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UniProtKB - Q52WX2 (SBK1_HUMAN)
Protein
Serine/threonine-protein kinase SBK1
Gene
SBK1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in signal-transduction pathways related to the control of brain development.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 82 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 174 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 59 – 67 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- brain development Source: Ensembl
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q52WX2 |
SignaLinki | Q52WX2 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)Alternative name(s): SH3-binding kinase 1 |
Gene namesi | Name:SBK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17699, SBK1 |
neXtProti | NX_Q52WX2 |
VEuPathDBi | HostDB:ENSG00000188322 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 388228 |
OpenTargetsi | ENSG00000188322 |
PharmGKBi | PA134887617 |
Miscellaneous databases
Pharosi | Q52WX2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1163129 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q52WX2 |
Genetic variation databases
BioMutai | SBK1 |
DMDMi | 74762155 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000238451 | 1 – 424 | Serine/threonine-protein kinase SBK1Add BLAST | 424 |
Proteomic databases
MassIVEi | Q52WX2 |
PaxDbi | Q52WX2 |
PeptideAtlasi | Q52WX2 |
PRIDEi | Q52WX2 |
ProteomicsDBi | 62433 |
PTM databases
iPTMneti | Q52WX2 |
PhosphoSitePlusi | Q52WX2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188322, Expressed in cortical plate and 173 other tissues |
Genevisiblei | Q52WX2, HS |
Organism-specific databases
HPAi | ENSG00000188322, Tissue enhanced (brain, skeletal muscle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 132609, 35 interactors |
STRINGi | 9606.ENSP00000343248 |
Chemistry databases
BindingDBi | Q52WX2 |
Miscellaneous databases
RNActi | Q52WX2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 318 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 266 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 321 – 373 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 390 – 412 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1345, Eukaryota |
GeneTreei | ENSGT00940000154852 |
HOGENOMi | CLU_000288_10_1_1 |
InParanoidi | Q52WX2 |
OMAi | IFCFIKY |
OrthoDBi | 1221624at2759 |
PhylomeDBi | Q52WX2 |
TreeFami | TF326736 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR016234, Ser/Thr_kinase_Sbk1 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF000566, Ser/Thr_PK_Sbk1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q52WX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EDCYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHGRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP
360 370 380 390 400
LKRTVLTESG SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP
410 420
GRTDGRADKS KGQVVLATAI EICV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A590UK17 | A0A590UK17_HUMAN | Serine/threonine-protein kinase SBK... | SBK1 | 512 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051665 | 12 | R → H. Corresponds to variant dbSNP:rs35448675Ensembl. | 1 | |
Natural variantiVAR_041068 | 92 | K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041069 | 250 | N → T1 PublicationCorresponds to variant dbSNP:rs56072383Ensembl. | 1 | |
Natural variantiVAR_041070 | 261 | A → S1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY874862 mRNA Translation: AAX59898.1 |
CCDSi | CCDS32416.1 |
RefSeqi | NP_001019572.1, NM_001024401.2 |
Genome annotation databases
Ensembli | ENST00000341901.5; ENSP00000343248.4; ENSG00000188322.8 |
GeneIDi | 388228 |
KEGGi | hsa:388228 |
MANE-Selecti | ENST00000341901.5; ENSP00000343248.4; NM_001024401.3; NP_001019572.1 |
UCSCi | uc002dpd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY874862 mRNA Translation: AAX59898.1 |
CCDSi | CCDS32416.1 |
RefSeqi | NP_001019572.1, NM_001024401.2 |
3D structure databases
AlphaFoldDBi | Q52WX2 |
SMRi | Q52WX2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132609, 35 interactors |
STRINGi | 9606.ENSP00000343248 |
Chemistry databases
BindingDBi | Q52WX2 |
ChEMBLi | CHEMBL1163129 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q52WX2 |
PTM databases
iPTMneti | Q52WX2 |
PhosphoSitePlusi | Q52WX2 |
Genetic variation databases
BioMutai | SBK1 |
DMDMi | 74762155 |
Proteomic databases
MassIVEi | Q52WX2 |
PaxDbi | Q52WX2 |
PeptideAtlasi | Q52WX2 |
PRIDEi | Q52WX2 |
ProteomicsDBi | 62433 |
Protocols and materials databases
Antibodypediai | 55882, 22 antibodies from 13 providers |
DNASUi | 388228 |
Genome annotation databases
Ensembli | ENST00000341901.5; ENSP00000343248.4; ENSG00000188322.8 |
GeneIDi | 388228 |
KEGGi | hsa:388228 |
MANE-Selecti | ENST00000341901.5; ENSP00000343248.4; NM_001024401.3; NP_001019572.1 |
UCSCi | uc002dpd.3, human |
Organism-specific databases
CTDi | 388228 |
DisGeNETi | 388228 |
GeneCardsi | SBK1 |
HGNCi | HGNC:17699, SBK1 |
HPAi | ENSG00000188322, Tissue enhanced (brain, skeletal muscle) |
neXtProti | NX_Q52WX2 |
OpenTargetsi | ENSG00000188322 |
PharmGKBi | PA134887617 |
VEuPathDBi | HostDB:ENSG00000188322 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1345, Eukaryota |
GeneTreei | ENSGT00940000154852 |
HOGENOMi | CLU_000288_10_1_1 |
InParanoidi | Q52WX2 |
OMAi | IFCFIKY |
OrthoDBi | 1221624at2759 |
PhylomeDBi | Q52WX2 |
TreeFami | TF326736 |
Enzyme and pathway databases
PathwayCommonsi | Q52WX2 |
SignaLinki | Q52WX2 |
Miscellaneous databases
BioGRID-ORCSi | 388228, 13 hits in 1101 CRISPR screens |
ChiTaRSi | SBK1, human |
GenomeRNAii | 388228 |
Pharosi | Q52WX2, Tchem |
PROi | PR:Q52WX2 |
RNActi | Q52WX2, protein |
Gene expression databases
Bgeei | ENSG00000188322, Expressed in cortical plate and 173 other tissues |
Genevisiblei | Q52WX2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR016234, Ser/Thr_kinase_Sbk1 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF000566, Ser/Thr_PK_Sbk1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SBK1_HUMAN | |
Accessioni | Q52WX2Primary (citable) accession number: Q52WX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families