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UniProtKB - Q53EP0 (FND3B_HUMAN)

Entry version 137 (02 Jun 2021)
Sequence version 2 (01 May 2007)
Previous versions | rss
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Protein

Fibronectin type III domain-containing protein 3B

Gene

FNDC3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a positive regulator of adipogenesis.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q53EP0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 3B
Alternative name(s):
Factor for adipocyte differentiation 104
HCV NS5A-binding protein 37
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC3B
Synonyms:FAD104, NS5ABP37
ORF Names:UNQ2421/PRO4979/PRO34274
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24670, FNDC3B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611909, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q53EP0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000075420.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1182 – 1202HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64778

Open Targets

More...OpenTargetsi		ENSG00000075420

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134936830

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q53EP0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FNDC3B

Domain mapping of disease mutations (DMDM)

More...DMDMi		146286181

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002848911 – 1204Fibronectin type III domain-containing protein 3BAdd BLAST1204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei208PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei1163PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q53EP0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q53EP0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q53EP0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q53EP0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q53EP0

PeptideAtlas

More...PeptideAtlasi		Q53EP0

PRoteomics IDEntifications database

More...PRIDEi		Q53EP0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62442 [Q53EP0-1]
62443 [Q53EP0-2]
62444 [Q53EP0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q53EP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q53EP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075420, Expressed in calcaneal tendon and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q53EP0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q53EP0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075420, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Isoform 3 [Q53EP0-3]
With#Exp.IntAct
ABHD11 - isoform 4 [Q8NFV4-4]3EBI-10242151,EBI-12318443
ABHD8 [Q96I13]3EBI-10242151,EBI-17180442
ADGRF5 [Q8IZF2]3EBI-10242151,EBI-7600130
BBS2 [Q9BXC9]3EBI-10242151,EBI-748297
BICRAL [Q6AI39]3EBI-10242151,EBI-1012434
BRWD1 - isoform D [Q9NSI6-4]3EBI-10242151,EBI-10693038
C10orf55 [Q5SWW7]3EBI-10242151,EBI-12809220
C10orf82 - isoform 2 [Q8WW14-2]3EBI-10242151,EBI-12831628
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-10242151,EBI-11976299
C22orf15 - isoform 2 [Q8WYQ4-2]3EBI-10242151,EBI-12030460
CAMK2D [Q13557]3EBI-10242151,EBI-351018
CEMP1 [Q6PRD7]3EBI-10242151,EBI-12907646
DAPL1 [A0PJW8]3EBI-10242151,EBI-12840152
DUSP10 [Q9Y6W6]3EBI-10242151,EBI-3443946
GAS2L3 [Q86XJ1]3EBI-10242151,EBI-9248152
HAPLN2 [Q9GZV7]3EBI-10242151,EBI-11956675
KLHDC7B [Q96G42]3EBI-10242151,EBI-9478422
KRTAP11-1 [Q8IUC1]3EBI-10242151,EBI-1052037
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-10242151,EBI-11985629
MBD3L1 [Q8WWY6]3EBI-10242151,EBI-12516603
MCCD1 [P59942]3EBI-10242151,EBI-11987923
MVP [Q14764]3EBI-10242151,EBI-2816254
NDUFAB1 [O14561]5EBI-10242151,EBI-1246261
PIK3R4 [Q99570]3EBI-10242151,EBI-1046979
POGZ [Q7Z3K3]6EBI-10242151,EBI-1389308
POU6F2 [P78424]3EBI-10242151,EBI-12029004
PRKAA2 [P54646]3EBI-10242151,EBI-1383852
REL - isoform 2 [Q04864-2]3EBI-10242151,EBI-10829018
RUSC1 [Q9BVN2]3EBI-10242151,EBI-6257312
SPSB2 [Q99619]3EBI-10242151,EBI-2323209
SRARP [Q8NEQ6]3EBI-10242151,EBI-17858294
STPG4 - isoform 2 [Q8N801-2]3EBI-10242151,EBI-12871202
SUOX [P51687]3EBI-10242151,EBI-3921347
TEKT5 [Q96M29]3EBI-10242151,EBI-10239812
TEPSIN [Q96N21]3EBI-10242151,EBI-11139477
TESMIN - isoform 2 [Q9Y4I5-2]3EBI-10242151,EBI-12840664
TEX43 [Q6ZNM6]3EBI-10242151,EBI-18115728
TEX48 [A0A1B0GUV7]3EBI-10242151,EBI-18583507
TOX4 [O94842]6EBI-10242151,EBI-948613
TRAF2 [Q12933]3EBI-10242151,EBI-355744
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-10242151,EBI-17716262
TRIM42 [Q8IWZ5]3EBI-10242151,EBI-5235829
TRIP13 [Q15645]6EBI-10242151,EBI-358993
UBAP2 [Q5T6F2]3EBI-10242151,EBI-2514383
USP54 - isoform 6 [Q70EL1-9]3EBI-10242151,EBI-11975223
VAC14 [Q08AM6]3EBI-10242151,EBI-2107455
ZMYND19 [Q96E35]3EBI-10242151,EBI-746595

