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Entry version 114 (11 Dec 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Collagen adhesin

Gene

cna

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Collagen-binding adhesin that mediates bacterial adherence to collagenous tissues such as cartilage (PubMed:8218209). Participates in the infectious process by acting as a virulence factor in many different animal models of staphylococcal infections including arthritis, endocarditis and keratitis (PubMed:10816547, PubMed:15181582). Inhibits the activation of the classical complement pathway by interacting with host C1q and interfering with the association between host C1r with C1q (PubMed:23720782).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei209Autocatalyzes isopeptide 176-293 formationSequence analysis1
Sitei601Autocatalyzes isopeptide 541-618 formationSequence analysis1
Sitei692Autocatalyzes isopeptide 631-715 formationSequence analysis1
Sitei788Autocatalyzes isopeptide 728-805 formationSequence analysis1
Sitei879Autocatalyzes isopeptide 818-902 formationSequence analysis1
Sitei975Autocatalyzes isopeptide 915-992 formationSequence analysis1
Sitei1066Autocatalyzes isopeptide 1005-1089 formationSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen adhesin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cna
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi175Y → K: More than 90% loss of collagen-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000559930 – 1154Collagen adhesinAdd BLAST1125
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000056001155 – 1183Removed by sortasePROSITE-ProRule annotationAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki176 ↔ 293Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki541 ↔ 618Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki631 ↔ 715Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki728 ↔ 805Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki818 ↔ 902Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki915 ↔ 992Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki1005 ↔ 1089Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1154Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Isopeptide bond, Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q53654

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with type I collagen (PubMed:16362049).

Interacts with host C1QA (PubMed:23720782).

2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q53654

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q53654

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati533 – 719B1Add BLAST187
Repeati720 – 906B2Add BLAST187
Repeati907 – 1093B3Add BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni151 – 318Collagen-bindingAdd BLAST168
Regioni533 – 10933 X 187 AA approximate tandem repeatsAdd BLAST561

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1151 – 1155LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1093 – 1157Lys/Pro-richAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of a N-terminal A-region and a number of B-repeats depending on the strain. At the C-terminal end are features required for surface targeting and covalently anchoring to the peptidoglycan. The collagen binding activity is located in the A-region.3 Publications

Keywords - Domaini

Repeat, Signal

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00222 CollagenBindB, 6 hits

Database of protein disorder

More...
DisProti
DP00098

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.1280, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008966 Adhesion_dom_sf
IPR008454 Collagen-bd_Cna-like_B-typ_dom
IPR008456 Collagen-bd_dom
IPR011252 Fibrogen-bd_dom1
IPR013783 Ig-like_fold
IPR019931 LPXTG_anchor
IPR041033 Prealbumin-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05738 Cna_B, 7 hits
PF05737 Collagen_bind, 1 hit
PF17802 SpaA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49401 SSF49401, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q53654-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKNVLKFMV FIMLLNIITP LFNKNEAFAA RDISSTNVTD LTVSPSKIED
60 70 80 90 100
GGKTTVKMTF DDKNGKIQNG DMIKVAWPTS GTVKIEGYSK TVPLTVKGEQ
110 120 130 140 150
VGQAVITPDG ATITFNDKVE KLSDVSGFAE FEVQGRNLTQ TNTSDDKVAT
160 170 180 190 200
ITSGNKSTNV TVHKSEAGTS SVFYYKTGDM LPEDTTHVRW FLNINNEKSY
210 220 230 240 250
VSKDITIKDQ IQGGQQLDLS TLNINVTGTH SNYYSGQSAI TDFEKAFPGS
260 270 280 290 300
KITVDNTKNT IDVTIPQGYG SYNSFSINYK TKITNEQQKE FVNNSQAWYQ
310 320 330 340 350
EHGKEEVNGK SFNHTVHNIN ANAGIEGTVK GELKVLKQDK DTKAPIANVK
360 370 380 390 400
FKLSKKDGSV VKDNQKEIEI ITDANGIANI KALPSGDYIL KEIEAPRPYT
410 420 430 440 450
FDKDKEYPFT MKDTDNQGYF TTIENAKAIE KTKDVSAQKV WEGTQKVKPT
460 470 480 490 500
IYFKLYKQDD NQNTTPVDKA EIKKLEDGTT KVTWSNLPEN DKNGKAIKYL
510 520 530 540 550
VKEVNAQGED TTPEGYTKKE NGLVVTNTEK PIETTSISGE KVWDDKDNQD
560 570 580 590 600
GKRPEKVSVN LLANGEKVKT LDVTSETNWK YEFKDLPKYD EGKKIEYTVT
610 620 630 640 650
EDHVKDYTTD INGTTITNKY TPGETSATVT KNWDDNNNQD GKRPTEIKVE
660 670 680 690 700
LYQDGKATGK TAILNESNNW THTWTGLDEK AKGQQVKYTV EELTKVKGYT
710 720 730 740 750
THVDNNDMGN LIVTNKYTPE TTSISGEKVW DDKDNQDGKR PEKVSVNLLA
760 770 780 790 800
DGEKVKTLDV TSETNWKYEF KDLPKYDEGK KIEYTVTEDH VKDYTTDING
810 820 830 840 850
TTITNKYTPG ETSATVTKNW DDNNNQDGKR PTEIKVELYQ DGKATGKTAI
860 870 880 890 900
LNESNNWTHT WTGLDEKAKG QQVKYTVEEL TKVKGYTTHV DNNDMGNLIV
910 920 930 940 950
TNKYTPETTS ISGEKVWDDK DNQDGKRPEK VSVNLLANGE KVKTLDVTSE
960 970 980 990 1000
TNWKYEFKDL PKYDEGKKIE YTVTEDHVKD YTTDINGTTI TNKYTPGETS
1010 1020 1030 1040 1050
ATVTKNWDDN NNQDGKRPTE IKVELYQDGK ATGKTAILNE SNNWTHTWTG
1060 1070 1080 1090 1100
LDEKAKGQQV KYTVDELTKV NGYTTHVDNN DMGNLIVTNK YTPKKPNKPI
1110 1120 1130 1140 1150
YPEKPKDKTP PTKPDHSNKV KPTPPDKPSK VDKDDQPKDN KTKPENPLKE
1160 1170 1180
LPKTGMKIIT SWITWVFIGI LGLYLILRKR FNS
Length:1,183
Mass (Da):133,067
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6A1CC072E575D76
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M81736 Genomic DNA Translation: AAA20874.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81736 Genomic DNA Translation: AAA20874.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AMXX-ray2.00A151-318[»]
1D2OX-ray2.00A/B533-719[»]
1D2PX-ray2.50A533-905[»]
2F68X-ray1.95X30-334[»]
2F6AX-ray3.29A/B/C/D30-330[»]
SMRiQ53654
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiQ53654

Miscellaneous databases

EvolutionaryTraceiQ53654

Protein Ontology

More...
PROi
PR:Q53654

Family and domain databases

CDDicd00222 CollagenBindB, 6 hits
DisProtiDP00098
Gene3Di2.60.40.10, 1 hit
2.60.40.1280, 1 hit
InterProiView protein in InterPro
IPR008966 Adhesion_dom_sf
IPR008454 Collagen-bd_Cna-like_B-typ_dom
IPR008456 Collagen-bd_dom
IPR011252 Fibrogen-bd_dom1
IPR013783 Ig-like_fold
IPR019931 LPXTG_anchor
IPR041033 Prealbumin-like
PfamiView protein in Pfam
PF05738 Cna_B, 7 hits
PF05737 Collagen_bind, 1 hit
PF17802 SpaA, 1 hit
SUPFAMiSSF49401 SSF49401, 2 hits
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNA_STAAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q53654
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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