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UniProtKB - Q53FP2 (TM35A_HUMAN)

Entry version 105 (10 Feb 2021)
Sequence version 2 (09 Jan 2007)
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Protein

Transmembrane protein 35A

Gene

TMEM35A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q53FP2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 35A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM35AImported
Synonyms:TMEM35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25864, TMEM35A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q53FP2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126950.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000126950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134905238

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q53FP2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM35A

Domain mapping of disease mutations (DMDM)

More...DMDMi		121957117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002716071 – 167Transmembrane protein 35AAdd BLAST167

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q53FP2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q53FP2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q53FP2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q53FP2

PeptideAtlas

More...PeptideAtlasi		Q53FP2

PRoteomics IDEntifications database

More...PRIDEi		Q53FP2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62467

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q53FP2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q53FP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q53FP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126950, Expressed in cortical plate and 176 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q53FP2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126950, Tissue enhanced (brain, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with NGFR.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121894, 31 interactors

Protein interaction database and analysis system

More...IntActi		Q53FP2, 32 interactors

Molecular INTeraction database

More...MINTi		Q53FP2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362021

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q53FP2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 54Interaction with NGFRBy similarityAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXPR, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_121618_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q53FP2

Identification of Orthologs from Complete Genome Data

More...OMAi		SKWYRRV

Database of Orthologous Groups

More...OrthoDBi		1615454at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q53FP2

TreeFam database of animal gene trees

More...TreeFami		TF300206

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032808, DoxX
IPR040399, TM35A/B
IPR029693, TMEM35A

The PANTHER Classification System

More...PANTHERi		PTHR13163, PTHR13163, 1 hit
PTHR13163:SF0, PTHR13163:SF0, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13564, DoxX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q53FP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA 
        60         70         80         90        100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA 
       110        120        130        140        150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE 
       160 
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,440
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i062A6E7700DB33B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50A → T in BAD96960 (Ref. 2) Curated1
Sequence conflicti60N → S in BAD96960 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK024146 mRNA Translation: BAB14840.1
AK223240 mRNA Translation: BAD96960.1
AL109952 Genomic DNA No translation available.
BC050273 mRNA Translation: AAH50273.1
BC078658 mRNA Translation: AAH78658.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14478.1

NCBI Reference Sequences

More...RefSeqi		NP_067650.1, NM_021637.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372930; ENSP00000362021; ENSG00000126950

Database of genes from NCBI RefSeq genomes

More...GeneIDi		59353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:59353

UCSC genome browser

More...UCSCi		uc004egw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024146 mRNA Translation: BAB14840.1
AK223240 mRNA Translation: BAD96960.1
AL109952 Genomic DNA No translation available.
BC050273 mRNA Translation: AAH50273.1
BC078658 mRNA Translation: AAH78658.1
CCDSiCCDS14478.1
RefSeqiNP_067650.1, NM_021637.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121894, 31 interactors
IntActiQ53FP2, 32 interactors
MINTiQ53FP2
STRINGi9606.ENSP00000362021

PTM databases

iPTMnetiQ53FP2
PhosphoSitePlusiQ53FP2

Genetic variation databases

BioMutaiTMEM35A
DMDMi121957117

Proteomic databases

EPDiQ53FP2
jPOSTiQ53FP2
MassIVEiQ53FP2
PaxDbiQ53FP2
PeptideAtlasiQ53FP2
PRIDEiQ53FP2
ProteomicsDBi62467
TopDownProteomicsiQ53FP2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28590, 31 antibodies

Genome annotation databases

EnsembliENST00000372930; ENSP00000362021; ENSG00000126950
GeneIDi59353
KEGGihsa:59353
UCSCiuc004egw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		59353

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM35A
HGNCiHGNC:25864, TMEM35A
HPAiENSG00000126950, Tissue enhanced (brain, seminal vesicle)
neXtProtiNX_Q53FP2
OpenTargetsiENSG00000126950
PharmGKBiPA134905238
VEuPathDBiHostDB:ENSG00000126950.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RXPR, Eukaryota
GeneTreeiENSGT00940000154325
HOGENOMiCLU_121618_0_0_1
InParanoidiQ53FP2
OMAiSKWYRRV
OrthoDBi1615454at2759
PhylomeDBiQ53FP2
TreeFamiTF300206

Enzyme and pathway databases

PathwayCommonsiQ53FP2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		59353, 3 hits in 501 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM35A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		59353
PharosiQ53FP2, Tdark

Protein Ontology

More...PROi		PR:Q53FP2
RNActiQ53FP2, protein

Gene expression databases

BgeeiENSG00000126950, Expressed in cortical plate and 176 other tissues
GenevisibleiQ53FP2, HS

Family and domain databases

InterProiView protein in InterPro
IPR032808, DoxX
IPR040399, TM35A/B
IPR029693, TMEM35A
PANTHERiPTHR13163, PTHR13163, 1 hit
PTHR13163:SF0, PTHR13163:SF0, 1 hit
PfamiView protein in Pfam
PF13564, DoxX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM35A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53FP2
Secondary accession number(s): Q9H7Y3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 10, 2021
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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