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Protein

Malto-oligosyltrehalose trehalohydrolase

Gene

treZ

Organism
Sulfolobus acidocaldarius
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan.UniRule annotation

Pathwayi: trehalose biosynthesis

This protein is involved in the pathway trehalose biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway trehalose biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei253NucleophileUniRule annotation1
Active sitei284Proton donorUniRule annotation1
Sitei376Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-5702
UniPathwayi
UPA00299

Protein family/group databases

CAZyiCBM48 Carbohydrate-Binding Module Family 48
GH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Malto-oligosyltrehalose trehalohydrolaseUniRule annotation (EC:3.2.1.141UniRule annotation)
Short name:
MTHaseUniRule annotation
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolaseUniRule annotation
Maltooligosyl trehalose trehalohydrolaseUniRule annotation
Gene namesi
Name:treZImported
ORF Names:ATY89_10830Imported, ATZ20_02385Imported
OrganismiSulfolobus acidocaldariusImported
Taxonomic identifieri2285 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000060043 Componenti: Chromosome
  • UP000065473 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ53641
SMRiQ53641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 483AamyInterPro annotationAdd BLAST377

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02951 Archaea
COG0296 LUCA

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR015156 Maltooligo_trehalose_arc_C
IPR012768 Trehalose_TreZ
PfamiView protein in Pfam
PF09071 Alpha-amyl_C, 1 hit
PF00128 Alpha-amylase, 2 hits
PIRSFiPIRSF006337 Trehalose_TreZ, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF81296 SSF81296, 1 hit
TIGRFAMsiTIGR02402 trehalose_TreZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q53641-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSFGGNIEK NKGIFKLWAP YVNSVKLKLS KKLIPMEKND EGFFEVEIDD
60 70 80 90 100
IEENLTYSYI IEDKREIPDP ASRYQPLGVH DKSQLIRTDY QILDLGKVKI
110 120 130 140 150
EDLIIYELHV GTFSQEGNFK GVIEKLDYLK DLGITGIELM PVAQFPGNRD
160 170 180 190 200
WGYDGVFLYA VQNTYGGPWE LAKLVNEAHK RGIAVILDVV YNHIGPEGNY
210 220 230 240 250
LLGLGPYFSD RYKTPWGLTF NFDDRGCDQV RKFILENVEY WFKTFKIDGL
260 270 280 290 300
RLDAVHAIFD NSPKHILQEI AEKAHQLGKF VIAESDLNDP KIVKDDCGYK
310 320 330 340 350
IDAQWVDDFH HAVHAFITKE KDYYYQDFGR IEDIEKTFKD VFVYDGKYSR
360 370 380 390 400
YRGRTHGAPV GDLPPRKFVV FIQNHDQVGN RGNGERLSIL TDKTTYLMAA
410 420 430 440 450
TLYILSPYIP LIFMGEEYYE TNPFFFFSDF SDPVLIKGVR EGRLKENNQM
460 470 480 490 500
IDPQSEEAFL KSKLSWKIDE EVLDYYKQLI NIRKRYNNCK RVKEVRREGN
510 520 530 540 550
CITLIMEKIG IIASFDDIVI NSKITGNLLI GIGFPKKLKK DELIKVNRGV

GVYQLE
Length:556
Mass (Da):64,374
Last modified:November 1, 1996 - v1
Checksum:i4215B45E6C8ED4E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013694 Genomic DNA Translation: ALU30385.1
CP013695 Genomic DNA Translation: ALU31106.1
D64131 Genomic DNA Translation: BAA11011.1
D83245 Genomic DNA Translation: BAA11863.1
PIRiJC5132
RefSeqiWP_011278268.1, NZ_LPSU01000003.1

Genome annotation databases

GeneIDi3473480

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013694 Genomic DNA Translation: ALU30385.1
CP013695 Genomic DNA Translation: ALU31106.1
D64131 Genomic DNA Translation: BAA11011.1
D83245 Genomic DNA Translation: BAA11863.1
PIRiJC5132
RefSeqiWP_011278268.1, NZ_LPSU01000003.1

3D structure databases

ProteinModelPortaliQ53641
SMRiQ53641
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM48 Carbohydrate-Binding Module Family 48
GH13 Glycoside Hydrolase Family 13

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3473480

Phylogenomic databases

eggNOGiarCOG02951 Archaea
COG0296 LUCA

Enzyme and pathway databases

UniPathwayi
UPA00299

BioCyciMetaCyc:MONOMER-5702

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR015156 Maltooligo_trehalose_arc_C
IPR012768 Trehalose_TreZ
PfamiView protein in Pfam
PF09071 Alpha-amyl_C, 1 hit
PF00128 Alpha-amylase, 2 hits
PIRSFiPIRSF006337 Trehalose_TreZ, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF81296 SSF81296, 1 hit
TIGRFAMsiTIGR02402 trehalose_TreZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ53641_9CREN
AccessioniPrimary (citable) accession number: Q53641
Secondary accession number(s): O08064, O08279, Q4J8W4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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