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UniProtKB - Q53EZ4 (CEP55_HUMAN)

Entry version 153 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Centrosomal protein of 55 kDa

Gene

CEP55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q53EZ4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q53EZ4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 55 kDaImported
Short name:
Cep55
Alternative name(s):
Up-regulated in colon cancer 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP55Imported
Synonyms:C10orf3Imported, URCC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000138180.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:1161, CEP55

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610000, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q53EZ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, congenital disease characterized by severe hydranencephaly with multinucleated neurons, renal aplasia or dysplasia, and hypoplastic kidneys. Hydranencephaly is an anomaly leading to replacement of the cerebral hemispheres with a fluid-filled cyst. MARCH results in death in utero or in the perinatal period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07936386 – 464Missing in MARCH. 1 PublicationAdd BLAST379
Natural variantiVAR_079364425 – 464Missing in MARCH; loss of protein localization to midbody ring; loss of function; fails to rescue craniofacial development when expressed in a zebrafish heterologous system. 1 PublicationAdd BLAST40

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi184W → A: Abolishes interaction with PDCD6IP. 1 Publication1
Mutagenesisi187Y → A: Abolishes interaction with PDCD6IP. 1 Publication1
Mutagenesisi188D → A: Diminishes interaction with PDCD6IP. 1 Publication1
Mutagenesisi191R → A: Abolishes interaction with PDCD6IP. 1 Publication1
Mutagenesisi192E → A: Abolishes interaction with PDCD6IP. 1 Publication1
Mutagenesisi396S → A: No effect on phosphorylation in mitotic cells. 1 Publication1
Mutagenesisi425S → A: Partial loss of phosphorylation in mitotic cells. Complete loss of phosphorylation in mitotic cells; when associated with A-428. Remains associated with the centrosome throughout mitosis; when associated with A-428. Arrests mitotic cells at the midbody stage; when associated with A-428 and A-436. 1 Publication1
Mutagenesisi428S → A: Partial loss of phosphorylation in mitotic cells. Complete loss of phosphorylation in mitotic cells; when associated with A-425. Remains associated with the centrosome throughout mitosis; when associated with A-425. Arrests mitotic cells at the midbody stage; when associated with A-425 and A-436. 1 Publication1
Mutagenesisi436S → A: No effect on phosphorylation in mitotic cells. Arrests mitotic cells at the midbody stage; when associated with A-425 and A-428. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		55165

MalaCards human disease database

More...MalaCardsi		CEP55
MIMi236500, phenotype

Open Targets

More...OpenTargetsi		ENSG00000138180

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		564, Meckel syndrome
500135, Multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q53EZ4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CEP55

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439403

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897771 – 464Centrosomal protein of 55 kDaAdd BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei96PhosphoserineBy similarity1
Modified residuei425Phosphoserine; by CDK1 and MAPK1Combined sources1 Publication1
Modified residuei428Phosphoserine; by CDK1 and MAPK1Combined sources1 Publication1
Modified residuei430PhosphothreonineCombined sources1
Modified residuei436Phosphoserine; by PLK1Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q53EZ4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q53EZ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q53EZ4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q53EZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q53EZ4

PeptideAtlas

More...PeptideAtlasi		Q53EZ4

PRoteomics IDEntifications database

More...PRIDEi		Q53EZ4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62452 [Q53EZ4-1]
62453 [Q53EZ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q53EZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q53EZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28295209, PubMed:28264986). Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138180, Expressed in female gonad and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q53EZ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q53EZ4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138180, Tissue enhanced (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:16406728).

Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1 (PubMed:16198290).

Interacts with AKAP9/CG-NAP; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290).

Interacts with PCNT/Kendrin; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Directly interacts with PDCD6IP; this interaction is required for PDCD6IP targeting to the midbody; CEP55 binds PDCD6IP in a 2:1 stoichiometry; PDCD6IP competes with TSG101 for the same binding site (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538).

Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding (PubMed:17853893, PubMed:17556548, PubMed:18948538).

