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Protein

Leucine-rich repeat-containing protein 23

Gene

LRRC23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 23
Alternative name(s):
Leucine-rich protein B7
Gene namesi
Name:LRRC23
Synonyms:LRPB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000010626.14
HGNCiHGNC:19138 LRRC23
neXtProtiNX_Q53EV4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000010626
PharmGKBiPA143485529

Polymorphism and mutation databases

BioMutaiLRRC23
DMDMi119371993

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642361 – 343Leucine-rich repeat-containing protein 23Add BLAST343

Proteomic databases

PaxDbiQ53EV4
PeptideAtlasiQ53EV4
PRIDEiQ53EV4
ProteomicsDBi62450
62451 [Q53EV4-2]

PTM databases

iPTMnetiQ53EV4
PhosphoSitePlusiQ53EV4

Expressioni

Gene expression databases

BgeeiENSG00000010626 Expressed in 171 organ(s), highest expression level in right uterine tube
CleanExiHS_LRRC23
ExpressionAtlasiQ53EV4 baseline and differential
GenevisibleiQ53EV4 HS

Organism-specific databases

HPAiHPA037766
HPA057533

Interactioni

Protein-protein interaction databases

BioGridi115527, 1 interactor
IntActiQ53EV4, 1 interactor
STRINGi9606.ENSP00000007969

Structurei

3D structure databases

ProteinModelPortaliQ53EV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 113LRR 1Add BLAST22
Repeati114 – 134LRR 2Add BLAST21
Repeati135 – 155LRR 3Add BLAST21
Repeati156 – 177LRR 4Add BLAST22
Repeati180 – 200LRR 5Add BLAST21
Repeati201 – 222LRR 6Add BLAST22
Repeati223 – 244LRR 7Add BLAST22
Repeati246 – 267LRR 8Add BLAST22
Domaini280 – 318LRRCTAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili307 – 329Sequence analysisAdd BLAST23

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00900000140836
HOGENOMiHOG000006511
HOVERGENiHBG052867
InParanoidiQ53EV4
OMAiQMPYLER
OrthoDBiEOG091G0DWM
PhylomeDBiQ53EV4
TreeFamiTF329158

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q53EV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDEDDLEDS EPDQDDSEKE EDEKETEEGE DYRKEGEEFP EEWLPTPLTE
60 70 80 90 100
DMMKEGLSLL CKTGNGLAHA YVKLEVKERD LTDIYLLRSY IHLRYVDISE
110 120 130 140 150
NHLTDLSPLN YLTHLLWLKA DGNRLRSAQM NELPYLQIAS FAYNQITDTE
160 170 180 190 200
GISHPRLETL NLKGNSIHMV TGLDPEKLIS LHTVELRGNQ LESTLGINLP
210 220 230 240 250
KLKNLYLAQN MLKKVEGLED LSNLTTLHLR DNQIDTLSGF SREMKSLQYL
260 270 280 290 300
NLRGNMVANL GELAKLRDLP KLRALVLLDN PCTDETSYRQ EALVQMPYLE
310 320 330 340
RLDKEFYEEE ERAEADVIRQ RLKEEKEQEP EPQRDLEPEQ SLI
Length:343
Mass (Da):39,761
Last modified:December 12, 2006 - v2
Checksum:i27FF858EC42AFE21
GO
Isoform 2 (identifier: Q53EV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-343: GNMVANLGEL...RDLEPEQSLI → RSKTLAFRPD...WAVWGAEWGA

Show »
Length:312
Mass (Da):36,081
Checksum:i7642881FAD2C4F41
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JEW3C9JEW3_HUMAN
Leucine-rich repeat-containing prot...
LRRC23
216Annotation score:
C9JKE8C9JKE8_HUMAN
Leucine-rich repeat-containing prot...
LRRC23
230Annotation score:
E9PDZ4E9PDZ4_HUMAN
Leucine-rich repeat-containing prot...
LRRC23
202Annotation score:
C9JQN5C9JQN5_HUMAN
Leucine-rich repeat-containing prot...
LRRC23
94Annotation score:
F2Z299F2Z299_HUMAN
Leucine-rich repeat-containing prot...
LRRC23
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153S → P in BAD97255 (Ref. 3) Curated1
Isoform 2 (identifier: Q53EV4-2)
Sequence conflicti276E → G in AAC51638 (PubMed:9074930).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05110665N → H. Corresponds to variant dbSNP:rs2071072Ensembl.1
Natural variantiVAR_051107124R → L1 PublicationCorresponds to variant dbSNP:rs2071073Ensembl.1
Natural variantiVAR_051108317V → E. Corresponds to variant dbSNP:rs1057077Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021889254 – 343GNMVA…EQSLI → RSKTLAFRPDQTPRGSHHMY DREQRMPVFAPKLEIHHNLR PRICSVPVLWAVWGAEWGA in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA Translation: AAB51319.1
U72508 mRNA Translation: AAC51638.1
AK223535 mRNA Translation: BAD97255.1
AK292291 mRNA Translation: BAF84980.1
CH471116 Genomic DNA Translation: EAW88716.1
CH471116 Genomic DNA Translation: EAW88714.1
CH471116 Genomic DNA Translation: EAW88715.1
BC029858 mRNA Translation: AAH29858.1
CCDSiCCDS8568.1 [Q53EV4-2]
CCDS8569.1 [Q53EV4-1]
RefSeqiNP_001128689.1, NM_001135217.1 [Q53EV4-1]
NP_008923.1, NM_006992.3 [Q53EV4-2]
NP_964013.1, NM_201650.2 [Q53EV4-1]
UniGeneiHs.155586
Hs.661103

Genome annotation databases

EnsembliENST00000007969; ENSP00000007969; ENSG00000010626 [Q53EV4-1]
ENST00000323702; ENSP00000317464; ENSG00000010626 [Q53EV4-2]
ENST00000443597; ENSP00000390932; ENSG00000010626 [Q53EV4-1]
GeneIDi10233
KEGGihsa:10233
UCSCiuc001qrp.4 human [Q53EV4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA Translation: AAB51319.1
U72508 mRNA Translation: AAC51638.1
AK223535 mRNA Translation: BAD97255.1
AK292291 mRNA Translation: BAF84980.1
CH471116 Genomic DNA Translation: EAW88716.1
CH471116 Genomic DNA Translation: EAW88714.1
CH471116 Genomic DNA Translation: EAW88715.1
BC029858 mRNA Translation: AAH29858.1
CCDSiCCDS8568.1 [Q53EV4-2]
CCDS8569.1 [Q53EV4-1]
RefSeqiNP_001128689.1, NM_001135217.1 [Q53EV4-1]
NP_008923.1, NM_006992.3 [Q53EV4-2]
NP_964013.1, NM_201650.2 [Q53EV4-1]
UniGeneiHs.155586
Hs.661103

3D structure databases

ProteinModelPortaliQ53EV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115527, 1 interactor
IntActiQ53EV4, 1 interactor
STRINGi9606.ENSP00000007969

PTM databases

iPTMnetiQ53EV4
PhosphoSitePlusiQ53EV4

Polymorphism and mutation databases

BioMutaiLRRC23
DMDMi119371993

Proteomic databases

PaxDbiQ53EV4
PeptideAtlasiQ53EV4
PRIDEiQ53EV4
ProteomicsDBi62450
62451 [Q53EV4-2]

Protocols and materials databases

DNASUi10233
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007969; ENSP00000007969; ENSG00000010626 [Q53EV4-1]
ENST00000323702; ENSP00000317464; ENSG00000010626 [Q53EV4-2]
ENST00000443597; ENSP00000390932; ENSG00000010626 [Q53EV4-1]
GeneIDi10233
KEGGihsa:10233
UCSCiuc001qrp.4 human [Q53EV4-1]

Organism-specific databases

CTDi10233
EuPathDBiHostDB:ENSG00000010626.14
GeneCardsiLRRC23
HGNCiHGNC:19138 LRRC23
HPAiHPA037766
HPA057533
neXtProtiNX_Q53EV4
OpenTargetsiENSG00000010626
PharmGKBiPA143485529
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00900000140836
HOGENOMiHOG000006511
HOVERGENiHBG052867
InParanoidiQ53EV4
OMAiQMPYLER
OrthoDBiEOG091G0DWM
PhylomeDBiQ53EV4
TreeFamiTF329158

Miscellaneous databases

ChiTaRSiLRRC23 human
GeneWikiiLRRC23
GenomeRNAii10233
PROiPR:Q53EV4

Gene expression databases

BgeeiENSG00000010626 Expressed in 171 organ(s), highest expression level in right uterine tube
CleanExiHS_LRRC23
ExpressionAtlasiQ53EV4 baseline and differential
GenevisibleiQ53EV4 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC23_HUMAN
AccessioniPrimary (citable) accession number: Q53EV4
Secondary accession number(s): A8K8C6
, D3DUT1, Q8N6K6, Q92977, Q99620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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