Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 92 (11 Dec 2019)
Sequence version 1 (24 May 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

BRCA1-like protein

Gene
N/A
Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BRCA1-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 69RING-typeInterPro annotationAdd BLAST42
Domaini1633 – 1717BRCTInterPro annotationAdd BLAST85
Domaini1737 – 1836BRCTInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 336DisorderedSequence analysisAdd BLAST30
Regioni641 – 672DisorderedSequence analysisAdd BLAST32
Regioni746 – 810DisorderedSequence analysisAdd BLAST65
Regioni904 – 925DisorderedSequence analysisAdd BLAST22
Regioni1085 – 1119DisorderedSequence analysisAdd BLAST35
Regioni1148 – 1219DisorderedSequence analysisAdd BLAST72
Regioni1262 – 1289DisorderedSequence analysisAdd BLAST28
Regioni1310 – 1382DisorderedSequence analysisAdd BLAST73
Regioni1415 – 1536DisorderedSequence analysisAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili218 – 238Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi312 – 329PolarSequence analysisAdd BLAST18
Compositional biasi641 – 661PolarSequence analysisAdd BLAST21
Compositional biasi783 – 807PolarSequence analysisAdd BLAST25
Compositional biasi904 – 921PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1091 – 1106PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1162 – 1189PolarSequence analysisAdd BLAST28
Compositional biasi1310 – 1332PolarSequence analysisAdd BLAST23
Compositional biasi1333 – 1356PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1364 – 1382PolarSequence analysisAdd BLAST19
Compositional biasi1415 – 1442PolarSequence analysisAdd BLAST28
Compositional biasi1443 – 1457PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1458 – 1510PolarSequence analysisAdd BLAST53
Compositional biasi1511 – 1535PolyampholyteSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITQ4 Eukaryota
ENOG4112BIH LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230969

KEGG Orthology (KO)

More...
KOi
K10605

Database of Orthologous Groups

More...
OrthoDBi
496760at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011364 BRCA1
IPR031099 BRCA1-associated
IPR025994 BRCA1_serine_dom
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR13763 PTHR13763, 1 hit
PTHR13763:SF0 PTHR13763:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533 BRCT, 2 hits
PF12820 BRCT_assoc, 1 hit
PF00097 zf-C3HC4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001734 BRCA1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00493 BRSTCANCERI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 2 hits
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113 SSF52113, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 2 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q52P67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ESKEMDLPTV TIEEVKNVLI GMQKILECPI CLELIKEPVS TTCDHIFCRF
60 70 80 90 100
CMLKLLSKKK GPSQCPLCKN NITKRSLRES TRFNQLVEGL LKTIRAFELD
110 120 130 140 150
TGFQFSNTQD FSKWERRTPE PLKKEAATIQ SIGYRNRSKR FKASESENST
160 170 180 190 200
LESSLGVQLY DLGIRKGSLR KQKKCIKNNA VYIKLGSDSS EDGVKNAICN
210 220 230 240 250
SVKDQGLCQT SPKGTRLKSK EKAEYEFSER AIKSLQQHQS NTVDVHVINE
260 270 280 290 300
NATEGHSEES RGVSSSDLNM KPWNTDIHAS SLPPEITSVL TNTVSMNIEK
310 320 330 340 350
AELCDKSKRP GLARSQQISQ DNSKEKCSAG KTSYAEVPHE LNPHHLYERQ
360 370 380 390 400
ELEEQPECPK YPRGNPQNCL SGTKLKSSIQ KVNDWLSRSN DILVSDYSSV
410 420 430 440 450
RIHEQNAEMA SVLEIGHPDT TDGNSSISGK TDLVADSTDG AWLHMSERSC
460 470 480 490 500
PRQAENNNIE DKIFGKTYHR KSVHTNLNYV TENLIVGAVA SDCLIPPEHV
510 520 530 540 550
KQTRLKRKRK TISDLQPEDF IKKTDTEFTH KSPEKKIHAV DQILEQEQNG
560 570 580 590 600
QVMNTVNGHL EQKALVDGHV EEVNDALASE LLPVEKESTF RTGTDSAAGS
610 620 630 640 650
INHGGLKLNG RNAKMTKKDK LRKKSSARIV HELELIVDKN PSSSNETELQ
660 670 680 690 700
IDSYPSSEEI RKGNNSEQKQ IRRSRRLQLL SEEIAMETKK AYEPDEQAEK
710 720 730 740 750
SCVNEVFPDL KMGNIPACDT VSLTTESDQM LASCSVTEEG HEKSLEAVQS
760 770 780 790 800
SQDQEDLAIS GGEGSQGQRA KGNLEALEVP DTDWDTQDST SLFPANTPQN
810 820 830 840 850
SKAGPNPHRS QCGIMETPKE LLDGCSSENT GSTTEDLRGL MRQGVKNASE
860 870 880 890 900
TTTEMEDSEL DTQYLQNTFK RSKRQTFALG SSPRQECMKP CAISQALHQR
910 920 930 940 950
GLHNATDCGD HEKEKLGNRE SNKPVQAKSA VMNLAVVCQI ERKPSDCASV
960 970 980 990 1000
SRICHIDPLH GGNDCEFIAG NNEEISQVPN QKQSVSPAGS STSKIIYTKK
1010 1020 1030 1040 1050
LLEENLDEIS PETAVGNEIL AQSSLSLVSP SNSRDCVSKV ADLNRFIGIG
1060 1070 1080 1090 1100
SNGEGSQAEK HKNKESELNT LPKLKLVQPQ VCQQSFPQDN FSKEPEREEK
1110 1120 1130 1140 1150
EENVKLTPAI SADSSPCLEQ TKENTHFTQV WSETPDLLDS DGELKENTSF
1160 1170 1180 1190 1200
AESDIKEQSA VFGKNGKSSQ VRKSRKNLSP LVHRNPSLSW KSRRQARKLE
1210 1220 1230 1240 1250
SSEEEASSEE GELPSFQDLI FGKAASTPFQ PTKNKTIAKE FSANEAKENL
1260 1270 1280 1290 1300
AFLNRNNMSV NNLQIPSGEA SQDHDSSQES ECSGSLFSSH SNSLEDLAGK
1310 1320 1330 1340 1350
ANDKDSALVF GSSHQESSHS RTQEIQSGSE MPKASQDKEE RETDLDEDHH
1360 1370 1380 1390 1400
PKDQGVDSNL VVEGSGYDSE TSHPGDTSQL SFQSDILTTQ QRDTMQDNLK
1410 1420 1430 1440 1450
KLQQEMAVLE AVLEQHSSQV TNNSSSQEPG LCPSMDQPDL KQTNSERGAE
1460 1470 1480 1490 1500
ENVDHHKSQN VQSFSADKSR AFPSDSNSKN EEAGVEGSSF SKSQMPNRVW
1510 1520 1530 1540 1550
SPLSRSRTPW EGDSPSEESG KVTTRKEEHK RQPNEQGVLK QNLEITTEPE
1560 1570 1580 1590 1600
SGVKVNLKNI KSNPHQNKDP ALRNIFNLPT STSALRSSQL QTIEATNTTA
1610 1620 1630 1640 1650
PCAPACNVRG QLKEDSASER LKKGGTGNRK ISLVSSGLTP KENMLVQKFA
1660 1670 1680 1690 1700
RKTHSTVSHQ ITEGTTHVIM KTDAEFVCER TLKYFLGIAG GKWVVSFLWV
1710 1720 1730 1740 1750
VQSFKEGKML PECDFEVRGD VINGRNHRGP ERARESQGMK IFRGLEICCY
1760 1770 1780 1790 1800
GPFTDMSTDQ LEWMVQLCGA SVVKKPSSLR FRVGSSPVVV VQPDAWEDDS
1810 1820 1830 1840
SFQEIGLVCE APVVTREWVL DSVACYQRQE LDTYLISQTS PSLC
Length:1,844
Mass (Da):204,541
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC88EC19A9080452D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY994160 mRNA Translation: AAX92675.1

NCBI Reference Sequences

More...
RefSeqi
NP_001029141.1, NM_001033969.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
554178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mdo:554178

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY994160 mRNA Translation: AAX92675.1
RefSeqiNP_001029141.1, NM_001033969.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi554178
KEGGimdo:554178

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
672

Phylogenomic databases

eggNOGiENOG410ITQ4 Eukaryota
ENOG4112BIH LUCA
HOGENOMiHOG000230969
KOiK10605
OrthoDBi496760at2759

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR011364 BRCA1
IPR031099 BRCA1-associated
IPR025994 BRCA1_serine_dom
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR13763 PTHR13763, 1 hit
PTHR13763:SF0 PTHR13763:SF0, 1 hit
PfamiView protein in Pfam
PF00533 BRCT, 2 hits
PF12820 BRCT_assoc, 1 hit
PF00097 zf-C3HC4, 1 hit
PIRSFiPIRSF001734 BRCA1, 1 hit
PRINTSiPR00493 BRSTCANCERI
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF52113 SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ52P67_MONDO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q52P67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: December 11, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again