Interacts with MVB12A, VPS37B, VPS37C and VPS28 (PubMed:17853893).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q53EZ4
With#Exp.IntAct
ANXA11 [P50995]8EBI-747776,EBI-715243
ANXA11 [Q5T0G8]3EBI-747776,EBI-10245225
ARHGEF15 [D3DTR7]3EBI-747776,EBI-10176602
ARHGEF15 [O94989]6EBI-747776,EBI-740691
C1orf109 [Q9NX04]6EBI-747776,EBI-8643161
C1orf216 [Q8TAB5]3EBI-747776,EBI-747505
CBY2 - isoform 2 [Q8NA61-2]3EBI-747776,EBI-11524851
CCBE1 [Q6UXH8]3EBI-747776,EBI-3923278
CCBE1 - isoform 3 [Q6UXH8-3]3EBI-747776,EBI-12013534
CCDC120 [Q96HB5]3EBI-747776,EBI-744556
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-747776,EBI-10175300
CDC37 [Q16543]3EBI-747776,EBI-295634
CDC45 [O75419]7EBI-747776,EBI-374969
itself3EBI-747776,EBI-747776
CEP57L1 [Q8IYX8]4EBI-747776,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-747776,EBI-10181988
COL8A1 [P27658]3EBI-747776,EBI-747133
DTNB [O60941]3EBI-747776,EBI-740402
DTNB - isoform 5 [O60941-5]3EBI-747776,EBI-11984733
EIF1AD [Q8N9N8]5EBI-747776,EBI-750700
ENKD1 [Q9H0I2]3EBI-747776,EBI-744099
FAM161B [Q96MY7]3EBI-747776,EBI-7225287
FAM90A1 [Q86YD7]6EBI-747776,EBI-6658203
FBF1 - isoform 6 [Q8TES7-6]3EBI-747776,EBI-10244131
FXR2 [P51116]3EBI-747776,EBI-740459
GOLGA8DP [Q0D2H9]3EBI-747776,EBI-10181276
HAUS1 [Q96CS2]3EBI-747776,EBI-2514791
HGS [O14964]5EBI-747776,EBI-740220
HSF2BP [O75031]3EBI-747776,EBI-7116203
KANK2 [Q63ZY3]3EBI-747776,EBI-2556193
KIFC3 [Q9BVG8]3EBI-747776,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-747776,EBI-14069005
LGALS4 [P56470]3EBI-747776,EBI-720805
LRRC23 [Q53EV4]3EBI-747776,EBI-13435308
MAPK1IP1L [Q8NDC0]3EBI-747776,EBI-741424
MFAP1 [P55081]6EBI-747776,EBI-1048159
MIA3 - isoform 2 [Q5JRA6-2]4EBI-747776,EBI-10244342
MORF4L2 [Q15014]6EBI-747776,EBI-399257
PDCD6IP [Q8WUM4]16EBI-747776,EBI-310624
PEF1 [Q9UBV8]6EBI-747776,EBI-724639
PIN1 [Q13526]3EBI-747776,EBI-714158
PLEKHG6 [Q3KR16]8EBI-747776,EBI-10240979
POLM [Q6PIY2]6EBI-747776,EBI-10253863
PPP1R16B [Q96T49]5EBI-747776,EBI-10293968
PTPN23 [Q9H3S7]3EBI-747776,EBI-724478
PWWP3A - isoform 2 [Q2TAK8-2]3EBI-747776,EBI-10239402
RBM17 [Q96I25]8EBI-747776,EBI-740272
RBM22 [Q9NW64]6EBI-747776,EBI-2602260
RCOR3 [Q9P2K3]3EBI-747776,EBI-743428
SDCBP [O00560]6EBI-747776,EBI-727004
SNRPB - isoform SM-B [P14678-2]3EBI-747776,EBI-372475
SNW1 [Q13573]3EBI-747776,EBI-632715
SS18L1 - isoform 5 [O75177-5]3EBI-747776,EBI-12035119
SSX2IP [Q9Y2D8]5EBI-747776,EBI-2212028
TCL1A [P56279]6EBI-747776,EBI-749995
TEAD4 [D3DUQ6]3EBI-747776,EBI-10176734
TEAD4 [Q15561]5EBI-747776,EBI-747736
TEX14 [Q8IWB6]3EBI-747776,EBI-6674697
TFG [Q92734]6EBI-747776,EBI-357061
TP53BP2 [Q05BL1]3EBI-747776,EBI-11952721
TSG101 [Q99816]24EBI-747776,EBI-346882
VPS37C [A5D8V6]8EBI-747776,EBI-2559305
WASHC3 [Q9Y3C0]7EBI-747776,EBI-712969
WDYHV1 [Q96HA8]5EBI-747776,EBI-741158
ZNF48 [Q96MX3]3EBI-747776,EBI-12006434
A8K9C13EBI-747776,EBI-10174800

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120465, 141 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q53EZ4

Database of interacting proteins

More...DIPi		DIP-44581N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q53EZ4

