellular channel protein
Gene
CLIC5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
- sensory perception of sound Source: InterPro
Keywordsi
Molecular function | Chloride channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Protein family/group databases
TCDBi | 1.A.12.1.3, the intracellular chloride channel (clic) family |
Names & Taxonomyi
Protein namesi | Recommended name: Chloride intracellular channel proteinUniRule annotation |
Gene namesi | Name:CLIC5Imported ORF Names:hCG_2001062Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112782.15 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Single-pass membrane protein UniRule annotation
- Cytoplasm UniRule annotation
Other locations
- chloride channel complex Source: UniProtKB-KW
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000112782, Expressed in renal glomerulus and 220 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 241 | GST C-terminalInterPro annotationAdd BLAST | 141 |
Domaini
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_061051_1_0_1 |
Family and domain databases
CDDi | cd10297, GST_C_CLIC5, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR002946, CLIC IPR030264, CLIC-5 IPR042069, CLIC5_C_GST IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR45476:SF4, PTHR45476:SF4, 1 hit |
Pfami | View protein in Pfam PF13409, GST_N_2, 1 hit |
PRINTSi | PR01263, INTCLCHANNEL |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR00862, O-ClC, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q53G01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVFN
60 70 80 90 100
VTTVDLKRKP ADLHNLAPGT HPPFLTFNGD VKTDVNKIEE FLEETLTPEK
110 120 130 140 150
YPKLAAKHRE SNTAGIDIFS KFSAYIKNTK QQNNAALERG LTKALKKLDD
160 170 180 190 200
YLNTPLPEEI DANTCGEDKG SRRKFLDGDE LTLADCNLLP KLHVVKIVAK
210 220 230 240 250
KYRNYDIPAE MTGLWRYLKN AYARDEFTNT CAADSEIELA YADVAKRLSR
S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ679794 mRNA Translation: ABG46342.1 AK222544 mRNA Translation: BAD96264.1 AK223130 mRNA Translation: BAD96850.1 CH471081 Genomic DNA Translation: EAX04285.1 |
RefSeqi | NP_001107558.1, NM_001114086.1 NP_058625.2, NM_016929.4 |
Genome annotation databases
GeneIDi | 53405 |
KEGGi | hsa:53405 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ679794 mRNA Translation: ABG46342.1 AK222544 mRNA Translation: BAD96264.1 AK223130 mRNA Translation: BAD96850.1 CH471081 Genomic DNA Translation: EAX04285.1 |
RefSeqi | NP_001107558.1, NM_001114086.1 NP_058625.2, NM_016929.4 |
3D structure databases
SMRi | Q53G01 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 1.A.12.1.3, the intracellular chloride channel (clic) family |
Proteomic databases
PRIDEi | Q53G01 |
Protocols and materials databases
Antibodypediai | 16850, 243 antibodies |
DNASUi | 53405 |
Genome annotation databases
GeneIDi | 53405 |
KEGGi | hsa:53405 |
Organism-specific databases
CTDi | 53405 |
EuPathDBi | HostDB:ENSG00000112782.15 |
PharmGKBi | PA26592 |
Phylogenomic databases
HOGENOMi | CLU_061051_1_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 53405, 4 hits in 841 CRISPR screens |
ChiTaRSi | CLIC5, human |
GenomeRNAii | 53405 |
Gene expression databases
Bgeei | ENSG00000112782, Expressed in renal glomerulus and 220 other tissues |
Family and domain databases
CDDi | cd10297, GST_C_CLIC5, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR002946, CLIC IPR030264, CLIC-5 IPR042069, CLIC5_C_GST IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR45476:SF4, PTHR45476:SF4, 1 hit |
Pfami | View protein in Pfam PF13409, GST_N_2, 1 hit |
PRINTSi | PR01263, INTCLCHANNEL |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR00862, O-ClC, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q53G01_HUMAN | |
Accessioni | Q53G01Primary (citable) accession number: Q53G01 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |