Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SBK1

Gene

SBK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in signal-transduction pathways related to the control of brain development.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82ATPPROSITE-ProRule annotation1
Active sitei174Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ52WX2

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)
Alternative name(s):
SH3-binding kinase 1
Gene namesi
Name:SBK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000188322.4
HGNCiHGNC:17699 SBK1
neXtProtiNX_Q52WX2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi388228
OpenTargetsiENSG00000188322
PharmGKBiPA134887617

Chemistry databases

ChEMBLiCHEMBL1163129

Polymorphism and mutation databases

BioMutaiSBK1
DMDMi74762155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384511 – 424Serine/threonine-protein kinase SBK1Add BLAST424

Proteomic databases

EPDiQ52WX2
PaxDbiQ52WX2
PeptideAtlasiQ52WX2
PRIDEiQ52WX2
ProteomicsDBi62433

PTM databases

iPTMnetiQ52WX2
PhosphoSitePlusiQ52WX2

Expressioni

Gene expression databases

BgeeiENSG00000188322 Expressed in 152 organ(s), highest expression level in brain
CleanExiHS_SBK1
GenevisibleiQ52WX2 HS

Interactioni

Protein-protein interaction databases

BioGridi132609, 7 interactors
STRINGi9606.ENSP00000343248

Chemistry databases

BindingDBiQ52WX2

Structurei

3D structure databases

ProteinModelPortaliQ52WX2
SMRiQ52WX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 318Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 400Pro-richAdd BLAST69

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
HOVERGENiHBG108481
InParanoidiQ52WX2
KOiK08858
OMAiEEMVKRC
OrthoDBiEOG091G0QNH
PhylomeDBiQ52WX2
TreeFamiTF326736

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR016234 Ser/Thr_kinase_Sbk1
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q52WX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EDCYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHGRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP
360 370 380 390 400
LKRTVLTESG SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP
410 420
GRTDGRADKS KGQVVLATAI EICV
Length:424
Mass (Da):46,252
Last modified:May 24, 2005 - v1
Checksum:i2E07FFDA5693311F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05166512R → H. Corresponds to variant dbSNP:rs35448675Ensembl.1
Natural variantiVAR_04106892K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041069250N → T1 PublicationCorresponds to variant dbSNP:rs56072383Ensembl.1
Natural variantiVAR_041070261A → S1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY874862 mRNA Translation: AAX59898.1
CCDSiCCDS32416.1
RefSeqiNP_001019572.1, NM_001024401.2
UniGeneiHs.97837

Genome annotation databases

EnsembliENST00000341901; ENSP00000343248; ENSG00000188322
GeneIDi388228
KEGGihsa:388228
UCSCiuc002dpd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY874862 mRNA Translation: AAX59898.1
CCDSiCCDS32416.1
RefSeqiNP_001019572.1, NM_001024401.2
UniGeneiHs.97837

3D structure databases

ProteinModelPortaliQ52WX2
SMRiQ52WX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132609, 7 interactors
STRINGi9606.ENSP00000343248

Chemistry databases

BindingDBiQ52WX2
ChEMBLiCHEMBL1163129

PTM databases

iPTMnetiQ52WX2
PhosphoSitePlusiQ52WX2

Polymorphism and mutation databases

BioMutaiSBK1
DMDMi74762155

Proteomic databases

EPDiQ52WX2
PaxDbiQ52WX2
PeptideAtlasiQ52WX2
PRIDEiQ52WX2
ProteomicsDBi62433

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341901; ENSP00000343248; ENSG00000188322
GeneIDi388228
KEGGihsa:388228
UCSCiuc002dpd.3 human

Organism-specific databases

CTDi388228
DisGeNETi388228
EuPathDBiHostDB:ENSG00000188322.4
GeneCardsiSBK1
HGNCiHGNC:17699 SBK1
neXtProtiNX_Q52WX2
OpenTargetsiENSG00000188322
PharmGKBiPA134887617
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
HOVERGENiHBG108481
InParanoidiQ52WX2
KOiK08858
OMAiEEMVKRC
OrthoDBiEOG091G0QNH
PhylomeDBiQ52WX2
TreeFamiTF326736

Enzyme and pathway databases

SignaLinkiQ52WX2

Miscellaneous databases

ChiTaRSiSBK1 human
GenomeRNAii388228
PROiPR:Q52WX2

Gene expression databases

BgeeiENSG00000188322 Expressed in 152 organ(s), highest expression level in brain
CleanExiHS_SBK1
GenevisibleiQ52WX2 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR016234 Ser/Thr_kinase_Sbk1
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBK1_HUMAN
AccessioniPrimary (citable) accession number: Q52WX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again