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Entry version 112 (12 Aug 2020)
Sequence version 3 (16 May 2012)
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Protein

Zinc finger C2HC domain-containing protein 1C

Gene

ZC2HC1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri387 – 411C2HC-typeAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q53FD0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger C2HC domain-containing protein 1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC2HC1C
Synonyms:C14orf140, FAM164C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119703.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20354, ZC2HC1C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q53FD0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79696

Open Targets

More...
OpenTargetsi
ENSG00000119703

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162386996

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q53FD0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC2HC1C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
387912891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899401 – 456Zinc finger C2HC domain-containing protein 1CAdd BLAST456

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q53FD0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q53FD0

PeptideAtlas

More...
PeptideAtlasi
Q53FD0

PRoteomics IDEntifications database

More...
PRIDEi
Q53FD0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62464 [Q53FD0-1]
62465 [Q53FD0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q53FD0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q53FD0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119703, Expressed in testis and 137 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q53FD0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q53FD0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000119703, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q53FD0
With#Exp.IntAct
BANP [Q8N9N5]3EBI-740767,EBI-744695
CBY2 [Q8NA61]3EBI-740767,EBI-741724
CCDC136 - isoform 2 [Q96JN2-2]3EBI-740767,EBI-10171416
EMILIN1 [Q9Y6C2]3EBI-740767,EBI-744586
FSD2 [A1L4K1]3EBI-740767,EBI-5661036
GFAP [P14136]3EBI-740767,EBI-744302
HOOK2 [Q96ED9]3EBI-740767,EBI-743290
KRT15 [P19012]4EBI-740767,EBI-739566
KRT40 [Q6A162]3EBI-740767,EBI-10171697
MID2 - isoform 2 [Q9UJV3-2]3EBI-740767,EBI-10172526
MTUS2 [Q5JR59]4EBI-740767,EBI-742948
PNMA1 [Q8ND90]4EBI-740767,EBI-302345
RABGEF1 [Q9UJ41]3EBI-740767,EBI-913954
SFN [P31947]3EBI-740767,EBI-476295
SPAG5 [Q96R06]3EBI-740767,EBI-413317
TFIP11 [Q9UBB9]4EBI-740767,EBI-1105213
TRAF1 [Q13077]3EBI-740767,EBI-359224
TRAF2 [Q12933]3EBI-740767,EBI-355744
TRIM23 [P36406]3EBI-740767,EBI-740098
TRIM27 [P14373]3EBI-740767,EBI-719493
Isoform 2 [Q53FD0-2]
With#Exp.IntAct
ACTN2 [P35609]3EBI-14104088,EBI-77797
ANKS1A [Q49AR9]3EBI-14104088,EBI-11954519
ARMC7 [Q9H6L4]3EBI-14104088,EBI-742909
BICD2 - isoform 2 [Q8TD16-2]3EBI-14104088,EBI-11975051
BYSL [Q13895]3EBI-14104088,EBI-358049
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-14104088,EBI-11976299
CABP5 [Q9NP86]3EBI-14104088,EBI-10311131
CARD9 - isoform 2 [Q9H257-2]3EBI-14104088,EBI-11530605
CCDC102B [Q68D86]6EBI-14104088,EBI-10171570
CCDC155 [Q8N6L0]3EBI-14104088,EBI-749265
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-14104088,EBI-10961624
CCDC88B [A6NC98]3EBI-14104088,EBI-347573
CIB3 [Q96Q77]3EBI-14104088,EBI-10292696
CLIC3 [O95833]3EBI-14104088,EBI-10192241
CRACR2A [Q9BSW2]3EBI-14104088,EBI-739773
DDX6 [P26196]3EBI-14104088,EBI-351257
EMILIN1 - isoform 2 [Q9Y6C2-2]3EBI-14104088,EBI-11748557
ENKD1 [Q9H0I2]3EBI-14104088,EBI-744099
FAM90A1 [Q86YD7]3EBI-14104088,EBI-6658203
FGFR1OP2 - isoform 3 [Q9NVK5-3]3EBI-14104088,EBI-12377025
GOLGA1 [Q92805]3EBI-14104088,EBI-6164177
GOLGA2 [Q08379]3EBI-14104088,EBI-618309
GOLGA6A [Q9NYA3]3EBI-14104088,EBI-11163335
GPRASP2 [Q96D09]3EBI-14104088,EBI-473189
HOOK2 - isoform 2 [Q96ED9-2]3EBI-14104088,EBI-10961706
HSF2BP [O75031]3EBI-14104088,EBI-7116203
KAT5 [Q92993]3EBI-14104088,EBI-399080
KATNBL1 [Q9H079]3EBI-14104088,EBI-715394
KIF9 [Q9HAQ2]3EBI-14104088,EBI-8472129
KRT15 [P19012]3EBI-14104088,EBI-739566
LMNB2 [Q03252]3EBI-14104088,EBI-2830427
LZTS2 [Q9BRK4]3EBI-14104088,EBI-741037
MAPK9 [P45984]3EBI-14104088,EBI-713568
MAPRE3 [Q9UPY8]3EBI-14104088,EBI-726739
NCKIPSD - isoform 3 [Q9NZQ3-3]3EBI-14104088,EBI-10963850
NDEL1 [Q9GZM8]3EBI-14104088,EBI-928842
NDOR1 [Q9UHB4]3EBI-14104088,EBI-10249760
NEK6 - isoform 4 [Q9HC98-4]3EBI-14104088,EBI-11750983
NOXA1 - isoform 2 [Q86UR1-2]3EBI-14104088,EBI-12025760
OSGIN1 [Q9UJX0]3EBI-14104088,EBI-9057006
PFDN5 [Q99471]3EBI-14104088,EBI-357275
PIBF1 [Q4G0R1]3EBI-14104088,EBI-14066006
POLR1C [O15160]3EBI-14104088,EBI-1055079
PRKAB2 [O43741]3EBI-14104088,EBI-1053424
PSTPIP1 [O43586]3EBI-14104088,EBI-1050964
RAD51D [O75771]3EBI-14104088,EBI-1055693
RINT1 [Q6NUQ1]3EBI-14104088,EBI-726876
SIKE1 [Q9BRV8]6EBI-14104088,EBI-1773646
SMARCD1 [Q96GM5]3EBI-14104088,EBI-358489
SORBS3 [O60504]3EBI-14104088,EBI-741237
TNPO2 - isoform 2 [O14787-2]3EBI-14104088,EBI-12076664
TRAF2 [Q12933]3EBI-14104088,EBI-355744
TRIM23 [P36406]3EBI-14104088,EBI-740098
UBASH3A - isoform 2 [P57075-2]3EBI-14104088,EBI-7353612
VPS52 [Q8N1B4]3EBI-14104088,EBI-2799833
WDYHV1 [Q96HA8]3EBI-14104088,EBI-741158
ZNF655 [Q8N720]5EBI-14104088,EBI-625509
ZNF76 [P36508]3EBI-14104088,EBI-7254550

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122817, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q53FD0, 80 interactors

Molecular INTeraction database

More...
MINTi
Q53FD0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000435550

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q53FD0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q53FD0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili211 – 265Sequence analysisAdd BLAST55

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC2HC1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 411C2HC-typeAdd BLAST25

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3940, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039058_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q53FD0

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQKSNWR

Database of Orthologous Groups

More...
OrthoDBi
1123751at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q53FD0

TreeFam database of animal gene trees

More...
TreeFami
TF319585

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026104, ZNF_C2HC_dom_1C

The PANTHER Classification System

More...
PANTHERi
PTHR14649, PTHR14649, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q53FD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLQRLASH LPVGVMLPHN TTEAPGPHSA KQDSYEQGDS SQQSLKGHLR
60 70 80 90 100
NNFQKQLLSN KELILDKVYT HPKWNTQTKA RSYSYPHCTG ISQQDPESDS
110 120 130 140 150
QGQGNGLFYS SGPQSWYPKA NNQDFIPFTK KRVGVDRAFP LKPMVHRKSC
160 170 180 190 200
STGEAGTDGD HNVYPRPPEP REFSSRNFGV RNQGNFSVVG TVLAATQAEK
210 220 230 240 250
AVANFDRTEW VQIRRLEAAG ESLEEEIRRK QILLRGKLKK TEEELRRIQT
260 270 280 290 300
QKEQAKENEN GELQKIILPR SRVKGNKSNT MYKPIFSPEF EFEEEFSRDR
310 320 330 340 350
REDETWGRSQ QNSGPFQFSD YRIQRLKRER LVASNNKIRD PVSEPSVEKF
360 370 380 390 400
SPPSETPVGA LQGSARNSSL SMAPDSSGSS GSIEEPQLGE CSHCGRKFLS
410 420 430 440 450
FRLERHSNIC SRMRGSKRKV FDSSRARAKG TELEQYLNWK GPASAKAEPP

QKSNWR
Length:456
Mass (Da):51,658
Last modified:May 16, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7BD49C093D2AC2B
GO
Isoform 2 (identifier: Q53FD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-456: Missing.

Show »
Length:275
Mass (Da):31,049
Checksum:iCCE2437D8E08F9DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KMY6J3KMY6_HUMAN
Zinc finger C2HC domain-containing ...
ZC2HC1C
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE08H0YE08_HUMAN
Zinc finger C2HC domain-containing ...
ZC2HC1C
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB15A0A669KB15_HUMAN
Zinc finger C2HC domain-containing ...
ZC2HC1C
423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMG6E9PMG6_HUMAN
Zinc finger C2HC domain-containing ...
ZC2HC1C
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15541 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72P → L in BAD97079 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043105276 – 456Missing in isoform 2. 3 PublicationsAdd BLAST181

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026746 mRNA Translation: BAB15541.1 Frameshift.
AK223359 mRNA Translation: BAD97079.1
AL049780 Genomic DNA No translation available.
BC004259 mRNA Translation: AAH04259.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41972.1 [Q53FD0-1]
CCDS45138.1 [Q53FD0-2]

NCBI Reference Sequences

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RefSeqi
NP_001035895.1, NM_001042430.2 [Q53FD0-2]
NP_078919.2, NM_024643.3 [Q53FD0-1]
XP_005268119.1, XM_005268062.3 [Q53FD0-1]
XP_011535457.1, XM_011537155.2 [Q53FD0-1]
XP_011535458.1, XM_011537156.2 [Q53FD0-1]
XP_016877133.1, XM_017021644.1 [Q53FD0-2]
XP_016877134.1, XM_017021645.1 [Q53FD0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000439583; ENSP00000390606; ENSG00000119703 [Q53FD0-2]
ENST00000524913; ENSP00000435550; ENSG00000119703 [Q53FD0-1]
ENST00000525046; ENSP00000435684; ENSG00000119703 [Q53FD0-2]
ENST00000526130; ENSP00000437160; ENSG00000119703 [Q53FD0-2]
ENST00000554763; ENSP00000451195; ENSG00000119703 [Q53FD0-2]
ENST00000673981; ENSP00000501014; ENSG00000119703 [Q53FD0-2]
ENST00000674017; ENSP00000501062; ENSG00000119703 [Q53FD0-2]
ENST00000674086; ENSP00000501056; ENSG00000119703 [Q53FD0-1]
ENST00000674097; ENSP00000501052; ENSG00000119703 [Q53FD0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79696

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79696

UCSC genome browser

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UCSCi
uc001xrh.5, human [Q53FD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026746 mRNA Translation: BAB15541.1 Frameshift.
AK223359 mRNA Translation: BAD97079.1
AL049780 Genomic DNA No translation available.
BC004259 mRNA Translation: AAH04259.1
CCDSiCCDS41972.1 [Q53FD0-1]
CCDS45138.1 [Q53FD0-2]
RefSeqiNP_001035895.1, NM_001042430.2 [Q53FD0-2]
NP_078919.2, NM_024643.3 [Q53FD0-1]
XP_005268119.1, XM_005268062.3 [Q53FD0-1]
XP_011535457.1, XM_011537155.2 [Q53FD0-1]
XP_011535458.1, XM_011537156.2 [Q53FD0-1]
XP_016877133.1, XM_017021644.1 [Q53FD0-2]
XP_016877134.1, XM_017021645.1 [Q53FD0-2]

3D structure databases

SMRiQ53FD0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122817, 27 interactors
IntActiQ53FD0, 80 interactors
MINTiQ53FD0
STRINGi9606.ENSP00000435550

PTM databases

iPTMnetiQ53FD0
PhosphoSitePlusiQ53FD0

Polymorphism and mutation databases

BioMutaiZC2HC1C
DMDMi387912891

Proteomic databases

MassIVEiQ53FD0
PaxDbiQ53FD0
PeptideAtlasiQ53FD0
PRIDEiQ53FD0
ProteomicsDBi62464 [Q53FD0-1]
62465 [Q53FD0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25790, 55 antibodies

Genome annotation databases

EnsembliENST00000439583; ENSP00000390606; ENSG00000119703 [Q53FD0-2]
ENST00000524913; ENSP00000435550; ENSG00000119703 [Q53FD0-1]
ENST00000525046; ENSP00000435684; ENSG00000119703 [Q53FD0-2]
ENST00000526130; ENSP00000437160; ENSG00000119703 [Q53FD0-2]
ENST00000554763; ENSP00000451195; ENSG00000119703 [Q53FD0-2]
ENST00000673981; ENSP00000501014; ENSG00000119703 [Q53FD0-2]
ENST00000674017; ENSP00000501062; ENSG00000119703 [Q53FD0-2]
ENST00000674086; ENSP00000501056; ENSG00000119703 [Q53FD0-1]
ENST00000674097; ENSP00000501052; ENSG00000119703 [Q53FD0-2]
GeneIDi79696
KEGGihsa:79696
UCSCiuc001xrh.5, human [Q53FD0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79696
DisGeNETi79696
EuPathDBiHostDB:ENSG00000119703.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZC2HC1C
HGNCiHGNC:20354, ZC2HC1C
HPAiENSG00000119703, Tissue enriched (testis)
neXtProtiNX_Q53FD0
OpenTargetsiENSG00000119703
PharmGKBiPA162386996

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3940, Eukaryota
GeneTreeiENSGT00940000160947
HOGENOMiCLU_039058_0_0_1
InParanoidiQ53FD0
OMAiPQKSNWR
OrthoDBi1123751at2759
PhylomeDBiQ53FD0
TreeFamiTF319585

Enzyme and pathway databases

PathwayCommonsiQ53FD0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79696, 1 hit in 877 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79696
PharosiQ53FD0, Tdark

Protein Ontology

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PROi
PR:Q53FD0
RNActiQ53FD0, protein

Gene expression databases

BgeeiENSG00000119703, Expressed in testis and 137 other tissues
ExpressionAtlasiQ53FD0, baseline and differential
GenevisibleiQ53FD0, HS

Family and domain databases

InterProiView protein in InterPro
IPR026104, ZNF_C2HC_dom_1C
PANTHERiPTHR14649, PTHR14649, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC21C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53FD0
Secondary accession number(s): E9PJQ0, Q9BTA8, Q9H5S9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 16, 2012
Last modified: August 12, 2020
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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