UniProtKB - Q53EP0 (FND3B_HUMAN)
Protein
Fibronectin type III domain-containing protein 3B
Gene
FNDC3B
Organism
Homo sapiens (Human)
Status
Functioni
May be a positive regulator of adipogenesis.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q53EP0 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibronectin type III domain-containing protein 3BAlternative name(s): Factor for adipocyte differentiation 104 HCV NS5A-binding protein 37 |
Gene namesi | Name:FNDC3B Synonyms:FAD104, NS5ABP37 ORF Names:UNQ2421/PRO4979/PRO34274 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000075420.12 |
HGNCi | HGNC:24670, FNDC3B |
MIMi | 611909, gene |
neXtProti | NX_Q53EP0 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1182 – 1202 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 64778 |
OpenTargetsi | ENSG00000075420 |
PharmGKBi | PA134936830 |
Miscellaneous databases
Pharosi | Q53EP0, Tbio |
Polymorphism and mutation databases
BioMutai | FNDC3B |
DMDMi | 146286181 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284891 | 1 – 1204 | Fibronectin type III domain-containing protein 3BAdd BLAST | 1204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Modified residuei | 393 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1163 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q53EP0 |
jPOSTi | Q53EP0 |
MassIVEi | Q53EP0 |
MaxQBi | Q53EP0 |
PaxDbi | Q53EP0 |
PeptideAtlasi | Q53EP0 |
PRIDEi | Q53EP0 |
ProteomicsDBi | 62442 [Q53EP0-1] 62443 [Q53EP0-2] 62444 [Q53EP0-3] |
PTM databases
iPTMneti | Q53EP0 |
PhosphoSitePlusi | Q53EP0 |
Expressioni
Tissue specificityi
Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.1 Publication
Gene expression databases
Bgeei | ENSG00000075420, Expressed in calcaneal tendon and 235 other tissues |
ExpressionAtlasi | Q53EP0, baseline and differential |
Genevisiblei | Q53EP0, HS |
Organism-specific databases
HPAi | ENSG00000075420, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 3 [Q53EP0-3]
Protein-protein interaction databases
BioGRIDi | 122288, 65 interactors |
IntActi | Q53EP0, 65 interactors |
MINTi | Q53EP0 |
STRINGi | 9606.ENSP00000338523 |
Miscellaneous databases
RNActi | Q53EP0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 278 – 377 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 381 – 473 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 477 – 570 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 574 – 669 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 673 – 765 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 766 – 859 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 871 – 957 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 958 – 1052 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1056 – 1153 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 231 – 243 | Poly-GlyAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the FNDC3 family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0613, Eukaryota |
GeneTreei | ENSGT00940000157005 |
HOGENOMi | CLU_2739328_0_0_1 |
InParanoidi | Q53EP0 |
OMAi | ETVPPMR |
OrthoDBi | 633003at2759 |
PhylomeDBi | Q53EP0 |
TreeFami | TF316401 |
Family and domain databases
CDDi | cd00063, FN3, 9 hits |
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00041, fn3, 9 hits |
SMARTi | View protein in SMART SM00060, FN3, 9 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q53EP0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYVTMMMTDQ IPLELPPLLN GEVAMMPHLV NGDAAQQVIL VQVNPGETFT
60 70 80 90 100
IRAEDGTLQC IQGPAEVPMM SPNGSIPPIH VPPGYISQVI EDSTGVRRVV
110 120 130 140 150
VTPQSPECYP PSYPSAMSPT HHLPPYLTHH PHFIHNSHTA YYPPVTGPGD
160 170 180 190 200
MPPQFFPQHH LPHTIYGEQE IIPFYGMSTY ITREDQYSKP PHKKLKDRQI
210 220 230 240 250
DRQNRLNSPP SSIYKSSCTT VYNGYGKGHS GGSGGGGSGS GPGIKKTERR
260 270 280 290 300
ARSSPKSNDS DLQEYELEVK RVQDILSGIE KPQVSNIQAR AVVLSWAPPV
310 320 330 340 350
GLSCGPHSGL SFPYSYEVAL SDKGRDGKYK IIYSGEELEC NLKDLRPATD
360 370 380 390 400
YHVRVYAMYN SVKGSCSEPV SFTTHSCAPE CPFPPKLAHR SKSSLTLQWK
410 420 430 440 450
APIDNGSKIT NYLLEWDEGK RNSGFRQCFF GSQKHCKLTK LCPAMGYTFR
460 470 480 490 500
