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UniProtKB - Q53139 (COBK_RHOER)
Protein
Precorrin-6A reductase
Gene
cobK
Organism
Rhodococcus erythropolis (Arthrobacter picolinophilus)
Status
Functioni
Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
Catalytic activityi
- EC:1.3.1.54
: adenosylcobalamin biosynthesis Pathwayi
This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route). This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- precorrin-6A reductase activity Source: UniProtKB-EC
GO - Biological processi
- cobalamin biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cobalamin biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00217 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cobK |
Organismi | Rhodococcus erythropolis (Arthrobacter picolinophilus) |
Taxonomic identifieri | 1833 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Nocardiaceae › Rhodococcus › Rhodococcus erythropolis group |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135922 | 1 – 248 | Precorrin-6A reductaseAdd BLAST | 248 |
Family & Domainsi
Sequence similaritiesi
Belongs to the precorrin-6x reductase family.PROSITE-ProRule annotation
Family and domain databases
InterProi | View protein in InterPro IPR003723, Precorrin-6x_reduct |
PANTHERi | PTHR36925, PTHR36925, 1 hit |
Pfami | View protein in Pfam PF02571, CbiJ, 1 hit |
TIGRFAMsi | TIGR00715, precor6x_red, 1 hit |
PROSITEi | View protein in PROSITE PS51014, COBK_CBIJ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q53139-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRILILGGT GEARALAAAL ADVPGVEAVS SLAGRVRDPR LPVGDVRIGG
60 70 80 90 100
FGGADGLAEC VRAHPVDAIV DATHPFAAQI TRNAADAAHR RGIPLVVLRR
110 120 130 140 150
PEWSPRPGEH WHGAADLADA AELLPDLGTR IFLTIGRQGV DAFADLQALW
160 170 180 190 200
FLIRAIDPPD VAMPPHSTLL LARGPFAVAD ETALMREHRI DVLVTKNSGG
210 220 230 240
GQTDAKLDAA RALGIPVLMI RRPPLPPATE TVDDVAGAIA WVGTLTRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L21196 Genomic DNA Translation: AAC37131.1 |
PIRi | T46837 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L21196 Genomic DNA Translation: AAC37131.1 |
PIRi | T46837 |
3D structure databases
SMRi | Q53139 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00217 |
Family and domain databases
InterProi | View protein in InterPro IPR003723, Precorrin-6x_reduct |
PANTHERi | PTHR36925, PTHR36925, 1 hit |
Pfami | View protein in Pfam PF02571, CbiJ, 1 hit |
TIGRFAMsi | TIGR00715, precor6x_red, 1 hit |
PROSITEi | View protein in PROSITE PS51014, COBK_CBIJ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COBK_RHOER | |
Accessioni | Q53139Primary (citable) accession number: Q53139 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families