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Protein

Protein Hikeshi

Gene

HIKESHI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.1 Publication

Miscellaneous

'Hikeshi' is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Hsp70 protein binding Source: UniProtKB
  • protein transporter activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3371453 Regulation of HSF1-mediated heat shock response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein HikeshiCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIKESHIImported
Synonyms:C11orf73
ORF Names:HSPC138, HSPC179, HSPC248
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000149196.15

Human Gene Nomenclature Database

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HGNCi
HGNC:26938 HIKESHI

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614908 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q53FT3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukodystrophy, hypomyelinating, 13 (HLD13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodegenerative disorder with infantile onset, affecting mainly the central white matter. Clinical features include early feeding difficulties, global developmental delay, postnatal progressive microcephaly, truncal hypotonia, spasticity, and variable neurologic deficits, such as visual impairment.
See also OMIM:616881
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07641154V → L in HLD13. 1 PublicationCorresponds to variant dbSNP:rs202003795EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18V → A: Impairs the nuclear migrating activity. 1 Publication1
Mutagenesisi24V → A: Reduces the nuclear migrating activity. 1 Publication1
Mutagenesisi55Y → A: Reduces the nuclear migrating activity. 1 Publication1
Mutagenesisi77K → A: Decreases nuclear import activity of HSPA8. Does not affect the dimer formation. Impairs binding to HSPA8. 1 Publication1
Mutagenesisi97F → A: Increases the nuclear migrating activity. 1 Publication1
Mutagenesisi132 – 135Missing : Decreases nuclear import activity of HSPA8. Does not affect the dimer formation. Markedly decreases binding to HSPA8. 1 Publication4
Mutagenesisi141F → A: Decreases nuclear import activity of HSPA8. Does not affect the dimer formation. Decreases binding to HSPA8. 1 Publication1

Keywords - Diseasei

Disease mutation, Leukodystrophy

Organism-specific databases

DisGeNET

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DisGeNETi
51501

MalaCards human disease database

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MalaCardsi
HIKESHI
MIMi616881 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000149196

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
495844 C11ORF73-related autosomal recessive hypomyelinating leukodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596492

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C11orf73

Domain mapping of disease mutations (DMDM)

More...
DMDMi
110278911

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452621 – 197Protein HikeshiAdd BLAST197

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q53FT3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q53FT3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q53FT3

PeptideAtlas

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PeptideAtlasi
Q53FT3

PRoteomics IDEntifications database

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PRIDEi
Q53FT3

ProteomicsDB human proteome resource

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ProteomicsDBi
62468

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q53FT3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q53FT3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q53FT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Following heat-shock treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000149196 Expressed in 200 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

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CleanExi
HS_C11orf73

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q53FT3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q53FT3 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA035063
HPA035064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins (PubMed:25760597). Interacts with ATP-bound HSP70 proteins (PubMed:22541429). Interacts with NUP62 and NUP153 (via F-X-F-G repeats) (PubMed:22541429). Interacts with HSPA8 (PubMed:25760597).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119574, 8 interactors

Protein interaction database and analysis system

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IntActi
Q53FT3, 8 interactors

Molecular INTeraction database

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MINTi
Q53FT3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000278483

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q53FT3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q53FT3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 55Required for F-X-F-G repeats-nucleoporins recognition and nuclear import1 PublicationAdd BLAST38
Regioni124 – 134Flexible linker region involved in nuclear import of HSP70 proteins1 PublicationAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OPI10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4067 Eukaryota
ENOG4111H6N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000004056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000175561

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081226

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q53FT3

Identification of Orthologs from Complete Genome Data

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OMAi
QRRMEQN

Database of Orthologous Groups

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OrthoDBi
EOG091G0LVQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q53FT3

TreeFam database of animal gene trees

More...
TreeFami
TF313222

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008493 DUF775
IPR031318 OPI10