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122288, 82 interactors

Protein interaction database and analysis system

More...IntActi		Q53EP0, 66 interactors

Molecular INTeraction database

More...MINTi		Q53EP0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338523

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q53EP0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q53EP0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini278 – 377Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini381 – 473Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini477 – 570Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini574 – 669Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini673 – 765Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93
Domaini766 – 859Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini871 – 957Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST87
Domaini958 – 1052Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1056 – 1153Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 215DisorderedSequence analysisAdd BLAST31
Regioni228 – 262DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi186 – 203Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi245 – 262Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNDC3 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0613, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157005

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_2739328_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q53EP0

Identification of Orthologs from Complete Genome Data

More...OMAi		ETVPPMR

Database of Orthologous Groups

More...OrthoDBi		633003at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q53EP0

TreeFam database of animal gene trees

More...TreeFami		TF316401

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q53EP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYVTMMMTDQ IPLELPPLLN GEVAMMPHLV NGDAAQQVIL VQVNPGETFT 
        60         70         80         90        100
IRAEDGTLQC IQGPAEVPMM SPNGSIPPIH VPPGYISQVI EDSTGVRRVV 
       110        120        130        140        150
VTPQSPECYP PSYPSAMSPT HHLPPYLTHH PHFIHNSHTA YYPPVTGPGD 
       160        170        180        190        200
MPPQFFPQHH LPHTIYGEQE IIPFYGMSTY ITREDQYSKP PHKKLKDRQI 
       210        220        230        240        250
DRQNRLNSPP SSIYKSSCTT VYNGYGKGHS GGSGGGGSGS GPGIKKTERR 
       260        270        280        290        300
ARSSPKSNDS DLQEYELEVK RVQDILSGIE KPQVSNIQAR AVVLSWAPPV 
       310        320        330        340        350
GLSCGPHSGL SFPYSYEVAL SDKGRDGKYK IIYSGEELEC NLKDLRPATD 
       360        370        380        390        400
YHVRVYAMYN SVKGSCSEPV SFTTHSCAPE CPFPPKLAHR SKSSLTLQWK 
       410        420        430        440        450
APIDNGSKIT NYLLEWDEGK RNSGFRQCFF GSQKHCKLTK LCPAMGYTFR 
       460        470        480        490        500
LAARNDIGTS GYSQEVVCYT LGNIPQMPSA PRLVRAGITW VTLQWSKPEG 
       510        520        530        540        550
CSPEEVITYT LEIQEDENDN LFHPKYTGED LTCTVKNLKR STQYKFRLTA 
       560        570        580        590        600
SNTEGKSCPS EVLVCTTSPD RPGPPTRPLV KGPVTSHGFS VKWDPPKDNG 
       610        620        630        640        650
GSEILKYLLE ITDGNSEANQ WEVAYSGSAT EYTFTHLKPG TLYKLRACCI 
       660        670        680        690        700
STGGHSQCSE SLPVRTLSIA PGQCRPPRVL GRPKHKEVHL EWDVPASESG 
       710        720        730        740        750
CEVSEYSVEM TEPEDVASEV YHGPELECTV GNLLPGTVYR FRVRALNDGG 
       760        770        780        790        800
YGPYSDVSEI TTAAGPPGQC KAPCISCTPD GCVLVGWESP DSSGADISEY 
       810        820        830        840        850
RLEWGEDEES LELIYHGTDT RFEIRDLLPA AQYCCRLQAF NQAGAGPYSE 
       860        870        880        890        900
LVLCQTPASA PDPVSTLCVL EEEPLDAYPD SPSACLVLNW EEPCNNGSEI 
       910        920        930        940        950
LAYTIDLGDT SITVGNTTMH VMKDLLPETT YRIRIQAINE IGAGPFSQFI 
       960        970        980        990       1000
KAKTRPLPPL PPRLECAAAG PQSLKLKWGD SNSKTHAAED IVYTLQLEDR 
      1010       1020       1030       1040       1050
NKRFISIYRG PSHTYKVQRL TEFTCYSFRI QAASEAGEGP FSETYTFSTT 
      1060       1070       1080       1090       1100
KSVPPTIKAP RVTQLEGNSC EILWETVPSM KGDPVNYILQ VLVGRESEYK 
      1110       1120       1130       1140       1150
QVYKGEEATF QISGLQTNTD YRFRVCACRR CLDTSQELSG AFSPSAAFVL 
      1160       1170       1180       1190       1200
QRSEVMLTGD MGSLDDPKMK SMMPTDEQFA AIIVLGFATL SILFAFILQY 

FLMK
Length:1,204
Mass (Da):132,888
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E883F4566276CE7
GO
Isoform 2 (identifier: Q53EP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-629: ANQWEVAYSGSA → GEVFGNCFIQIQ
     630-1204: Missing.

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Length:629
Mass (Da):69,572
Checksum:i86EC7CCBCD47B7B3
GO
Isoform 3 (identifier: Q53EP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-71: GPAEVPMMS → DEVVKRACD
     72-1204: Missing.

Show »
Length:71
Mass (Da):7,844
Checksum:i99DC350E3B6A3AC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKH7C9JKH7_HUMAN
Fibronectin type III domain-contain...
FNDC3B
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH12204 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33635 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ88513 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ88733 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15639 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11480 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37Q → H in AAQ88733 (PubMed:12975309).Curated1
Sequence conflicti208S → R in BAC53727 (PubMed:15564382).Curated1
Sequence conflicti212S → A in BAC53727 (PubMed:15564382).Curated1
Sequence conflicti360N → D in BAG37083 (PubMed:14702039).Curated1
Sequence conflicti393S → G in BAG37083 (PubMed:14702039).Curated1
Sequence conflicti448T → A in BAG37083 (PubMed:14702039).Curated1
Sequence conflicti481P → L in AAQ88513 (PubMed:12975309).Curated1
Sequence conflicti545K → T in BAC53727 (PubMed:15564382).Curated1
Sequence conflicti676P → S in BAD97319 (Ref. 4) Curated1
Sequence conflicti854C → W in AAH39297 (PubMed:15489334).Curated1
Sequence conflicti895N → D in BAC11480 (PubMed:14702039).Curated1
Sequence conflicti1067G → V in AAQ88513 (PubMed:12975309).Curated1
Sequence conflicti1083D → G in BAG37083 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031856179T → S5 PublicationsCorresponds to variant dbSNP:rs7652177Ensembl.1
Natural variantiVAR_035921927P → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0478141080M → V. Corresponds to variant dbSNP:rs2276806Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02473963 – 71GPAEVPMMS → DEVVKRACD in isoform 3. 1 Publication9
Alternative sequenceiVSP_02474072 – 1204Missing in isoform 3. 1 PublicationAdd BLAST1133
Alternative sequenceiVSP_024741618 – 629ANQWE…YSGSA → GEVFGNCFIQIQ in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_024742630 – 1204Missing in isoform 2. 1 PublicationAdd BLAST575

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB098597 mRNA Translation: BAC53727.1
AY358146 mRNA Translation: AAQ88513.1 Different initiation.
AY358367 mRNA Translation: AAQ88733.1 Different initiation.
AK027052 mRNA Translation: BAB15639.1 Different initiation.
AK075220 mRNA Translation: BAC11480.1 Different initiation.
AK127826 mRNA Translation: BAG54580.1
AK314478 mRNA Translation: BAG37083.1
AK223599 mRNA Translation: BAD97319.1
CH471052 Genomic DNA Translation: EAW78476.1
CH471052 Genomic DNA Translation: EAW78472.1
CH471052 Genomic DNA Translation: EAW78474.1
CH471052 Genomic DNA Translation: EAW78475.1
BC012204 mRNA Translation: AAH12204.1 Different initiation.
BC033635 mRNA Translation: AAH33635.1 Different initiation.
BC039297 mRNA Translation: AAH39297.1
AF543840 mRNA Translation: AAN65261.1
AL157482 mRNA Translation: CAB75672.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3217.1 [Q53EP0-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T46917

NCBI Reference Sequences

More...RefSeqi		NP_001128567.1, NM_001135095.1 [Q53EP0-1]
NP_073600.3, NM_022763.3 [Q53EP0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336824; ENSP00000338523; ENSG00000075420 [Q53EP0-1]
ENST00000415807; ENSP00000411242; ENSG00000075420 [Q53EP0-1]
ENST00000416957; ENSP00000389094; ENSG00000075420 [Q53EP0-1]
ENST00000421757; ENSP00000408496; ENSG00000075420 [Q53EP0-3]
ENST00000423424; ENSP00000392471; ENSG00000075420 [Q53EP0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64778

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64778

UCSC genome browser

More...UCSCi		uc003fhx.4, human [Q53EP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098597 mRNA Translation: BAC53727.1
AY358146 mRNA Translation: AAQ88513.1 Different initiation.
AY358367 mRNA Translation: AAQ88733.1 Different initiation.
AK027052 mRNA Translation: BAB15639.1 Different initiation.
AK075220 mRNA Translation: BAC11480.1 Different initiation.
AK127826 mRNA Translation: BAG54580.1
AK314478 mRNA Translation: BAG37083.1
AK223599 mRNA Translation: BAD97319.1
CH471052 Genomic DNA Translation: EAW78476.1
CH471052 Genomic DNA Translation: EAW78472.1
CH471052 Genomic DNA Translation: EAW78474.1
CH471052 Genomic DNA Translation: EAW78475.1
BC012204 mRNA Translation: AAH12204.1 Different initiation.
BC033635 mRNA Translation: AAH33635.1 Different initiation.
BC039297 mRNA Translation: AAH39297.1
AF543840 mRNA Translation: AAN65261.1
AL157482 mRNA Translation: CAB75672.1
CCDSiCCDS3217.1 [Q53EP0-1]
PIRiT46917
RefSeqiNP_001128567.1, NM_001135095.1 [Q53EP0-1]
NP_073600.3, NM_022763.3 [Q53EP0-1]

3D structure databases

SMRiQ53EP0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122288, 82 interactors
IntActiQ53EP0, 66 interactors
MINTiQ53EP0
STRINGi9606.ENSP00000338523

PTM databases

iPTMnetiQ53EP0
PhosphoSitePlusiQ53EP0

Genetic variation databases

BioMutaiFNDC3B
DMDMi146286181

Proteomic databases

EPDiQ53EP0
jPOSTiQ53EP0
MassIVEiQ53EP0
MaxQBiQ53EP0
PaxDbiQ53EP0
PeptideAtlasiQ53EP0
PRIDEiQ53EP0
ProteomicsDBi62442 [Q53EP0-1]
62443 [Q53EP0-2]
62444 [Q53EP0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2120, 132 antibodies

The DNASU plasmid repository

More...DNASUi		64778

Genome annotation databases

EnsembliENST00000336824; ENSP00000338523; ENSG00000075420 [Q53EP0-1]
ENST00000415807; ENSP00000411242; ENSG00000075420 [Q53EP0-1]
ENST00000416957; ENSP00000389094; ENSG00000075420 [Q53EP0-1]
ENST00000421757; ENSP00000408496; ENSG00000075420 [Q53EP0-3]
ENST00000423424; ENSP00000392471; ENSG00000075420 [Q53EP0-3]
GeneIDi64778
KEGGihsa:64778
UCSCiuc003fhx.4, human [Q53EP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64778
DisGeNETi64778

GeneCards: human genes, protein and diseases

More...GeneCardsi		FNDC3B
HGNCiHGNC:24670, FNDC3B
HPAiENSG00000075420, Low tissue specificity
MIMi611909, gene
neXtProtiNX_Q53EP0
OpenTargetsiENSG00000075420
PharmGKBiPA134936830
VEuPathDBiHostDB:ENSG00000075420.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0613, Eukaryota
GeneTreeiENSGT00940000157005
HOGENOMiCLU_2739328_0_0_1
InParanoidiQ53EP0
OMAiETVPPMR
OrthoDBi633003at2759
PhylomeDBiQ53EP0
TreeFamiTF316401

Enzyme and pathway databases

PathwayCommonsiQ53EP0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64778, 31 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FNDC3B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64778
PharosiQ53EP0, Tbio

Protein Ontology

More...PROi		PR:Q53EP0
RNActiQ53EP0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075420, Expressed in calcaneal tendon and 236 other tissues
ExpressionAtlasiQ53EP0, baseline and differential
GenevisibleiQ53EP0, HS

Family and domain databases

CDDicd00063, FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00041, fn3, 9 hits
SMARTiView protein in SMART
SM00060, FN3, 9 hits
SUPFAMiSSF49265, SSF49265, 5 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 9 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFND3B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53EP0
Secondary accession number(s): B2RB36
, B3KXR8, D3DNQ7, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: June 2, 2021
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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