TMEM35A

Functionⁱ

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 35A
Gene namesⁱ	Name:TMEM35AImported Synonyms:TMEM35
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126950.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25864 TMEM35A
neXtProtⁱ	NX_Q53FP2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	6 – 26	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	62 – 82	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	89 – 109	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	115 – 132	HelicalSequence analysisAdd BLAST	18

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Membrane, Peroxisome

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000126950
PharmGKBⁱ	PA134905238

Polymorphism and mutation databases

BioMutaⁱ	TMEM35
DMDMⁱ	121957117

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271607	1 – 167	Transmembrane protein 35AAdd BLAST		167

Proteomic databases

EPDⁱ	Q53FP2
PaxDbⁱ	Q53FP2
PeptideAtlas More...PeptideAtlasⁱ	Q53FP2
PRIDEⁱ	Q53FP2
ProteomicsDBⁱ	62467
TopDownProteomicsⁱ	Q53FP2

PTM databases

iPTMnetⁱ	Q53FP2
PhosphoSitePlusⁱ	Q53FP2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000126950
CleanExⁱ	HS_TMEM35
Genevisibleⁱ	Q53FP2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048583

HPAⁱ

HPA048583

Interactionⁱ

Subunit structureⁱ

May interact with NGFR.By similarity

Protein-protein interaction databases

BioGridⁱ	121894, 1 interactor
IntActⁱ	Q53FP2, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q53FP2
STRINGⁱ	9606.ENSP00000362021

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q53FP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	43 – 54	Interaction with NGFRBy similarityAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the DoxX family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGYA Eukaryota ENOG4111K2N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014255
HOGENOMⁱ	HOG000046204
HOVERGENⁱ	HBG054829
InParanoidⁱ	Q53FP2
OMAⁱ	SKWYRRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TZU
PhylomeDBⁱ	Q53FP2
TreeFamⁱ	TF300206

Family and domain databases

InterProⁱ	View protein in InterPro IPR032808 DoxX IPR029693 TMEM35A
PANTHERⁱ	PTHR13163:SF0 PTHR13163:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13564 DoxX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q53FP2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA 
        60         70         80         90        100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA 
       110        120        130        140        150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE 
       160 
EQPSLYEKAP QGKVKVS

Length:167

Mass (Da):18,440

Last modified:January 9, 2007 - v2

Checksum:ⁱ062A6E7700DB33B7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	50	A → T in BAD96960 (Ref. 2) Curated		1
Sequence conflictⁱ	60	N → S in BAD96960 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024146 mRNA Translation: BAB14840.1 AK223240 mRNA Translation: BAD96960.1 AL109952 Genomic DNA No translation available. BC050273 mRNA Translation: AAH50273.1 BC078658 mRNA Translation: AAH78658.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14478.1
NCBI Reference Sequences More...RefSeqⁱ	NP_067650.1, NM_021637.2
UniGeneⁱ	Hs.45140 Hs.714277

Genome annotation databases

Ensemblⁱ	ENST00000372930; ENSP00000362021; ENSG00000126950
GeneIDⁱ	59353
KEGGⁱ	hsa:59353
UCSC genome browser More...UCSCⁱ	uc004egw.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q53FP2	Transmembrane protein 35A		RAT		167
UPI0002C6692C		southern white rhinoceros		187
Transmembrane protein 35A		PIG		179
UPI000812D5AB		MANJA		179
Transmembrane protein 35A		BOVIN		177
+71

Protein	Similar proteins		Species	Score	Length
Q53FP2	Transmembrane protein 35A		RAT		167
UPI0002C6692C		southern white rhinoceros		187
UPI000812D5AB		MANJA		179
Transmembrane protein 35A		PIG		179
Transmembrane protein 35		CAMFR		177
+213

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024146 mRNA Translation: BAB14840.1 AK223240 mRNA Translation: BAD96960.1 AL109952 Genomic DNA No translation available. BC050273 mRNA Translation: AAH50273.1 BC078658 mRNA Translation: AAH78658.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14478.1
NCBI Reference Sequences More...RefSeqⁱ	NP_067650.1, NM_021637.2
UniGeneⁱ	Hs.45140 Hs.714277

3D structure databases

ProteinModelPortalⁱ	Q53FP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121894, 1 interactor
IntActⁱ	Q53FP2, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q53FP2
STRINGⁱ	9606.ENSP00000362021

PTM databases

iPTMnetⁱ	Q53FP2
PhosphoSitePlusⁱ	Q53FP2

Polymorphism and mutation databases

BioMutaⁱ	TMEM35
DMDMⁱ	121957117

Proteomic databases

EPDⁱ	Q53FP2
PaxDbⁱ	Q53FP2
PeptideAtlas More...PeptideAtlasⁱ	Q53FP2
PRIDEⁱ	Q53FP2
ProteomicsDBⁱ	62467
TopDownProteomicsⁱ	Q53FP2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000372930; ENSP00000362021; ENSG00000126950
GeneIDⁱ	59353
KEGGⁱ	hsa:59353
UCSC genome browser More...UCSCⁱ	uc004egw.4 human

Organism-specific databases

CTDⁱ	59353
EuPathDBⁱ	HostDB:ENSG00000126950.7
GeneCardsⁱ	TMEM35A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25864 TMEM35A
Human Protein Atlas More...HPAⁱ	HPA048583
neXtProtⁱ	NX_Q53FP2
Open Targets More...OpenTargetsⁱ	ENSG00000126950
PharmGKBⁱ	PA134905238
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGYA Eukaryota ENOG4111K2N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014255
HOGENOMⁱ	HOG000046204
HOVERGENⁱ	HBG054829
InParanoidⁱ	Q53FP2
OMAⁱ	SKWYRRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TZU
PhylomeDBⁱ	Q53FP2
TreeFamⁱ	TF300206

Miscellaneous databases

GenomeRNAiⁱ	59353
Protein Ontology More...PROⁱ	PR:Q53FP2

Gene expression databases

Bgeeⁱ	ENSG00000126950
CleanExⁱ	HS_TMEM35
Genevisibleⁱ	Q53FP2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR032808 DoxX IPR029693 TMEM35A
PANTHERⁱ	PTHR13163:SF0 PTHR13163:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13564 DoxX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM35A_HUMAN
Accessionⁱ	Q53FP2Primary (citable) accession number: Q53FP2 Secondary accession number(s): Q9H7Y3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	January 9, 2007
	Last modified:	June 20, 2018
	This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q53FP2 (TM35A_HUMAN)

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Transmembrane protein 35A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Other locations

Peroxisome

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