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Protein

Transmembrane protein 35A

Gene

TMEM35A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35A
Gene namesi
Name:TMEM35AImported
Synonyms:TMEM35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126950.7
HGNCiHGNC:25864 TMEM35A
neXtProtiNX_Q53FP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126950
PharmGKBiPA134905238

Polymorphism and mutation databases

BioMutaiTMEM35
DMDMi121957117

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716071 – 167Transmembrane protein 35AAdd BLAST167

Proteomic databases

EPDiQ53FP2
PaxDbiQ53FP2
PeptideAtlasiQ53FP2
PRIDEiQ53FP2
ProteomicsDBi62467
TopDownProteomicsiQ53FP2

PTM databases

iPTMnetiQ53FP2
PhosphoSitePlusiQ53FP2

Expressioni

Gene expression databases

BgeeiENSG00000126950
CleanExiHS_TMEM35
GenevisibleiQ53FP2 HS

Organism-specific databases

HPAiHPA048583

Interactioni

Subunit structurei

May interact with NGFR.By similarity

Protein-protein interaction databases

BioGridi121894, 1 interactor
IntActiQ53FP2, 3 interactors
MINTiQ53FP2
STRINGi9606.ENSP00000362021

Structurei

3D structure databases

ProteinModelPortaliQ53FP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 54Interaction with NGFRBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA Eukaryota
ENOG4111K2N LUCA
GeneTreeiENSGT00390000014255
HOGENOMiHOG000046204
HOVERGENiHBG054829
InParanoidiQ53FP2
OMAiSKWYRRV
OrthoDBiEOG091G0TZU
PhylomeDBiQ53FP2
TreeFamiTF300206

Family and domain databases

InterProiView protein in InterPro
IPR032808 DoxX
IPR029693 TMEM35A
PANTHERiPTHR13163:SF0 PTHR13163:SF0, 1 hit
PfamiView protein in Pfam
PF13564 DoxX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q53FP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE
160
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,440
Last modified:January 9, 2007 - v2
Checksum:i062A6E7700DB33B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50A → T in BAD96960 (Ref. 2) Curated1
Sequence conflicti60N → S in BAD96960 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024146 mRNA Translation: BAB14840.1
AK223240 mRNA Translation: BAD96960.1
AL109952 Genomic DNA No translation available.
BC050273 mRNA Translation: AAH50273.1
BC078658 mRNA Translation: AAH78658.1
CCDSiCCDS14478.1
RefSeqiNP_067650.1, NM_021637.2
UniGeneiHs.45140
Hs.714277

Genome annotation databases

EnsembliENST00000372930; ENSP00000362021; ENSG00000126950
GeneIDi59353
KEGGihsa:59353
UCSCiuc004egw.4 human

Similar proteinsi

Entry informationi

Entry nameiTM35A_HUMAN
AccessioniPrimary (citable) accession number: Q53FP2
Secondary accession number(s): Q9H7Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 20, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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