LAARNDIGTS GYSQEVVCYT LGNIPQMPSA PRLVRAGITW VTLQWSKPEG
510 520 530 540 550
CSPEEVITYT LEIQEDENDN LFHPKYTGED LTCTVKNLKR STQYKFRLTA
560 570 580 590 600
SNTEGKSCPS EVLVCTTSPD RPGPPTRPLV KGPVTSHGFS VKWDPPKDNG
610 620 630 640 650
GSEILKYLLE ITDGNSEANQ WEVAYSGSAT EYTFTHLKPG TLYKLRACCI
660 670 680 690 700
STGGHSQCSE SLPVRTLSIA PGQCRPPRVL GRPKHKEVHL EWDVPASESG
710 720 730 740 750
CEVSEYSVEM TEPEDVASEV YHGPELECTV GNLLPGTVYR FRVRALNDGG
760 770 780 790 800
YGPYSDVSEI TTAAGPPGQC KAPCISCTPD GCVLVGWESP DSSGADISEY
810 820 830 840 850
RLEWGEDEES LELIYHGTDT RFEIRDLLPA AQYCCRLQAF NQAGAGPYSE
860 870 880 890 900
LVLCQTPASA PDPVSTLCVL EEEPLDAYPD SPSACLVLNW EEPCNNGSEI
910 920 930 940 950
LAYTIDLGDT SITVGNTTMH VMKDLLPETT YRIRIQAINE IGAGPFSQFI
960 970 980 990 1000
KAKTRPLPPL PPRLECAAAG PQSLKLKWGD SNSKTHAAED IVYTLQLEDR
1010 1020 1030 1040 1050
NKRFISIYRG PSHTYKVQRL TEFTCYSFRI QAASEAGEGP FSETYTFSTT
1060 1070 1080 1090 1100
KSVPPTIKAP RVTQLEGNSC EILWETVPSM KGDPVNYILQ VLVGRESEYK
1110 1120 1130 1140 1150
QVYKGEEATF QISGLQTNTD YRFRVCACRR CLDTSQELSG AFSPSAAFVL
1160 1170 1180 1190 1200
QRSEVMLTGD MGSLDDPKMK SMMPTDEQFA AIIVLGFATL SILFAFILQY
FLMK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JKH7 | C9JKH7_HUMAN | Fibronectin type III domain-contain... | FNDC3B | 208 | Annotation score: |
Sequence cautioni
The sequence AAH12204 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33635 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ88513 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ88733 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15639 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11480 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | Q → H in AAQ88733 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 208 | S → R in BAC53727 (PubMed:15564382).Curated | 1 | |
Sequence conflicti | 212 | S → A in BAC53727 (PubMed:15564382).Curated | 1 | |
Sequence conflicti | 360 | N → D in BAG37083 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 393 | S → G in BAG37083 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 448 | T → A in BAG37083 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 481 | P → L in AAQ88513 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 545 | K → T in BAC53727 (PubMed:15564382).Curated | 1 | |
Sequence conflicti | 676 | P → S in BAD97319 (Ref. 4) Curated | 1 | |
Sequence conflicti | 854 | C → W in AAH39297 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 895 | N → D in BAC11480 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1067 | G → V in AAQ88513 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 1083 | D → G in BAG37083 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031856 | 179 | T → S5 PublicationsCorresponds to variant dbSNP:rs7652177Ensembl. | 1 | |
Natural variantiVAR_035921 | 927 | P → S in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_047814 | 1080 | M → V. Corresponds to variant dbSNP:rs2276806Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024739 | 63 – 71 | GPAEVPMMS → DEVVKRACD in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_024740 | 72 – 1204 | Missing in isoform 3. 1 PublicationAdd BLAST | 1133 | |
Alternative sequenceiVSP_024741 | 618 – 629 | ANQWE…YSGSA → GEVFGNCFIQIQ in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_024742 | 630 – 1204 | Missing in isoform 2. 1 PublicationAdd BLAST | 575 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098597 mRNA Translation: BAC53727.1 AY358146 mRNA Translation: AAQ88513.1 Different initiation. AY358367 mRNA Translation: AAQ88733.1 Different initiation. AK027052 mRNA Translation: BAB15639.1 Different initiation. AK075220 mRNA Translation: BAC11480.1 Different initiation. AK127826 mRNA Translation: BAG54580.1 AK314478 mRNA Translation: BAG37083.1 AK223599 mRNA Translation: BAD97319.1 CH471052 Genomic DNA Translation: EAW78476.1 CH471052 Genomic DNA Translation: EAW78472.1 CH471052 Genomic DNA Translation: EAW78474.1 CH471052 Genomic DNA Translation: EAW78475.1 BC012204 mRNA Translation: AAH12204.1 Different initiation. BC033635 mRNA Translation: AAH33635.1 Different initiation. BC039297 mRNA Translation: AAH39297.1 AF543840 mRNA Translation: AAN65261.1 AL157482 mRNA Translation: CAB75672.1 |
