UniProtKB - Q53FP2 (TM35A_HUMAN)
Protein
Transmembrane protein 35A
Gene
TMEM35A
Organism
Homo sapiens (Human)
Status
Functioni
A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity
Enzyme and pathway databases
PathwayCommonsi | Q53FP2 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 35A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25864, TMEM35A |
neXtProti | NX_Q53FP2 |
VEuPathDBi | HostDB:ENSG00000126950.7 |
Subcellular locationi
Peroxisome
- Peroxisome membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Cytoplasmic vesicle By similarity
Note: Shedding may lead to a soluble peptide.By similarity
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 89 – 109 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 115 – 132 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Membrane, PeroxisomePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000126950 |
PharmGKBi | PA134905238 |
Miscellaneous databases
Pharosi | Q53FP2, Tdark |
Genetic variation databases
BioMutai | TMEM35A |
DMDMi | 121957117 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271607 | 1 – 167 | Transmembrane protein 35AAdd BLAST | 167 |
Proteomic databases
EPDi | Q53FP2 |
jPOSTi | Q53FP2 |
MassIVEi | Q53FP2 |
PaxDbi | Q53FP2 |
PeptideAtlasi | Q53FP2 |
PRIDEi | Q53FP2 |
ProteomicsDBi | 62467 |
TopDownProteomicsi | Q53FP2 |
PTM databases
iPTMneti | Q53FP2 |
PhosphoSitePlusi | Q53FP2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126950, Expressed in cortical plate and 176 other tissues |
Genevisiblei | Q53FP2, HS |
Organism-specific databases
HPAi | ENSG00000126950, Tissue enhanced (brain, seminal vesicle) |
Interactioni
Subunit structurei
May interact with NGFR.
By similarityBinary interactionsi
Hide detailsQ53FP2
Protein-protein interaction databases
BioGRIDi | 121894, 31 interactors |
IntActi | Q53FP2, 32 interactors |
MINTi | Q53FP2 |
STRINGi | 9606.ENSP00000362021 |
Miscellaneous databases
RNActi | Q53FP2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 54 | Interaction with NGFRBy similarityAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the DoxX family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RXPR, Eukaryota |
GeneTreei | ENSGT00940000154325 |
HOGENOMi | CLU_121618_0_0_1 |
InParanoidi | Q53FP2 |
OMAi | SKWYRRV |
OrthoDBi | 1615454at2759 |
PhylomeDBi | Q53FP2 |
TreeFami | TF300206 |
Family and domain databases
InterProi | View protein in InterPro IPR032808, DoxX IPR040399, TM35A/B IPR029693, TMEM35A |
PANTHERi | PTHR13163, PTHR13163, 1 hit PTHR13163:SF0, PTHR13163:SF0, 1 hit |
Pfami | View protein in Pfam PF13564, DoxX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53FP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE
160
EQPSLYEKAP QGKVKVS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | A → T in BAD96960 (Ref. 2) Curated | 1 | |
Sequence conflicti | 60 | N → S in BAD96960 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024146 mRNA Translation: BAB14840.1 AK223240 mRNA Translation: BAD96960.1 AL109952 Genomic DNA No translation available. BC050273 mRNA Translation: AAH50273.1 BC078658 mRNA Translation: AAH78658.1 |
CCDSi | CCDS14478.1 |
RefSeqi | NP_067650.1, NM_021637.2 |
Genome annotation databases
Ensembli | ENST00000372930; ENSP00000362021; ENSG00000126950 |
GeneIDi | 59353 |
KEGGi | hsa:59353 |
UCSCi | uc004egw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024146 mRNA Translation: BAB14840.1 AK223240 mRNA Translation: BAD96960.1 AL109952 Genomic DNA No translation available. BC050273 mRNA Translation: AAH50273.1 BC078658 mRNA Translation: AAH78658.1 |
CCDSi | CCDS14478.1 |
RefSeqi | NP_067650.1, NM_021637.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121894, 31 interactors |
IntActi | Q53FP2, 32 interactors |
MINTi | Q53FP2 |
STRINGi | 9606.ENSP00000362021 |
PTM databases
iPTMneti | Q53FP2 |
PhosphoSitePlusi | Q53FP2 |
Genetic variation databases
BioMutai | TMEM35A |
DMDMi | 121957117 |
Proteomic databases
EPDi | Q53FP2 |
jPOSTi | Q53FP2 |
MassIVEi | Q53FP2 |
PaxDbi | Q53FP2 |
PeptideAtlasi | Q53FP2 |
PRIDEi | Q53FP2 |
ProteomicsDBi | 62467 |
TopDownProteomicsi | Q53FP2 |
Protocols and materials databases
Antibodypediai | 28590, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000372930; ENSP00000362021; ENSG00000126950 |
GeneIDi | 59353 |
KEGGi | hsa:59353 |
UCSCi | uc004egw.4, human |
Organism-specific databases
CTDi | 59353 |
GeneCardsi | TMEM35A |
HGNCi | HGNC:25864, TMEM35A |
HPAi | ENSG00000126950, Tissue enhanced (brain, seminal vesicle) |
neXtProti | NX_Q53FP2 |
OpenTargetsi | ENSG00000126950 |
PharmGKBi | PA134905238 |
VEuPathDBi | HostDB:ENSG00000126950.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RXPR, Eukaryota |
GeneTreei | ENSGT00940000154325 |
HOGENOMi | CLU_121618_0_0_1 |
InParanoidi | Q53FP2 |
OMAi | SKWYRRV |
OrthoDBi | 1615454at2759 |
PhylomeDBi | Q53FP2 |
TreeFami | TF300206 |
Enzyme and pathway databases
PathwayCommonsi | Q53FP2 |
Miscellaneous databases
BioGRID-ORCSi | 59353, 3 hits in 501 CRISPR screens |
ChiTaRSi | TMEM35A, human |
GenomeRNAii | 59353 |
Pharosi | Q53FP2, Tdark |
PROi | PR:Q53FP2 |
RNActi | Q53FP2, protein |
Gene expression databases
Bgeei | ENSG00000126950, Expressed in cortical plate and 176 other tissues |
Genevisiblei | Q53FP2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032808, DoxX IPR040399, TM35A/B IPR029693, TMEM35A |
PANTHERi | PTHR13163, PTHR13163, 1 hit PTHR13163:SF0, PTHR13163:SF0, 1 hit |
Pfami | View protein in Pfam PF13564, DoxX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM35A_HUMAN | |
Accessioni | Q53FP2Primary (citable) accession number: Q53FP2 Secondary accession number(s): Q9H7Y3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 10, 2021 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM