SBK1

Functionⁱ

May be involved in signal-transduction pathways related to the control of brain development.By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	82	ATPPROSITE-ProRule annotation		1
Active siteⁱ	174	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	59 – 67	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

peptidyl-serine phosphorylation Source: GO_Central
peptidyl-threonine phosphorylation Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q52WX2

SignaLinkⁱ

Q52WX2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase SBK1 (EC:2.7.11.1) Alternative name(s): SH3-binding kinase 1
Gene namesⁱ	Name:SBK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188322.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17699 SBK1
neXtProtⁱ	NX_Q52WX2

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	388228
Open Targets More...OpenTargetsⁱ	ENSG00000188322
PharmGKBⁱ	PA134887617

Chemistry databases

ChEMBLⁱ	CHEMBL1163129

ChEMBLⁱ

CHEMBL1163129

Polymorphism and mutation databases

BioMutaⁱ	SBK1
DMDMⁱ	74762155

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000238451	1 – 424	Serine/threonine-protein kinase SBK1Add BLAST		424

Proteomic databases

EPDⁱ	Q52WX2
PaxDbⁱ	Q52WX2
PeptideAtlas More...PeptideAtlasⁱ	Q52WX2
PRIDEⁱ	Q52WX2
ProteomicsDBⁱ	62433

PTM databases

iPTMnetⁱ	Q52WX2
PhosphoSitePlusⁱ	Q52WX2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188322 Expressed in 152 organ(s), highest expression level in brain
CleanExⁱ	HS_SBK1
Genevisibleⁱ	Q52WX2 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	132609, 7 interactors
STRINGⁱ	9606.ENSP00000343248

Chemistry databases

BindingDBⁱ

Q52WX2

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q52WX2
SMRⁱ	Q52WX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	53 – 318	Protein kinasePROSITE-ProRule annotationAdd BLAST		266

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	332 – 400	Pro-richAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1345 Eukaryota ENOG41112JR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099954
HOGENOMⁱ	HOG000063666
HOVERGENⁱ	HBG108481
InParanoidⁱ	Q52WX2
KEGG Orthology (KO) More...KOⁱ	K08858
OMAⁱ	LTCCGPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QNH
PhylomeDBⁱ	Q52WX2
TreeFamⁱ	TF326736

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR016234 Ser/Thr_kinase_Sbk1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q52WX2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT 
        60         70         80         90        100
KHYELVRELG KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI 
       110        120        130        140        150
TNSLSSSPFI IKVFDVVFET EDCYVFAQEY APAGDLFDII PPQVGLPEDT 
       160        170        180        190        200
VKRCVQQLGL ALDFMHGRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR 
       210        220        230        240        250
VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG VLIFCVLTGN 
       260        270        280        290        300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP 
       310        320        330        340        350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP 
       360        370        380        390        400
LKRTVLTESG SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP 
       410        420 
GRTDGRADKS KGQVVLATAI EICV

Length:424

Mass (Da):46,252

Last modified:May 24, 2005 - v1

Checksum:ⁱ2E07FFDA5693311F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_051665	12	R → H. Corresponds to variant dbSNP:rs35448675Ensembl.	1
Natural variantⁱVAR_041068	92	K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041069	250	N → T1 PublicationCorresponds to variant dbSNP:rs56072383Ensembl.	1
Natural variantⁱVAR_041070	261	A → S1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY874862 mRNA Translation: AAX59898.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32416.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001019572.1, NM_001024401.2
UniGeneⁱ	Hs.97837

Genome annotation databases

Ensemblⁱ	ENST00000341901; ENSP00000343248; ENSG00000188322
GeneIDⁱ	388228
KEGGⁱ	hsa:388228
UCSC genome browser More...UCSCⁱ	uc002dpd.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q52WX2	Serine/threonine-protein kinase SBK1		MACNE		424	UniRef90_Q52WX2
Serine/threonine-protein kinase SBK1		PANTR		424
Serine/threonine-protein kinase SBK1		PAPAN		424
Serine/threonine-protein kinase SBK1		CERAT		424
Serine/threonine-protein kinase SBK1 (Fragment)		MACMU		338
+18

Protein	Similar proteins		Species	Score	Length	Source
Q52WX2	Serine/threonine-protein kinase SBK1		RAT		417	UniRef50_Q9Z335
Serine/threonine-protein kinase SBK1		MOUSE		417
Serine/threonine-protein kinase SBK1		CALJA		426
Serine/threonine-protein kinase SBK1		Cebus capucinus imitator		426
Serine/threonine-protein kinase SBK1		PONAB		426
+237

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY874862 mRNA Translation: AAX59898.1
CCDSⁱ	CCDS32416.1
RefSeqⁱ	NP_001019572.1, NM_001024401.2
UniGeneⁱ	Hs.97837

3D structure databases

ProteinModelPortalⁱ	Q52WX2
SMRⁱ	Q52WX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	132609, 7 interactors
STRINGⁱ	9606.ENSP00000343248

Chemistry databases

BindingDBⁱ	Q52WX2
ChEMBLⁱ	CHEMBL1163129

PTM databases

iPTMnetⁱ	Q52WX2
PhosphoSitePlusⁱ	Q52WX2

Polymorphism and mutation databases

BioMutaⁱ	SBK1
DMDMⁱ	74762155

Proteomic databases

EPDⁱ	Q52WX2
PaxDbⁱ	Q52WX2
PeptideAtlasⁱ	Q52WX2
PRIDEⁱ	Q52WX2
ProteomicsDBⁱ	62433

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000341901; ENSP00000343248; ENSG00000188322
GeneIDⁱ	388228
KEGGⁱ	hsa:388228
UCSCⁱ	uc002dpd.3 human

Organism-specific databases

CTDⁱ	388228
DisGeNETⁱ	388228
EuPathDBⁱ	HostDB:ENSG00000188322.4
GeneCardsⁱ	SBK1
HGNCⁱ	HGNC:17699 SBK1
neXtProtⁱ	NX_Q52WX2
OpenTargetsⁱ	ENSG00000188322
PharmGKBⁱ	PA134887617
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1345 Eukaryota ENOG41112JR LUCA
GeneTreeⁱ	ENSGT00680000099954
HOGENOMⁱ	HOG000063666
HOVERGENⁱ	HBG108481
InParanoidⁱ	Q52WX2
KOⁱ	K08858
OMAⁱ	LTCCGPG
OrthoDBⁱ	EOG091G0QNH
PhylomeDBⁱ	Q52WX2
TreeFamⁱ	TF326736

Enzyme and pathway databases

SignaLinkⁱ	Q52WX2

SignaLinkⁱ

Q52WX2

Miscellaneous databases

ChiTaRSⁱ	SBK1 human
GenomeRNAiⁱ	388228
Protein Ontology More...PROⁱ	PR:Q52WX2

Gene expression databases

Bgeeⁱ	ENSG00000188322 Expressed in 152 organ(s), highest expression level in brain
CleanExⁱ	HS_SBK1
Genevisibleⁱ	Q52WX2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR016234 Ser/Thr_kinase_Sbk1
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SBK1_HUMAN
Accessionⁱ	Q52WX2Primary (citable) accession number: Q52WX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	May 24, 2005
	Last modified:	September 12, 2018
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q52WX2 (SBK1_HUMAN)

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Serine/threonine-protein kinase SBK1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