The PANTHER Classification System

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PANTHERi
PTHR12925 PTHR12925, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05603 DUF775, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q53FT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGCLVAGRL VQTAAQQVAE DKFVFDLPDY ESINHVVVFM LGTIPFPEGM
60 70 80 90 100
GGSVYFSYPD SNGMPVWQLL GFVTNGKPSA IFKISGLKSG EGSQHPFGAM
110 120 130 140 150
NIVRTPSVAQ IGISVELLDS MAQQTPVGNA AVSSVDSFTQ FTQKMLDNFY
160 170 180 190
NFASSFAVSQ AQMTPSPSEM FIPANVVLKW YENFQRRLAQ NPLFWKT
Length:197
Mass (Da):21,628
Last modified:July 11, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FA524439B630511
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPG8E9PPG8_HUMAN
Protein Hikeshi
HIKESHI
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJB2E9PJB2_HUMAN
Protein Hikeshi
HIKESHI
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYW7A0A087WYW7_HUMAN
Protein Hikeshi
HIKESHI
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29102 differs from that shown. Reason: Frameshift at positions 62 and 68.Curated
The sequence AAF29142 differs from that shown. Reason: Frameshift at positions 9 and 57.Curated
The sequence AAF36168 differs from that shown. Reason: Frameshift at position 67.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82F → L in AAF29102 (PubMed:11042152).Curated1
Sequence conflicti82F → L in BAD96918 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02696847P → A1 PublicationCorresponds to variant dbSNP:rs11539213Ensembl.1
Natural variantiVAR_07641154V → L in HLD13. 1 PublicationCorresponds to variant dbSNP:rs202003795EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151082 mRNA Translation: AAF36168.1 Frameshift.
AF161487 mRNA Translation: AAF29102.1 Frameshift.
AF161527 mRNA Translation: AAF29142.1 Frameshift.
AK001447 mRNA Translation: BAA91698.1
AK223198 mRNA Translation: BAD96918.1
BC001677 mRNA Translation: AAH01677.1
BC006476 mRNA Translation: AAH06476.1
BC015991 mRNA Translation: AAH15991.1
BC018080 mRNA Translation: AAH18080.1
BC021621 mRNA Translation: AAH21621.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8275.1

NCBI Reference Sequences

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RefSeqi
NP_057485.2, NM_016401.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.283322

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000278483; ENSP00000278483; ENSG00000149196

Database of genes from NCBI RefSeq genomes

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GeneIDi
51501

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51501

UCSC genome browser

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UCSCi
uc001pbu.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151082 mRNA Translation: AAF36168.1 Frameshift.
AF161487 mRNA Translation: AAF29102.1 Frameshift.
AF161527 mRNA Translation: AAF29142.1 Frameshift.
AK001447 mRNA Translation: BAA91698.1
AK223198 mRNA Translation: BAD96918.1
BC001677 mRNA Translation: AAH01677.1
BC006476 mRNA Translation: AAH06476.1
BC015991 mRNA Translation: AAH15991.1
BC018080 mRNA Translation: AAH18080.1
BC021621 mRNA Translation: AAH21621.1
CCDSiCCDS8275.1
RefSeqiNP_057485.2, NM_016401.3
UniGeneiHs.283322

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WVZX-ray1.88A/B1-197[»]
3WW0X-ray2.50A/B1-197[»]
ProteinModelPortaliQ53FT3
SMRiQ53FT3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119574, 8 interactors
IntActiQ53FT3, 8 interactors
MINTiQ53FT3
STRINGi9606.ENSP00000278483

PTM databases

iPTMnetiQ53FT3
PhosphoSitePlusiQ53FT3

Polymorphism and mutation databases

BioMutaiC11orf73
DMDMi110278911

Proteomic databases

EPDiQ53FT3
MaxQBiQ53FT3
PaxDbiQ53FT3
PeptideAtlasiQ53FT3
PRIDEiQ53FT3
ProteomicsDBi62468
TopDownProteomicsiQ53FT3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51501
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278483; ENSP00000278483; ENSG00000149196
GeneIDi51501
KEGGihsa:51501
UCSCiuc001pbu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51501
DisGeNETi51501
EuPathDBiHostDB:ENSG00000149196.15

GeneCards: human genes, protein and diseases

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GeneCardsi
HIKESHI
HGNCiHGNC:26938 HIKESHI
HPAiHPA035063
HPA035064
MalaCardsiHIKESHI
MIMi614908 gene
616881 phenotype
neXtProtiNX_Q53FT3
OpenTargetsiENSG00000149196
Orphaneti495844 C11ORF73-related autosomal recessive hypomyelinating leukodystrophy
PharmGKBiPA144596492

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4067 Eukaryota
ENOG4111H6N LUCA
GeneTreeiENSGT00390000004056
HOGENOMiHOG000175561
HOVERGENiHBG081226
InParanoidiQ53FT3
OMAiQRRMEQN
OrthoDBiEOG091G0LVQ
PhylomeDBiQ53FT3
TreeFamiTF313222

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HIKESHI human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C11orf73

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51501

Protein Ontology

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PROi
PR:Q53FT3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000149196 Expressed in 200 organ(s), highest expression level in quadriceps femoris
CleanExiHS_C11orf73
ExpressionAtlasiQ53FT3 baseline and differential
GenevisibleiQ53FT3 HS

Family and domain databases

InterProiView protein in InterPro
IPR008493 DUF775
IPR031318 OPI10
PANTHERiPTHR12925 PTHR12925, 1 hit
PfamiView protein in Pfam
PF05603 DUF775, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIKES_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53FT3
Secondary accession number(s): Q8WVE8
, Q9NVQ2, Q9NZZ1, Q9P022, Q9P0N1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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