CCDSi | CCDS3217.1 [Q53EP0-1] |
PIRi | T46917 |
RefSeqi | NP_001128567.1, NM_001135095.1 [Q53EP0-1] NP_073600.3, NM_022763.3 [Q53EP0-1] |
Genome annotation databases
Ensembli | ENST00000336824; ENSP00000338523; ENSG00000075420 [Q53EP0-1] ENST00000415807; ENSP00000411242; ENSG00000075420 [Q53EP0-1] ENST00000416957; ENSP00000389094; ENSG00000075420 [Q53EP0-1] ENST00000421757; ENSP00000408496; ENSG00000075420 [Q53EP0-3] ENST00000423424; ENSP00000392471; ENSG00000075420 [Q53EP0-3] |
GeneIDi | 64778 |
KEGGi | hsa:64778 |
UCSCi | uc003fhx.4, human [Q53EP0-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098597 mRNA Translation: BAC53727.1 AY358146 mRNA Translation: AAQ88513.1 Different initiation. AY358367 mRNA Translation: AAQ88733.1 Different initiation. AK027052 mRNA Translation: BAB15639.1 Different initiation. AK075220 mRNA Translation: BAC11480.1 Different initiation. AK127826 mRNA Translation: BAG54580.1 AK314478 mRNA Translation: BAG37083.1 AK223599 mRNA Translation: BAD97319.1 CH471052 Genomic DNA Translation: EAW78476.1 CH471052 Genomic DNA Translation: EAW78472.1 CH471052 Genomic DNA Translation: EAW78474.1 CH471052 Genomic DNA Translation: EAW78475.1 BC012204 mRNA Translation: AAH12204.1 Different initiation. BC033635 mRNA Translation: AAH33635.1 Different initiation. BC039297 mRNA Translation: AAH39297.1 AF543840 mRNA Translation: AAN65261.1 AL157482 mRNA Translation: CAB75672.1 |
CCDSi | CCDS3217.1 [Q53EP0-1] |
PIRi | T46917 |
RefSeqi | NP_001128567.1, NM_001135095.1 [Q53EP0-1] NP_073600.3, NM_022763.3 [Q53EP0-1] |
3D structure databases
SMRi | Q53EP0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122288, 65 interactors |
IntActi | Q53EP0, 65 interactors |
MINTi | Q53EP0 |
STRINGi | 9606.ENSP00000338523 |
PTM databases
iPTMneti | Q53EP0 |
PhosphoSitePlusi | Q53EP0 |
Polymorphism and mutation databases
BioMutai | FNDC3B |
DMDMi | 146286181 |
Proteomic databases
EPDi | Q53EP0 |
jPOSTi | Q53EP0 |
MassIVEi | Q53EP0 |
MaxQBi | Q53EP0 |
PaxDbi | Q53EP0 |
PeptideAtlasi | Q53EP0 |
PRIDEi | Q53EP0 |
ProteomicsDBi | 62442 [Q53EP0-1] 62443 [Q53EP0-2] 62444 [Q53EP0-3] |
Protocols and materials databases
Antibodypediai | 2120, 131 antibodies |
Genome annotation databases
Ensembli | ENST00000336824; ENSP00000338523; ENSG00000075420 [Q53EP0-1] ENST00000415807; ENSP00000411242; ENSG00000075420 [Q53EP0-1] ENST00000416957; ENSP00000389094; ENSG00000075420 [Q53EP0-1] ENST00000421757; ENSP00000408496; ENSG00000075420 [Q53EP0-3] ENST00000423424; ENSP00000392471; ENSG00000075420 [Q53EP0-3] |
GeneIDi | 64778 |
KEGGi | hsa:64778 |
UCSCi | uc003fhx.4, human [Q53EP0-1] |
Organism-specific databases
CTDi | 64778 |
DisGeNETi | 64778 |
EuPathDBi | HostDB:ENSG00000075420.12 |
GeneCardsi | FNDC3B |
HGNCi | HGNC:24670, FNDC3B |
HPAi | ENSG00000075420, Low tissue specificity |
MIMi | 611909, gene |
neXtProti | NX_Q53EP0 |
OpenTargetsi | ENSG00000075420 |
PharmGKBi | PA134936830 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0613, Eukaryota |
GeneTreei | ENSGT00940000157005 |
HOGENOMi | CLU_2739328_0_0_1 |
InParanoidi | Q53EP0 |
OMAi | ETVPPMR |
OrthoDBi | 633003at2759 |
PhylomeDBi | Q53EP0 |
TreeFami | TF316401 |
Enzyme and pathway databases
PathwayCommonsi | Q53EP0 |
Miscellaneous databases
BioGRID-ORCSi | 64778, 23 hits in 850 CRISPR screens |
ChiTaRSi | FNDC3B, human |
GenomeRNAii | 64778 |
Pharosi | Q53EP0, Tbio |
PROi | PR:Q53EP0 |
RNActi | Q53EP0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075420, Expressed in calcaneal tendon and 235 other tissues |
ExpressionAtlasi | Q53EP0, baseline and differential |
Genevisiblei | Q53EP0, HS |
Family and domain databases
CDDi | cd00063, FN3, 9 hits |
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00041, fn3, 9 hits |
SMARTi | View protein in SMART SM00060, FN3, 9 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FND3B_HUMAN | |
Accessioni | Q53EP0Primary (citable) accession number: Q53EP0 Secondary accession number(s): B2RB36 Q9NSQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations