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Entry version 137 (16 Oct 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Programmed cell death protein 4

Gene

PDCD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q53EL6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Programmed cell death protein 4
Alternative name(s):
Neoplastic transformation inhibitor protein
Nuclear antigen H731-like
Protein 197/15a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDCD4
Synonyms:H731
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8763 PDCD4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608610 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q53EL6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67S → A: Loss of phosphorylation site. Reduces interaction with BTRC. Abolishes phosphorylation by PKB; when associated with A-457. 2 Publications1
Mutagenesisi71S → A: Strongly reduced interaction with BTRC. Strongly reduced ubiquitination. 1 Publication1
Mutagenesisi76S → A: Strongly reduced interaction with BTRC. Strongly reduced ubiquitination. 1 Publication1
Mutagenesisi174E → A: Reduced inhibition of EIF4A1 helicase activity. 1 Publication1
Mutagenesisi210E → A: Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi249E → A: Reduced interaction with EIF4A1. 1 Publication1
Mutagenesisi252L → A: Strongly reduced interaction with EIF4A1. Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi253D → A: Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. Reduced inhibition of EIF4A1 helicase activity. 2 Publications1
Mutagenesisi255P → A: Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi333M → A: No effect on inhibition of EIF4A1 and on inhibition of translation; when associated with A-340. 1 Publication1
Mutagenesisi337E → A: No effect on inhibition of EIF4A1 and on inhibition of translation. 1 Publication1
Mutagenesisi340L → A: No effect on inhibition of EIF4A1 and on inhibition of translation; when associated with A-333. 1 Publication1
Mutagenesisi358H → A: Strongly reduced interaction with EIF4A1. 1 Publication1
Mutagenesisi359F → A: Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi361H → A: Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi414D → A: Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi418D → A: Reduced interaction with EIF4A1. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi420P → A: Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. 1 Publication1
Mutagenesisi457S → A: Loss of phosphorylation site, and loss of nuclear accumulation. Abolishes phosphorylation by PKB; when associated with A-67. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
27250

Open Targets

More...
OpenTargetsi
ENSG00000150593

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33113

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q53EL6

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1781868

DrugCentral

More...
DrugCentrali
Q53EL6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDCD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002565191 – 469Programmed cell death protein 4Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei67Phosphoserine; by PKB and RPS6KB1Combined sources2 Publications1
Modified residuei68PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei152PhosphotyrosineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei457Phosphoserine; by PKBCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.1 Publication
Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q53EL6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q53EL6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q53EL6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q53EL6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q53EL6

PeptideAtlas

More...
PeptideAtlasi
Q53EL6

PRoteomics IDEntifications database

More...
PRIDEi
Q53EL6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6218
62437 [Q53EL6-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q53EL6

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q53EL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q53EL6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q53EL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150593 Expressed in 231 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q53EL6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q53EL6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037024
HPA001032
HPA027214

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via MI domains) with EIF4A2 (By similarity).

Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1.

Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118098, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q53EL6

Database of interacting proteins

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DIPi
DIP-29756N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q53EL6

Protein interaction database and analysis system

More...
IntActi
Q53EL6, 31 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280154

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q53EL6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q53EL6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q53EL6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 284MI 1PROSITE-ProRule annotationAdd BLAST122
Domaini326 – 449MI 2PROSITE-ProRule annotationAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi58 – 64Nuclear localization signalSequence analysis7
Motifi70 – 76Phosphodegron7
Motifi241 – 250Nuclear localization signalSequence analysis10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds EIF4A1 via both MI domains.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDCD4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0403 Eukaryota
ENOG410XQZZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015948

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261612

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q53EL6

KEGG Orthology (KO)

More...
KOi
K16865

Identification of Orthologs from Complete Genome Data

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OMAi
GEKTFKM

Database of Orthologous Groups

More...
OrthoDBi
434771at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q53EL6

TreeFam database of animal gene trees

More...
TreeFami
TF323207

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.180, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR039778 PDCD4

The PANTHER Classification System

More...
PANTHERi
PTHR12626 PTHR12626, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847 MA3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00544 MA3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366 MI, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q53EL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI
60 70 80 90 100
NEARINAKAK RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL
110 120 130 140 150
DRRSRSGKGR GLPKKGGAGG KGVWGTPGQV YDVEEVDVKD PNYDDDQENC
160 170 180 190 200
VYETVVLPLD ERAFEKTLTP IIQEYFEHGD TNEVAEMLRD LNLGEMKSGV
210 220 230 240 250
PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF DKLLKDLPEL
260 270 280 290 300
ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV
310 320 330 340 350
LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC
360 370 380 390 400
LKELEVPHFH HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ
410 420 430 440 450
MKRGYERIYN EIPDINLDVP HSYSVLERFV EECFQAGIIS KQLRDLCPSR
460
GRKRFVSEGD GGRLKPESY
Length:469
Mass (Da):51,735
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CAE1D2055491177
GO
Isoform 2 (identifier: Q53EL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MDVENEQILNVNPAD → MTKY

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):50,576
Checksum:iE887AA311F3EB4D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VZS7Q5VZS7_HUMAN
Programmed cell death protein 4
PDCD4
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB42218 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH15036 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79D → E in AAB42218 (Ref. 1) Curated1
Sequence conflicti102R → G in AAB67706 (PubMed:9759869).Curated1
Sequence conflicti130V → G in AAB67706 (PubMed:9759869).Curated1
Sequence conflicti220S → T in AAB42218 (Ref. 1) Curated1
Sequence conflicti222L → F in AAB67706 (PubMed:9759869).Curated1
Sequence conflicti309K → R in BAG37701 (PubMed:14702039).Curated1
Sequence conflicti314V → A in BAG37701 (PubMed:14702039).Curated1
Sequence conflicti440S → W in AAB67706 (PubMed:9759869).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02890136I → VCombined sources5 PublicationsCorresponds to variant dbSNP:rs7081726Ensembl.1
Natural variantiVAR_02890248S → Y1 PublicationCorresponds to variant dbSNP:rs11548765Ensembl.1
Natural variantiVAR_036375120G → R in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0456221 – 15MDVEN…VNPAD → MTKY in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U83908 Genomic DNA Translation: AAB42218.1 Sequence problems.
U96628 mRNA Translation: AAB67706.1
AK315295 mRNA Translation: BAG37701.1
AK223623 mRNA Translation: BAD97343.1
AL158163 Genomic DNA No translation available.
AL136368 Genomic DNA No translation available.
BC015036 mRNA Translation: AAH15036.1 Sequence problems.
BC026104 mRNA Translation: AAH26104.1
BC031049 mRNA Translation: AAH31049.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44478.1 [Q53EL6-2]
CCDS7567.1 [Q53EL6-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC5193

NCBI Reference Sequences

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RefSeqi
NP_055271.2, NM_014456.4 [Q53EL6-1]
NP_663314.1, NM_145341.3 [Q53EL6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000280154; ENSP00000280154; ENSG00000150593 [Q53EL6-1]
ENST00000393104; ENSP00000376816; ENSG00000150593 [Q53EL6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27250

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27250

UCSC genome browser

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UCSCi
uc001kzg.4 human [Q53EL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83908 Genomic DNA Translation: AAB42218.1 Sequence problems.
U96628 mRNA Translation: AAB67706.1
AK315295 mRNA Translation: BAG37701.1
AK223623 mRNA Translation: BAD97343.1
AL158163 Genomic DNA No translation available.
AL136368 Genomic DNA No translation available.
BC015036 mRNA Translation: AAH15036.1 Sequence problems.
BC026104 mRNA Translation: AAH26104.1
BC031049 mRNA Translation: AAH31049.1
CCDSiCCDS44478.1 [Q53EL6-2]
CCDS7567.1 [Q53EL6-1]
PIRiJC5193
RefSeqiNP_055271.2, NM_014456.4 [Q53EL6-1]
NP_663314.1, NM_145341.3 [Q53EL6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GGFNMR-A327-450[»]
2KZTNMR-A157-318[»]
2RG8X-ray1.80A/B157-320[»]
2ZU6X-ray2.80B/E163-469[»]
3EIJX-ray2.80A/B157-469[»]
SMRiQ53EL6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118098, 54 interactors
CORUMiQ53EL6
DIPiDIP-29756N
ELMiQ53EL6
IntActiQ53EL6, 31 interactors
STRINGi9606.ENSP00000280154

Chemistry databases

BindingDBiQ53EL6
ChEMBLiCHEMBL1781868
DrugCentraliQ53EL6

PTM databases

CarbonylDBiQ53EL6
iPTMnetiQ53EL6
PhosphoSitePlusiQ53EL6
SwissPalmiQ53EL6

Polymorphism and mutation databases

BioMutaiPDCD4
DMDMi317373317

Proteomic databases

EPDiQ53EL6
jPOSTiQ53EL6
MassIVEiQ53EL6
MaxQBiQ53EL6
PaxDbiQ53EL6
PeptideAtlasiQ53EL6
PRIDEiQ53EL6
ProteomicsDBi6218
62437 [Q53EL6-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27250

Genome annotation databases

EnsembliENST00000280154; ENSP00000280154; ENSG00000150593 [Q53EL6-1]
ENST00000393104; ENSP00000376816; ENSG00000150593 [Q53EL6-2]
GeneIDi27250
KEGGihsa:27250
UCSCiuc001kzg.4 human [Q53EL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27250
DisGeNETi27250

GeneCards: human genes, protein and diseases

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GeneCardsi
PDCD4
HGNCiHGNC:8763 PDCD4
HPAiCAB037024
HPA001032
HPA027214
MIMi608610 gene
neXtProtiNX_Q53EL6
OpenTargetsiENSG00000150593
PharmGKBiPA33113

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0403 Eukaryota
ENOG410XQZZ LUCA
GeneTreeiENSGT00390000015948
HOGENOMiHOG000261612
InParanoidiQ53EL6
KOiK16865
OMAiGEKTFKM
OrthoDBi434771at2759
PhylomeDBiQ53EL6
TreeFamiTF323207

Enzyme and pathway databases

ReactomeiR-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiQ53EL6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDCD4 human
EvolutionaryTraceiQ53EL6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PDCD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27250
PharosiQ53EL6

Protein Ontology

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PROi
PR:Q53EL6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150593 Expressed in 231 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ53EL6 baseline and differential
GenevisibleiQ53EL6 HS

Family and domain databases

Gene3Di1.25.40.180, 2 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR039778 PDCD4
PANTHERiPTHR12626 PTHR12626, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 2 hits
SMARTiView protein in SMART
SM00544 MA3, 2 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS51366 MI, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDCD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53EL6
Secondary accession number(s): B2RCV4
, B5ME91, O15501, Q5VZS6, Q6PJI5, Q8TAR5, Q99834
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 11, 2011
Last modified: October 16, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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