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UniProtKB - Q53591 (HYSA_STRA3)
Protein
Hyaluronate lyase
Gene
hylB
Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Functioni
Catalytic activityi
- EC:4.2.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 429 | 1 | ||
Active sitei | 479 | 1 | ||
Active sitei | 488 | 1 |
GO - Molecular functioni
- carbohydrate binding Source: InterPro
- hyaluronate lyase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
Keywordsi
Molecular function | Lyase |
Enzyme and pathway databases
BRENDAi | 4.2.2.1, 5917 |
Protein family/group databases
CAZyi | CBM70, Carbohydrate-Binding Module Family 70 PL8, Polysaccharide Lyase Family 8 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:hylB Ordered Locus Names:gbs1270 |
Organismi | Streptococcus agalactiae serotype III (strain NEM316) |
Taxonomic identifieri | 211110 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Miscellaneous databases
PHI-basei | PHI:3461 |
Chemistry databases
DrugBanki | DB04548, 4-Deoxy-D-Glucuronic Acid |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 40 | Sequence analysisAdd BLAST | 40 | |
ChainiPRO_0000024932 | 41 – 984 | Hyaluronate lyaseAdd BLAST | 944 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q53591 |
SMRi | Q53591 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q53591 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 49 – 68 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 701 – 728 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 52 – 68 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 701 – 727 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the polysaccharide lyase 8 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG5492, Bacteria |
HOGENOMi | CLU_004172_0_0_9 |
Family and domain databases
Gene3Di | 1.50.10.100, 1 hit 2.60.220.10, 1 hit 2.60.40.1380, 1 hit 2.70.98.10, 1 hit |
InterProi | View protein in InterPro IPR008929, Chondroitin_lyas IPR011013, Gal_mutarotase_sf_dom IPR008979, Galactose-bd-like_sf IPR014718, GH-type_carb-bd IPR023295, Hyaluronate_lyase_beta_dom_sf IPR014756, Ig_E-set IPR038970, Lyase_8 IPR011071, Lyase_8-like_C IPR012970, Lyase_8_alpha_N IPR004103, Lyase_8_C IPR003159, Lyase_8_central_dom |
PANTHERi | PTHR38481, PTHR38481, 1 hit |
Pfami | View protein in Pfam PF02278, Lyase_8, 1 hit PF02884, Lyase_8_C, 1 hit PF08124, Lyase_8_N, 1 hit |
SUPFAMi | SSF48230, SSF48230, 1 hit SSF49785, SSF49785, 1 hit SSF49863, SSF49863, 1 hit SSF74650, SSF74650, 1 hit SSF81296, SSF81296, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q53591-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQVVDNQTQ NKELVKNGDF NQTNPVSGSW SHTSAREWSA WIDKENTADK
60 70 80 90 100
SPIIQRTEQG QVSLSSDKGF RGAVTQKVNI DPTKKYEVKF DIETSNKAGQ
110 120 130 140 150
AFLRIMEKKD NNTRLWLSEM TSGTTNKHTL TKIYNPKLNV SEVTLELYYE
160 170 180 190 200
KGTGSATFDN ISMKAKGPKD SEHPQPVTTQ IEESVNTALN KNYVFNKADY
210 220 230 240 250
QYTLTNPSLG KIVGGILYPN ATGSTTVKIS DKSGKIIKEV PLSVTASTED
260 270 280 290 300
KFTKLLDKWN DVTIGNHVYD TNDSNMQKIN QKLDETNAKN IKTIKLDSNH
310 320 330 340 350
TFLWKDLDNL NNSAQLTATY RRLEDLAKQI TNPHSTIYKN EKAIRTVKES
360 370 380 390 400
LAWLHQNFYN VNKDIEGSAN WWDFEIGVPR SITATLALMN NYFTDAEIKT
410 420 430 440 450
YTDPIEHFVP DAGYFRKTLD NPFKALGGNL VDMGRVKIIE GLLRKDNTII
460 470 480 490 500
EKTSHSLKNL FTTATKAEGF YADGSYIDHT NVAYTGAYGN VLIDGLTQLL
510 520 530 540 550
PIIQETDYKI SNQELDMVYK WINQSFLPLI VKGELMDMSR GRSISREAAS
560 570 580 590 600
SHAAAVEVLR GFLRLANMSN EERNLDLKST IKTIITSNKF YNVFNNLKSY
610 620 630 640 650
SDIANMNKML NDSTVATKPL KSNLSTFNSM DRLAYYNAEK DFGFALSLHS
660 670 680 690 700
KRTLNYEGMN DENTRDWYTG DGMFYLYNSD QSHYSNHFWP TVNPYKMAGT
710 720 730 740 750
TEKDAKREDT TKEFMSKHSK DAKEKTGQVT GTSDFVGSVK LNDHFALAAM
760 770 780 790 800
DFTNWDRTLT AQKGWVILND KIVFLGSNIK NTNGIGNVST TIDQRKDDSK
810 820 830 840 850
TPYTTYVNGK TIDLKQASSQ QFTDTKSVFL ESKEPGRNIG YIFFKNSTID
860 870 880 890 900
IERKEQTGTW NSINRTSKNT SIVSNPFITI SQKHDNKGDS YGYMMVPNID
910 920 930 940 950
RTSFDKLANS KEVELLENSS KQQVIYDKNS QTWAVIKHDN QESLINNQFK
960 970 980
MNKAGLYLVQ KVGNDYQNVY YQPQTMTKTD QLAI
Sequence cautioni
The sequence CAD46929 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | E → G in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 155 – 156 | SA → FV in AAA56749 (PubMed:7982914).Curated | 2 | |
Sequence conflicti | 183 | E → K in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 246 – 251 | ASTEDK → GSPEDN in AAA56749 (PubMed:7982914).Curated | 6 | |
Sequence conflicti | 267 | H → Y in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 279 – 280 | IN → LT in AAA56749 (PubMed:7982914).Curated | 2 | |
Sequence conflicti | 288 | A → G in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 292 – 293 | KT → EA in AAA56749 (PubMed:7982914).Curated | 2 | |
Sequence conflicti | 300 | H → R in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 384 | A → G in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 387 | A → S in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 413 | G → E in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 420 | D → V in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 583 | T → A in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 609 | M → L in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 639 | E → K in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 666 | D → G in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 676 | L → I in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 688 – 689 | FW → LG in AAA56749 (PubMed:7982914).Curated | 2 | |
Sequence conflicti | 882 | Q → L in AAA56749 (PubMed:7982914).Curated | 1 | |
Sequence conflicti | 894 | M → L in AAA56749 (PubMed:7982914).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15050 Genomic DNA Translation: AAA56749.1 AL766849 Genomic DNA Translation: CAD46929.1 Different initiation. |
PIRi | A55137 |
Genome annotation databases
EnsemblBacteriai | CAD46929; CAD46929; CAD46929 |
KEGGi | san:gbs1270 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15050 Genomic DNA Translation: AAA56749.1 AL766849 Genomic DNA Translation: CAD46929.1 Different initiation. |
PIRi | A55137 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F1S | X-ray | 2.10 | A | 171-984 | [»] | |
1I8Q | X-ray | 2.20 | A | 171-984 | [»] | |
1LXM | X-ray | 2.20 | A | 171-984 | [»] | |
AlphaFoldDBi | Q53591 | |||||
SMRi | Q53591 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 211110.gbs1270 |
Chemistry databases
DrugBanki | DB04548, 4-Deoxy-D-Glucuronic Acid |
Protein family/group databases
CAZyi | CBM70, Carbohydrate-Binding Module Family 70 PL8, Polysaccharide Lyase Family 8 |
Genome annotation databases
EnsemblBacteriai | CAD46929; CAD46929; CAD46929 |
KEGGi | san:gbs1270 |
Phylogenomic databases
eggNOGi | COG5492, Bacteria |
HOGENOMi | CLU_004172_0_0_9 |
Enzyme and pathway databases
BRENDAi | 4.2.2.1, 5917 |
Miscellaneous databases
EvolutionaryTracei | Q53591 |
PHI-basei | PHI:3461 |
Family and domain databases
Gene3Di | 1.50.10.100, 1 hit 2.60.220.10, 1 hit 2.60.40.1380, 1 hit 2.70.98.10, 1 hit |
InterProi | View protein in InterPro IPR008929, Chondroitin_lyas IPR011013, Gal_mutarotase_sf_dom IPR008979, Galactose-bd-like_sf IPR014718, GH-type_carb-bd IPR023295, Hyaluronate_lyase_beta_dom_sf IPR014756, Ig_E-set IPR038970, Lyase_8 IPR011071, Lyase_8-like_C IPR012970, Lyase_8_alpha_N IPR004103, Lyase_8_C IPR003159, Lyase_8_central_dom |
PANTHERi | PTHR38481, PTHR38481, 1 hit |
Pfami | View protein in Pfam PF02278, Lyase_8, 1 hit PF02884, Lyase_8_C, 1 hit PF08124, Lyase_8_N, 1 hit |
SUPFAMi | SSF48230, SSF48230, 1 hit SSF49785, SSF49785, 1 hit SSF49863, SSF49863, 1 hit SSF74650, SSF74650, 1 hit SSF81296, SSF81296, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HYSA_STRA3 | |
Accessioni | Q53591Primary (citable) accession number: Q53591 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 17, 2003 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families