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Entry version 127 (13 Feb 2019)
Sequence version 2 (27 Sep 2005)
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Protein

Quinone oxidoreductase PIG3

Gene

TP53I3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=215 µM for 1,2-naphthoquinone1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41NADP1 Publication1
    Binding sitei192NADP1 Publication1
    Binding sitei322NADP1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi148 – 154NADP1 Publication7
    Nucleotide bindingi173 – 177NADP1 Publication5
    Nucleotide bindingi264 – 266NADP1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Quinone oxidoreductase PIG3 (EC:1.-.-.-)
    Alternative name(s):
    Tumor protein p53-inducible protein 3
    p53-induced gene 3 protein
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TP53I3
    Synonyms:PIG3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000115129.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19373 TP53I3

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605171 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q53FA7

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51Y → A: Loss of enzyme activity. 1 Publication1
    Mutagenesisi51Y → F: Increased enzyme activity. 1 Publication1
    Mutagenesisi151S → V: Loss of enzyme activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    9540

    Open Targets

    More...
    OpenTargetsi
    ENSG00000115129

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134923704

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    TP53I3

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    76789665

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001609171 – 332Quinone oxidoreductase PIG3Add BLAST332

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q53FA7

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q53FA7

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q53FA7

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q53FA7

    PeptideAtlas

    More...
    PeptideAtlasi
    Q53FA7

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q53FA7

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    62462
    62463 [Q53FA7-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q53FA7

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q53FA7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation. Isoform 2 is highly activated by UV radiation.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000115129 Expressed in 184 organ(s), highest expression level in lower esophagus mucosa

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q53FA7 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q53FA7 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB017479
    HPA022012
    HPA028742

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114915, 11 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q53FA7, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000238721

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1332
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2J8ZX-ray2.50A1-332[»]
    2OBYX-ray3.00A/B/C/D/E1-332[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q53FA7

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q53FA7

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q53FA7

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1198 Eukaryota
    COG0604 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161217

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000294672

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG097584

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q53FA7

    KEGG Orthology (KO)

    More...
    KOi
    K10133

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MVGGDYI

    Database of Orthologous Groups

    More...
    OrthoDBi
    1085436at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q53FA7

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300079

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd05276 p53_inducible_oxidoreductase, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR020843 PKS_ER
    IPR014189 Quinone_OxRdtase_PIG3

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00829 PKS_ER, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50129 SSF50129, 1 hit
    SSF51735 SSF51735, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02824 quinone_pig3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Note: UV radiation favors the production of isoform 2.

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q53FA7-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ
    60 70 80 90 100
    YDPPPGASNI LGLEASGHVA ELGPGCQGHW KIGDTAMALL PGGGQAQYVT
    110 120 130 140 150
    VPEGLLMPIP EGLTLTQAAA IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL
    160 170 180 190 200
    SGVGTAAIQL TRMAGAIPLV TAGSQKKLQM AEKLGAAAGF NYKKEDFSEA
    210 220 230 240 250
    TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL MGGGDINGPL
    260 270 280 290 300
    FSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV
    310 320 330
    LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ
    Note: Major isoform under normal light conditions.
    Length:332
    Mass (Da):35,536
    Last modified:September 27, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5A33C46B3F96473
    GO
    Isoform 2 (identifier: Q53FA7-2) [UniParc]FASTAAdd to basket
    Also known as: PIG3AS

    The sequence of this isoform differs from the canonical sequence as follows:
         207-248: GAGVNLILDC...GLMGGGDING → VQANAGECFH...LPSDRNPGGP
         249-332: Missing.

    Note: Major isoform under UV light exposure. Undergoes rapid proteolytic degradation by the proteasome.
    Show »
    Length:248
    Mass (Da):25,402
    Checksum:i8899613C763DDDDC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7BZH6H7BZH6_HUMAN
    Quinone oxidoreductase PIG3
    TP53I3
    216Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAC39535 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36A → AA in AAC39535 (PubMed:9305847).Curated1
    Sequence conflicti263T → A in BAD97102 (Ref. 4) Curated1
    Sequence conflicti315 – 332KYMEA…LELPQ → STWRPTRT in AAC39528 (PubMed:9305847).CuratedAdd BLAST18

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033032180M → K in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs899619458Ensembl.1
    Natural variantiVAR_048201223E → K. Corresponds to variant dbSNP:rs35176319Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015783207 – 248GAGVN…GDING → VQANAGECFHGANSASLLHG GPPTSAAGSGQNLPSDRNPG GP in isoform 2. 1 PublicationAdd BLAST42
    Alternative sequenceiVSP_015784249 – 332Missing in isoform 2. 1 PublicationAdd BLAST84