Protein interaction database and analysis system

More...IntActi		Q53EZ4, 118 interactors

Molecular INTeraction database

More...MINTi		Q53EZ4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360540

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q53EZ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q53EZ4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q53EZ4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 236Interaction with TSG101Add BLAST80
Regioni160 – 214Interaction with PDCD6IPAdd BLAST55
Regioni355 – 464Required for localization to the interphase centrosome and to the midbody during cytokinesis1 PublicationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 186Sequence analysisAdd BLAST165
Coiled coili238 – 337Sequence analysisAdd BLAST100
Coiled coili374 – 403Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTDI, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000047961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047132_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q53EZ4

KEGG Orthology (KO)

More...KOi		K16456

Identification of Orthologs from Complete Genome Data

More...OMAi		SNIHEME

Database of Orthologous Groups

More...OrthoDBi		850483at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q53EZ4

TreeFam database of animal gene trees

More...TreeFami		TF331107

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038926, CEP55
IPR022008, EABR

The PANTHER Classification System

More...PANTHERi		PTHR31838, PTHR31838, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12180, EABR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q53EZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSRSTKDLI KSKWGSKPSN SKSETTLEKL KGEIAHLKTS VDEITSGKGK 
        60         70         80         90        100
LTDKERHRLL EKIRVLEAEK EKNAYQLTEK DKEIQRLRDQ LKARYSTTTL 
       110        120        130        140        150
LEQLEETTRE GERREQVLKA LSEEKDVLKQ QLSAATSRIA ELESKTNTLR 
       160        170        180        190        200
LSQTVAPNCF NSSINNIHEM EIQLKDALEK NQQWLVYDQQ REVYVKGLLA 
       210        220        230        240        250
KIFELEKKTE TAAHSLPQQT KKPESEGYLQ EEKQKCYNDL LASAKKDLEV 
       260        270        280        290        300
ERQTITQLSF ELSEFRRKYE ETQKEVHNLN QLLYSQRRAD VQHLEDDRHK 
       310        320        330        340        350
TEKIQKLREE NDIARGKLEE EKKRSEELLS QVQFLYTSLL KQQEEQTRVA 
       360        370        380        390        400
LLEQQMQACT LDFENEKLDR QHVQHQLHVI LKELRKARNQ ITQLESLKQL 
       410        420        430        440        450
HEFAITEPLV TFQGETENRE KVAASPKSPT AALNESLVEC PKCNIQYPAT 
       460 
EHRDLLVHVE YCSK
Length:464
Mass (Da):54,178
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA652F86EBCE46A51
GO
Isoform 2 (identifier: Q53EZ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-400: NQITQLESLKQL → KNNTVGILETAS
     401-464: Missing.

Show »
Length:400
Mass (Da):46,857
Checksum:i61FCFE0A0965559F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y432H0Y432_HUMAN
Centrosomal protein of 55 kDa
CEP55
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91670 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155V → A in BAD97215 (Ref. 4) Curated1
Sequence conflicti204E → G in BAD97215 (Ref. 4) Curated1
Sequence conflicti298R → G in CAE45837 (PubMed:17974005).Curated1
Sequence conflicti334F → S in AAX14687 (PubMed:16406728).Curated1
Sequence conflicti334F → S in BAA91670 (PubMed:14702039).Curated1
Sequence conflicti435E → G in AAX14687 (PubMed:16406728).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02655957H → Q Polymorphism; no effect on protein localization to midbody ring. 3 PublicationsCorresponds to variant dbSNP:rs3740370Ensembl.1
Natural variantiVAR_07936386 – 464Missing in MARCH. 1 PublicationAdd BLAST379
Natural variantiVAR_02299699T → ACombined sources7 PublicationsCorresponds to variant dbSNP:rs7080916Ensembl.1
Natural variantiVAR_056791236C → R. Corresponds to variant dbSNP:rs7072484Ensembl.1
Natural variantiVAR_022997378H → L Polymorphism; no effect on protein localization to midbody ring; rescues craniofacial development when expressed in a zebrafish heterologous system. 5 PublicationsCorresponds to variant dbSNP:rs2293277Ensembl.1
Natural variantiVAR_079364425 – 464Missing in MARCH; loss of protein localization to midbody ring; loss of function; fails to rescue craniofacial development when expressed in a zebrafish heterologous system. 1 PublicationAdd BLAST40

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014750389 – 400NQITQ…SLKQL → KNNTVGILETAS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_014751401 – 464Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY788918 mRNA Translation: AAX14687.1
AB091343 mRNA Translation: BAE45243.1
AK001402 mRNA Translation: BAA91670.1 Different initiation.
AK315536 mRNA Translation: BAG37915.1
AK223495 mRNA Translation: BAD97215.1
BX640718 mRNA Translation: CAE45837.1
AL356214 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50071.1
CH471066 Genomic DNA Translation: EAW50072.1
BC008947 mRNA Translation: AAH08947.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7428.1 [Q53EZ4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001120654.1, NM_001127182.1 [Q53EZ4-1]
NP_060601.3, NM_018131.4 [Q53EZ4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371485; ENSP00000360540; ENSG00000138180 [Q53EZ4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55165

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55165

UCSC genome browser

More...UCSCi		uc001kiq.4, human [Q53EZ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY788918 mRNA Translation: AAX14687.1
AB091343 mRNA Translation: BAE45243.1
AK001402 mRNA Translation: BAA91670.1 Different initiation.
AK315536 mRNA Translation: BAG37915.1
AK223495 mRNA Translation: BAD97215.1
BX640718 mRNA Translation: CAE45837.1
AL356214 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50071.1
CH471066 Genomic DNA Translation: EAW50072.1
BC008947 mRNA Translation: AAH08947.1
CCDSiCCDS7428.1 [Q53EZ4-1]
RefSeqiNP_001120654.1, NM_001127182.1 [Q53EZ4-1]
NP_060601.3, NM_018131.4 [Q53EZ4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E1RX-ray2.00A/B160-217[»]
3WUTX-ray2.30A/B/D/E/G/H/J/K160-217[»]
3WUUX-ray2.90A/B/D/E/G/H/J/K160-217[»]
3WUVX-ray2.79A/B/D/E/G/H/J/K/M/N/P/Q160-217[»]
SMRiQ53EZ4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120465, 141 interactors
CORUMiQ53EZ4
DIPiDIP-44581N
ELMiQ53EZ4
IntActiQ53EZ4, 118 interactors
MINTiQ53EZ4
STRINGi9606.ENSP00000360540

PTM databases

iPTMnetiQ53EZ4
PhosphoSitePlusiQ53EZ4

Polymorphism and mutation databases

BioMutaiCEP55
DMDMi296439403

Proteomic databases

EPDiQ53EZ4
jPOSTiQ53EZ4
MassIVEiQ53EZ4
MaxQBiQ53EZ4
PaxDbiQ53EZ4
PeptideAtlasiQ53EZ4
PRIDEiQ53EZ4
ProteomicsDBi62452 [Q53EZ4-1]
62453 [Q53EZ4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30468, 299 antibodies

The DNASU plasmid repository

More...DNASUi		55165

Genome annotation databases

EnsembliENST00000371485; ENSP00000360540; ENSG00000138180 [Q53EZ4-1]
GeneIDi55165
KEGGihsa:55165
UCSCiuc001kiq.4, human [Q53EZ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55165
DisGeNETi55165
EuPathDBiHostDB:ENSG00000138180.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		CEP55
HGNCiHGNC:1161, CEP55
HPAiENSG00000138180, Tissue enhanced (lymphoid tissue, testis)
MalaCardsiCEP55
MIMi236500, phenotype
610000, gene
neXtProtiNX_Q53EZ4
OpenTargetsiENSG00000138180
Orphaneti564, Meckel syndrome
500135, Multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome
PharmGKBiPA25475

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTDI, Eukaryota
GeneTreeiENSGT00510000047961
HOGENOMiCLU_047132_0_0_1
InParanoidiQ53EZ4
KOiK16456
OMAiSNIHEME
OrthoDBi850483at2759
PhylomeDBiQ53EZ4
TreeFamiTF331107

Enzyme and pathway databases

PathwayCommonsiQ53EZ4
SIGNORiQ53EZ4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55165, 180 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CEP55, human
EvolutionaryTraceiQ53EZ4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CEP55

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55165
PharosiQ53EZ4, Tbio

Protein Ontology

More...PROi		PR:Q53EZ4
RNActiQ53EZ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138180, Expressed in female gonad and 140 other tissues
ExpressionAtlasiQ53EZ4, baseline and differential
GenevisibleiQ53EZ4, HS

Family and domain databases

InterProiView protein in InterPro
IPR038926, CEP55
IPR022008, EABR
PANTHERiPTHR31838, PTHR31838, 1 hit
PfamiView protein in Pfam
PF12180, EABR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP55_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53EZ4
Secondary accession number(s): B2RDG8
, D3DR37, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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