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF010309 mRNA Translation: AAC39528.1
    AF010317 Genomic DNA Translation: AAC39535.1 Sequence problems.
    AY371700 mRNA Translation: AAQ90166.1
    BT007149 mRNA Translation: AAP35813.1
    AK223382 mRNA Translation: BAD97102.1
    DQ232851 Genomic DNA Translation: ABB02183.1
    AC008073 Genomic DNA Translation: AAY14665.1
    CH471053 Genomic DNA Translation: EAX00762.1
    CH471053 Genomic DNA Translation: EAX00763.1
    CH471053 Genomic DNA Translation: EAX00766.1
    BC000474 mRNA Translation: AAH00474.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1708.1 [Q53FA7-1]
    CCDS56112.1 [Q53FA7-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001193731.1, NM_001206802.2 [Q53FA7-2]
    NP_004872.2, NM_004881.4 [Q53FA7-1]
    NP_671713.1, NM_147184.3 [Q53FA7-1]
    XP_006712213.1, XM_006712150.2 [Q53FA7-2]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.50649
    Hs.733381

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000238721; ENSP00000238721; ENSG00000115129 [Q53FA7-1]
    ENST00000335934; ENSP00000337834; ENSG00000115129 [Q53FA7-1]
    ENST00000407482; ENSP00000384414; ENSG00000115129 [Q53FA7-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9540

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:9540

    UCSC genome browser

    More...
    UCSCi
    uc002rex.3 human [Q53FA7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF010309 mRNA Translation: AAC39528.1
    AF010317 Genomic DNA Translation: AAC39535.1 Sequence problems.
    AY371700 mRNA Translation: AAQ90166.1
    BT007149 mRNA Translation: AAP35813.1
    AK223382 mRNA Translation: BAD97102.1
    DQ232851 Genomic DNA Translation: ABB02183.1
    AC008073 Genomic DNA Translation: AAY14665.1
    CH471053 Genomic DNA Translation: EAX00762.1
    CH471053 Genomic DNA Translation: EAX00763.1
    CH471053 Genomic DNA Translation: EAX00766.1
    BC000474 mRNA Translation: AAH00474.1
    CCDSiCCDS1708.1 [Q53FA7-1]
    CCDS56112.1 [Q53FA7-2]
    RefSeqiNP_001193731.1, NM_001206802.2 [Q53FA7-2]
    NP_004872.2, NM_004881.4 [Q53FA7-1]
    NP_671713.1, NM_147184.3 [Q53FA7-1]
    XP_006712213.1, XM_006712150.2 [Q53FA7-2]
    UniGeneiHs.50649
    Hs.733381

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2J8ZX-ray2.50A1-332[»]
    2OBYX-ray3.00A/B/C/D/E1-332[»]
    ProteinModelPortaliQ53FA7
    SMRiQ53FA7
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi114915, 11 interactors
    IntActiQ53FA7, 4 interactors
    STRINGi9606.ENSP00000238721

    PTM databases

    iPTMnetiQ53FA7
    PhosphoSitePlusiQ53FA7

    Polymorphism and mutation databases

    BioMutaiTP53I3
    DMDMi76789665

    Proteomic databases

    EPDiQ53FA7
    jPOSTiQ53FA7
    MaxQBiQ53FA7
    PaxDbiQ53FA7
    PeptideAtlasiQ53FA7
    PRIDEiQ53FA7
    ProteomicsDBi62462
    62463 [Q53FA7-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    9540
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000238721; ENSP00000238721; ENSG00000115129 [Q53FA7-1]
    ENST00000335934; ENSP00000337834; ENSG00000115129 [Q53FA7-1]
    ENST00000407482; ENSP00000384414; ENSG00000115129 [Q53FA7-2]
    GeneIDi9540
    KEGGihsa:9540
    UCSCiuc002rex.3 human [Q53FA7-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9540
    DisGeNETi9540
    EuPathDBiHostDB:ENSG00000115129.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    TP53I3
    HGNCiHGNC:19373 TP53I3
    HPAiCAB017479
    HPA022012
    HPA028742
    MIMi605171 gene
    neXtProtiNX_Q53FA7
    OpenTargetsiENSG00000115129
    PharmGKBiPA134923704

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1198 Eukaryota
    COG0604 LUCA
    GeneTreeiENSGT00940000161217
    HOGENOMiHOG000294672
    HOVERGENiHBG097584
    InParanoidiQ53FA7
    KOiK10133
    OMAiMVGGDYI
    OrthoDBi1085436at2759
    PhylomeDBiQ53FA7
    TreeFamiTF300079

    Enzyme and pathway databases

    ReactomeiR-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

    Miscellaneous databases

    EvolutionaryTraceiQ53FA7

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    TP53I3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9540

    Protein Ontology

    More...
    PROi
    PR:Q53FA7

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000115129 Expressed in 184 organ(s), highest expression level in lower esophagus mucosa
    ExpressionAtlasiQ53FA7 baseline and differential
    GenevisibleiQ53FA7 HS

    Family and domain databases

    CDDicd05276 p53_inducible_oxidoreductase, 1 hit
    InterProiView protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR020843 PKS_ER
    IPR014189 Quinone_OxRdtase_PIG3
    PfamiView protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit
    SMARTiView protein in SMART
    SM00829 PKS_ER, 1 hit
    SUPFAMiSSF50129 SSF50129, 1 hit
    SSF51735 SSF51735, 1 hit
    TIGRFAMsiTIGR02824 quinone_pig3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQORX_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53FA7
    Secondary accession number(s): D6W533
    , O14679, O14685, Q38G78, Q6JLE7, Q9BWB8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: February 13, 2019
    This is version 127 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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